Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5679-5692

  Burland, Peter A ^a   Osborn, Helen M I ^a   Turkson, Andrea ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Carbohydrate synthesis; Glycosidase inhibitor; Reductive amination

Indexed keywords

(4 N BENZYL METHOXY MORPHOLIN YL)METHANOL; (HYDROXYMETHYL) METHOXY [1,4] OXAZEPAN OL; (METHOXY MORPHOLIN YL)METHANOL; 2 (2 HYDROXYMETHYL 6 METHOXYMORPHOLIN 4 YL) 9 (4 HYDROXYPHENYL)PROPIONIC ACID METHYL ESTER; 2 (2 HYDROXYMETHYL 6 METHOXYMORPHOLIN 4 YL) 9 PHENYL PROPIONIC ACID METHYL ESTER; 2 (2 HYDROXYMETHYL 6 METHOXYMORPHOLIN 4 YL)PROPIONIC ACID METHYL ESTER; 2 (6 HYDROXY 2 HYDROXYMETHYL 7 METHOXY [1,4] OXAZEPAN 4 YL) 10 (4 HYDROXYPHENYL)PROPIONIC ACID METHYL ESTER; 2 (6 HYDROXY 2 HYDROXYMETHYL 7 METHOXY [1,4] OXAZEPAN 4 YL) 10 PHENYL PROPIONIC ACID METHYL ESTER; 2 HYDROXYMETHYL 6 METHOXY MORPHOLIN 4 OL; 2 HYDROXYMETHYL 6 METHOXYMORPHOLIN 4 YL ACETIC ACID METHYL ESTER; 2 HYDROXYMETHYL 7 METHOXY 4 OCTYL [1,4] OXAZEPAN 6 OL; 2 HYDROXYMETHYL 7 METHOXY 4 PROPYL [1,4] OXAZEPAN 6 OL; 2 HYDROXYMETHYL 7 METHOXY [1,4] OXAZEPAN 6 OLS; 4 BUTYL 2 HYDROXYMETHYL 7 METHOXY [1,4] OXAZEPAN 6 OL; 4 N BENZYL HYDROXYMETHYL METHOXY [1,4] OXAZEPAN OL; 6 HYDROXY 2 HYDROXYMETHYL 7 METHOXY [1,4] OXAZEPAN 4 YL ACETIC ACID METHYL ESTER; 6 METHOXY 4 BUTYLMORPHOLIN 2 YL METHANOL; 6 METHOXY 4 METHYL MORPHOLIN 2 YL METHANOL; 6 METHOXY 4 OCTYLMORPHOLIN 2 YL METHANOL; 6 METHOXY 4 PROPYL MORPHOLIN 2 YL METHANOL; GLYCOSIDASE INHIBITOR; METHYL 2,3,4 TRI O BENZYL 6 DEOXY 6 (BENZYLOXYMETHYL BENZYLOXY METHOXY [1,4] OXAZEPAN 4 YL) ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL 2,3,4 TRI O BENZYL 6 DEOXY 6 (METHOXY HYDROXYMETHYL MORPHOLIN 4 YL) ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL 2,6 DI O BENZYL ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL 6 DEOXY 6 (M ETHOXY HYDROXYMETHYL MORPHOLIN 4 YL) ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL 6 DEOXY 6 AMINO 2,3,4 TRI O BENZYL ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL 6 DEOXY 6 AZIDO 2,3,4 TRI O BENZYL ALPHA DEXTRO GLUCOPYRANOSIDE; MORPHOLINE DERIVATIVE; OXAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINATION; ARTICLE; CARBOHYDRATE SYNTHESIS; CHEMICAL REACTION; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HYDROGENATION; MICHAELIS MENTEN KINETICS; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; MOLECULAR STRUCTURE; MORPHOLINES; OXAZEPINES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 80052565467     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.019     Document Type: Article

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