Regulation of intracellular signaling by extracellular glycan remodeling

ACS Chemical Biology

Volumn 5, Issue 1, 2010, Pages 35-46

  Parker, Randy B ^a   Kohler, Jennifer J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CATHEPSIN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GANGLIOSIDE; GLUCOSAMINE; GLUCURONIC ACID; GLYCAN; GLYCOPROTEIN; HEPARIN; OLIGOSACCHARIDE; PROTEOGLYCAN; SIALIC ACID; SIALIDASE; VASCULOTROPIN; WNT PROTEIN;

ACETYLATION; APOPTOSIS; B LYMPHOCYTE; BIOSYNTHESIS; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CATABOLISM; CELL MATURATION; CELL PROLIFERATION; COLON CANCER; EMBRYO DEATH; EUKARYOTIC CELL; EXTRACELLULAR MATRIX; GOLGI COMPLEX; HEMATOPOIESIS; LUNG CANCER; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; REVIEW; SIALYLATION; SULFATION;

ANIMALS; CELL COMMUNICATION; EXTRACELLULAR SPACE; HUMANS; POLYSACCHARIDES; SIGNAL TRANSDUCTION;

EUKARYOTA; MAMMALIA;

EID: 75749084864     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb9002514     Document Type: Review

References (114)

1. Roseman, S. (2001) Reflections on glycobiology, J. Biol. Chem. 276, 41527-41542.
2. Bernfield, M., Gotte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J., and Zako, M. (1999) Functions of cell surface heparan sulfate proteoglycans, Annu. Rev. Biochem. 68, 729-777.
3. Lopez, P. H., and Schnaar, R. L. (2009) Gangliosides in cell recognition and membrane protein regulation, Curr. Opin. Struct. Biol. 19, 549-557.
4. Haltiwanger, R. S. (2002) Regulation of signal transduction pathways in development by glycosylation, Curr. Opin. Struct. Biol. 12, 593-598.
5. Stanley, P. (2007) Regulation of Notch signaling by glycosylation, Curr. Opin. Struct. Biol. 17, 530-535.
6. Mehta, N. R., Lopez, P. H. H., Vyas, A. A., and Schnaar, R. L. (2007) Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells, J. Biol. Chem. 282, 27875-27886.
7. Grewal, P. K., Boton, M., Ramirez, K., Collins, B. E., Saito, A., Green, R. S., Ohtsubo, K., Chui, D., and Marth, J. D. (2006) ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling, Mol. Cell. Biol. 26, 4970-4981.
8. Van Dyken, S. J., Green, R. S., and Marth, J. D. (2007) Structural and mechanistic features of protein O-glycosylation linked to CD8+ T-cell apoptosis, Mol. Cell. Biol. 27, 1096-1111.
9. Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H., and Kato, S. (2009) GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis, Nature 459, 455-459.
10. Lau, K. S., Partridge, E. A., Grigorian, A., Silvescu, C. I., Reinhold, V. N., Demetriou, M., and Dennis, J. W. (2007) Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation, Cell 129, 123-134.
11. Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., and Vogt, T. F. (2000) Fringe is a glycosyltransferase that modifies Notch, Nature 406, 369-375.
12. Cummings, R. D. (2009) The repertoire of glycan determinants in the human glycome, Mol. Biosyst. 5, 1087-1104.
13. Varki, A. (2007) Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins, Nature 446, 1023-1029.
14. Angata, T., and Varki, A. (2002) Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective, Chem. Rev. 102, 439-469.
15. Yu, H., and Chen, X. (2007) Carbohydrate post-glycosylational modifications, Org. Biomol. Chem. 5, 865-872.
16. Gottschalk, A. (1957) Neuraminidase: the specific enzyme of influenza virus and Vibrio cholerae, Biochim. Biophys. Acta 23, 645-646.
17. Miyagi, T., Konno, K., Emori, Y., Kawasaki, H., Suzuki, K., Yasui, A., and Tsuik, S. (1993) Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase, J. Biol. Chem. 268, 26435-26440.
18. Monti, E., Preti, A., Rossi, E., Ballabio, A., and Borsani, G. (1999) Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases, Genomics 57, 137-143.
19. Bonten, E., van der Spoel, A., Fornerod, M., Grosveld, G., and d'Azzo, A. (1996) Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis, Genes Dev. 10, 3156-3169.
20. Miyagi, T., Hata, K., Hasegawa, T., and Aoyagi, T. (1993) Differential effect of various inhibitors on four types of rat sialidase, Glycoconjugate J. 10, 45-49.
21. Liang, F., Seyrantepe, V., Landry, K., Ahmad, R., Ahmad, A., Stamatos, N. M., and Pshezhetsky, A. V. (2006) Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments, J. Biol. Chem. 281, 27526-27538.
22. Valaperta, R., Chigorno, V., Basso, L., Prinetti, A., Bresciani, R., Preti, A., Miyagi, T., and Sonnino, S. (2006) Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts, FASEB J. 20, 1227-1229.
23. Tringali, C., Papini, N., Fusi, P., Croci, G., Borsani, G., Preti, A., Tortora, P., Tettamanti, G., Venerando, B., and Monti, E. (2004) Properties of recombinant human cytosolic sialidase hsNEU2, J. Biol. Chem. 279, 3169-3179.
24. Monti, E., Bassi, M. T., Papini, N., Riboni, M., Manzoni, M., Venerando, B., Croci, G., Preti, A., Ballabio, A., Tettamanti, G., and Borsani, G. (2000) Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane, Biochem. J. 349, 343-351.
25. Hata, K., Wada, T., Hasegawa, A., Kiso, M., and Miyagi, T. (1998) Purification and characterization of a membrane-associated ganglioside sialidase from bovine brain, J. Biochem. 123, 899-905.
26. Zanchetti, G., Colombi, P., Manzoni, M., Anastasia, L., Caimi, L., Borsani, G., Venerando, B., Tettamanti, G., Preti, A., Monti, E., and Bresciani, R. (2007) Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures, Biochem. J. 408, 211-219.
27. Wang, Y., Yamaguchi, K., Wada, T., Hata, K., Zhao, X. J., Fujimoto, T., and Miyagi, T. (2002) A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains, J. Biol. Chem. 277, 26252-26259.
28. Comelli, E. M., Amado, M., Lustig, S. R., and Paulson, J. C. (2003) Identification and expression of Neu4, a novel murine sialidase, Gene 321, 155-161.
29. Monti, E., Bassi, M. T., Bresciani, R., Civini, S., Croci, G. L., Papini, N., Riboni, M., Zanchetti, G., Ballabio, A., Preti, A., Tettamanti, G., Venerando, B., and Borsani, G. (2004) Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family, Genomics 83, 445-453.
30. Yamaguchi, K., Hata, K., Koseki, K., Shiozaki, K., Akita, H., Wada, T., Moriya, S., and Miyagi, T. (2005) Evidence for mitochondrial localization of a novel human sialidase (NEU4), Biochem. J. 390, 85-93.
31. Seyrantepe, V., Landry, K., Trudel, S., Hassan, J. A., Morales, C. R., and Pshezhetsky, A. V. (2004) Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells, J. Biol. Chem. 279, 37021-37029.
32. Cha, S. K., Ortega, B., Kurosu, H., Rosenblatt, K. P., Kuro-O, M., and Huang, C. L. (2008) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1, Proc. Natl. Acad. Sci. U.S.A. 105, 9805-9810.
33. Shi, W. X., Chammas, R., and Varki, A. (1998) Induction of sialic acid 9-O-acetylation by diverse gene products: implications for the expression cloning of sialic acid O-acetyltransferases, Glycobiology 8, 199-205.
34. Chen, H. Y., Challa, A. K., and Varki, A. (2006) 9-O-Acetylation of exogenously added ganglioside GD3, J. Biol. Chem. 281, 7825-7833.
35. Takematsu, H., Diaz, S., Stoddart, A., Zhang, Y., and Varki, A. (1999) Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus, J. Biol. Chem. 274, 25623-25631.
36. Cariappa, A., Takematsu, H., Liu, H., Diaz, S., Haider, K., Boboila, C., Kalloo, G., Connole, M., Shi, H. N., Varki, N., Varki, A., and Pillai, S. (2009) B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase, J. Exp. Med. 206, 125-138.
37. Lin, X. (2004) Functions of heparan sulfate proteoglycans in cell signaling during development, Development 131, 6009-6021.
38. Gama, C. I., and Hsieh-Wilson, L. C. (2005) Chemical approaches to deciphering the glycosaminoglycan code, Curr. Opin. Chem. Biol. 9, 609-619.
39. Morimoto-Tomita, M., Uchimura, K., Werb, Z., Hemmerich, S., and Rosen, S. D. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans, J. Biol. Chem. 277, 49175-49185.
40. Ai, X., Do, A. T., Kusche-Gullberg, M., Lindahl, U., Lu, K., and Emerson, C. P., Jr. (2006) Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2, J. Biol. Chem. 281, 4969-4976.
41. Papini, N., Anastasia, L., Tringali, C., Croci, G., Bresciani, R., Yamaguchi, K., Miyagi, T., Preti, A., Prinetti, A., Prioni, S., Sonnino, S., Tettamanti, G., Venerando, B., and Monti, E. (2004) The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions, J. Biol. Chem. 279, 16989-16995.
42. Dhoot, G. K., Gustafsson, M. K., Ai, X., Sun, W., Standiford, D. M., and Emerson, C. P., Jr. (2001) Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase, Science 293, 1663-1666.
43. Ai, X., Do, A.-T., Lozynska, O., Kusche-Gullberg, M., Lindahl, U., and Emerson, C. P., Jr. (2003) QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling, J. Cell Biol. 162, 341-351.
44. Wang, S., Ai, X., Freeman, S. D., Pownall, M. E., Lu, Q., Kessler, D. S., and Emerson, C. P. (2004) QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis, Proc. Natl. Acad. Sci. U.S.A. 101, 4833-4838.
45. Holst, C. R., Bou-Reslan, H., Gore, B. B., Wong, K., Grant, D., Chalasani, S., Carano, R. A., Frantz, G. D., Tessier-Lavigne, M., Bolon, B., French, D. M., and Ashkenazi, A. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival, PLoS One 2, e575.
46. Ratzka, A., Kalus, I., Moser, M., Dierks, T., Mundlos, S., and Vortkamp, A. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development, Dev. Dyn. 237, 339-353.
47. Lamanna, W. C., Baldwin, R. J., Padva, M., Kalus, I., Dam, G. T., Kuppevelt, T. H. V., Gallagher, J. T., Figura, K. V., Dierks, T., and Merry, C. L. R. (2006) Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity, Biochem. J. 400, 63-73.
48. Zhao, G.-Q. (2003) Consequences of knocking out BMP signaling in the mouse, Genesis 35, 43-56.
49. Paine-Saunders, S., Viviano, B. L., Economides, A. N., and Saunders, S. (2002) Heparan sulfate proteoglycans retain Noggin at the cell surface, J. Biol. Chem. 277, 2089-2096.
50. Viviano, B. L., Paine-Saunders, S., Gasiunas, N., Gallagher, J., and Saunders, S. (2004) Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin, J. Biol. Chem. 279, 5604-5611.
51. Hu, Z., Wang, C., Xiao, Y., Sheng, N., Chen, Y., Xu, Y., Zhang, L., Mo, W., Jing, N., and Hu, G. (2009) NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, J. Cell. Sci. 122, 1145-1154.
52. Freeman, S. D., Moore, W. M., Guiral, E. C., Holme, A. D., Turnbull, J. E., and Pownall, M. E. (2008) Extracellular regulation of developmental cell signaling by XtSulf1, Dev. Biol. 320, 436-445.
53. Lamanna, W. C., Frese, M. A., Balleininger, M., and Dierks, T. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling, J. Biol. Chem. 283, 27724-27735.
54. Lai, J., Chien, J., Staub, J., Avula, R., Greene, E. L., Matthews, T. A., Smith, D. I., Kaufmann, S. H., Roberts, L. R., and Shridhar, V. (2003) Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer, J. Biol. Chem. 278, 23107-23117.
55. Lai, J. P., Chien, J. R., Moser, D. R., Staub, J. K., Aderca, I., Montoya, D. P., Matthews, T. A., Nagorney, D. M., Cunningham, J. M., Smith, D. I., Greene, E. L., Shridhar, V., and Roberts, L. R. (2004) hSulf1 sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling, Gastroenterology 126, 231-248.
56. Lai, J., Sandhu, D. S., Shire, A. M., and Roberts, L. R. (2008) The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis, J. Gastrointest. Cancer 39, 149-158.
57. Narita, K., Staub, J., Chien, J., Meyer, K., Bauer, M., Friedl, A., Ramakrishnan, S., and Shridhar, V. (2006) HSulf-1 inhibits angiogenesis and tumorigenesis in vivo, Cancer Res. 66, 6025-6032.
58. Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A. C., Shriver, Z., Venkataraman, G., Sasisekharan, R., and Sanderson, R. D. (2005) HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo, J. Biol. Chem. 280, 40066-40073.
59. Nawroth, R., van Zante, A., Cervantes, S., McManus, M., Hebrok, M., and Rosen, S. D. (2007) Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells, PLoS One 2, e392.
60. Abiatari, I., Kleeff, J., Li, J., Felix, K., Buchler, M. W., and Friess, H. (2006) Hsulf-1 regulates growth and invasion of pancreatic cancer cells, J. Clin. Pathol. 59, 1052-1058.
61. Grigoriadis, A., Mackay, A., Reis-Filho, J., Steele, D., Iseli, C., Stevenson, B., Jongeneel, C. V., Valgeirsson, H., Fenwick, K., Iravani, M., Leao, M., Simpson, A., Strausberg, R., Jat, P., Ashworth, A., Neville, A. M., and O'Hare, M. (2006) Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data, Breast Cancer Res. 8, R56.
62. Castro, N., Osorio, C., Torres, C., Bastos, E., Mourao-Neto, M., Soares, F., Brentani, H., and Carraro, D. (2008) Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma, Breast Cancer Res. 10, R87.
63. Kudo, Y., Ogawa, I., Kitajima, S., Kitagawa, M., Kawai, H., Gaffney, P. M., Miyauchi, M., and Takata, T. (2006) Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer, Cancer Res. 66, 6928-6935.
64. Lai, J. P., Sandhu, D. S., Yu, C., Han, T., Moser, C. D., Jackson, K. K., Guerrero, R. B., Aderca, I., Isomoto, H., Garrity-Park, M. M., Zou, H., Shire, A. M., Nagorney, D. M., Sanderson, S. O., Adjei, A. A., Lee, J. S., Thorgeirsson, S. S., and Roberts, L. R. (2008) Sulfatase 2 upregulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma, Hepatology 47, 1211-1222.
65. Uchimura, K., Morimoto-Tomita, M., Bistrup, A., Li, J., Lyon, M., Gallagher, J., Werb, Z., and Rosen, S. D. (2006) HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparinbound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1, BMC Biochem. 7, 2.
66. McKenzie, E., Tyson, K., Stamps, A., Smith, P., Turner, P., Barry, R., Hircock, M., Patel, S., Barry, E., Stubberfield, C., Terrett, J., and Page, M. (2000) Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member, Biochem. Biophys. Res. Commun. 276, 1170-1177.
67. Goldshmidt, O., Zcharia, E., Abramovitch, R., Metzger, S., Aingorn, H., Friedmann, Y., Schirrmacher, V., Mitrani, E., and Vlodavsky, I. (2002) Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis, Proc. Nat. Acad. Sci. U.S.A. 99, 10031-10036.
68. Fux, L., Ilan, N., Sanderson, R. D., and Vlodavsky, I. (2009) Heparanase: busy at the cell surface, Trends Biochem. Sci. 34, 511-519.
69. Vlodavsky, I., and Friedmann, Y. (2001) Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis, J. Clin. Invest. 108, 341-347.
70. Vlodavsky, I., Goldshmidt, O., Zcharia, E., Atzmon, R., Rangini-Guatta, Z., Elkin, M., Peretz, T., and Friedmann, Y. (2002) Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development, Semin. Cancer Biol. 12, 121-129.
71. Vreys, V., and David, G. (2007) Mammalian heparanase: what is the message? J. Cell. Mol. Med. 11, 427-452.
72. Miyagi, T., Wada, T., Yamaguchi, K., and Hata, K. (2004) Sialidase and malignancy: a minireview, Glycoconjugate J. 20, 189-198.
73. Miyagi, T., Wada, T., Yamaguchi, K., Shiozaki, K., Sato, I., Kakugawa, Y., Yamanami, H., and Fujiya, T. (2008) Human sialidase as a cancer marker, Proteomics 8, 3303-3311.
74. Kakugawa, Y., Wada, T., Yamaguchi, K., Yamanami, H., Ouchi, K., Sato, I., and Miyagi, T. (2002) Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression, Proc. Nat. Acad. Sci. U.S.A. 99, 10718-10723.
75. Ueno, S., Saito, S., Wada, T., Yamaguchi, K., Satoh, M., Arai, Y., and Miyagi, T. (2006) Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility, J. Biol. Chem. 281, 7756-7764.
76. Nomura, H., Tamada, Y., Miyagi, T., Suzuki, A., Taira, M., Suzuki, N., Susumu, N., Irimura, T., and Aoki, D. (2006) Expression of NEU3 (plasma membrane-associated sialidase) in clear cell adenocarcinoma of the ovary: its relationship with T factor of pTNM classification, Oncol. Res. 16, 289-297.
77. Tringali, C., Lupo, B., Cirillo, F., Papini, N., Anastasia, L., Lamorte, G., Colombi, P., Bresciani, R., Monti, E., Tettamanti, G., and Venerando, B. (2009) Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3, Cell Death Differ. 16, 164-174.
78. Yoon, S. J., Nakayama, K., Hikita, T., Handa, K., and Hakomori, S. I. (2006) Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor, Proc. Natl. Acad. Sci. U.S.A. 103, 18987-18991.
79. Anastasia, L., Papini, N., Colazzo, F., Palazzolo, G., Tringali, C., Dileo, L., Piccoli, M., Conforti, E., Sitzia, C., Monti, E., Sampaolesi, M., Tettamanti, G., and Venerando, B. (2008) NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis, J. Biol. Chem. 283, 36265-36271.
80. Kato, K., Shiga, K., Yamaguchi, K., Hata, K., Kobayashi, T., Miyazaki, K., Saijo, S., and Miyagi, T. (2006) Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectinderived signalling, Biochem. J. 394, 647-656.
81. Toledo, M. S., Suzuki, E., Handa, K., and Hakomori, S. (2005) Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor, J. Biol. Chem. 280, 16227-16234.
82. Gopalakrishna, P., Rangaraj, N., and Pande, G. (2004) Cholesterol alters the interaction of glycosphingolipid GM3 with alpha5beta1 integrin and increases integrin-mediated cell adhesion to fibronectin, Exp. Cell Res. 300, 43-53.
83. Hinek, A., Pshezhetsky, A. V., von Itzstein, M., and Starcher, B. (2006) Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly, J. Biol. Chem. 281, 3698-3710.
84. Gadhoum, S. Z., and Sackstein, R. (2008) CD15 expression in human myeloid cell differentiation is regulated by sialidase activity, Nat. Chem. Biol. 4, 751-757.
85. Uemura, T., Shiozaki, K., Yamaguchi, K., Miyazaki, S., Satomi, S., Kato, K., Sakuraba, H., and Miyagi, T. (2009) Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta 4, Oncogene 28, 1218-1229.
86. Starcher, B., d'Azzo, A., Keller, P. W., Rao, G. K., Nadarajah, D., and Hinek, A. (2008) Neuraminidase-1 is required for the normal assembly of elastic fibers, Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L637-L647.
87. Duca, L., Blanchehpvoye, C., Cantarelli, B., Ghoneim, C., Dedieu, S., Delacoux, F., Hornebeck, W., Hinek, A., Martiny, L., and Debelle, L. (2007) The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit, J. Biol. Chem. 282, 12484-12491.
88. Phillips, M. L., Nudelman, E., Gaeta, F. C., Perez, M., Singhal, A. K., Hakomori, S., and Paulson, J. C. (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-LeX, Science 250, 1130-1132.
89. van Gisbergen, K. P. J. M., Sanchez-Hernandez, M., Geijtenbeek, T. B. H., and van Kooyk, Y. (2005) Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN, J. Exp. Med. 201, 1281-1292.
90. Gross, A. J., Lyandres, J. R., Panigrahi, A. K., Prak, E. T. L., and De-Franco, A. L. (2009) Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance, J. Immunol. 182, 5382-5392.
91. Guimaraes, M. J., Bazan, J. F., Castagnola, J., Diaz, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Varki, A., and Zlotnik, A. (1996) Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase, J. Biol. Chem. 271, 13697-13705.
92. Pillai, S., Cariappa, A., and Pirnie, S. P. (2009) Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance, Trends Immunol. 30, 488-493.
93. Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., and Nabeshima, Y.-I. (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing, Nature 390, 45-51.
94. Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., Shimomura, I., Takayama, Y., Herz, J., Kahn, C. R., Rosenblatt, K. P., and Kuro-o, M. (2005) Suppression of aging in mice by the hormone Klotho, Science 309, 1829-1833.
95. Wang, Y., and Sun, Z. (2009) Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage, Hypertension 54, 810-817.
96. Rodriguez, J. A., Piddini, E., Hasegawa, T., Miyagi, T., and Dotti, C. G. (2001) Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture, J. Neurosci. 21, 8387-8395.
97. Farooqui, T., Franklin, T., Pearl, D. K., and Yates, A. (1997) Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA, J. Neurochem. 68, 2348-2355.
98. Valaperta, R., Valsecchi, M., Rocchetta, F., Aureli, M., Prioni, S., Prinetti, A., Chigorno, V., and Sonnino, S. (2007) Induction of axonal differentiation by silencing plasma membrane-associated sialidase Neu3 in neuroblastoma cells, J. Neurochem. 100, 708-719.
99. Proshin, S., Yamaguchi, K., Wada, T., and Miyagi, T. (2002) Modulation of neuritogenesis by ganglioside-specific sialidase (Neu 3) in human neuroblastoma NB-1 cells, Neurochem. Res. 27, 841-846.
100. von Reitzenstein, C., Kopitz, J., Schuhmann, V., and Cantz, M. (2001) Differential functional relevance of a plasma membrane ganglioside sialidase in cholinergic and adrenergic neuroblastoma cell lines, Eur. J. Biochem. 268, 326-333.
101. Kalka, D., von Reitzenstein, C., Kopitz, J., and Cantz, M. (2001) The plasma membrane ganglioside sialidase cofractionates with markers of lipid rafts, Biochem. Biophys. Res. Commun. 283, 989-993.
102. Da Silva, J. S., Hasegawa, T., Miyagi, T., Dotti, C. G., and Abad-Rodriguez, J. (2005) Asymmetric membrane ganglioside sialidase activity specifies axonal fate, Nat. Neurosci. 8, 606-615.
103. Yang, L. J. S., Lorenzini, I., Vajn, K., Mountney, A., Schramm, L. P., and Schnaar, R. L. (2006) Sialidase enhances spinal axon outgrowth in vivo, Proc. Nat. Acad. Sci. U.S.A. 103, 11057-11062.
104. Porwoll, S., Loch, N., Kannicht, C., Nuck, R., Grunow, D., Reutter, W., and Tauber, R. (1998) Cell surface glycoproteins undergo post-biosynthetic modification of their N-glycans by stepwise demannosylation, J. Biol. Chem. 273, 1075-1085.
105. Porwoll, S., Fuchs, H., and Tauber, R. (1999) Characterization of a soluble class I alpha-mannosidase in human serum, FEBS Lett. 449, 175-178.
106. Khunsook, S., Bean, B. S., McGowan, S. R., and Alhadeff, J. A. (2003) Purification and characterization of plasma membrane-associated human sperm alpha-L-fucosidase, Biol. Reprod. 68, 709-716.
107. Khunsook, S., Alhadeff, J. A., and Bean, B. S. (2002) Purification and characterization of human seminal plasma α-L-fucosidase, Mol. Hum. Reprod. 8, 221-227.
108. Li, C., Qian, J., and Lin, J. S. (2006) Purification and characterization of alpha-L-fucosidase from human primary hepatocarcinoma tissue, World J. Gastroenterol. 12, 3770-3775.
109. Ali, S., Jenkins, Y., Kirkley, M., Dagkalis, A., Manivannan, A., Crane, I. J., and Kirby, J. A. (2008) Leukocyte extravasation: An immunoregulatory role for α-L-fucosidase? J. Immunol. 181, 2407-2413.
110. Mencarelli, S., Cavalieri, C., Magini, A., Tancini, B., Basso, L., Lemansky, P., Hasilik, A., Li, Y. T., Chigorno, V., Orlacchio, A., Emiliani, C., and Sonnino, S. (2005) Identification of plasma membrane associated mature beta-hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts, FEBS Lett. 579, 5501-5506.
111. Jenkins, N., Parekh, R. B., and James, D. C. (1996) Getting the glycosylation right: Implications for the biotechnology industry, Nat. Biotechnol. 14, 975-981.
112. Gramer, M. J. (2000) Detecting and minimizing glycosidase activities that can hydrolyze sugars from cell culture-produced glycoproteins, Mol. Biotechnol. 15, 69-75.
113. Severi, E., Hood, D. W., and Thomas, G. H. (2007) Sialic acid utilization by bacterial pathogens, Microbiology 153, 2817-2822.
114. Katayama, T., Fujita, K., and Yamamoto, K. (2005) Novel bifidobacterial glycosidases acting on sugar chains of mucin glycoproteins, J. Biosci. Bioeng. 99, 457-465.