Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation

Biochemistry

Volumn 46, Issue 34, 2007, Pages 9830-9839

  Sinha, Dipali ^a   Marcinkiewicz, Mariola ^a   Navaneetham, Duraiswamy ^a   Walsh, Peter N ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENZYME ACTIVITY; ENZYME INHIBITION; MACROMOLECULES; SUBSTRATES;

BINDING EXOSITES; CLEAVAGE PRODUCTS; MACROMOLECULAR SUBSTRATES; REVERSIBLE INHIBITORS;

TRANSCRIPTION FACTORS;

4 AMINOBENZAMIDINE; ARGININE; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 9A; CALCIUM ION; SERINE PROTEINASE INHIBITOR; VALINE;

ARTICLE; HEAVY CHAIN; LIGHT CHAIN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CALCIUM; CATALYSIS; CATALYTIC DOMAIN; FACTOR IX; FACTOR XIA; HUMANS; HYDROLYSIS; KINETICS; PROTEIN BINDING; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

EID: 34548274439     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062296c     Document Type: Article

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