Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis

FEBS Journal

Volumn 278, Issue 18, 2011, Pages 3277-3286

  Shiryaev, Sergey A ^a   Cieplak, Piotr ^a   Aleshin, Alexander E ^a   Sun, Qing ^a   Zhu, Wenhong ^a   Motamedchaboki, Khatereh ^a   Sloutsky, Alexander ^b   Strongin, Alex Y ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

HSP65; MMP; Mycobacterium; proteolysis; tuberculosis

Indexed keywords

CHAPERONE; GELATINASE A; GELATINASE B; GLYCOSYLPHOSPHATIDYLINOSITOL; HEAT SHOCK PROTEIN 65; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 17; MATRIX METALLOPROTEINASE 24; MATRIX METALLOPROTEINASE 25; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VIVO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; TUBERCULOSIS;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CHAPERONIN 60; EPITOPES; HUMANS; HYDROLYSIS; IMMUNOMODULATION; ISOENZYMES; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 80052461153     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08244.x     Document Type: Article

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