Flavin-containing monooxygenase mRNA levels are up-regulated in ALS brain areas in SOD1-mutant mice

Neurotoxicity Research

Volumn 20, Issue 2, 2011, Pages 150-158

  Gagliardi, Stella ^a,b   Ogliari, Paolo ^a   Davin, Annalisa ^a   Corato, Manuel ^a,b   Cova, Emanuela ^a   Abel, Kenneth ^c   Cashman, John R ^c   Ceroni, Mauro ^a   Cereda, Cristina ^a  

^a C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Exposure to toxins; FMO; qPCR; SOD1

Indexed keywords

DIMETHYLANILINE MONOOXYGENASE; MESSENGER RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MAPPING; BRAIN STEM; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; FMO2 GENE; FMO3 GENE; FMO4 GENE; FMO5 GENE; GENE; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HPRT GENE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOD1 GENE; SPINAL CORD; TRANSGENE; UPREGULATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXYGENASES; RNA, MESSENGER; SEX FACTORS; STATISTICS, NONPARAMETRIC; SUPEROXIDE DISMUTASE; UP-REGULATION;

MUS;

EID: 80052623000     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-010-9230-y     Document Type: Article

References (46)

1. Abel EL (2007) Football increases the risk for Lou Gehrig's disease, amyotrophic lateral sclerosis. Percept Mot Skills 104(3 pt 2):1251-1254
2. Behl C, Widmann M, Trapp T, Holsboer F (1995) 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216(2):473-812
3. Cashman JR (1995) Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem Res Toxicol 8(2):166-181
4. Cereda C, Gabanti E, Corato M, de Silvestri A, Alimonti D, Cova E, Malaspina A, Ceroni M (2006) Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 7(4):227-234
5. Choi CI, Lee YD, Gwag BJ, Cho SI, Kim SS, Suh-Kim H (2008) Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice. J Neurol Sci 268:40-47 (Pubitemid 351389466)
6. Cleveland DW, Rothstein JD (2001) From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2:806-819 (Pubitemid 33674062)
7. Coecke S, Debast G, Phillips IR, Vercruysse A, Shephard EA, Rogiers V (1998) Hormonal regulation of microsomal flavincontaining monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes. Biochem Pharmacol 56(8):1047-1051 (Pubitemid 28454571)
8. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlong CE (2003) Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 8(1):1-12 (Pubitemid 36097533)
9. Elfarra AA (1995) Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds. Chem Biol Interact 96(1):47-55
10. Falls JG, Ryu DJ, Cao Y, Levi PE, Hodgson E (1997) Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids. Arch Biochem Biophys 342(2):212-223 (Pubitemid 27251241)
11. Frutiger K, Lukas TJ, Gorrie G, Ajroud-Driss S, Siddique T (2008) Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9(3):184-187 (Pubitemid 351983181)
12. Gagliardi S, Cova E, Davin A, Guareschi S, Abel K, Alvisi E, Laforenza U, Ghidoni R, Cashman JR, Ceroni M, Cereda C (2010) SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis. Neurobiol Dis 39(2):198-203
13. Garbuzova-Davis S, Saporta S, Haller E, Kolomey I, Bennett SP, Potter H, Sanberg PR (2007) Evidence of compromised bloodspinal cord barrier in early and late symptomatic SOD1 mice modelling ALS. PloS One 2(11):e1205
14. Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM (1994) The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. Toxicol Appl Pharmacol 125:1-6 (Pubitemid 24104447)
15. Janmohamed A, Hernandez D, Phillips IR, Shephard EA (2004) Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Biochem Pharmacol 68(1):73-83 (Pubitemid 38746543)
16. Johnson FO, Atchison WD (2009) The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis. Neurotoxicology 30(5):761-765
17. Kruman II, Pedersen WA, Springer JE, Mattson MP (1999) ALSlinked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol 160(1):28-39
18. LeBel CP, Ali S, McKee M, Bondy SC (1990) Organometal-induced increases in oxygen reactive species: the potential of 20,70- dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:341-346
19. Leoni C, Buratti FM, Testai E (2008) The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol Appl Pharmacol 233(2):343-352 (Pubitemid 50308142)
20. Li CY, Sung FC (2003) Association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis: a review. Am J Ind Med 43(2):212-220
21. Liu D (1996) The roles of free radicals in amyotrophic lateral sclerosis. J Mol Neurosci 7(3):159-167 (Pubitemid 126718447)
22. Liu R, Althaus JS, Ellerbrock BR, Becker DA, Gurney ME (1998) Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann Neurol 44(5):763-770 (Pubitemid 28516047)
23. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25(4):402-408 (Pubitemid 34164012)
24. Mahoney DJ, Kaczor JJ, Bourgeois J, Yasuda N, Tarnopolsky MA (2006) Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle. Muscle Nerve 33(6): 809-816 (Pubitemid 43856799)
25. Malaspina A, Kaushik N, de Belleroche J (2001) Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays. J Neurochem 77(1):132-145 (Pubitemid 32245087)
26. Manjaly ZR, Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH, Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M, Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A (2010) The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler 11(5):439-442
27. Mulder DW, Kurland LT, Iriarte LL (1954) Neurologic diseases on the island of Guam. U S Armed Forces Med J 5(12):1724-1739
28. Pamphlett R, Patricia W (1996) Motor neuron uptake of low dose inorganic mercury. J Neurol Sci 135:63-67 (Pubitemid 26019023)
29. Rao AK, Ziegler YS, McLeod IX, Yates JR, Nardulli AM (2008) Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells. Mol Endocrinol 22(5):1113-1124 (Pubitemid 351629612)
30. Ricci C, Battistini S, Cozzi L, Benigni M, Origone P, Verriello L, Lunetta C, Cereda C, Milani P, Greco G, Patrosso MC, Causarano R, Caponnetto C, Giannini F, Corbo M, Penco S (2010) Lack of association of PON polymorphisms with sporadic ALS in an Italian population. Neurobiol Aging Apr 7 [Epub ahead of print]
31. Rizzardini M, Lupi M, Bernasconi S, Mangolini A, Cantoni L (2003) Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. J Neurol Sci 207(1-2):51-58 (Pubitemid 36287103)
32. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362(6415): 59-62 (Pubitemid 23087289)
33. Saeed M, Siddique N, Hung WY, Usacheva E, Liu E, Sufit RL, Heller SL, Haines JL, Pericak-Vance M, Siddique T (2006) Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology 67(5):771-776 (Pubitemid 44394187)
34. Shaw PJ (2005) Molecular and cellular pathways of neurodegeneration in motor neurone disease. J Neurol Neurosurg Psychiatry 76:1046-1057 (Pubitemid 41081274)
35. Siddens LK, Henderson MC, Vandyke JE, Williams DE, Krueger SK (2008) Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms. Biochem Pharmacol 75(2):570-579 (Pubitemid 350298474)
36. Slowik A, Tomik B, Wolkow PP, Partyka D, Turaj W, Malecki MT, Pera J, Dziedzic T, Szczudlik A, Figlewicz DA (2006) Paraoxonase gene polymorphisms and sporadic ALS. Neurology 67(5):766-770 (Pubitemid 44394186)
37. Steele JC, McGeer PL (2008) The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology 70(21):1984-1990
38. Su M, Wakabayashi K, Kakita A, Ikuta F, Takahashi H (1998) Selective involvement of large motor neurons in the spinal cord of rats treated with methylmercury. J Neurol Sci 156:12-17 (Pubitemid 28141033)
39. Suh JK, Robertus JD (2000) Yeast flavin-containing monooxygenase is induced by the unfolded protein response. Proc Natl Acad Sci U S A 97(1):121-126 (Pubitemid 30055794)
40. Suh JK, Poulsen LL, Ziegler DM, Robertus JD (1999) Yeast flavincontaining monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum. Proc Natl Acad Sci U S A 96(6):2687-2691 (Pubitemid 29148779)
41. Venkatesh K, Levi PE, Hodgson E (1991) The flavin-containing monooxygenase of mouse kidney. A comparison with the liver enzyme. Biochem Pharmacol 42(7):1411-1420
42. Venkatesh K, Blake B, Levi PE, Hodgson E (1992) The flavincontaining monooxygenase in mouse lung: evidence for expression of multiple forms. J Biochem Toxicol 7(3):163-169
43. Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD (2001) Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol Dis 8(6):933-941 (Pubitemid 34017087)
44. Weisskopf MG, Ascherio A (2009) Cigarettes and amyotrophic lateral sclerosis: only smoke or also fire? Ann Neurol 65(4):361-362
45. Wills AM, Cronin S, Slowik A, Kasperaviciute D, Van Es MA, Morahan JM, Valdmanis PN, Meininger V, Melki J, Shaw CE, Rouleau GA, Fisher EM, Shaw PJ, Morrison KE, Pamphlett R, Van den Berg LH, Figlewicz DA, Andersen PM, Al-Chalabi A, Hardiman O, Purcell S, Landers JE, Brown RH Jr (2009) A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology 73(1):16-24
46. Zhang J, Cashman JR (2006) Quantitative analysis of FMO gene mRNA levels in human tissue. Drug Metab Dispos 34(1):19-26 (Pubitemid 43042642)