-
1
-
-
0035093737
-
DNA double-strand breaks: signaling, repair and the cancer connection
-
Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 2001, 27:247-254.
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
3
-
-
59849089955
-
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
-
Mahaney B.L., Meek K., Lees-Miller S.P. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 2009, 417:639-650.
-
(2009)
Biochem. J.
, vol.417
, pp. 639-650
-
-
Mahaney, B.L.1
Meek, K.2
Lees-Miller, S.P.3
-
4
-
-
33847355994
-
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer
-
Lee M.N., Tseng R.C., Hsu H.S., Chen J.Y., Tzao C., Ho W.L., Wang Y.C. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin. Cancer Res. 2007, 13:832-838.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 832-838
-
-
Lee, M.N.1
Tseng, R.C.2
Hsu, H.S.3
Chen, J.Y.4
Tzao, C.5
Ho, W.L.6
Wang, Y.C.7
-
5
-
-
67649618877
-
Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiplegenotype-phenotype study
-
Tseng R.C., Hsieh F.J., Shih C.M., Hsu H.S., Chen C.Y., Wang Y.C. Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiplegenotype-phenotype study. Cancer 2009, 115:2939-2948.
-
(2009)
Cancer
, vol.115
, pp. 2939-2948
-
-
Tseng, R.C.1
Hsieh, F.J.2
Shih, C.M.3
Hsu, H.S.4
Chen, C.Y.5
Wang, Y.C.6
-
7
-
-
0034011881
-
Ku autoantigen: a multifunctional DNA-binding protein
-
Tuteja R., Tuteja N. Ku autoantigen: a multifunctional DNA-binding protein. Crit. Rev. Biochem. Mol. Biol. 2000, 35:1-33.
-
(2000)
Crit. Rev. Biochem. Mol. Biol.
, vol.35
, pp. 1-33
-
-
Tuteja, R.1
Tuteja, N.2
-
8
-
-
0030339852
-
The DNA-dependent protein kinase, DNA-PK: 10years and no ends in sight
-
Lees-Miller S.P. The DNA-dependent protein kinase, DNA-PK: 10years and no ends in sight. Biochem. Cell Biol. 1996, 74:503-512.
-
(1996)
Biochem. Cell Biol.
, vol.74
, pp. 503-512
-
-
Lees-Miller, S.P.1
-
9
-
-
13944277701
-
The life and death of DNA-PK
-
Collis S.J., DeWeese T.L., Jeggo P.A., Parker A.R. The life and death of DNA-PK. Oncogene 2005, 24:949-961.
-
(2005)
Oncogene
, vol.24
, pp. 949-961
-
-
Collis, S.J.1
DeWeese, T.L.2
Jeggo, P.A.3
Parker, A.R.4
-
10
-
-
0027397867
-
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen
-
Gottlieb T.M., Jackson S.P. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 1993, 72:131-142.
-
(1993)
Cell
, vol.72
, pp. 131-142
-
-
Gottlieb, T.M.1
Jackson, S.P.2
-
11
-
-
0033198709
-
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
-
Gell D., Jackson S.P. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 1999, 27:3494-3502.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 3494-3502
-
-
Gell, D.1
Jackson, S.P.2
-
12
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001, 412:607-614.
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
13
-
-
0031974492
-
Identification of Two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding
-
Wang J., Dong X., Myung K., Hendrickson E.A., Reeves W.H. Identification of Two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J. Biol. Chem. 1998, 273:842-848.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 842-848
-
-
Wang, J.1
Dong, X.2
Myung, K.3
Hendrickson, E.A.4
Reeves, W.H.5
-
14
-
-
33846010517
-
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
-
Rivera-Calzada A., Spagnolo L., Pearl L.H., Llorca O. Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. EMBO Rep. 2007, 8:56-62.
-
(2007)
EMBO Rep.
, vol.8
, pp. 56-62
-
-
Rivera-Calzada, A.1
Spagnolo, L.2
Pearl, L.H.3
Llorca, O.4
-
15
-
-
77953292595
-
Post-translational modifications in signal integration
-
Deribe Y.L., Pawson T., Dikic I. Post-translational modifications in signal integration. Nat. Struct. Mol. Biol. 2010, 17:666-672.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 666-672
-
-
Deribe, Y.L.1
Pawson, T.2
Dikic, I.3
-
16
-
-
49349107518
-
Lysine acetylation: codified crosstalk with other posttranslational modifications
-
Yang X.J., Seto E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol. Cell 2008, 31:449-461.
-
(2008)
Mol. Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
17
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller K.M., Tjeertes J.V., Coates J., Legube G., Polo S.E., Britton S., Jackson S.P. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat. Struct. Mol. Biol. 2010, 17:1144-1151.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1144-1151
-
-
Miller, K.M.1
Tjeertes, J.V.2
Coates, J.3
Legube, G.4
Polo, S.E.5
Britton, S.6
Jackson, S.P.7
-
18
-
-
12144286529
-
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
-
Cohen H.Y., Lavu S., Bitterman K.J., Hekking B., Imahiyerobo T.A., Miller C., Frye R., Ploegh H., Kessler B.M., Sinclair D.A. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell 2004, 13:627-638.
-
(2004)
Mol. Cell
, vol.13
, pp. 627-638
-
-
Cohen, H.Y.1
Lavu, S.2
Bitterman, K.J.3
Hekking, B.4
Imahiyerobo, T.A.5
Miller, C.6
Frye, R.7
Ploegh, H.8
Kessler, B.M.9
Sinclair, D.A.10
-
19
-
-
34347206854
-
Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation
-
Chen C.S., Wang Y.C., Yang H.C., Huang P.H., Kulp S.K., Yang C.C., Lu Y.S., Matsuyama S., Chen C.Y., Chen C.S. Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Res. 2007, 67:5318-5327.
-
(2007)
Cancer Res.
, vol.67
, pp. 5318-5327
-
-
Chen, C.S.1
Wang, Y.C.2
Yang, H.C.3
Huang, P.H.4
Kulp, S.K.5
Yang, C.C.6
Lu, Y.S.7
Matsuyama, S.8
Chen, C.Y.9
Chen, C.S.10
-
20
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
Mann, M.8
-
21
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
Misteli T., Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell Biol. 2009, 10:243-254.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
22
-
-
0032573467
-
Subcellular localization and protein-protein interaction regions of Ku proteins
-
Koike M., Miyasaka T., Mimori T., Shiomi T. Subcellular localization and protein-protein interaction regions of Ku proteins. Biochem. Biophys. Res. Commun. 1998, 252:679-685.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.252
, pp. 679-685
-
-
Koike, M.1
Miyasaka, T.2
Mimori, T.3
Shiomi, T.4
-
23
-
-
0033539946
-
Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal
-
Koike M., Ikuta T., Miyasaka T., Shiomi T. Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal. Oncogene 1999, 18:7495-7505.
-
(1999)
Oncogene
, vol.18
, pp. 7495-7505
-
-
Koike, M.1
Ikuta, T.2
Miyasaka, T.3
Shiomi, T.4
-
24
-
-
79958027980
-
Establishment of Ku70-deficient lung epithelial cell lines and their hypersensitivity to low-dose X-irradiation
-
Koike M., Yutoku Y., Koike A. Establishment of Ku70-deficient lung epithelial cell lines and their hypersensitivity to low-dose X-irradiation. J. Vet. Med. Sci. 2011, 73:549-554.
-
(2011)
J. Vet. Med. Sci.
, vol.73
, pp. 549-554
-
-
Koike, M.1
Yutoku, Y.2
Koike, A.3
-
25
-
-
39549104283
-
Accumulation of Ku80 proteins at DNA double-strand breaks in living cells
-
Koike M., Koike A. Accumulation of Ku80 proteins at DNA double-strand breaks in living cells. Exp. Cell Res. 2008, 314:1061-1070.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 1061-1070
-
-
Koike, M.1
Koike, A.2
-
26
-
-
0033179309
-
The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex
-
Koike M., Ikuta T., Miyasaka T., Shiomi T. The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex. Exp. Cell Res. 1999, 250:401-413.
-
(1999)
Exp. Cell Res.
, vol.250
, pp. 401-413
-
-
Koike, M.1
Ikuta, T.2
Miyasaka, T.3
Shiomi, T.4
-
27
-
-
0035815607
-
Dimerization and nuclear localization of Ku proteins
-
Koike M., Shiomi T., Koike A. Dimerization and nuclear localization of Ku proteins. J. Biol. Chem. 2001, 276:11167-11173.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11167-11173
-
-
Koike, M.1
Shiomi, T.2
Koike, A.3
-
28
-
-
16244382514
-
The Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair
-
Koike M., Koike A. The Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair. Exp. Cell Res. 2005, 305:266-276.
-
(2005)
Exp. Cell Res.
, vol.305
, pp. 266-276
-
-
Koike, M.1
Koike, A.2
-
29
-
-
0033490108
-
Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis
-
Koike M., Awaji T., Kataoka M., Tsujimoto G., Kartasova T., Koike A., Shiomi T. Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis. J. Cell Sci. 1999, 112:4031-4039.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4031-4039
-
-
Koike, M.1
Awaji, T.2
Kataoka, M.3
Tsujimoto, G.4
Kartasova, T.5
Koike, A.6
Shiomi, T.7
-
30
-
-
0030733163
-
Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions
-
Jin S., Weaver D.T. Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J. 1997, 16:6874-6885.
-
(1997)
EMBO J.
, vol.16
, pp. 6874-6885
-
-
Jin, S.1
Weaver, D.T.2
-
31
-
-
0040077747
-
Dimerization, translocation and localization of Ku70 and Ku80 proteins
-
Koike M. Dimerization, translocation and localization of Ku70 and Ku80 proteins. J. Radiat. Res. 2002, 43:223-236.
-
(2002)
J. Radiat. Res.
, vol.43
, pp. 223-236
-
-
Koike, M.1
-
32
-
-
0032553326
-
A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen
-
Wang J., Dong X., Reeves W.H. A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen. J. Biol. Chem. 1998, 273:31068-31074.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31068-31074
-
-
Wang, J.1
Dong, X.2
Reeves, W.H.3
-
33
-
-
61749092799
-
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends
-
Weterings E., Verkaik N.S., Keijzers G., Florea B.I., Wang S.Y., Ortega L.G., Uematsu N., Chen D.J., van Gent D.C. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol. Cell. Biol. 2009, 29:1134-1142.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1134-1142
-
-
Weterings, E.1
Verkaik, N.S.2
Keijzers, G.3
Florea, B.I.4
Wang, S.Y.5
Ortega, L.G.6
Uematsu, N.7
Chen, D.J.8
van Gent, D.C.9
-
34
-
-
33748872519
-
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends
-
Drouet J., Frit P., Delteil C., de Villartay J.P., Salles B., Calsou P. Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends. J. Biol. Chem. 2006, 281:27784-27793.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 27784-27793
-
-
Drouet, J.1
Frit, P.2
Delteil, C.3
de Villartay, J.P.4
Salles, B.5
Calsou, P.6
-
35
-
-
23744447715
-
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
-
Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., Yokomori K.J. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 2005, 170:341-347.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 341-347
-
-
Kim, J.S.1
Krasieva, T.B.2
Kurumizaka, H.3
Chen, D.J.4
Taylor, A.M.5
Yokomori, K.J.6
-
36
-
-
33845484385
-
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
-
Mari P.O., Florea B.I., Persengiev S.P., Verkaik N.S., Bruggenwirth H.T., Modesti M., Giglia-Mari G., Bezstarosti K., Demmers J.A., Luider T.M., Houtsmuller A.B., van Gent D.C. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18597-18602.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 18597-18602
-
-
Mari, P.O.1
Florea, B.I.2
Persengiev, S.P.3
Verkaik, N.S.4
Bruggenwirth, H.T.5
Modesti, M.6
Giglia-Mari, G.7
Bezstarosti, K.8
Demmers, J.A.9
Luider, T.M.10
Houtsmuller, A.B.11
van Gent, D.C.12
-
37
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S., Lukas C., Kitagawa R., Melander F., Kastan M.B., Bartek J., Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 2006, 173:195-206.
-
(2006)
J. Cell Biol.
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
Melander, F.4
Kastan, M.B.5
Bartek, J.6
Lukas, J.7
-
38
-
-
8744233919
-
After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available
-
Rapp A., Greulich K.O. After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available. J. Cell Sci. 2004, 117:4935-4945.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4935-4945
-
-
Rapp, A.1
Greulich, K.O.2
-
39
-
-
0026571874
-
Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen
-
Chou C.H., Wang J., Knuth M.W., Reeves W.H. Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen. J. Exp. Med. 1992, 175:1677-1684.
-
(1992)
J. Exp. Med.
, vol.175
, pp. 1677-1684
-
-
Chou, C.H.1
Wang, J.2
Knuth, M.W.3
Reeves, W.H.4
-
40
-
-
37849018404
-
Ku recruits XLF to DNA double-strand breaks
-
Yano K., Morotomi-Yano K., Wang S.Y., Uematsu N., Lee K.J., Asaithamby A., Weterings E., Chen D.J. Ku recruits XLF to DNA double-strand breaks. EMBO Rep. 2008, 9:91-96.
-
(2008)
EMBO Rep.
, vol.9
, pp. 91-96
-
-
Yano, K.1
Morotomi-Yano, K.2
Wang, S.Y.3
Uematsu, N.4
Lee, K.J.5
Asaithamby, A.6
Weterings, E.7
Chen, D.J.8
-
41
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
Riballo E., Kühne M., Rief N., Doherty A., Smith G.C., Recio M.J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A., Jeggo P.A., Löbrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell 2004, 16:715-724.
-
(2004)
Mol. Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kühne, M.2
Rief, N.3
Doherty, A.4
Smith, G.C.5
Recio, M.J.6
Reis, C.7
Dahm, K.8
Fricke, A.9
Krempler, A.10
Parker, A.R.11
Jackson, S.P.12
Gennery, A.13
Jeggo, P.A.14
Löbrich, M.15
-
42
-
-
70350763838
-
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
-
Beucher A., Birraux J., Tchouandong L., Barton O., Shibata A., Conrad S., Goodarzi A.A., Krempler A., Jeggo P.A., Löbrich M. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J. 2009, 28:3413-3427.
-
(2009)
EMBO J.
, vol.28
, pp. 3413-3427
-
-
Beucher, A.1
Birraux, J.2
Tchouandong, L.3
Barton, O.4
Shibata, A.5
Conrad, S.6
Goodarzi, A.A.7
Krempler, A.8
Jeggo, P.A.9
Löbrich, M.10
-
43
-
-
29144533365
-
Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis
-
Gama V., Yoshida T., Gomez J.A., Basile D.P., Mayo L.D., Haas A.L., Matsuyama S. Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Exp. Cell Res. 2006, 312:88-99.
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 88-99
-
-
Gama, V.1
Yoshida, T.2
Gomez, J.A.3
Basile, D.P.4
Mayo, L.D.5
Haas, A.L.6
Matsuyama, S.7
-
44
-
-
0344012187
-
Biochemical evidence for Ku-independent backup pathways of NHEJ
-
Wang H., Perrault A.R., Takeda Y., Qin W., Wang H., Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2003, 31:5377-5388.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 5377-5388
-
-
Wang, H.1
Perrault, A.R.2
Takeda, Y.3
Qin, W.4
Wang, H.5
Iliakis, G.6
|