The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31904-31914

  Su, Ya Chi ^a   Miller, Tara N ^a   Navaneetham, Duraiswamy ^a   Schoonmaker, Robert T ^a   Sinha, Dipali ^a   Walsh, Peter N ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAINS; COAGULATION FACTOR; MUTATIONAL ANALYSIS; PROTEASE INHIBITOR; SUBSTRATE BINDING; SUBSTRATE INTERACTION; SYNTHETIC SUBSTRATES;

CATALYSIS; COAGULATION; CRYSTAL STRUCTURE; HYDROLYSIS; MACROMOLECULES;

SUBSTRATES;

4 AMINOBENZAMIDINE; BLOOD CLOTTING FACTOR 11A; PROTEASE NEXIN; PROTEASE NEXIN 2; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROLYSIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; APROTININ; CATALYSIS; CATALYTIC DOMAIN; FACTOR XIA; HUMANS; KINETICS; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY;

EID: 80052394097     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.257527     Document Type: Article

References (54)

1. Bouma, B. N., and Griffin, J. H. (1977) J. Biol. Chem. 252, 6432-6437
2. Thompson, R. E., Mandle, R., Jr., and Kaplan, A. P. (1977) J. Clin. Invest. 60, 1376-1380
3. Rapaport, S. I., Proctor, R. R., Patch, M. J., and Yettra, M. (1961) Blood 18, 149-165
4. Leiba, H., Ramot, B., and Many, A. (1965) Br. J. Haematol. 11, 654-665
5. Naito, K., and Fujikawa, K. (1991) J. Biol. Chem. 266, 7353-7358
6. Gailani, D., and Broze, G. J., Jr. (1991) Science 253, 909-912
7. Halfon, S., and Craik, C. S. (1998) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rowlings, N. D., and Woessner, J. F., eds) pp. 12-21, Academic Press, London
8. Fujikawa, K., Legaz, M. E., Kato, H., and Davie, E. W. (1974) Biochemistry 13, 4508-4516
9. Di Scipio, R. G., Kurachi, K., and Davie, E. W. (1978) J. Clin. Invest. 61, 1528-1538
10. Sinha, D., Seaman, F. S., and Walsh, P. N. (1987) Biochemistry 26, 3768-3775
11. Baglia, F. A., Jameson, B. A., and Walsh, P. N. (1991) J. Biol. Chem. 266,24190-24197
12. Sun, Y., and Gailani, D. (1996) J. Biol. Chem. 271, 29023-29028
13. Sun, M. F., Zhao, M., and Gailani, D. (1999) J. Biol. Chem. 274, 36373-36378
14. Sinha, D., Marcinkiewicz, M., Navaneetham, D., and Walsh, P. N. (2007) Biochemistry 46, 9830-9839
15. Lindquist, P. A., Fujikawa, K., and Davie, E. W. (1978) J. Biol. Chem. 253, 1902-1909
16. Osterud, B., and Rapaport, S. I. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5260-5264
17. Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., and Ito, H. (1988) Nature 331, 530-532
18. Smith, R. P., Higuchi, D. A., and Broze, G. J., Jr. (1990) Science 248, 1126-1128
19. Van Nostrand, W. E., Schmaier, A. H., Farrow, J. S., and Cunningham, D. D. (1990) Science 248, 745-748
20. Badellino, K. O., and Walsh, P. N. (2000) Biochemistry 39, 4769-4777
21. Navaneetham, D., Jin, L., Pandey, P., Strickler, J. E., Babine, R. E., Abdel- Meguid, S. S., and Walsh, P. N. (2005) J. Biol. Chem. 280, 36165-36175
22. Ogawa, T., Verhamme, I. M., Sun, M. F., Bock, P. E., and Gailani, D. (2005) J. Biol. Chem. 280, 23523-23530
23. Sinha, D., Koshy, A., Seaman, F. S., and Walsh, P. N. (1985) J. Biol. Chem. 260, 10714-10719
24. Jameson, G. W., Roberts, D. V., Adams, R. W., Kyle, W. S., and Elmore, D. T. (1973) Biochem. J. 131, 107-117
25. Coleman, P. L., Lathham, H. G., Jr., and Shaw, E. N. (1976) Methods Enzymol. 45, 12-26
26. Bode, W., and Schwager, P. (1975) J. Mol. Biol. 98, 693-717
27. Evans, S. A., Olson, S. T., and Shore, J. D. (1982) J. Biol. Chem. 257, 3014-3017
28. Schmidt, A. E., Ogawa, T., Gailani, D., and Bajaj, S. P. (2004) J. Biol. Chem. 279, 29485-29492
29. Scandura, J. M., Zhang, Y., Van Nostrand, W. E., and Walsh, P. N. (1997) Biochemistry 36, 412-420
30. Wilkinson, F. H., Ahmad, S. S., and Walsh, P. N. (2002) J. Biol. Chem. 277, 5734-5741
31. Navaneetham, D., Sinha, D., and Walsh, P. N. (2010) J. Biochem. 148, 467-479
32. Wilkinson, F. H., London, F. S., and Walsh, P. N. (2002) J. Biol. Chem. 277, 5725-5733
33. Yang, X., and Walsh, P. N. (2005) Biochem. J. 390, 157-167
34. Perona, J. J., and Craik, C. S. (1995) Protein Sci. 4, 337-360
35. Bashtovyy, D., Jones, M. K., Anantharamaiah, G. M., and Segrest, J. P. (2011) J. Lipid Res. 52, 435-450
36. Perona, J. J., and Craik, C. S. (1997) J. Biol. Chem. 272, 29987-29990
37. Jin, L., Pandey, P., Babine, R. E., Gorga, J. C., Seidl, K. J., Gelfand, E., Weaver, D. T., Abdel-Meguid, S. S., and Strickler, J. E. (2005) J. Biol. Chem. 280, 4704-4712
38. Jin, L., Pandey, P., Babine, R. E., Weaver, D. T., Abdel-Meguid, S. S., and Strickler, J. E. (2005) Acta Crystallogr. D Biol. Crystallogr. 61, 1418-1425
39. McGrath, M. E., Vásquez, J. R., Craik, C. S., Yang, A. S., Honig, B., and Fletterick, R. J. (1992) Biochemistry 31, 3059-3064
40. Krem, M. M., Prasad, S., and Di Cera, E. (2002) J. Biol. Chem. 277, 40260-40264
41. Hedstrom, L. (2002) Chem. Rev. 102, 4501-4524
42. Page, M. J., and Di Cera, E. (2008) Cell Mol. Life Sci. 65, 1220-1236
43. Yang, L., Manithody, C., Olson, S. T., and Rezaie, A. R. (2003) J. Biol. Chem. 278, 25032-25038
44. Manithody, C., Yang, L., and Rezaie, A. R. (2002) Biochemistry 41, 6780-6788
45. Rezaie, A. R., Sun, M. F., and Gailani, D. (2006) Biochemistry 45, 9427-9433
46. Le Bonniec, B. F., Guinto, E. R., and Esmon, C. T. (1992) J. Biol. Chem. 267, 19341-19348
47. Blouse, G. E., Bøtkjaer, K. A., Deryugina, E., Byszuk, A. A., Jensen, J. M., Mortensen, K. K., Quigley, J. P., and Andreasen, P. A. (2009) J. Biol. Chem. 284, 4647-4657
48. Shen, L., Villoutreix, B. O., and Dahlbäck, B. (1999) Thromb. Haemost. 82, 1078-1087
49. Rezaie, A. R., and Esmon, C. T. (1993) J. Biol. Chem. 268, 19943-19948
50. Le Bonniec, B. F., and Esmon, C. T. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7371-7375
51. Sandler, B., Murakami, M., and Clardy, J. (1998) J. Am. Chem. Soc. 120, 595-596
52. Adler, M., Davey, D. D., Phillips, G. B., Kim, S. H., Jancarik, J., Rumennik, G., Light, D. R., and Whitlow, M. (2000) Biochemistry 39, 12534-12542
53. Narasimhan, L. S., Rubin, J. R., Holland, D. R., Plummer, J. S., Rapundalo, S. T., Edmunds, J. E., St-Denis, Y., Siddiqui, M. A., and Humblet, C. (2000) J. Med. Chem. 43, 361-368
54. Papagrigoriou, E., McEwan, P. A., Walsh, P. N., and Emsley, J. (2006) Nat. Struct. Mol. Biol. 13, 557-558