Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domain

Infection and Immunity

Volumn 69, Issue 12, 2001, Pages 7349-7355

  Lewthwaite, J C ^a   Coates, A R M ^a   Tormay, P ^a   Singh, M ^a   Mascagni, P ^a   Poole, S ^a   Roberts, M ^a   Sharp, L ^a   Henderson, B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CHAPERONIN; HEAT SHOCK PROTEIN 65;

AMINO ACID SEQUENCE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENETIC CODE; HEAT TOLERANCE; MOLECULAR CLONING; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTIGENS, CD14; BACTERIAL PROTEINS; BINDING SITES; CHAPERONIN 60; CHAPERONINS; CYTOKINES; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 0035183063     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.12.7349-7355.2001     Document Type: Article

References (27)

1. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
2. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity
3. AIDS vaccine predictions
4. Chaperonin nomenclature
5. Immunological aspects of chaperonins
6. Autoimmunity, microbial immunity and the immunological homunculus
7. JPred: A consensus secondary structure prediction server
8. Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country
9. Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells
10. Homologous plant and bacterial proteins chaperone oligomeric protein assembly
11. The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL
12. Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells
13. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
14. Mycobacterium tuberculosis expresses two chaperonin-60 homologs
15. Are molecular chaperones microbial virulence factors?
16. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
17. Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: A potential contributory factor in Pott's disease
18. Murine peritoneal macrophages activated by the mycobacterial 65-kilodalton heat shock protein express enhanced microbicidal activity in vitro
19. Partial agonism: Mechanisms based on ligand-receptor interactions and on stimulus-response coupling
20. Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures
21. Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation
22. Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in Escherichia coli K-12
23. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
24. Heat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes
25. The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex
26. Heat shock proteins and antigens of Mycobacterium tuberculosis
27. Mechanisms of stimulation of interleukin-1 beta and tumor necrosis factoralpha by Mycobacterium tuberculosis components