메뉴 건너뛰기




Volumn 250, Issue 2, 1999, Pages 401-413

The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex

Author keywords

GFP; Ku; NLS; PTAC58; PTAC97

Indexed keywords

AMINO ACID; AUTOANTIGEN; DNA; DNA DEPENDENT PROTEIN KINASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; KU ANTIGEN; UNCLASSIFIED DRUG;

EID: 0033179309     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4507     Document Type: Article
Times cited : (51)

References (54)
  • 1
    • 0019374013 scopus 로고
    • Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap
    • Mimori T., Akizuki H., Yamagata S., Inada S., Yoshida S., Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest. 68:1981;611-620.
    • (1981) J. Clin. Invest. , vol.68 , pp. 611-620
    • Mimori, T.1    Akizuki, H.2    Yamagata, S.3    Inada, S.4    Yoshida, S.5    Homma, M.6
  • 3
    • 0024524581 scopus 로고
    • Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen
    • Reeves W. H., Sthoeger Z. M. Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. J. Biol. Chem. 264:1989;5047-5052.
    • (1989) J. Biol. Chem. , vol.264 , pp. 5047-5052
    • Reeves, W.H.1    Sthoeger, Z.M.2
  • 4
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori T., Hardin J. A. Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261:1986;10375-10379.
    • (1986) J. Biol. Chem. , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 5
    • 0028158320 scopus 로고
    • Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues
    • Cai Q-Q., Plet A., Imbert J., Lafage-Pochitaloff M., Cerdan C., Blanchard J-M. Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues. Cytogenet. Cell Genet. 65:1994;221-227.
    • (1994) Cytogenet. Cell Genet. , vol.65 , pp. 221-227
    • Cai, Q.-Q.1    Plet, A.2    Imbert, J.3    Lafage-Pochitaloff, M.4    Cerdan, C.5    Blanchard, J.-M.6
  • 6
    • 0030588639 scopus 로고    scopus 로고
    • Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues
    • Koike M., Matsuda Y., Mimor T., Harada Y-N., Shiomi N., Shiomi T. Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues. Genomics. 38:1996;38-44.
    • (1996) Genomics , vol.38 , pp. 38-44
    • Koike, M.1    Matsuda, Y.2    Mimor, T.3    Harada, Y.-N.4    Shiomi, N.5    Shiomi, T.6
  • 8
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller S. P., Chen Y. R., Anderson C. W. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 12:1990;6472-6481.
    • (1990) Mol. Cell. Biol. , vol.12 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.R.2    Anderson, C.W.3
  • 9
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb T. M., Jackson S. P. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell. 72:1993;131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 10
    • 0028791446 scopus 로고
    • DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK
    • Jackson S. P., Jeggo P. A. DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK. Trends Biochem. Sci. 20:1995;412-415.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 412-415
    • Jackson, S.P.1    Jeggo, P.A.2
  • 11
    • 0029395076 scopus 로고
    • Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK
    • Jeggo P. A., Taccioli G. E., Jackson S. P. Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK. Bioessays. 17:1995;949-957.
    • (1995) Bioessays , vol.17 , pp. 949-957
    • Jeggo, P.A.1    Taccioli, G.E.2    Jackson, S.P.3
  • 15
    • 0024999553 scopus 로고
    • Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter
    • Knuth M. W., Gunderson S. I., Thompson N. E., Strasheim L. A., Burgess R. R. Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. J. Biol. Chem. 265:1990;17911-17920.
    • (1990) J. Biol. Chem. , vol.265 , pp. 17911-17920
    • Knuth, M.W.1    Gunderson, S.I.2    Thompson, N.E.3    Strasheim, L.A.4    Burgess, R.R.5
  • 16
    • 0028898262 scopus 로고
    • Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: Subunits with homology to Ku antigen
    • Genersch E., Eckerskorn C., Lottspeich F., Herzog C., Kuhn K., Poschl E. Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. EMBO J. 15:1995;791-800.
    • (1995) EMBO J. , vol.15 , pp. 791-800
    • Genersch, E.1    Eckerskorn, C.2    Lottspeich, F.3    Herzog, C.4    Kuhn, K.5    Poschl, E.6
  • 17
    • 0029009013 scopus 로고
    • A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen
    • Kim D., Ouyang H., Yang S. H., Nussenzweig A., Burgman P., Li G. C. A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. J. Biol. Chem. 270:1995;15277-15284.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15277-15284
    • Kim, D.1    Ouyang, H.2    Yang, S.H.3    Nussenzweig, A.4    Burgman, P.5    Li, G.C.6
  • 19
    • 0022902699 scopus 로고
    • A 10S particle released from deoxyribonuclease-sensitive regions of HeLa cell nuclei contains the 86-kilodalton-70-kilodalton protein complex
    • Yaneva M., Busch H. A 10S particle released from deoxyribonuclease-sensitive regions of HeLa cell nuclei contains the 86-kilodalton-70-kilodalton protein complex. Biochemistry. 25:1986;5057-5063.
    • (1986) Biochemistry , vol.25 , pp. 5057-5063
    • Yaneva, M.1    Busch, H.2
  • 20
    • 0026072331 scopus 로고
    • Expression of the Ku protein during cell proliferation
    • Yaneva M., Jhiang S. Expression of the Ku protein during cell proliferation. Biochim. Biophys. Acta. 1090:1991;181-187.
    • (1991) Biochim. Biophys. Acta , vol.1090 , pp. 181-187
    • Yaneva, M.1    Jhiang, S.2
  • 21
    • 0026505959 scopus 로고
    • Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus
    • Reeves W. H. Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus. Rheum. Dis. Clin. N. Am. 18:1992;391-414.
    • (1992) Rheum. Dis. Clin. N. Am. , vol.18 , pp. 391-414
    • Reeves, W.H.1
  • 22
    • 0028060111 scopus 로고
    • Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer
    • Wang J., Satoh M., Chou C. H., Reeves W. H. Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer. FEBS Lett. 351:1994;219-224.
    • (1994) FEBS Lett. , vol.351 , pp. 219-224
    • Wang, J.1    Satoh, M.2    Chou, C.H.3    Reeves, W.H.4
  • 23
    • 0028123813 scopus 로고
    • Systemic lupus erythematosus. Antibodies to DNA, DNA-binding proteins, and histones
    • Reeves W. H., Satoh M., Wang J., Chou C. H., Ajmani A. K. Systemic lupus erythematosus. Antibodies to DNA, DNA-binding proteins, and histones. Rheum. Dis. Clin. N. Am. 20:1994;1-28.
    • (1994) Rheum. Dis. Clin. N. Am. , vol.20 , pp. 1-28
    • Reeves, W.H.1    Satoh, M.2    Wang, J.3    Chou, C.H.4    Ajmani, A.K.5
  • 25
    • 0029884756 scopus 로고    scopus 로고
    • Intracellular redistribution of Ku immunoreactivity in response to cell-cell contact and growth modulating components in the medium
    • Fewell J. W., Kuff E. L. Intracellular redistribution of Ku immunoreactivity in response to cell-cell contact and growth modulating components in the medium. J. Cell Sci. 109:1996;1937-1946.
    • (1996) J. Cell Sci. , vol.109 , pp. 1937-1946
    • Fewell, J.W.1    Kuff, E.L.2
  • 26
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Gorlich D., Mattaj I. W. Nucleocytoplasmic transport. Science. 271:1996;1513-1518.
    • (1996) Science , vol.271 , pp. 1513-1518
    • Gorlich, D.1    Mattaj, I.W.2
  • 27
    • 0030964105 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport: Signals, mechanisms and regulation
    • Nigg E. A. Nucleocytoplasmic transport: Signals, mechanisms and regulation. Nature. 386:1997;779-787.
    • (1997) Nature , vol.386 , pp. 779-787
    • Nigg, E.A.1
  • 28
    • 0028559537 scopus 로고
    • Cytosolic factors in nuclear transport: What's importin
    • Powers M. A., Forbes D. J. Cytosolic factors in nuclear transport: What's importin. Cell. 79:1994;931-934.
    • (1994) Cell , vol.79 , pp. 931-934
    • Powers, M.A.1    Forbes, D.J.2
  • 30
    • 0027379247 scopus 로고
    • Common target for 12-O-tetradecanoylphorbol-13-Acetate 13-acetate and ras in the transcriptional enhancer of the growth factor-Inducible inducible JE gene
    • Koike M., Kuroki T., Nose K. Common target for 12-O-tetradecanoylphorbol-13-Acetate 13-acetate and ras in the transcriptional enhancer of the growth factor-Inducible inducible JE gene. Mol. Carcinog. 8:1993;105-111.
    • (1993) Mol. Carcinog. , vol.8 , pp. 105-111
    • Koike, M.1    Kuroki, T.2    Nose, K.3
  • 31
    • 0030859287 scopus 로고    scopus 로고
    • A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex
    • Eguchi H., Ikuta T., Tachibana T., Yoneda Y., Kawajiri K. A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. J. Biol. Chem. 272:1997;17640-17647.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17640-17647
    • Eguchi, H.1    Ikuta, T.2    Tachibana, T.3    Yoneda, Y.4    Kawajiri, K.5
  • 32
    • 0032579265 scopus 로고    scopus 로고
    • Nuclear localization and export signals of the human aryl hydrocarbon receptor
    • Ikuta T., Eguchi H., Tachibana T., Yoneda Y., Kawajiri K. Nuclear localization and export signals of the human aryl hydrocarbon receptor. J. Biol. Chem. 273:1998;2895-2904.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2895-2904
    • Ikuta, T.1    Eguchi, H.2    Tachibana, T.3    Yoneda, Y.4    Kawajiri, K.5
  • 33
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon D., Roberts B. L., Richardson W. D., Smith A. E. A short amino acid sequence able to specify nuclear location. Cell. 39:1984;499-509.
    • (1984) Cell , vol.39 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 34
    • 0028291833 scopus 로고
    • Growth inhibition of SV40-transformed transformed human keratinocytes by TGF-beta s is not linked to dephosphorylation of the Rb gene product
    • Koike M., Ishino K., Huh N., Kuroki T. Growth inhibition of SV40-transformed transformed human keratinocytes by TGF-beta s is not linked to dephosphorylation of the Rb gene product. Biochem. Biophys. Res. Commun. 201:1994;673-681.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 673-681
    • Koike, M.1    Ishino, K.2    Huh, N.3    Kuroki, T.4
  • 35
    • 0028795345 scopus 로고
    • Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblastoma susceptibility gene
    • Koike M., Ishino K., Ikuta T., Huh N., Kuroki T. Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblastoma susceptibility gene. Oncogene. 10:1995;117-122.
    • (1995) Oncogene , vol.10 , pp. 117-122
    • Koike, M.1    Ishino, K.2    Ikuta, T.3    Huh, N.4    Kuroki, T.5
  • 36
    • 0030606261 scopus 로고    scopus 로고
    • DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes
    • Koike M., Ishino K., Kohno Y., Tachikawa T., Kartasova T., Kuroki T., Huh N. DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes. Cancer Lett. 108:1996b;185-193.
    • (1996) Cancer Lett. , vol.108 , pp. 185-193
    • Koike, M.1    Ishino, K.2    Kohno, Y.3    Tachikawa, T.4    Kartasova, T.5    Kuroki, T.6    Huh, N.7
  • 37
    • 0023631970 scopus 로고
    • Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cells
    • Yoneda Y., Imamoto-Sonobe N., Yamaizumi M., Uchida T. Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cells. Exp. Cell Res. 173:1987;586-595.
    • (1987) Exp. Cell Res. , vol.173 , pp. 586-595
    • Yoneda, Y.1    Imamoto-Sonobe, N.2    Yamaizumi, M.3    Uchida, T.4
  • 40
    • 0025083331 scopus 로고
    • Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
    • Adam S. A., Sterne-Marr R., Gerace L. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111:1990;807-816.
    • (1990) J. Cell Biol. , vol.111 , pp. 807-816
    • Adam, S.A.1    Sterne-Marr, R.2    Gerace, L.3
  • 41
    • 0032573467 scopus 로고    scopus 로고
    • Subcellular localization and protein-protein interaction regions of Ku proteins
    • Koike M., Miyasaka T., Mimori T., Shiomi T. Subcellular localization and protein-protein interaction regions of Ku proteins. Biochem. Biophys. Res. Commun. 252:1998;679-685.
    • (1998) Biochem. Biophys. Res. Commun. , vol.252 , pp. 679-685
    • Koike, M.1    Miyasaka, T.2    Mimori, T.3    Shiomi, T.4
  • 42
    • 0022000813 scopus 로고
    • Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera
    • Reeves W. H. Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J. Exp. Med. 161:1985;18-39.
    • (1985) J. Exp. Med. , vol.161 , pp. 18-39
    • Reeves, W.H.1
  • 44
    • 0028802362 scopus 로고
    • The regulation of protein transport to the nucleus by phosphorylation
    • Jans D. A. The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311:1995;705-716.
    • (1995) Biochem. J. , vol.311 , pp. 705-716
    • Jans, D.A.1
  • 45
    • 0040251482 scopus 로고    scopus 로고
    • Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomalproteins in mammalian cells
    • Jakel S., Gorlich D. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomalproteins in mammalian cells. EMBO J. 17:1998;4491-4502.
    • (1998) EMBO J. , vol.17 , pp. 4491-4502
    • Jakel, S.1    Gorlich, D.2
  • 46
    • 0028088993 scopus 로고
    • Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation
    • Hoff C. M., Ghosh A. K., Prabhakar B. S., Jacob S. T. Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. Proc. Natl. Acad. Sci. USA. 91:1994;762-766.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 762-766
    • Hoff, C.M.1    Ghosh, A.K.2    Prabhakar, B.S.3    Jacob, S.T.4
  • 47
    • 0029988716 scopus 로고    scopus 로고
    • Sequence-specific DNA binding by Ku autoantigen and its effects on transcription
    • Giffin W., Torrance H., Rodda D. J., Prefontain G. G., Pope L., Hache R. J. Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. Nature. 380:1996;265-268.
    • (1996) Nature , vol.380 , pp. 265-268
    • Giffin, W.1    Torrance, H.2    Rodda, D.J.3    Prefontain, G.G.4    Pope, L.5    Hache, R.J.6
  • 48
    • 0026078249 scopus 로고
    • Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
    • Robbins J., Dilworth S. M., Laskey R. A., Dingwall C. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence. Cell. 64:1991;615-623.
    • (1991) Cell , vol.64 , pp. 615-623
    • Robbins, J.1    Dilworth, S.M.2    Laskey, R.A.3    Dingwall, C.4
  • 49
    • 0030671402 scopus 로고    scopus 로고
    • Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors
    • Miyamoto Y., Imamoto N., Sekimoto T., Tachibana T., Seki T., Tada S., Enomoto T., Yoneda Y. Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J. Biol. Chem. 272:1997;26375-26381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26375-26381
    • Miyamoto, Y.1    Imamoto, N.2    Sekimoto, T.3    Tachibana, T.4    Seki, T.5    Tada, S.6    Enomoto, T.7    Yoneda, Y.8
  • 50
    • 0030913267 scopus 로고    scopus 로고
    • How proteins are transported from cytoplasm to the nucleus
    • Yoneda Y. How proteins are transported from cytoplasm to the nucleus. J. Biochem. 121:1997;811-817.
    • (1997) J. Biochem. , vol.121 , pp. 811-817
    • Yoneda, Y.1
  • 51
    • 0027467268 scopus 로고
    • Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2
    • Hennekes H., Peter M., Weber K., Nigg E. A. Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2. J. Cell Biol. 120:1993;1293-1304.
    • (1993) J. Cell Biol. , vol.120 , pp. 1293-1304
    • Hennekes, H.1    Peter, M.2    Weber, K.3    Nigg, E.A.4
  • 52
    • 0031974492 scopus 로고    scopus 로고
    • Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding
    • Wang J., Dong X., Myung K., Hendrickson E. A., Reeves W. H. Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J. Biol. Chem. 273:1998;842-848.
    • (1998) J. Biol. Chem. , vol.273 , pp. 842-848
    • Wang, J.1    Dong, X.2    Myung, K.3    Hendrickson, E.A.4    Reeves, W.H.5
  • 53
    • 0030733163 scopus 로고    scopus 로고
    • Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions
    • Jin S., Weaver D. T. Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J. 16:1997;6874-6885.
    • (1997) EMBO J. , vol.16 , pp. 6874-6885
    • Jin, S.1    Weaver, D.T.2
  • 54
    • 0029029232 scopus 로고
    • Nuclear localization signals overlap DNA- Or RNA-binding domains in nucleic acid-binding proteins
    • LaCasse E. C., Lefebvre Y. A. Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res. 23:1995;1647-1656.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1647-1656
    • Lacasse, E.C.1    Lefebvre, Y.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.