Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: Potent and selective β-N-acetylhexosaminidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5598-5604

  Li, Hongqing ^a   Marcelo, Filipa ^a,d   Bello, Claudia ^b   Vogel, Pierre ^b   Butters, Terry D ^c   Rauter, Amélia P ^d   Zhang, Yongmin ^a   Sollogoub, Matthieu ^a   Blériot, Yves ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b EPFL   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

Azepane; Glycosidase; Hexosaminidase; Iminosugar; Inhibitor

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; BETA N ACETYLHEXOSAMINIDASE INHIBITOR; ENZYME INHIBITOR; IMINOSUGAR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS;

ACETAMIDES; ANIMALS; AZEPINES; BACTERIAL PROTEINS; BETA-N-ACETYLHEXOSAMINIDASES; FUNGAL PROTEINS; IMINO SUGARS; MOLECULAR STRUCTURE; PLANT PROTEINS;

TETRA;

EID: 67749127528     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.022     Document Type: Article

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