Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys

Neuropsychopharmacology

Volumn 30, Issue 10, 2005, Pages 1861-1869

  Tsukada, Hideo ^a   Nishiyama, Shingo ^a   Fukumoto, Dai ^a   Sato, Kengo ^a   Kakiuchi, Takeharu ^a   Domino, Edward F ^b  

^a CENTRAL RESEARCH LABORATORY   (Japan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Dopamine D1 receptors; Microdialysis; NMDA; Positron emission tomography; Prefrontal cortex; Working memory

Indexed keywords

5 (7 BENZOFURANYL) 8 CHLORO 2,3,4,5 TETRAHYDRO 7 HYDROXY 3 METHYL 1H 3 BENZAZEPINE; CARBON 11; DIZOCILPINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; ISOREMOXIPRIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CONSCIOUSNESS; CONTROLLED STUDY; EYE MOVEMENT CONTROL; MALE; MEASUREMENT; MEMORY DISORDER; MENTAL PERFORMANCE; MICRODIALYSIS; MONKEY; NEOCORTEX; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIMATE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RADIOACTIVITY; RECEPTOR BINDING; SACCADIC EYE MOVEMENT; TASK PERFORMANCE; WORKING MEMORY;

ANIMALS; BEHAVIOR, ANIMAL; BENZAZEPINES; BENZOFURANS; DIZOCILPINE MALEATE; DOPAMINE; DOPAMINE ANTAGONISTS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MACACA MULATTA; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICRODIALYSIS; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PROTEIN BINDING; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D1; SALICYLAMIDES; TIME FACTORS; TRITIUM; WAKEFULNESS;

EID: 27144512730     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300732     Document Type: Article

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