메뉴 건너뛰기




Volumn 69, Issue 9, 2011, Pages 550-557

Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids

Author keywords

Branched chain amino acid; Intracellular signaling; Leucine; Protein synthesis

Indexed keywords

LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MUSCLE PROTEIN;

EID: 80052377760     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2011.00420.x     Document Type: Article
Times cited : (41)

References (61)
  • 1
    • 0033834961 scopus 로고    scopus 로고
    • Protein and amino acid metabolism during and after exercise and the effects of nutrition
    • Rennie MJ, Tipton KD. Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr. 2000;20:457-483.
    • (2000) Annu Rev Nutr , vol.20 , pp. 457-483
    • Rennie, M.J.1    Tipton, K.D.2
  • 2
    • 25144506499 scopus 로고    scopus 로고
    • Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise
    • Bolster DR, Pikosky MA, Gaine PC, etal. Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise. Am J Physiol. 2005;289:E678-E683.
    • (2005) Am J Physiol , vol.289
    • Bolster, D.R.1    Pikosky, M.A.2    Gaine, P.C.3
  • 3
    • 34447290867 scopus 로고    scopus 로고
    • Nutrient signalling in the regulation of human muscle protein synthesis
    • Fujita S, Dreyer HC, Drummond MJ, etal. Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol. 2007;582(Pt 2):813-823.
    • (2007) J Physiol , vol.582 , Issue.PART 2 , pp. 813-823
    • Fujita, S.1    Dreyer, H.C.2    Drummond, M.J.3
  • 4
    • 77949689943 scopus 로고    scopus 로고
    • Acute energy deprivation affects skeletal muscle protein synthesis and associated intracellular signaling proteins in physically active adults
    • Pasiakos SM, Vislocky LM, Carbone JW, etal. Acute energy deprivation affects skeletal muscle protein synthesis and associated intracellular signaling proteins in physically active adults. J Nutr. 2010;140:745-751.
    • (2010) J Nutr , vol.140 , pp. 745-751
    • Pasiakos, S.M.1    Vislocky, L.M.2    Carbone, J.W.3
  • 5
    • 79551614788 scopus 로고    scopus 로고
    • Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies
    • Dodson S, Baracos VE, Jatoi A, etal. Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med. 2011;62:265-279.
    • (2011) Annu Rev Med , vol.62 , pp. 265-279
    • Dodson, S.1    Baracos, V.E.2    Jatoi, A.3
  • 6
    • 77950485782 scopus 로고    scopus 로고
    • Skeletal muscle loss: cachexia, sarcopenia, and inactivity
    • Evans WJ. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr. 2010;91(Suppl):S1123-S1127.
    • (2010) Am J Clin Nutr , vol.91 , Issue.SUPPL.
    • Evans, W.J.1
  • 7
    • 70350520654 scopus 로고    scopus 로고
    • Anabolic resistance in critically ill patients
    • Rennie MJ. Anabolic resistance in critically ill patients. Crit Care Med. 2009;37(Suppl):S398-S399.
    • (2009) Crit Care Med , vol.37 , Issue.SUPPL.
    • Rennie, M.J.1
  • 8
    • 80052363045 scopus 로고    scopus 로고
    • Obesity, sarcopenia and their functional consequences in old age
    • Visser M. Obesity, sarcopenia and their functional consequences in old age. Proc Nutr Soc. 2010;22:1-5.
    • (2010) Proc Nutr Soc , vol.22 , pp. 1-5
    • Visser, M.1
  • 9
    • 0033429098 scopus 로고    scopus 로고
    • Amino acid availability controls muscle protein metabolism
    • Wolfe RR, Miller SL. Amino acid availability controls muscle protein metabolism. Diabetes Nutr Metab. 1999;12:322-328.
    • (1999) Diabetes Nutr Metab , vol.12 , pp. 322-328
    • Wolfe, R.R.1    Miller, S.L.2
  • 10
    • 0036790054 scopus 로고    scopus 로고
    • Regulation of muscle protein by amino acids
    • Wolfe RR. Regulation of muscle protein by amino acids. J Nutr. 2002;132(Suppl):S3219-S3224.
    • (2002) J Nutr , vol.132 , Issue.SUPPL.
    • Wolfe, R.R.1
  • 11
    • 78149304854 scopus 로고    scopus 로고
    • Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling
    • Atherton PJ, Etheridge T, Watt PW, etal. Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr. 2010;92:1080-1088.
    • (2010) Am J Clin Nutr , vol.92 , pp. 1080-1088
    • Atherton, P.J.1    Etheridge, T.2    Watt, P.W.3
  • 12
    • 0018128453 scopus 로고
    • Influence of amino acid availability on protein turnover in perfused skeletal muscle
    • Li JB, Jefferson LS. Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim Biophys Acta. 1978;544:351-359.
    • (1978) Biochim Biophys Acta , vol.544 , pp. 351-359
    • Li, J.B.1    Jefferson, L.S.2
  • 13
    • 0035674440 scopus 로고    scopus 로고
    • Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements
    • Rennie MJ. Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements. Int J Sport Nutr Exerc Metab. 2001;11(Suppl):S170-S176.
    • (2001) Int J Sport Nutr Exerc Metab , vol.11 , Issue.SUPPL.
    • Rennie, M.J.1
  • 14
    • 0142062041 scopus 로고    scopus 로고
    • Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study
    • Bohe J, Low A, Wolfe RR, Rennie MJ. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. J Physiol. 2003;552(Pt 1):315-324.
    • (2003) J Physiol , vol.552 , Issue.PART 1 , pp. 315-324
    • Bohe, J.1    Low, A.2    Wolfe, R.R.3    Rennie, M.J.4
  • 16
    • 0023723070 scopus 로고
    • Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids
    • Garlick PJ, Grant I. Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J. 1988;254:579-584.
    • (1988) Biochem J , vol.254 , pp. 579-584
    • Garlick, P.J.1    Grant, I.2
  • 17
    • 0021259503 scopus 로고
    • Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles
    • Hong SO, Layman DK. Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles. J Nutr. 1984;114:1204-1212.
    • (1984) J Nutr , vol.114 , pp. 1204-1212
    • Hong, S.O.1    Layman, D.K.2
  • 18
    • 0033047248 scopus 로고    scopus 로고
    • Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers
    • Tipton KD, Gurkin BE, Matin S, Wolfe RR. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem. 1999;10:89-95.
    • (1999) J Nutr Biochem , vol.10 , pp. 89-95
    • Tipton, K.D.1    Gurkin, B.E.2    Matin, S.3    Wolfe, R.R.4
  • 19
    • 0042068305 scopus 로고    scopus 로고
    • Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    • Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr. 2003;78:250-258.
    • (2003) Am J Clin Nutr , vol.78 , pp. 250-258
    • Volpi, E.1    Kobayashi, H.2    Sheffield-Moore, M.3    Mittendorfer, B.4    Wolfe, R.R.5
  • 20
    • 0016824053 scopus 로고
    • Leucine. A possible regulator of protein turnover in muscle
    • Buse MG, Reid SS. Leucine. A possible regulator of protein turnover in muscle. J Clin Invest. 1975;56:1250-1261.
    • (1975) J Clin Invest , vol.56 , pp. 1250-1261
    • Buse, M.G.1    Reid, S.S.2
  • 21
    • 42149157213 scopus 로고    scopus 로고
    • Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
    • Drummond MJ, Rasmussen BB. Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care. 2008;11:222-226.
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 222-226
    • Drummond, M.J.1    Rasmussen, B.B.2
  • 22
    • 36048970325 scopus 로고    scopus 로고
    • Cell signaling. mTOR, unleashed
    • Proud CG. Cell signaling. mTOR, unleashed. Science. 2007;318:926-927.
    • (2007) Science , vol.318 , pp. 926-927
    • Proud, C.G.1
  • 23
    • 36749047009 scopus 로고    scopus 로고
    • Amino acids and mTOR signalling in anabolic function
    • Proud CG. Amino acids and mTOR signalling in anabolic function. Biochem Soc Trans. 2007;35(Pt 5):1187-1190.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 5 , pp. 1187-1190
    • Proud, C.G.1
  • 24
    • 34247573364 scopus 로고    scopus 로고
    • Leucine and protein synthesis: mTOR and beyond
    • Stipanuk MH. Leucine and protein synthesis: mTOR and beyond. Nutr Rev. 2007;65:122-129.
    • (2007) Nutr Rev , vol.65 , pp. 122-129
    • Stipanuk, M.H.1
  • 25
    • 0017336399 scopus 로고
    • Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats
    • Buse MG, Weigand DA. Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats. Biochim Biophys Acta. 1977;475:81-89.
    • (1977) Biochim Biophys Acta , vol.475 , pp. 81-89
    • Buse, M.G.1    Weigand, D.A.2
  • 26
    • 0016431688 scopus 로고
    • Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm
    • Fulks RM, Li JB, Goldberg AL. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem. 1975;250:290-298.
    • (1975) J Biol Chem , vol.250 , pp. 290-298
    • Fulks, R.M.1    Li, J.B.2    Goldberg, A.L.3
  • 27
    • 0033006694 scopus 로고    scopus 로고
    • Leucine supplementation enhances skeletal muscle recovery in rats following exercise
    • Anthony JC, Anthony TG, Layman DK. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr. 1999;129:1102-1106.
    • (1999) J Nutr , vol.129 , pp. 1102-1106
    • Anthony, J.C.1    Anthony, T.G.2    Layman, D.K.3
  • 28
    • 0033980371 scopus 로고    scopus 로고
    • Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation
    • Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr. 2000;130:139-145.
    • (2000) J Nutr , vol.130 , pp. 139-145
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Vary, T.C.4    Jefferson, L.S.5
  • 29
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
    • Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. 2000;130:2413-2419.
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3    Vary, T.C.4    Jefferson, L.S.5    Kimball, S.R.6
  • 30
    • 3042701690 scopus 로고    scopus 로고
    • Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation
    • Bolster DR, Vary TC, Kimball SR, Jefferson LS. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J Nutr. 2004;134:1704-1710.
    • (2004) J Nutr , vol.134 , pp. 1704-1710
    • Bolster, D.R.1    Vary, T.C.2    Kimball, S.R.3    Jefferson, L.S.4
  • 31
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    • Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr. 2005;135:376-382.
    • (2005) J Nutr , vol.135 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthony, J.C.4    Jefferson, L.S.5
  • 32
    • 34548427995 scopus 로고    scopus 로고
    • Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats
    • Vary TC. Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr. 2007;137:2074-2079.
    • (2007) J Nutr , vol.137 , pp. 2074-2079
    • Vary, T.C.1
  • 33
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol. 2006;291:E381-E387.
    • (2006) Am J Physiol , vol.291
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 34
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    • Rieu I, Balage M, Sornet C, etal. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol. 2006;575(Pt 1):305-315.
    • (2006) J Physiol , vol.575 , Issue.PART 1 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3
  • 35
    • 57349198370 scopus 로고    scopus 로고
    • Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids
    • Drummond MJ, McCarthy JJ, Fry CS, Esser KA, Rasmussen BB. Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. Am J Physiol Endocrinol Metab. 2008;295:E1333-E1340.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Drummond, M.J.1    McCarthy, J.J.2    Fry, C.S.3    Esser, K.A.4    Rasmussen, B.B.5
  • 36
    • 45149131733 scopus 로고    scopus 로고
    • Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
    • Drummond MJ, Dreyer HC, Pennings B, etal. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol. 2008;104:1452-1461.
    • (2008) J Appl Physiol , vol.104 , pp. 1452-1461
    • Drummond, M.J.1    Dreyer, H.C.2    Pennings, B.3
  • 37
    • 38949126221 scopus 로고    scopus 로고
    • Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    • Dreyer HC, Drummond MJ, Pennings B, etal. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab. 2008;294:E392-E400.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Dreyer, H.C.1    Drummond, M.J.2    Pennings, B.3
  • 39
    • 38949086515 scopus 로고    scopus 로고
    • Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    • Koopman R, Verdijk LB, Beelen M, etal. Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men. Br J Nutr. 2008;99:571-580.
    • (2008) Br J Nutr , vol.99 , pp. 571-580
    • Koopman, R.1    Verdijk, L.B.2    Beelen, M.3
  • 41
    • 66149097065 scopus 로고    scopus 로고
    • Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
    • Drummond MJ, Dreyer HC, Fry CS, Glynn EL, Rasmussen BB. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol. 2009;106:1374-1384.
    • (2009) J Appl Physiol , vol.106 , pp. 1374-1384
    • Drummond, M.J.1    Dreyer, H.C.2    Fry, C.S.3    Glynn, E.L.4    Rasmussen, B.B.5
  • 42
    • 31544466776 scopus 로고    scopus 로고
    • Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
    • Kimball SR, Jefferson LS. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr. 2006;136(Suppl 1):S227-S231.
    • (2006) J Nutr , vol.136 , Issue.SUPPL. 1
    • Kimball, S.R.1    Jefferson, L.S.2
  • 43
    • 36749014636 scopus 로고    scopus 로고
    • The role of nutrition in stimulating muscle protein accretion at the molecular level
    • Kimball SR. The role of nutrition in stimulating muscle protein accretion at the molecular level. Biochem Soc Trans. 2007;35(Pt 5):1298-1301.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 5 , pp. 1298-1301
    • Kimball, S.R.1
  • 44
    • 0036081155 scopus 로고    scopus 로고
    • Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
    • Anthony JC, Lang CH, Crozier SJ, etal. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol. 2002;82:E1092-E1101.
    • (2002) Am J Physiol , vol.82
    • Anthony, J.C.1    Lang, C.H.2    Crozier, S.J.3
  • 45
    • 0036230645 scopus 로고    scopus 로고
    • Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    • Anthony JC, Reiter AK, Anthony TG, etal. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. 2002;51:928-936.
    • (2002) Diabetes , vol.51 , pp. 928-936
    • Anthony, J.C.1    Reiter, A.K.2    Anthony, T.G.3
  • 46
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem. 2005;280:33076-33082.
    • (2005) J Biol Chem , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 47
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    • Nobukuni T, Joaquin M, Roccio M, etal. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A. 2005;102:14238-14243.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14238-14243
    • Nobukuni, T.1    Joaquin, M.2    Roccio, M.3
  • 48
    • 34147141941 scopus 로고    scopus 로고
    • A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
    • Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J. 2007;403:13-20.
    • (2007) Biochem J , vol.403 , pp. 13-20
    • Findlay, G.M.1    Yan, L.2    Procter, J.3    Mieulet, V.4    Lamb, R.F.5
  • 49
    • 66149116366 scopus 로고    scopus 로고
    • Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis
    • Drummond MJ, Miyazaki M, Dreyer HC, etal. Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol. 2009;106:1403-1411.
    • (2009) J Appl Physiol , vol.106 , pp. 1403-1411
    • Drummond, M.J.1    Miyazaki, M.2    Dreyer, H.C.3
  • 50
    • 14644444464 scopus 로고    scopus 로고
    • Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    • Cuthbertson D, Smith K, Babraj J, etal. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:422-424.
    • (2005) FASEB J , vol.19 , pp. 422-424
    • Cuthbertson, D.1    Smith, K.2    Babraj, J.3
  • 51
    • 58149389265 scopus 로고    scopus 로고
    • Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men
    • Moore DR, Robinson MJ, Fry JL, etal. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr. 2009;89:161-168.
    • (2009) Am J Clin Nutr , vol.89 , pp. 161-168
    • Moore, D.R.1    Robinson, M.J.2    Fry, J.L.3
  • 52
    • 78149245600 scopus 로고    scopus 로고
    • Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
    • Glynn EL, Fry CS, Drummond MJ, etal. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr. 2010;140:1970-1976.
    • (2010) J Nutr , vol.140 , pp. 1970-1976
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3
  • 53
    • 0028914883 scopus 로고
    • Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans
    • Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol. 1995;268(3 Pt 1):E514-E520.
    • (1995) Am J Physiol , vol.268 , Issue.3 PART 1
    • Biolo, G.1    Maggi, S.P.2    Williams, B.D.3    Tipton, K.D.4    Wolfe, R.R.5
  • 54
    • 65649152957 scopus 로고    scopus 로고
    • Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling
    • Hundal HS, Taylor PM. Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab. 2009;296:E603-E613.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Hundal, H.S.1    Taylor, P.M.2
  • 55
    • 53149125147 scopus 로고    scopus 로고
    • Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle
    • Greenhaff PL, Karagounis LG, Peirce N, etal. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab. 2008;295:E595-E604.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Greenhaff, P.L.1    Karagounis, L.G.2    Peirce, N.3
  • 56
    • 1442349755 scopus 로고    scopus 로고
    • Amino acid ingestion improves muscle protein synthesis in the young and elderly
    • Paddon-Jones D, Sheffield-Moore M, Zhang XJ, etal. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol. 2004;286:E321-E328.
    • (2004) Am J Physiol , vol.286
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Zhang, X.J.3
  • 58
    • 77956925995 scopus 로고    scopus 로고
    • Molecular responses to moderate endurance exercise in skeletal muscle
    • Pasiakos SM, McClung HL, McClung JP, etal. Molecular responses to moderate endurance exercise in skeletal muscle. Int J Sport Nutr Exerc Metab. 2010;20:282-290.
    • (2010) Int J Sport Nutr Exerc Metab , vol.20 , pp. 282-290
    • Pasiakos, S.M.1    McClung, H.L.2    McClung, J.P.3
  • 59
    • 0025057089 scopus 로고
    • Activation of branched-chain alpha-keto acid dehydrogenase complex by exercise: effect of high-fat diet intake
    • Shimomura Y, Suzuki T, Saitoh S, Tasaki Y, Harris RA, Suzuki M. Activation of branched-chain alpha-keto acid dehydrogenase complex by exercise: effect of high-fat diet intake. J Appl Physiol. 1990;68:161-165.
    • (1990) J Appl Physiol , vol.68 , pp. 161-165
    • Shimomura, Y.1    Suzuki, T.2    Saitoh, S.3    Tasaki, Y.4    Harris, R.A.5    Suzuki, M.6
  • 60
    • 0347417903 scopus 로고    scopus 로고
    • Age and aerobic exercise training effects on whole body and muscle protein metabolism
    • Short KR, Vittone JL, Bigelow ML, Proctor DN, Nair KS. Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol. 2004;286:E92-101.
    • (2004) Am J Physiol , vol.286
    • Short, K.R.1    Vittone, J.L.2    Bigelow, M.L.3    Proctor, D.N.4    Nair, K.S.5
  • 61
    • 0029806713 scopus 로고    scopus 로고
    • Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise
    • Tipton KD, Ferrando AA, Williams BD, Wolfe RR. Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise. J Appl Physiol. 1996;81:2034-2038.
    • (1996) J Appl Physiol , vol.81 , pp. 2034-2038
    • Tipton, K.D.1    Ferrando, A.A.2    Williams, B.D.3    Wolfe, R.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.