Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia

Brain Research

Volumn 1017, Issue 1-2, 2004, Pages 98-107

  Andrabi, Shaida A ^a   Spina, Mariarosa G ^a   Lorenz, Peter ^a   Ebmeyer, Uwe ^a   Wolf, Gerald ^a   Horn, Thomas F W ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Brain infarct; Hydroxystilbene; Ischemia; MCAO; Middle cerebral artery occlusion; Natural compound; Neuroprotection; Stroke

Indexed keywords

ANTIOXIDANT; CASPASE 3; CYTOCHROME C; DNA; OXYRESVERATROL; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REPERFUSION INJURY; SCORING SYSTEM; STAINING;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL CORTEX; CEREBRAL INFARCTION; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; NEUROLOGIC EXAMINATION; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHOPYRUVATE HYDRATASE; PLANT EXTRACTS; RATS; RATS, WISTAR; STILBENES; TIME FACTORS;

EID: 3142655732     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.038     Document Type: Article

References (53)

1. Antonsson B. Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion. Cell Tissue Res. 306:2001;347-361
2. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 17:1986;472-476
3. Belayev L., Alonso O.F., Busto R., Zhao W., Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1996;1616-1622
4. Bhalla A., Wolfe C.D., Rudd A.G. Management of acute physiological parameters after stroke. QJM. 94:2001;167-172
5. Chakraborti T., Das S., Mondal M., Roychoudhury S., Chakraborti S. Oxidant, mitochondria and calcium: an overview. Cell. Signal. 11:1999;77-85
6. Chan P.H. Oxygen radicals in focal cerebral ischemia. Brain Pathol. 4:1994;59-65
7. Chan P.H. Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21:2001;2-14
8. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11:1988;465-469
9. Chung K.O., Kim B.Y., Lee M.H., Kim Y.R., Chung H.Y., Park J.H., Moon J.O. In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. J. Pharm. Pharmacol. 55:2003;1695-1700
10. Dawson T.M., Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science. 302:2003;819-822
11. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50
12. Faraci F.M., Brian J.E. Jr. Nitric oxide and the cerebral circulation. Stroke. 25:1994;692-703
13. Finklestein S.P., Caday C.G., Kano M., Berlove D.J., Hsu C.Y., Moskowitz M., Klagsbrun M. Growth factor expression after stroke. Stroke. 21:1990;122-124
14. Fremont L. Biological effects of resveratrol. Life Sci. 66:2000;663-673
15. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312
16. Hattori I., Takagi Y., Nakamura H., Nozaki K., Bai J., Kondo N., Sugino T., Nishimura M., Hashimoto N., Yodoi J. Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice. Antioxid. Redox Signal. 6:2004;81-87
17. Hirakura K., Hano Y., Fukai T., Nomura T., Uzawa J., Fukushima K. Structures of three new natural diels-alder type adducts, kuwanons P and X, and mulberrofuran J, from the cultivated mulberry tree (Morus Ihou KOIDZ.). Chem. Pharm. Bull. 33:1985;1088-1096
18. Huang S.S., Tsai M.C., Chih C.L., Hung L.M., Tsai S.K. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci. 69:2001;1057-1065
19. Hung L.M., Chen J.K., Lee R.S., Liang H.C., Su M.J. Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart. Free Radic. Biol. Med. 30:2001;877-883
20. Hurtado O., De Cristobal J., Sanchez V., Lizasoain I., Cardenas A., Pereira M.P., Colado M.I., Leza J.C., Lorenzo P., Moro M.A. Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke. FASEB J. 17:2003;2082-2084
21. Ikeda Y., Long D.M. The molecular basis of brain injury and brain edema: the role of oxygen free radicals. Neurosurgery. 27:1990;1-11
22. Ikeda K., Negishi H., Yamori Y. Antioxidant nutrients and hypoxia/ischemia brain injury in rodents. Toxicology. 189:2003;55-61
23. Jemmerson R., Liu J., Hausauer D., Lam K.P., Mondino A., Nelson R.D. A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles. Biochemistry. 38:1999;3599-3609
24. Kowaltowski A.J., Castilho R.F., Vercesi A.E. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 495:2001;12-15
25. Kunduzova O.R., Escourrou G., Seguelas M.H., Delagrange P., De La Farge F., Cambon C., Parini A. Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion. FASEB J. 17:2003;872-874
26. Laing R.J., Jakubowski J., Laing R.W. Middle cerebral artery occlusion without craniectomy in rats. Which method works best? Stroke. 24:1993;294-297. (discussion 297-8)
27. Leker R.R., Gai N., Mechoulam R., Ovadia H. Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. Stroke. 34:2003;2000-2006
28. Levine W.G. Glutathione, lipid peroxidation and regulation of cytochrome P-450 activity. Life Sci. 31:1982;779-784
29. Lewen A., Matz P., Chan P.H. Free radical pathways in CNS injury. J. Neurotrauma. 17:2000;871-890
30. Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304:2003;1-7
31. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157
32. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91
33. Lorenz P., Roychowdhury S., Engelmann M., Wolf G., Horn T.F. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide. 9:2003;64-76
34. Martin L.J., Al-Abdulla N.A., Brambrink A.M., Kirsch J.R., Sieber F.E., Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. 46:1998;281-309
35. Martinou J.C., Green D.R. Breaking the mitochondrial barrier. Nat. Rev., Mol. Cell Biol. 2:2001;63-67
36. Mattson M.P., Culmsee C., Yu Z.F. Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 301:2000;173-187
37. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:1985;159-163
38. Mongolsuk S., Robertson A., Towers R. 2:4:3′:5′- Tetrahydroxystilbene from Artocarpus lakoocha. J. Org. Chem. 1957;2231-2233
39. Nakashima M.N., Yamashita K., Kataoka Y., Yamashita Y.S., Niwa M. Time course of nitric oxide synthase activity in neuronal, glial, and endothelial cells of rat striatum following focal cerebral ischemia. Cell. Mol. Neurobiol. 15:1995;341-349
40. Namura S., Nagata I., Takami S., Masayasu H., Kikuchi H. Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke. 32:2001;1906-1911
41. Oh H., Ko E.K., Jun J.Y., Oh M.H., Park S.U., Kang K.H., Lee H.S., Kim Y.C. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Planta Med. 68:2002;932-934
42. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, Sydney
43. Petrosillo G., Ruggiero F.M., Paradies G. Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J. 17:2003;2202-2208
44. Qiu F., Komatsu K., Kawasaki K., Saito K., Yao X., Kano Y. A novel stilbene glucoside, oxyresveratrol 3′-O-b-Glucopyranoside, from the root bark of Morus alba. Planta Med. 62:1996;559-561
45. Ryu J., Pyo H., Jou I., Joe E. Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. J. Biol. Chem. 275:2000;29955-29959
46. Sakahira H., Enari M., Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:1998;96-99
47. Scatton B. Excitatory amino acid receptor antagonists: a novel treatment for ischemic cerebrovascular diseases. Life Sci. 55:1994;2115-2124
48. Simonian N.A., Coyle J.T. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36:1996;83-106
49. Skaper S.D., Floreani M., Ceccon M., Facci L., Giusti P. Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin. Ann. N.Y. Acad. Sci. 890:1999;107-118
50. Sugawara T., Noshita N., Lewen A., Gasche Y., Ferrand-Drake M., Fujimura M., Morita-Fujimura Y., Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 22:2002;209-217
51. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 15:2001;2922-2933
52. Wang Q., Xu J., Rottinghaus G.E., Simonyi A., Lubahn D., Sun G.Y., Sun A.Y. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 958:2002;439-447
53. Andrabi S., Wolf G., Sayeed I., Siemen D., Horn T.F.W. Melatonin inhibits mitochondrial cytochrome c release after cerebral ischemia via direct inhibition of the permeability transition pore. FASEB J. 18:2004;869-871