Permanent deficits in brain functions caused by long-term ketamine treatment in mice

Human and Experimental Toxicology

Volumn 30, Issue 9, 2011, Pages 1287-1296

  Sun, L ^a,b   Lam, W P ^b   Wong, Y W ^b   Lam, L H ^b   Tang, H C ^b   Wai, M S ^b   Mak, Y T ^b   Pan, F ^a   Yew, D T ^b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

apoptosis; behavioral test; brain deficits; noncompetitive NMDA antagonist; prefrontal cortex

Indexed keywords

CASPASE 3; KETAMINE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BEHAVIORAL SCIENCE; BRAIN DYSFUNCTION; CONTROLLED STUDY; DRUG ABUSE; HOT PLATE TEST; LEARNING; LONG TERM CARE; MALE; MAZE TEST; MOUSE; MUSCLE STRENGTH; NEUROMUSCULAR FUNCTION; NOCICEPTION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; TREATMENT DURATION; WORKING MEMORY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BODY WEIGHT; CASPASE 3; DATA INTERPRETATION, STATISTICAL; IN SITU NICK-END LABELING; KETAMINE; MALE; MAZE LEARNING; MICE; MICE, INBRED ICR; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE-RELATED DISORDERS;

MUS;

EID: 80052536192     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110388958     Document Type: Article

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