Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Journal of Infectious Diseases

Volumn 195, Issue 8, 2007, Pages 1194-1202

  Zhang, Qibo ^a   Bagrade, Linda ^a   Bernatoniene, Jolanta ^a   Clarke, Ed ^a   Paton, James C ^c   Mitchell, Tim J ^b   Nunez, Desmond A ^a   Finn, Adam ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PNEUMOLYSIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADENOIDECTOMY; ARTICLE; BACTERIUM CARRIER; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MONONUCLEAR CELL; NASOPHARYNX; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CARRIER STATE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INTERFERON TYPE II; MALE; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; TIME FACTORS; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34047234575     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/512617     Document Type: Article

References (36)

1. Siber GR. Pneumococcal disease: prospects for a new generation of vaccines. Science 1994; 265:1385-7.
2. Austrian R. Some aspects of the pneumococcal carrier state. J Antimicrob Chemother 1986; 18(Suppl A):35-45.
3. Eskola J, Kilpi T, Palmu A, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001; 344:403-9.
4. Paton JC. Novel pneumococcal surface proteins: role in virulence and vaccine potential. Trends Microbiol 1998; 6:85-7.
5. Briles DE, Hollingshead SK, Paton JC, et al. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J Infect Dis 2003; 188:339-48.
6. Goldblatt D, Hussain M, Andrews N, et al. Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study. J Infect Dis 2005; 192:387-93.
7. Malley R, Stack AM, Ferretti ML, Thompson CM, Saladino RA. Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats. J Infect Dis 1998; 178: 878-82.
8. Dagan R, Melamed R, Muallem M, et al. Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine. J Infect Dis 1996; 174:1271-8.
9. Lipsitch M, Whitney CG, Zell E, Kaijalainen T, Dagan R, Malley R. Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease? PLoS Med 2005;2:e15.
10. Zhang Q, Bernatoniene J, Bagrade L, et al. Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur J Immunol 2006;36:46-57.
11. McCool TL, Weiser JN. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 2004;72:5807-13.
12. + T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci USA 2005; 102:4848-53.
13. Kadioglu A, Coward W, Colston MJ, Hewitt CR, Andrew PW CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun 2004; 72:2689-97.
14. O'Brien KL, Nohynek H. Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae. Pediatr Infect Dis J 2003; 22:e1-11.
15. Ogunniyi AD, Woodrow MC, Poolman JT, Paton JC. Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA. Infect Immun 2001; 69:5997-6003.
16. Mitchell TJ, Mendez F, Paton JC, Andrew PW, Boulnois GJ. Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2. Nucleic Acids Res 1990; 18:4010.
17. Paton JC, Lock RA, Lee CJ, et al. Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infect Immun 1991; 59:2297-304.
18. Zhang Q, Choo S, Finn A. Immune responses to novel pneumococcal proteins pneumolysin, PspA, PsaA and CbpA in adenoidal B cells from children. Infect Immun 2002; 70:5363-9.
19. Kemp K, Bruunsgaard H, Skinhoj P, Klarlund PB. Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells. Infect Immun 2002; 70: 5019-25.
20. Baril L, Dietemann J, Essevaz-Roulet M, et al. Pneumococcal surface protein A (PspA) is effective at eliciting T cell mediated responses during invasive pneumococcal disease in adults. Clin Exp Immunol 2006; 145: 277-86.
21. Zhang Q, Bernatoniene J, Bagrade L, et al. Regulation of mucosal antibody production to pneumococcal protein antigens by T-cell derived gamma interferon and interleukin-10 in children. Infect Immun 2006; 74:4735-43.
22. Kadioglu A, Cingles NA, Grattan K, Kerr A, Mitchell TJ, Andrew PW. Host cellular immune response to pneumococcal lung infection in mice. Infect Immun 2000; 68:492-501.
23. Michie CA, McLean A, Alcock C, Beverley PC. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 1992; 360:264-5.
24. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-12.
25. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.
26. Pulendran B. Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol Rev 2004; 199:227-50.
27. Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol 2001; 2:487-92.
28. Dutton RW, Bradley LM, Swain SL. T cell memory. Annu Rev Immunol 1998; 16:201-23.
29. Malley R, Henneke P, Morse SC, et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci USA 2003; 100:1966-71.
30. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003;21:335-76.
31. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430:257-63.
32. Spellberg B, Edwards JE Jr. Type 1/type 2 immunity in infectious diseases. Clin Infect Dis 2001; 32:76-102.
33. Rubins JB, Pomeroy C. Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. Infect Immun 1997; 65:2975-7.
34. Weigent DA, Huff TL, Peterson JW, Stanton GJ, Baron S. Role of interferon in streptococcal infection in the mouse. Micro Pathog 1986; 1: 399-407.
35. Pfeffer K. Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev 2003; 14:185-91.
36. McGuirk P, Mills KH. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol 2002; 23:450-5.