Rationalizing 5000-fold differences in receptor-binding rate constants of four cytokines

Biophysical Journal

Volumn 101, Issue 5, 2011, Pages 1175-1183

  Pang, Xiaodong ^a   Qin, Sanbo ^a   Zhou, Huan Xiang ^a  

^a Florida State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; OSMOLARITY; PROTEIN BINDING; PROTEIN CONFORMATION;

CYTOKINES; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; OSMOLAR CONCENTRATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOKINE;

EID: 80052476429     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.06.056     Document Type: Article

References (47)

1. S. Dubé, J.W. Fisher, and J.S. Powell Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion, and biological function J. Biol. Chem. 263 1988 17516 17521 (Pubitemid 19029333)
2. E. Tsuda, and G. Kawanishi R. Sasaki The role of carbohydrate in recombinant human erythropoietin Eur. J. Biochem. 188 1990 405 411 (Pubitemid 20106255)
3. J.S. Philo, and K.H. Aoki J. Wen Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction Biochemistry 35 1996 1681 1691 (Pubitemid 26055303)
4. R.S. Syed, and S.W. Reid R.M. Stroud Efficiency of signaling through cytokine receptors depends critically on receptor orientation Nature 395 1998 511 516 (Pubitemid 28462447)
5. S.A. Middleton, and F.P. Barbone L.K. Jolliffe Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide J. Biol. Chem. 274 1999 14163 14169
6. R.J. Darling, and U. Kuchibhotla J.M. Beals Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions Biochemistry 41 2002 14524 14531 (Pubitemid 35440264)
7. S.J. Frank Receptor dimerization in GH and erythropoietin action - it takes two to tango, but how? Endocrinology 143 2002 2 10 (Pubitemid 34056396)
8. Y.H. Wang, B.J. Shen, and W. Sebald A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain Proc. Natl. Acad. Sci. USA 94 1997 1657 1662 (Pubitemid 27113891)
9. T. Hage, W. Sebald, and P. Reinemer Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface Cell 97 1999 271 281 (Pubitemid 29194277)
10. A.M. de Vos, M. Ultsch, and A.A. Kossiakoff Human growth hormone and extracellular domain of its receptor: crystal structure of the complex Science 255 1992 306 312
11. G. Fuh, and B.C. Cunningham J.A. Wells Rational design of potent antagonists to the human growth hormone receptor Science 256 1992 1677 1680
12. T. Clackson, and J.A. Wells A hot spot of binding energy in a hormone-receptor interface Science 267 1995 383 386
13. K.H. Pearce Jr., and M.H. Ultsch J.A. Wells Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface Biochemistry 35 1996 10300 10307 (Pubitemid 26277288)
14. T. Clackson, and M.H. Ultsch A.M. de Vos Structural and functional analysis of the 1:1 growth hormone: receptor complex reveals the molecular basis for receptor affinity J. Mol. Biol. 277 1998 1111 1128 (Pubitemid 28190850)
15. B. Bernat, and M. Sun A.A. Kossiakoff Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries Biochemistry 43 2004 6076 6084 (Pubitemid 38669475)
16. S.T.R. Walsh, J.E. Sylvester, and A.A. Kossiakoff The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled Proc. Natl. Acad. Sci. USA 101 2004 17078 17083 (Pubitemid 39627777)
17. J.B. Jomain, and E. Tallet V. Goffin Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: x-ray structure of Del1-9-G129R-hPRL J. Biol. Chem. 282 2007 33118 33131 (Pubitemid 350159283)
18. J. van Agthoven, and C. Zhang I. Broutin Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone J. Mol. Biol. 404 2010 112 126
19. R. Alsallaq, and H.X. Zhou Energy landscape and transition state of protein-protein association Biophys. J. 92 2007 1486 1502 (Pubitemid 46393461)
20. R. Alsallaq, and H.-X. Zhou Electrostatic rate enhancement and transient complex of protein-protein association Proteins 71 2008 320 335 (Pubitemid 351358613)
21. S.B. Qin, and H.X. Zhou Prediction of salt and mutational effects on the association rate of U1A protein and U1 small nuclear RNA stem/loop II J. Phys. Chem. B 112 2008 5955 5960
22. H.X. Zhou Rate theories for biologists Q. Rev. Biophys. 43 2010 219 293
23. A.J. McCoy, V. Chandana Epa, and P.M. Colman Electrostatic complementarity at protein/protein interfaces J. Mol. Biol. 268 1997 570 584 (Pubitemid 27208075)
24. A. Fiser, R.K.G. Do, and A. Sali Modeling of loops in protein structures Protein Sci. 9 2000 1753 1773
25. X.Z. Zhou Calculation of translational friction and intrinsic viscosity. II. Application to globular proteins Biophys. J. 69 1995 2298 2303
26. R. Alsallaq, and H.X. Zhou Prediction of protein-protein association rates from a transition-state theory Structure 15 2007 215 224 (Pubitemid 46209818)
27. S.B. Qin, and H.X. Zhou Dissection of the high rate constant for the binding of a ribotoxin to the ribosome Proc. Natl. Acad. Sci. USA 106 2009 6974 6979
28. N.A. Baker, and D. Sept J.A. McCammon Electrostatics of nanosystems: application to microtubules and the ribosome Proc. Natl. Acad. Sci. USA 98 2001 10037 10041 (Pubitemid 32802969)
29. W.D. Cornell, and P. Cieplak P.A. Kollman A 2nd generation force-field for the simulation of proteins, nucleic-acids, and organic-molecules J. Am. Chem. Soc. 117 1995 5179 5197
30. A. Bondi van der Waals volumes and radii J Phys Chem. 68 1964 441 451
31. G. Schreiber, G. Haran, and H.X. Zhou Fundamental aspects of protein-protein association kinetics Chem. Rev. 109 2009 839 860
32. R.R. Gabdoulline, and R.C. Wade Simulation of the diffusional association of barnase and barstar Biophys. J. 72 1997 1917 1929 (Pubitemid 27184422)
33. A.H. Elcock, and R.R. Gabdoulline J.A. McCammon Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin J. Mol. Biol. 291 1999 149 162 (Pubitemid 29391411)
34. R.R. Gabdoulline, and R.C. Wade Protein-protein association: investigation of factors influencing association rates by Brownian dynamics simulations J. Mol. Biol. 306 2001 1139 1155 (Pubitemid 33030010)
35. T. Frembgen-Kesner, and A.H. Elcock Absolute protein-protein association rate constants from flexible, coarse-grained Brownian dynamics simulations: the role of intermolecular hydrodynamic interactions in barnase-barstar association Biophys. J. 99 2010 L75 L77
36. T.R. Lappin, A.P. Maxwell, and P.G. Johnston EPO's alter ego: erythropoietin has multiple actions Stem Cells 20 2002 485 492 (Pubitemid 35463061)
37. A. Wickrema, and S.B. Krantz M.C. Bondurant Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells Blood 80 1992 1940 1949
38. F. Letzelter, Y.H. Wang, and W. Sebald The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain Eur. J. Biochem. 257 1998 11 20 (Pubitemid 28462575)
39. S.R. Husain, and P. Leland R.K. Puri Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene AIDS Res. Hum. Retroviruses 12 1996 1349 1359 (Pubitemid 26336862)
40. R.M. Ehrlich, and P.J. Randle Immunoassay of growth hormone in human serum Lancet 2 1961 230 233
41. M. Villalba, and M.T. Zabala J.P. Garcia-Ruiz Prolactin increases cytosolic free calcium concentration in hepatocytes of lactating rats Endocrinology 129 1991 2857 2861
42. R.C. Baxter Measurement of growth hormone and prolactin receptor turnover in rat liver Endocrinology 117 1985 650 655 (Pubitemid 15237885)
43. T. Selzer, S. Albeck, and G. Schreiber Rational design of faster associating and tighter binding protein complexes Nat. Struct. Biol. 7 2000 537 541 (Pubitemid 30445907)
44. C. Kiel, and T. Selzer C. Herrmann Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex Proc. Natl. Acad. Sci. USA 101 2004 9223 9228 (Pubitemid 38812856)
45. S. Wenzel, and D. Wilbraham M. Longphre Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431 (Pubitemid 47576168)
46. H.P. Tony, and B.J. Shen W. Sebald Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency Eur. J. Biochem. 225 1994 659 665 (Pubitemid 24325584)
47. A.L. Andrews, and J.W. Holloway D.E. Davies IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets J. Immunol. 176 2006 7456 7461 (Pubitemid 43849048)