Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells

European Journal of Pharmacology

Volumn 623, Issue 1-3, 2009, Pages 1-9

  Lai, Jin Mei ^a   Chang, Jinghua Tsai ^b   Wen, Chi Luan ^c,d   Hsu, Shih Lan ^b,c,e  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d FISHERIES RESEARCH INSTITUTE   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Ataxia telangiectasia mutated (ATM); Bax; Emodin; p53; Reactive oxygen species

Indexed keywords

ATM PROTEIN; CASPASE 3; CYTOCHROME C; EMODIN; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SERINE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; EMODIN; ENZYME ACTIVATION; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 70350203951     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.08.031     Document Type: Article

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