Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5559-5568

  Hara, Hirokazu ^a   Nakamura, Yoko ^a   Ninomiya, Masayuki ^b   Mochizuki, Ryosuke ^b   Kamiya, Tetsuro ^a   Aizenman, Elias ^c   Koketsu, Mamoru ^b   Adachi, Tetsuo ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Brassica rapa L. 'hidabeni'; Chalcone glycoside; Inducible nitric oxide synthase; Microglia; Signal transduction and activator of transcription 1

Indexed keywords

3 O ACETYL 3',4 DIMETHOXY 4' HYDROXYCHALCONE; 3',4 DIMETHOXY 4' HYDROXYCHALCONE; 4 O ACETYL 4' HYDROXY 3' METHOXYCHALCONE; 4 O ACETYL 4' HYDROXY 3,3',5 TRIMETHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 3 O ACETYL 3',4 DIMETHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 3' METHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 3',4 DIMETHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 3,3',4 TRIMETHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 3,3',4,5 TETRAMETHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 4 O ACETYL 3' METHOXYCHALCONE; 4' (2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 4 O ACETYL 3,3',5 TRIMETHOXYCHALCONE; 4' HYDROXY 3' METHOXYCHALCONE; 4' HYDROXY 3,3',4 TRIMETHOXYCHALCONE; 4' HYDROXY 3,3',4,5 TETRAMETHOXYCHALCONE; 4' O BETA DEXTRO GLUCOPYRANOSYL 3' METHOXYCHALCONE; 4' O BETA DEXTRO GLUCOPYRANOSYL 3',4 DIMETHOXYCHALCONE; 4' O BETA DEXTRO GLUCOPYRANOSYL 3,3',4 TRIMETHOXYCHALCONE; 4' O BETA DEXTRO GLUCOPYRANOSYL 3,3',4,5 TETRAMETHOXYCHALCONE; 4' O BETA DEXTRO GLUCOPYRANOSYL 4 HYDROXY 3,3',5 TRIMETHOXYCHALCONE; BETA INTERFERON; CHALCONE GLYCOSIDE; GLYCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; STAT1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; MICROGLIA; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TURNIP;

ANIMALS; BRASSICA RAPA; CELLS, CULTURED; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDES; LIPOPOLYSACCHARIDES; MICROGLIA; MOLECULAR STRUCTURE; NITRIC OXIDE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BRASSICA RAPA; RATTUS;

EID: 80052567792     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.036     Document Type: Article

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