Microsecond unfolding kinetics of sheep prion protein reveals an intermediate that correlates with susceptibility to classical scrapie

Biophysical Journal

Volumn 101, Issue 5, 2011, Pages 1221-1230

  Chen, Kai Chun ^a   Xu, Ming ^c   Wedemeyer, William J ^a,b,e   Roder, Heinrich ^c,d,e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE; TRYPTOPHAN; UREA;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE PREDISPOSITION; DRUG EFFECT; HUMAN; KINETICS; METABOLISM; PH; PRION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; SCRAPIE; SHEEP; SPECTROFLUOROMETRY;

ANIMALS; DISEASE SUSCEPTIBILITY; GUANIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PRIONS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; SCRAPIE; SHEEP; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN; UREA;

OVIS; OVIS ARIES;

EID: 80052500506     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.07.024     Document Type: Article

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