Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin i induces Ca2+-independent mechanical tone and acute myocyte remodeling

Circulation Research

Volumn 100, Issue 10, 2007, Pages 1494-1502

  Davis, Jennifer ^a   Wen, Haitao ^a   Edwards, Terri ^a   Metzger, Joseph M ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b 7730 Med Sci II   (United States)

Author keywords

Cardiomyopathy; Contraction; Troponin

Indexed keywords

BLEBBISTATIN; CALCIUM; MUTANT PROTEIN; MYOSIN; TROPONIN I;

ALLELE; ANIMAL CELL; ARTICLE; CELL PERMEABILIZATION; CELL REGENERATION; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLE; GENETIC ENGINEERING; HEART CONTRACTION; HEART MUSCLE CELL; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RAT; RESTRICTIVE CARDIOMYOPATHY; SARCOMERE; SARCOPLASMIC RETICULUM; STOICHIOMETRY; THIN FILAMENT; WILD TYPE;

ANIMALS; CALCIUM; CARDIOMYOPATHY, RESTRICTIVE; DIASTOLE; FEMALE; MICROFILAMENTS; MUTATION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; TROPONIN I;

EID: 34249673442     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000268412.34364.50     Document Type: Article

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