Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet

Nutrition and Metabolism

Volumn 8, Issue , 2011, Pages

  Torres Leal, Francisco L ^a   Fonseca Alaniz, Miriam H ^a   Teodoro, Gabriela Fr ^a   De Capitani, Mariana D ^a   Vianna, Daiana ^a   Pantaleão, Lucas C ^a   Matos Neto, Emidio M ^a   Rogero, Marcelo M ^a   Donato, Jose ^b   Tirapegui, Julio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Adiponectin; Adipose tissue; Body composition; Endurance training; Leucine; Obesity

Indexed keywords

ADIPONECTIN; AMINO ACID; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LEUCINE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CELL VOLUME; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDURANCE TRAINING; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; LIPID DIET; LOW FAT DIET; MALE; NONHUMAN; OBESITY; RAT; SUPPLEMENTATION;

ANIMALIA; RATTUS;

EID: 80052576066     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-8-62     Document Type: Article

References (44)

1. Antiobesity effects of yerba mate extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Arcari DP, Bartchewsky W, dos Santos TW, Oliveira KA, Funck A, Pedrazzoli J, de Souza MF, Saad MJ, Bastos DH, Gambero A, et al. Obesity (Silver Spring) 2009 17 2127 2133 10.1038/oby.2009.158
2. L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ, Diabetologia 2007 50 1949 1959 10.1007/s00125-007-0723-z 17604977 (Pubitemid 47222847)
3. Inflammation and metabolic disorders. Hotamisligil GS, Nature 2006 444 860 867 10.1038/nature05485 17167474 (Pubitemid 46024993)
4. Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats. Donato J, Pedrosa RG, de Araujo JA, Pires IS, Tirapegui J, Life Sci 2007 81 31 39 10.1016/j.lfs.2007. 04.015 17512018 (Pubitemid 46900943)
5. Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Donato J, Pedrosa RG, Cruzat VF, Pires IS, Tirapegui J, Nutrition 2006 22 520 527 10.1016/j.nut.2005.12.008 16600817
6. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. Halton TL, Hu FB, J Am Coll Nutr 2004 23 373 385 15466943
7. The role of leucine in weight loss diets and glucose homeostasis. Layman DK, J Nutr 2003 133 261S 267S 12514305 (Pubitemid 36070614)
8. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH, Diabetes 2007 56 1647 1654 10.2337/db07-0123 17360978 (Pubitemid 46842599)
9. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. Nairizi A, She P, Vary TC, Lynch CJ, J Nutr 2009 139 715 719 10.3945/jn.108.100081 19244380
10. Hypothalamic mTOR signaling regulates food intake. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ, Science 2006 312 927 930 10.1126/science.1124147 16690869 (Pubitemid 43727328)
11. Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. Lynch CJ, Gern B, Lloyd C, Hutson SM, Eicher R, Vary TC, Am J Physiol Endocrinol Metab 2006 291 621 630 10.1152/ajpendo.00462.2005 16638821 (Pubitemid 44352270)
12. Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes. Blumer RM, van Roomen CP, Meijer AJ, Houben-Weerts JH, Sauerwein HP, Dubbelhuis PF, Metabolism 2008 57 1655 1662 10.1016/j.metabol.2008.07.020 19013287
13. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Sun X, Zemel MB, Lipids 2007 42 297 305 10.1007/s11745-007-3029-5 17406924 (Pubitemid 46668925)
14. The effect of physical activity on body weight. Jakicic JM, Obesity (Silver Spring) 2009 17 Suppl 3 34 38
15. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK, Med Sci Sports Exerc 2009 41 459 471 19127177
16. Aerobic exercise attenuates inducible TNF production in humans. Sloan RP, Shapiro PA, Demeersman RE, McKinley PS, Tracey KJ, Slavov I, Fang Y, Flood PD, J Appl Physiol 2007 103 1007 1011 10.1152/japplphysiol.00147.2007 17626836 (Pubitemid 47358887)
17. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB, Obes Res 2003 11 1055 1064 10.1038/oby.2003.145 12972675 (Pubitemid 41151582)
18. Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women. Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC, J Clin Endocrinol Metab 2008 93 2263 2268 10.1210/jc.2007-2028 18334592 (Pubitemid 351831545)
19. Effect of exercise on circulating adipokine levels in obese young women. Kondo T, Kobayashi I, Murakami M, Endocr J 2006 53 189 195 10.1507/endocrj.53. 189 16618976
20. Dietary protein and exercise have additive effects on body composition during weight loss in adult women. Layman DK, Evans E, Baum JI, Seyler J, Erickson DJ, Boileau RA, J Nutr 2005 135 1903 1910 16046715 (Pubitemid 41099748)
21. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Reeves PG, Nielsen FH, Fahey GC Jr, J Nutr 1993 123 1939 1951 8229312 (Pubitemid 23342492)
22. Thirteen-week oral toxicity study of branched-chain amino acids in rats. Tsubuku S, Hatayama K, Katsumata T, Nishimura N, Mawatari K, Smriga M, Kimura T, Int J Toxicol 2004 23 119 126 10.1080/10915810490444424 15204732 (Pubitemid 38724773)
23. Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Zeanandin G, Balage M, Schneider SM, Dupont J, Hebuterne X, Mothe-Satney I, Dardevet D, Age (Dordr) 2011
24. Effect of chronic supplementation with branched-chain amino acids on the performance and hepatic and muscle glycogen content in trained rats. de Araujo JA, Falavigna G, Rogero MM, Pires IS, Pedrosa RG, Castro IA, Donato J, Tirapegui J, Life Sci 2006 79 1343 1348 10.1016/j.lfs.2006.03.045 16698042 (Pubitemid 44215929)
25. Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise. Rogero MM, Tirapegui J, Pedrosa RG, Castro IA, Pires IS, Nutrition 2006 22 564 571 10.1016/j.nut.2005.11.002 16472983
26. Metabolism of Isolated Fat Cells. I. Effects of Hormones on Glucose Metabolism and Lipolysis. Rodbell M, J Biol Chem 1964 239 375 380 14169133
27. A simple method to predict cellular density in adipocyte metabolic incubations. Fine JB, DiGirolamo M, Int J Obes Relat Metab Disord 1997 21 764 768 10.1038/sj.ijo.0800469 9376888 (Pubitemid 27375891)
28. An evaluation of the Waters Pico-Tag system for the amino-acid analysis of food materials. White JA, Hart RJ, Fry JC, J Automat Chem 1986 8 170 177 10.1155/S1463924686000330 18925132 (Pubitemid 17168319)
29. Precolumn phenylisothiocyanate derivatization and liquid chromatography of amino acids in food. Hagen SR, Frost B, Augustin J, J Assoc Off Anal Chem 1989 72 912 916 2592313
30. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. Layman DK, Boileau RA, Erickson DJ, Painter JE, Shiue H, Sather C, Christou DD, J Nutr 2003 133 411 417 12566476 (Pubitemid 36172892)
31. Potential importance of leucine in treatment of obesity and the metabolic syndrome. Layman DK, Walker DA, J Nutr 2006 136 319S 323S 16365106 (Pubitemid 43156532)
32. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Mourier A, Bigard AX, de Kerviler E, Roger B, Legrand H, Guezennec CY, Int J Sports Med 1997 18 47 55 10.1055/s-2007-972594 9059905 (Pubitemid 27075909)
33. Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction. Pedrosa RG, Donato J, Pires IS, Tirapegui J, Appl Physiol Nutr Metab 2010 35 180 183 10.1139/H09-132 20383228
34. Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt. Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DM, Silveira LR, Curi R, Carvalheira JB, Velloso LA, Saad MJ, Diabetologia 2009 52 2425 2434 10.1007/s00125-009-1498-1 19730809
35. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, et al. J Neurosci 2009 29 359 370 19144836
36. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Chakrabarti P, English T, Shi J, Smas CM, Kandror KV, Diabetes 2010 59 775 781 10.2337/db09-1602 20068142
37. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Polak P, Cybulski N, Feige JN, Auwerx J, Ruegg MA, Hall MN, Cell Metab 2008 8 399 410 10.1016/j.cmet.2008.09.003 19046571
38. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K, Genes Cells 2004 9 359 366 10.1111/j.1356-9597. 2004.00727.x 15066126 (Pubitemid 38514871)
39. Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. Hinault C, Mothe-Satney I, Gautier N, Lawrence JC, Van Obberghen E, FASEB J 2004 18 1894 1896 15479767 (Pubitemid 39602275)
40. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E, Am J Physiol Endocrinol Metab 2008 295 586 594 10.1152/ajpendo.00309.2007 18577694
41. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. Zhang HH, Huang J, Duvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD, PLoS One 2009 4 6189 10.1371/journal.pone.0006189 19593385
42. The role of inflamed adipose tissue in the insulin resistance. Torres-Leal FL, Fonseca-Alaniz MH, Rogero MM, Tirapegui J, Cell Biochem Funct 2010 28 623 631 10.1002/cbf.1706 21104928
43. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE, J Biol Chem 2003 278 9073 9085 10.1074/jbc.M207198200 12496257 (Pubitemid 36800387)
44. A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, et al. Diabetes 2008 57 594 605 10.2337/db07-0573 18057094