A novel β-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model

Clinical Science

Volumn 114, Issue 5-6, 2008, Pages 431-440

  Kaneda, Tomoya ^a   Naruse, Chie ^b   Kawashima, Atsuhiro ^c   Fujino, Noboru ^a   Oshima, Toru ^a   Namura, Masanobu ^d   Nunoda, Shinichi ^e   Mori, Sumio ^f   Konno, Tetsuo ^a   Ino, Hidekazu ^a   Yamagishi, Masakazu ^a   Asano, Masahide ^b  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION KANAZAWA MEDICAL CENTER   (Japan)

^d KANAZAWA CARDIOVASCULAR HOSPITAL   (Japan)

^e TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^f Division of Cardiology   (Japan)

Author keywords

Cardiomyopathy; Left ventricular non compaction; Mutation; Myosin heavy chain; Transgenic mouse

Indexed keywords

ARGININE; METHIONINE; MYOSIN HEAVY CHAIN BETA; MYOSIN HEAVY CHAIN; VENTRICULAR MYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSGENIC MOUSE; ADULT; AGED; ANIMAL; DISEASE COURSE; DISEASE MODEL; GENETICS; HEART MUSCLE CELL; HEART VENTRICLE; METHODOLOGY; MIDDLE AGED; POINT MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HEART VENTRICLES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VENTRICULAR MYOSINS;

EID: 40649085619     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20070179     Document Type: Article

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