Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium

Science

Volumn 327, Issue 5964, 2010, Pages 466-469

  Volkman, Hannah E ^a   Pozos, Tamara C ^b,f   Zheng, John ^b   Davis, J Muse ^c   Rawls, John F ^d,e   Ramakrishnan, Lalita ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY SECRETORY ANTIGENIC TARGET 6; GELATINASE B; ANTISENSE OLIGONUCLEOTIDE; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; ESAT 6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; RECOMBINANT PROTEIN; VIRULENCE FACTOR;

ANTIGEN; CYPRINID; ENZYME; GROWTH RATE; HOST-PATHOGEN INTERACTION; PATHOTYPE; TUBERCULOSIS; VIRULENCE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM; GRANULOMA; HOST; MACROPHAGE; MYCOBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TUMOR GROWTH; WILD TYPE; ANIMAL; ANIMAL EMBRYO; ATYPICAL MYCOBACTERIOSIS; DISEASE MODEL; ENZYME INDUCTION; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; PATHOGENICITY; PHYSIOLOGY; PRENATAL DEVELOPMENT; TUBERCULOSIS; ZEBRA FISH;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; DANIO RERIO; MYCOBACTERIUM MARINUM;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; ENZYME INDUCTION; EPITHELIAL CELLS; GRANULOMA; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MYCOBACTERIUM INFECTIONS, ATYPICAL; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; OLIGORIBONUCLEOTIDES, ANTISENSE; RECOMBINANT PROTEINS; TUBERCULOSIS; VIRULENCE FACTORS; ZEBRAFISH;

EID: 75649141266     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1179663     Document Type: Article

References (32)

1. H. Clay et al., Cell Host Microbe 2, 29 (2007).
2. A. J. Wolf et al., J. Immunol. 179, 2509 (2007).
3. D. O. Adams, Am. J. Pathol. 84, 164 (1976).
4. T. Ulrichs, S. H. Kaufmann, J. Pathol. 208, 261 (2006).
5. H. E. Volkman et al., PLoS Biol. 2, e367 (2004).
6. J. M. Davis, L. Ramakrishnan, Cell 136, 37 (2009).
7. P. E. Van den Steen et al., Crit. Rev. Biochem. Mol. Biol. 37, 375 (2002).
8. K. J. Greenlee, Z. Werb, F. Kheradmand, Physiol. Rev. 87, 69 (2007).
9. N. M. Price et al., J. Immunol. 166, 4223 (2001).
10. J. L. Taylor et al., Infect. Immun. 74, 6135 (2006).
11. K. J. Park et al., Respiration 72, 166 (2005).
12. P. Sheen et al., Eur. Respir. J. 33, 134 (2009).
13. H. Clay, H. E. Volkman, L. Ramakrishnan, Immunity 29, 283 (2008).
14. P. A. DiGiuseppe Champion, J. S. Cox, Cell. Microbiol. 9, 1376 (2007).
15. R. Simeone, D. Bottai, R. Brosch, Curr. Opin. Microbiol. 12, 4 (2009).
16. S. C. Derrick, S. L. Morris, Cell. Microbiol. 9, 1547 (2007).
17. J. C. Chang et al., Thorax 51, 306 (1996).
18. N. M. Price, R. H. Gilman, J. Uddin, S. Recavarren, J. S. Friedland, J.. Immunol. 171, 5579 (2003).
19. S. Shi et al., J. Exp. Med. 198, 987 (2003).
20. P. T. Elkington et al., Am. J. Respir. Cell Mol. Biol. 37, 431-437 (2007).
21. X. W. Zhu, N. M. Price, R. H. Gilman, S. Recarvarren, J. S. Friedland, J. Infect. Dis. 196, 1076 (2007).
22. D. Le Guellec, G. Morvan-Dubois, J. Y. Sire, Int. J. Dev. Biol. 48, 217 (2004).
23. D. R. Sherman et al., J. Infect. Dis. 190, 123 (2004).
24. I. C. Koo et al., Cell. Microbiol. 10, 1866 (2008).
25. S. A. Stanley, S. Raghavan, W. W. Hwang, J. S. Cox, Proc. Natl. Acad. Sci. USA. 100, 13001 (2003).
26. L. M. Stamm et al., J. Exp. Med. 198, 1361 (2003).
27. M. Hagedorn, K. H. Rohde, D. G. Russell, T. Soldati, Science 323, 1729 (2009).
28. D. G. Russell, Nat Rev. Microbiol. 5, 39 (2007).
29. T. Hsu et al., Proc. Natl. Acad. Sci. USA 100, 12420 (2003).
30. M. I. de Jonge et al., J. Bacteriol. 189, 6028 (2007).
31. Materials and methods are available as supporting material on Science Online.
32. We thank J. I. Gordon, W. Parks, D. Raible, D. Sherman, K. Urdahl, and P. Elkington for advice and discussion: D. Beery and R. Kim for help with microinjections: and J. Cameron, L. Swaim, and H. Wiedenhoft for fish facility maintenance. We also thank K. Winglee for developing FPC analysis methods, R. Burmeister for graphic design, and D. Tobin, B. Cormack, W. Parks, D. Stetson, R. Berg, and F. Chu for review of the manuscript. This work was supported by the Burroughs Wellcome Fund (L.R.), the Pew Scholars Program (J.F.R.), the NIH (L.R. and J.F.R.), an American Heart Association predoctoral fellowship (H.E.V.), a Pediatric Infectious Diseases Society postdoctoral award, the Children's Health Research Center new investigator award, an NIH diversity supplement (T.C.P.), and a National Defense Science and Engineering predoctoral fellowship (J.M.D.).