Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5920-5923

  Singh, Raushan K ^a   Mandal, Tanmay ^b   Balsubramanian, Narayanaganesh ^a   Viaene, Tajae ^a   Leedahl, Travis ^a   Sule, Nitesh ^a   Cook, Gregory ^a   Srivastava, D K ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Enzyme activation; Epigenetic regulation; Histone deacetylase; Isozyme selectivity; Thiourea derivative

Indexed keywords

ENZYME ACTIVATOR; HISTONE DEACETYLASE 8; THIOUREA DERIVATIVE;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBSTRATE; EPIGENETICS; FLUORESCENCE; HUMAN;

BENZAMIDES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME ACTIVATORS; FLUORESCENT DYES; HISTONE DEACETYLASES; HUMANS; ISOENZYMES; KINETICS; MODELS, CHEMICAL; MOLECULAR TARGETED THERAPY; PHENYLTHIOUREA; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOUREA;

EID: 80052569200     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.080     Document Type: Article

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