An ordered sequential mechanism for Factor IX and Factor IXa binding to platelet receptors in the assembly of the Factor X-activating complex

Biochemical Journal

Volumn 390, Issue 1, 2005, Pages 157-167

  Yang, Xia ^a   Walsh, Peter N ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Factor IXa; Factor X activation; Phospholipid membrane; Surface binding; Surface catalysis; Vitamin K dependent coagulation enzyme

Indexed keywords

BIOLOGICAL MEMBRANES; BIOMATERIALS; PHOSPHOLIPIDS;

FACTOR ACTIVATION; FACTOR IXA; SURFACE BINDING; SURFACE CATALYSIS;

ORGANIC ACIDS;

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; PEPTIDE; THROMBOCYTE RECEPTOR;

ARTICLE; CHIMERA; HUMAN; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; THROMBOCYTE; TITRIMETRY;

AMINO ACID SEQUENCE; BINDING SITES; BLOOD PLATELETS; CELL LINE; FACTOR IX; FACTOR IXA; HUMANS; MUTAGENESIS, SITE-DIRECTED; PLATELET ACTIVATION; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 23944517270     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050029     Document Type: Article

References (50)

1. Thompson, A. R. (2001) Molecular biology of Factor IX. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, chapter 7 (Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. W. and George, J. N., eds.), pp. 123-134, Lippincott Williams & Wilkins, Philadelphia
2. Kaufman, R. J., Antonarakis, S. E. and Fay, P. J. (2001) Factor VIII and hemophilia A. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, chapter 8 (Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. W. and George, J. N., eds.), pp. 135-156, Lippincott Williams & Wilkins, Philadelphia
3. Roberts, H. R. and White, Jr, G. C. (2001) Inherted disorders of prothrombin conversion. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, chapter 52 (Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. W. and George, D., eds.), pp. 840-853, Lippincott Williams & Wilkins, Philadelphia
4. Rao, A. K. (2001) Acquired qualitative platelet defects. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, chapter 55 (Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. W. and George, D., eds.), pp. 905-919, Lippincott Williams & Wilkins, Philadelphia
5. Tracy, P. B. (2001) Role of platelets and leukocytes in coagulation. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, chapter 33 (Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. W. and George, J. N., eds.), pp. 575-596, Lippincott Williams & Wilkins, Philadelphia
6. 2+ and phospholipids to the activation of human blood-coagulation Factor X by activated Factor IX. Biochem. J. 223, 607-615
7. Elodi, S., Varadi, K. and Voros, E. (1981) Kinetics of formation of factor IXa-factor VIII complex on the surface of platelets. Thromb. Res. 21, 695-700
8. Rawala-Sheikh, R., Ahmad, S. S., Ashby, B. and Walsh, P. N. (1990) Kinetics of coagulation factor X activation by platelet-bound factor IXa. Biochemistry 29, 2606-2611
9. Ahmad, S. S., Rawala-Sheikh, R. and Walsh, P. N. (1989) Comparative interactions of factor IX and factor IXa with human platelets. J. Biol. Chem. 264, 3244-3251
10. Ahmad, S. S., Rawala-Sheikh, R. and Walsh, P. N. (1989) Platelet receptor occupancy with factor IXa promotes factor X activation. J. Biol. Chem. 264, 20012-20016
11. Scandura, J. M., Ahmad, S. S. and Walsh, P. N. (1996) A binding site expressed on the surface of activated human platelets is shared by factor X and prothrombin. Biochemistry 35, 8890-8902
12. Scandura, J. M. and Walsh, P. N. (1996) Factor X bound to the surface of activated human platelets is preferentially activated by platelet-bound factor IXa. Biochemistry 35, 8903-8913
13. 35S-labeled recombinant factor VIII to activated and unactivated human platelets. J. Biol. Chem. 263, 16467-16470
14. Ahmad, S. S., Scandura, J. M. and Walsh, P. N. (2000) Structural and functional characterization of platelet receptor-mediated factor VIII binding. J. Biol. Chem. 275, 13071-13081
15. van Dieijen, G., Tans, G., Rosing, J. and Hemker, H. C. (1981) The role of phospholipid and factor VIIIa in the activation of bovine factor X. J. Biol. Chem. 256, 3433-3442
16. Ahmad, S. S. and Walsh, P. N. (2002) Lipid raft association of the factor VIII C2 domain mediates platelet membrane assembly of factor VIIIa into the factor-X-activating complex. Blood 100, 126a
17. Foster, P. A., Fulcher, C. A., Houghten, R. A. and Zimmerman, T. S. (1990) Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine. Blood 75, 1999-2004
18. Pratt, K. P., Shen, B. W., Takeshima, K., Davie, E. W., Fujikawa, K. and Stoddard, B. L. (1999) Structure of the C2 domain of human factor VIII at 1.5 Å resolution. Nature (London) 402, 439-442
19. Saenko, E. L. and Scandella, D. (1995) A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor. J. Biol. Chem. 270, 13826-13833
20. Ahmad, S. S. and Walsh, P. N. (2002) Coordinate binding studies of the substrate (factor X) with the cofactor (factor VIII) in the assembly of the factor X activating complex on the activated platelet surface. Biochemistry 41, 11269-11276
21. Ahmad, S. S., Wong, M. Y., Rawala, R., Jameson, B. A. and Walsh, P. N. (1998) Coagulation factor IX residues G4-Q11 mediate its interaction with a shared factor IX/IXa binding site on activated platelets but not the assembly of the functional factor X activating complex. Biochemistry 37, 1671-1679
22. Ahmad, S. S., Rawala, R., Cheung, W. F, Stafford, D. W. and Walsh, P. N. (1995) The role of the second growth-factor domain of human factor IXa in binding to platelets and in factor-X activation. Biochem. J. 310, 427-431
23. Ahmad, S. S., Rawala-Sheikh, R., Cheung, W. F, Jameson, B. A., Stafford, D. W. and Walsh, P. N. (1994) High-affinity, specific factor IXa binding to platelets is mediated in part by residues 3-11. Biochemistry 33, 12048-12055
24. Ahmad, S. S., Rawala-Sheikh, R., Monroe, D. M., Roberts, H. R. and Walsh, P. N. (1990) Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules. J. Biol. Chem. 265, 20907-20911
25. Rawala-Sheikh, R., Ahmad, S. S., Monroe, D. M, Roberts, H. R. and Walsh, P. N. (1992) Role of γ-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation. Blood 79, 398-405
26. Wilkinson, F. H., Ahmad, S. S. and Walsh, P. N. (2002) The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex. J. Biol. Chem. 277, 5734-5741
27. Wilkinson, F. H., London, F. S. and Walsh, P. N. (2002) Residues 88-109 of factor IXa are important for assembly of the factor-X activating complex. J. Biol. Chem. 277, 5725-5733
28. Wong, M. Y., Gurr, J. A. and Walsh, P. N. (1999) The second epidermal growth factor-like domain of human factor IXa mediates factor IXa binding to platelets and assembly of the factor X activating complex. Biochemistry 38, 8948-8960
29. 107 of the Factor IXa second epidermal growth factor domain that are essential for the assembly of the Factor X-activating complex on activated platelets. J. Biol. Chem. 279, 46400-46405
30. Geiser, M., Gebe, R., Drewello, D. and Schmitz, R. (2001) Integration of PCR fragments at any specific site within cloning vectors without the use of restriction enzymes and DNA ligase. Biotechniques 31, 88-92
31. Yan, S. B. (1996) Review of conformation-specific affinity purification methods for plasma vitamin K-dependent proteins. J. Mol. Recognit. 9, 211-218
32. Smith, P. K., Krohn, R. I., Hermanson, G. I, Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85
33. Winer, B. J., Brown, D. R. and Michels, K. M. (1991) Statistical Principles in Experimental Design, chapter 7, pp. 158-166, McGraw-Hill, New York
34. Leebeek, F. W., Kappers-Klunne, M. C. and Jie, K. S. (2004) Effective and safe use of recombinant factor Vila (NovoSeven) in elderly mild haemophilia A patients with high-titre antibodies against factor VIII. Haemophilia 10, 250-253
35. Hoffman, M. (2003) A cell-based model of coagulation and the role of factor Vila. Blood Rev. 17 (suppl. 1), S1-S5
36. Monroe, D. M., Hoffman, M., Oliver, J. A. and Roberts, H. R. (1998) A possible mechanism of action of activated factor VII independent of tissue factor. Blood Coagul. Fibrinolysis 9 (suppl. 1), S15-S20
37. London, F. and Walsh, P. N. (1996) The role of electrostatic interactions in the assembly of the factor X activating complex on both activated platelets and negatively-charged phospholipid vesicles. Biochemistry 35, 12146-12154
38. London, F, Ahmad, S. S. and Walsh, P. N. (1996) Annexin V inhibition of factor IXa-catalyzed factor X activation on human platelets and on negatively-charged phospholipid vesicles. Biochemistry 35, 16886-16897
39. London, F. S. and Walsh, P. N. (2000) Zymogen factor IX potentiates factor IXa-catalyzed factor X activation. Biochemistry 39, 9850-9858
40. Zwaal, R. F., Severs, E. M., Comfurius, P., Rosing, J., Tilly, R. H. and Verhallen, P. F. (1989) Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells: mechanisms and physiological significance. Mol. Cell. Biochem. 91, 23-31
41. Zwaal, R. F, Comfurius, P. and Bevers, E. M. (1992) Platelet procoagulant activity and microvesicle formation. Its putative role in hemostasis and thrombosis. Biochim. Biophys. Acta 1180, 1-8
42. Zwaal, R. F., Comfurius, P. and Bevers, E. M. (1993) Mechanism and function of changes in membrane-phospholipid asymmetry in platelets and erythrocytes. Biochem. Soc. Trans. 21, 248-253
43. Zwaal, R. F., Comfurius, P. and van Deenen, L. L. (1977) Membrane asymmetry and blood coagulation. Nature (London) 268, 358-360
44. Christiansen, W. T, Jalbert, L R., Robertson, R. M., Jhingan, A., Prorok, M. and Castellino, F. J. (1995) Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid vesicles. Biochemistry 34, 10376-10382
45. Nelsestuen, G. L., Kisiel, W. and Di Scipio, R. G. (1978) Interaction of vitamin K-dependent proteins with membranes. Biochemistry 17, 2134-2138
46. Schwalbe, R. A., Ryan, J., Stern, D. M., Kisiel, W., Dahlback, B. and Nelsestuen, G. L. (1989) Protein structural requirements and properties of membrane binding by γ-carboxyglutamic acid-containing plasma proteins and peptides. J. Biol. Chem. 264, 20288-20296
47. Gilbert, G. E., Furie, B. C. and Furie, B. (1990) Binding of human factor VIII to phospholipid vesicles. J. Biol. Chem. 265, 815-822
48. London, F. S. and Walsh, P. N. (1992) Activation-dependent appearance of a platelet protein that recognizes factor IXa. Circulation 86, 1-465
49. Ahmad, S. S. and Walsh, P. N. (2003) Association of factor X with lipid rafts in the presence of active cofactor (factor Villa) promotes the assembly of factor-X activating complex on the activated platelet membrane. J. Thromb. Haemost. (suppl. 1), OC114
50. Nguyen, D., London, F. S., Ahmad, S. S. and Walsh, P. N. (2003) Sterol-rich membrane rafts regulate exposure of platelet binding sites for factor IXa. Blood 102, 772a