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Volumn 309, Issue 1-2, 2011, Pages 45-54

Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats

Author keywords

Middle cerebral artery occlusion; Neurobehavioral; Neuroprotection; Oxidative stress; Silymarin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CARBOXYMETHYLCELLULOSE; CASPASE 9; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; PROTEIN P53; SILYMARIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 80052382226     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.07.035     Document Type: Article
Times cited : (88)

References (64)
  • 2
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • D. Lloyd-Jones, R. Adams, M. Carnethon, G. De Simone, T.B. Ferguson, and K. Flegal Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 119 2009 480 486
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.B.5    Flegal, K.6
  • 3
    • 58149279285 scopus 로고    scopus 로고
    • Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
    • S. Yousuf, F. Atif, M. Ahmad, N. Hoda, T. Ishrat, and B. Khan Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia Brain Res 1250 2009 242 253
    • (2009) Brain Res , vol.1250 , pp. 242-253
    • Yousuf, S.1    Atif, F.2    Ahmad, M.3    Hoda, N.4    Ishrat, T.5    Khan, B.6
  • 4
    • 0027264907 scopus 로고
    • Demonstration of hydroxyl radical and its role in hydrogen peroxide-induced myocardial injury: Hydroxyl radical dependent and independent mechanisms
    • DOI 10.1016/0891-5849(93)90121-A
    • G. Takemura, T. Onodera, R.W. Millard, and M. Ashraf Demonstration of hydroxyl radical and its role in hydrogen peroxide-induced myocardial injury: hydroxyl radical dependent and independent mechanisms Free Radic Biol Med 15 1993 13 25 (Pubitemid 23171439)
    • (1993) Free Radical Biology and Medicine , vol.15 , Issue.1 , pp. 13-25
    • Takemura, G.1    Onodera, T.2    Millard, R.W.3    Ashraf, M.4
  • 5
    • 0031962869 scopus 로고    scopus 로고
    • Correlation between direct esr spectroscopic measurements and electromechanical and biochemical assessments of exogenous free radical injury in isolated rat cardiac myocytes
    • DOI 10.1016/S0891-5849(97)00167-6, PII S0891584997001676
    • M. Courtois, V. Maupoil, E. Fantini, I. Durot, A. Javouhey-Donzel, and P. Athias Correlation between direct ESR spectroscopic measurements and electromechanical and biochemical assessments of exogenous free radical injury in isolated rat cardiac myocytes Free Radic Biol Med 24 1998 121 131 (Pubitemid 28006443)
    • (1998) Free Radical Biology and Medicine , vol.24 , Issue.1 , pp. 121-131
    • Courtois, M.1    Maupoil, V.2    Fantini, E.3    Durot, I.4    Javouhey-Donzel, A.5    Athias, P.6    Grynberg, A.7    Rochette, L.8
  • 6
    • 0032818386 scopus 로고    scopus 로고
    • Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion
    • DOI 10.1016/S0891-5849(99)00100-8, PII S0891584999001008
    • M.C. McDonald, K. Zacharowski, J. Bowes, S. Cuzzocrea, and C. Thiemermann Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion Free Radic Biol Med 27 1999 493 503 (Pubitemid 29408634)
    • (1999) Free Radical Biology and Medicine , vol.27 , Issue.5-6 , pp. 493-503
    • McDonald, M.C.1    Zacharowski, K.2    Bowes, J.3    Cuzzocrea, S.4    Thiemermann, C.5
  • 8
    • 68149180674 scopus 로고    scopus 로고
    • Ischemia-induced mitochondrial apoptosis is significantly attenuated by ischemic preconditioning
    • P. Racay, M. Chomova, Z. Tatarkova, P. Kaplan, J. Hatok, and D. Dobrota Ischemia-induced mitochondrial apoptosis is significantly attenuated by ischemic preconditioning Cell Mol Neurobiol 29 2009 901 908
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 901-908
    • Racay, P.1    Chomova, M.2    Tatarkova, Z.3    Kaplan, P.4    Hatok, J.5    Dobrota, D.6
  • 9
    • 0030273118 scopus 로고    scopus 로고
    • Ischemia-induced neuronal apoptosis
    • DOI 10.1016/S0959-4388(96)80101-2
    • D.W. Choi Ischemia-induced neuronal apoptosis Curr Opin Neurobiol 6 1996 667 672 (Pubitemid 26387723)
    • (1996) Current Opinion in Neurobiology , vol.6 , Issue.5 , pp. 667-672
    • Choi, D.W.1
  • 12
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    • N.K. Singhal, G. Srivastava, D.K. Patel, S.K. Jain, and M.P. Singh Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse J Pineal Res 50 2011 97 109
    • (2011) J Pineal Res , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3    Jain, S.K.4    Singh, M.P.5
  • 13
    • 0032715311 scopus 로고    scopus 로고
    • Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
    • S.K. Manna, A. Mukhopadhyay, N.T. Van, and B.B. Aggarwal Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis J Immunol 163 1999 6800 6809
    • (1999) J Immunol , vol.163 , pp. 6800-6809
    • Manna, S.K.1    Mukhopadhyay, A.2    Van, N.T.3    Aggarwal, B.B.4
  • 14
    • 0026532350 scopus 로고
    • Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes
    • E. Bosisio, C. Benelli, and O. Pirola Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes Pharmacol Res 25 1992 147 154
    • (1992) Pharmacol Res , vol.25 , pp. 147-154
    • Bosisio, E.1    Benelli, C.2    Pirola, O.3
  • 15
    • 0032078089 scopus 로고    scopus 로고
    • Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells
    • DOI 10.1016/S0891-5849(97)00456-5, PII S0891584997004565
    • U. Rauen, and H. de Groot Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells Free Radic Biol Med 24 1998 1316 1323 (Pubitemid 28246748)
    • (1998) Free Radical Biology and Medicine , vol.24 , Issue.7-8 , pp. 1316-1323
    • Rauen, U.1    De Groot, H.2
  • 16
    • 0024455859 scopus 로고
    • Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat
    • A. Valenzuela, M. Aspillaga, S. Vial, and R. Guerra Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat Planta Med 55 1989 420 422 (Pubitemid 19249809)
    • (1989) Planta Medica , vol.55 , Issue.5 , pp. 420-422
    • Valenzuela, A.1    Aspillaga, M.2    Vial, S.3    Guerra, R.4
  • 17
    • 0026006786 scopus 로고
    • Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme
    • G. Müzes, G. Deák, I. Láng, K. Nékám, P. Gergely, and J. Fehér Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme Acta Physiol Hung 78 1991 3 9
    • (1991) Acta Physiol Hung , vol.78 , pp. 3-9
    • Müzes, G.1    Deák, G.2    Láng, I.3    Nékám, K.4    Gergely, P.5    Fehér, J.6
  • 18
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91 (Pubitemid 19040218)
    • (1989) Stroke , vol.20 , Issue.1 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3    Cummins, R.4
  • 19
    • 0037212415 scopus 로고    scopus 로고
    • Protective effect of Nardostachys jatamansi in rat cerebral ischemia
    • DOI 10.1016/S0091-3057(02)01030-4, PII S0091305702010304
    • S. Salim, M. Ahmad, K.S. Zafar, A.S. Ahmad, and F. Islam Protective effect of Nardostachys jatamansi in rat cerebral ischemia Pharmacol Biochem Behav 74 2003 481 486 (Pubitemid 35449534)
    • (2003) Pharmacology Biochemistry and Behavior , vol.74 , Issue.2 , pp. 481-486
    • Salim, S.1    Ahmad, M.2    Zafar, K.S.3    Ahmad, A.S.4    Islam, F.5
  • 20
    • 33846345425 scopus 로고    scopus 로고
    • Protective effect of silymarin on oxidative stress in rat brain
    • DOI 10.1016/j.phymed.2006.02.005, PII S0944711306000419
    • C. Nencini, G. Giorgi, and L. Micheli Protective effect of silymarin on oxidative stress in rat brain Phytomedicine 14 2007 129 135 (Pubitemid 46136941)
    • (2007) Phytomedicine , vol.14 , Issue.2-3 , pp. 129-135
    • Nencini, C.1    Giorgi, G.2    Micheli, L.3
  • 21
    • 70349337734 scopus 로고    scopus 로고
    • Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice
    • P. Lu, T. Mamiya, L.L. Lu, A. Mouri, L. Zou, and T. Nagai Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice Br J Pharmacol 157 2009 1270 1277
    • (2009) Br J Pharmacol , vol.157 , pp. 1270-1277
    • Lu, P.1    Mamiya, T.2    Lu, L.L.3    Mouri, A.4    Zou, L.5    Nagai, T.6
  • 22
    • 20244389989 scopus 로고    scopus 로고
    • Locomotor activity in D2 dopamine receptor deficient mice in determined by gene dosage, genetic background and developmental adaptations
    • M.A. Kelly, M. Rubinstein, T.J. Phillips, C.N. Lessov, S. Burkhart-Kasch, and G. Zhang Locomotor activity in D2 dopamine receptor deficient mice in determined by gene dosage, genetic background and developmental adaptations J Neurosci 18 1998 7470 7479
    • (1998) J Neurosci , vol.18 , pp. 7470-7479
    • Kelly, M.A.1    Rubinstein, M.2    Phillips, T.J.3    Lessov, C.N.4    Burkhart-Kasch, S.5    Zhang, G.6
  • 23
    • 0029055738 scopus 로고
    • Age related learning deficits in transgenic mice expressing the 721-amino acid isoform of human beta-amyloid precursor protein
    • P.M. Moran, L.S. Higgins, B. Cordel, and P.C. Moser Age related learning deficits in transgenic mice expressing the 721-amino acid isoform of human beta-amyloid precursor protein Proc Natl Acad Sci USA 92 1995 5341 5345
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5341-5345
    • Moran, P.M.1    Higgins, L.S.2    Cordel, B.3    Moser, P.C.4
  • 24
    • 0002433688 scopus 로고
    • Effect of sulfhydryl reagent on peroxidation in microsome
    • H.C. Utley, F. Bernheim, and P. Hochslein Effect of sulfhydryl reagent on peroxidation in microsome Arch Biochem Biophys 260 1967 521 531
    • (1967) Arch Biochem Biophys , vol.260 , pp. 521-531
    • Utley, H.C.1    Bernheim, F.2    Hochslein, P.3
  • 25
    • 0016151122 scopus 로고
    • Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite
    • D.J. Jollow, J.R. Mitchell, N. Zampaglione, and J.R. Gillette Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite Pharmacology 11 1974 151 169
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaglione, N.3    Gillette, J.R.4
  • 26
    • 0016808562 scopus 로고
    • Purification and characterization of the flavoenzyme glutathione reductase from rat liver
    • I. Carlberg, and B. Mannervik Purification and characterization of the flavoenzyme glutathione reductase from rat liver J Biol Chem 250 1975 5475 5480
    • (1975) J Biol Chem , vol.250 , pp. 5475-5480
    • Carlberg, I.1    Mannervik, B.2
  • 27
    • 0021752183 scopus 로고
    • Differential distribution of glutathione and glutathione related enzymes in rabbit kidneys: Possible implication in analgesic neuropathy
    • J. Mohandas, J.J. Marshall, G.G. Duggin, J.S. Horvath, and D. Tiller Differential distribution of glutathione and glutathione related enzymes in rabbit kidneys: possible implication in analgesic neuropathy Cancer Res 44 1984 5086 5091
    • (1984) Cancer Res , vol.44 , pp. 5086-5091
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.5
  • 28
    • 0034038502 scopus 로고    scopus 로고
    • Effects of DL-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
    • M. Stevens, I. Obrosova, X. Cao, C.V. Huysen, and D.A. Green Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative stress in experimental diabetic neuropathy Diabetes 49 2000 1006 1015 (Pubitemid 30349424)
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 1006-1015
    • Stevens, M.J.1    Obrosova, I.2    Cao, X.3    Van Huysen, C.4    Greene, D.A.5
  • 29
    • 0019350315 scopus 로고
    • Catecholamines and the brain microsomal Na,K-adenosinetriphosphatase. I. Protection against lipoperoxidative damage
    • DOI 10.1016/0006-2952(81)90626-2
    • P. Svoboda, and B. Mossinger Catecholamines and the brain microsomal Na, Kadenosinetriphosphatase-I, protection against lipoperoxidative damage Biochem Pharmacol 30 1981 427 432 (Pubitemid 11188910)
    • (1981) Biochemical Pharmacology , vol.30 , Issue.5 , pp. 427-432
    • Svoboda, P.1    Mosinger, B.2
  • 30
    • 0000154206 scopus 로고
    • The colorimetric determination of phosphorus
    • C.H. Fiske, and Y. Subbarow The colorimetric determination of phosphorus J Biol Chem 65 1925 375 400
    • (1925) J Biol Chem , vol.65 , pp. 375-400
    • Fiske, C.H.1    Subbarow, Y.2
  • 31
    • 0023732415 scopus 로고    scopus 로고
    • (S)-Emopamil, a novel calcium channel blocker and serotonin S2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in rat
    • H. Nakayama, M.D. Ginsberg, and W.D. Dietrich (S)-Emopamil, a novel calcium channel blocker and serotonin S2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in rat Neurology 38 1998 1667 1673
    • (1998) Neurology , vol.38 , pp. 1667-1673
    • Nakayama, H.1    Ginsberg, M.D.2    Dietrich, W.D.3
  • 33
    • 79951514678 scopus 로고    scopus 로고
    • Antioxidant enzymes are differently changed in experimental ischemic hippocampal CA1 region following repeated restraint stress
    • K.Y. Yoo, C.H. Lee, J.H. Park, I.K. Hwang, O.K. Park, and S.H. Kwon Antioxidant enzymes are differently changed in experimental ischemic hippocampal CA1 region following repeated restraint stress J Neurol Sci 302 2011 33 42
    • (2011) J Neurol Sci , vol.302 , pp. 33-42
    • Yoo, K.Y.1    Lee, C.H.2    Park, J.H.3    Hwang, I.K.4    Park, O.K.5    Kwon, S.H.6
  • 34
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • B. Halliwell Reactive oxygen species and the central nervous system J Neurochem 59 1992 1609 1623
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 35
    • 0033899176 scopus 로고    scopus 로고
    • Glutathione metabolism in brain: Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species
    • DOI 10.1046/j.1432-1327.2000.01597.x
    • R. Dringen, J.M. Gutterer, and J. Hirrlinger Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species Eur J Biochem 267 2000 4912 4916 (Pubitemid 30641287)
    • (2000) European Journal of Biochemistry , vol.267 , Issue.16 , pp. 4912-4916
    • Dringen, R.1    Gutterer, J.M.2    Hirrlinger, J.3
  • 36
    • 3142655732 scopus 로고    scopus 로고
    • Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia
    • DOI 10.1016/j.brainres.2004.05.038, PII S0006899304007541
    • S.A. Andrabi, M.G. Spina, P. Lorenz, U. Ebmeyer, G. Wolf, and T.F. Horn Oxyresveratrol (trans-2, 3, 4, 5-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia Brain Res 1017 2004 98 107 (Pubitemid 38917149)
    • (2004) Brain Research , vol.1017 , Issue.1-2 , pp. 98-107
    • Andrabi, S.A.1    Spina, M.G.2    Lorenz, P.3    Ebmeyer, U.4    Wolf, G.5    Horn, T.F.W.6
  • 38
  • 39
    • 0029879066 scopus 로고    scopus 로고
    • Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin
    • DOI 10.1053/jhep.1996.v23.pm0008666328
    • C. Dehmlow, J. Erhard, and H. de Groot Inhibition of Kupffer cell functions as an explanation for hepatoprotective properties of silibinin Hepatology 22 1996 749 754 (Pubitemid 26111988)
    • (1996) Hepatology , vol.23 , Issue.4 , pp. 749-754
    • Dehmlow, C.1    Erhard, J.2    De Groot, H.3
  • 42
    • 77955267120 scopus 로고    scopus 로고
    • Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity
    • Z. Wang, T. Liu, L. Gan, T. Wang, X. Yuan, and B. Zhang Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity Eur J Pharmacol 643 2010 211 217
    • (2010) Eur J Pharmacol , vol.643 , pp. 211-217
    • Wang, Z.1    Liu, T.2    Gan, L.3    Wang, T.4    Yuan, X.5    Zhang, B.6
  • 44
    • 0031950858 scopus 로고    scopus 로고
    • To what extent have functional studies of ischaemia in animals been useful in the assessment of potential neuroprotective agents?
    • DOI 10.1016/S0165-6147(97)01157-7
    • A.J. Hunter, K.B. Mackay, and D.C. Rogers To what extent have functional studies of ischaemia in animals been useful in the assessment of potential neuroprotective agents Trends Pharmacol Sci 19 1998 59 66 (Pubitemid 28137715)
    • (1998) Trends in Pharmacological Sciences , vol.19 , Issue.2 , pp. 59-66
    • Hunter, A.J.1    Mackay, K.B.2    Rogers, D.C.3
  • 45
    • 0019268092 scopus 로고
    • The free radical pathology and the microcirculation in the major central nervous system disorders
    • H.B. Demopoulos, E.S. Flamm, D.D. Pietronigro, and M.L. Seligman The free radical pathology and the microcirculation in the major central nervous system disorders Acta Physiol Scand Suppl 492 1980 91 119 (Pubitemid 11152702)
    • (1980) Acta Physiologica Scandinavica , vol.110 , Issue.SUPPL. 492 , pp. 91-119
    • Demopoulos, H.B.1    Flamm, E.S.2    Pietronigro, D.D.3    Seligman, M.L.4
  • 46
    • 0032948625 scopus 로고
    • Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: A possible involvement of reactive oxygen species
    • M. Kale, N. Rathore, S. John, and D. Bhatnagar Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species Toxicol Lett 105 1993 197 205
    • (1993) Toxicol Lett , vol.105 , pp. 197-205
    • Kale, M.1    Rathore, N.2    John, S.3    Bhatnagar, D.4
  • 47
    • 0037316636 scopus 로고    scopus 로고
    • Dose-dependent protective effect of selenium in rat model of Parkinson's disease: Neurobehavioral and neurochemical evidences
    • DOI 10.1046/j.1471-4159.2003.01531.x
    • K.S. Zafar, A. Siddiqui, I. Sayeed, M. Ahmad, S. Salim, and F. Islam J Dose-dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences Neurochem 84 2003 438 446 (Pubitemid 36182242)
    • (2003) Journal of Neurochemistry , vol.84 , Issue.3 , pp. 438-446
    • Zafar, K.S.1    Siddiqui, A.2    Sayeed, I.3    Ahmad, M.4    Salim, S.5    Islam, F.6
  • 48
    • 0033971069 scopus 로고    scopus 로고
    • Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation
    • DOI 10.1016/S0006-8993(99)02249-0, PII S0006899399022490
    • S.Z. Imam, and S.F. Ali Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation Brain Res 855 2000 186 191 (Pubitemid 30067713)
    • (2000) Brain Research , vol.855 , Issue.1 , pp. 186-191
    • Imam, S.Z.1    Ali, S.F.2
  • 49
    • 0028263767 scopus 로고
    • Glutathione-ascorbic acid antioxidant system in animals
    • A. Meister Glutathione-ascorbic acid antioxidant system in animals J Biol Chem 269 1994 9397 9400 (Pubitemid 24196524)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.13 , pp. 9397-9400
    • Meister, A.1
  • 51
    • 0029785583 scopus 로고
    • Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis
    • B.P. Yu, and R. Yang Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis Ann N Y Acad Sci 786 1994 1 11
    • (1994) Ann N y Acad Sci , vol.786 , pp. 1-11
    • Yu, B.P.1    Yang, R.2
  • 52
    • 61449215012 scopus 로고    scopus 로고
    • Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke
    • M. Sun, Y. Zhao, Y. Gu, and C. Xu Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke Neurochem Int 54 2009 339 346
    • (2009) Neurochem Int , vol.54 , pp. 339-346
    • Sun, M.1    Zhao, Y.2    Gu, Y.3    Xu, C.4
  • 53
    • 0036906534 scopus 로고    scopus 로고
    • Silymarin protects dopaminergic neurons against lipopolysaccharide- induced neurotoxicity by inhibiting microglia activation
    • M.J. Wang, W.W. Lin, H.L. Chen, Y.H. Chang, H.C. Ou, and J.S. Kuo Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation Eur J Neurosci 16 2002 2103 2112
    • (2002) Eur J Neurosci , vol.16 , pp. 2103-2112
    • Wang, M.J.1    Lin, W.W.2    Chen, H.L.3    Chang, Y.H.4    Ou, H.C.5    Kuo, J.S.6
  • 54
    • 77954956439 scopus 로고    scopus 로고
    • Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress
    • T. Baluchnejadmojarad, M. Roghani, and M. Mafakheri Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress Neurosci Lett 480 2010 206 210
    • (2010) Neurosci Lett , vol.480 , pp. 206-210
    • Baluchnejadmojarad, T.1    Roghani, M.2    Mafakheri, M.3
  • 55
    • 78349312428 scopus 로고    scopus 로고
    • Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats
    • Y. Chtourou, H. Fetoui, M. Sefi, K. Trabelsi, M. Barkallah, and T. Boudawara Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats Biometals 23 2010 985 996
    • (2010) Biometals , vol.23 , pp. 985-996
    • Chtourou, Y.1    Fetoui, H.2    Sefi, M.3    Trabelsi, K.4    Barkallah, M.5    Boudawara, T.6
  • 56
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • P.H. Chan Role of oxidants in ischemic brain damage Stroke 27 1996 1124 1129 (Pubitemid 26177617)
    • (1996) Stroke , vol.27 , Issue.6 , pp. 1124-1129
    • Chan, P.H.1
  • 57
    • 67651006168 scopus 로고    scopus 로고
    • Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats
    • H. Xu, X.K. Li, Q. Zheng, Y.D. Huang, C.C. Yao, and Z.J. Su Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats Injury 40 2009 963 967
    • (2009) Injury , vol.40 , pp. 963-967
    • Xu, H.1    Li, X.K.2    Zheng, Q.3    Huang, Y.D.4    Yao, C.C.5    Su, Z.J.6
  • 58
    • 66149171367 scopus 로고    scopus 로고
    • Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia
    • J.E. Jung, G.S. Kim, P. Narasimhan, Y.S. Song, and P.H. Chan Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia J Neurosci 29 2009 7003 7014
    • (2009) J Neurosci , vol.29 , pp. 7003-7014
    • Jung, J.E.1    Kim, G.S.2    Narasimhan, P.3    Song, Y.S.4    Chan, P.H.5
  • 59
    • 67349106386 scopus 로고    scopus 로고
    • Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation
    • T. Wang, J. Gu, P.F. Wu, F. Wang, Z. Xiong, and Y.J. Yang Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation Free Radic Biol Med 47 2009 229 240
    • (2009) Free Radic Biol Med , vol.47 , pp. 229-240
    • Wang, T.1    Gu, J.2    Wu, P.F.3    Wang, F.4    Xiong, Z.5    Yang, Y.J.6
  • 60
    • 34249797890 scopus 로고    scopus 로고
    • Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: A mechanism for neuroprotection
    • X. Ji, Y. Luo, F. Ling, R.A. Stetler, J. Lan, and G. Cao Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection Front Biosci 12 2007 1734 1747
    • (2007) Front Biosci , vol.12 , pp. 1734-1747
    • Ji, X.1    Luo, Y.2    Ling, F.3    Stetler, R.A.4    Lan, J.5    Cao, G.6
  • 61
    • 71349087001 scopus 로고    scopus 로고
    • Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats
    • M.M. Khan, T. Ishrat, A. Ahmad, M.N. Hoda, M.B. Khan, and G. Khuwaja Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats Chem Biol Interact 183 2010 255 263
    • (2010) Chem Biol Interact , vol.183 , pp. 255-263
    • Khan, M.M.1    Ishrat, T.2    Ahmad, A.3    Hoda, M.N.4    Khan, M.B.5    Khuwaja, G.6
  • 63
    • 0037338625 scopus 로고    scopus 로고
    • L, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin J Cereb Blood Flow Metab 23 2003 320 330 (Pubitemid 36307576)
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , Issue.3 , pp. 320-330
    • Chong, Z.Z.1    Kang, J.-Q.2    Maiese, K.3
  • 64
    • 57049169080 scopus 로고    scopus 로고
    • Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats
    • A. Diaz-Ruiz, C. Zavala, S. Montes, A. Ortiz-Plata, H. Salgado-Ceballos, and S. Orozco-Suarez Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats J Neurosci Res 86 2008 3410 3419
    • (2008) J Neurosci Res , vol.86 , pp. 3410-3419
    • Diaz-Ruiz, A.1    Zavala, C.2    Montes, S.3    Ortiz-Plata, A.4    Salgado-Ceballos, H.5    Orozco-Suarez, S.6


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