Ligation of α4β1 integrin on human intestinal mucosal mesenchymal cells selectively up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype

American Journal of Pathology

Volumn 157, Issue 6, 2000, Pages 1955-1962

  Pender, Sylvia L F ^a   Salmela, Mikko T ^b   Monteleone, Giovanni ^a   Schnapp, Denni ^a   McKenzie, Catriona ^a   Spencer, Jo ^c   Fong, Sherman ^d   Saarialho Kere, Ulpu ^b   MacDonald, Thomas T ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VERY LATE ACTIVATION ANTIGEN; ANTIBODY; GELATINASE A; HOMING RECEPTOR; IMMUNOGLOBULIN G; INTEGRIN; INTERSTITIAL COLLAGENASE; MESSENGER RNA; STROMELYSIN; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; CELL MIGRATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; INTESTINE MUCOSA; LAMINA PROPRIA; MESENCHYME CELL; MULTIGENE FAMILY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR UPREGULATION; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; EMBRYO; ENTERITIS; ENZYME ACTIVATION; GENETICS; IMMUNOLOGY; MESODERM; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; TISSUE DISTRIBUTION; ULCER; UPREGULATION;

ANTIBODIES; CELL MOVEMENT; EMBRYO; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN G; INFLAMMATORY BOWEL DISEASES; INTEGRIN ALPHA4BETA1; INTEGRINS; INTESTINAL MUCOSA; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MESODERM; PHENOTYPE; RECEPTORS, LYMPHOCYTE HOMING; RNA, MESSENGER; TISSUE DISTRIBUTION; ULCER; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033622478     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64834-1     Document Type: Article

References (47)

1. Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha
2. Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues
3. Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4
4. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
5. IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma
6. Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110
7. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture
8. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
9. Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells
10. Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence
11. T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells
12. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
13. Matrix metalloproteinases and their inhibitors in connective tissue remodeling
14. The matrix-degrading metalloproteinases
15. Matrix metalloproteinases: A review
16. Matrix metalloproteinases
17. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage
18. Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: Evidence that breakdown is mediated by metalloproteinases
19. Extracellular matrix degradation
20. Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine
21. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers
22. A major role for matrix metalloproteinases in T cell injury in the gut
23. Suppression of T cell-mediated injury in human gut by interleukin-10: Role of matrix metalloproteinases
24. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations
25. The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent
26. Expression of the VLA family of integrins in human intestine
27. Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents
28. Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to alpha 4 beta 1
29. Similar but nonidentical amino acid residues on vascular cell adhesion molecule-1 are involved in the interaction with alpha 4 beta 1 and alpha 4 beta 7 under different activity states
30. Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury
31. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
32. Overview of matrix metalloproteinase expression in cultured human cells
33. Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate
34. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization
35. Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma
36. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing
37. Myofibroblasts. II. Intestinal subepithelial myofibroblasts
38. A matrix metalloproteinase expressed on the surface of invasive tumour cells
39. Expression of matrix metalloproteinases during rat skin wound healing: Evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A
40. Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells
41. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma
42. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
43. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
44. Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice
45. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
46. Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells
47. Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense