Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization

Infection and Immunity

Volumn 72, Issue 10, 2004, Pages 5807-5813

  McCool, Tera L ^a,c   Weiser, Jeffrey N ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Medical Diagnostic Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PHOSPHATE BUFFERED SALINE; PNEUMOCOCCAL SURFACE PROTEIN A; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BACTERIAL COLONIZATION; BACTERIUM ISOLATE; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITY; DISEASE MODEL; DRUG MECHANISM; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMORAL IMMUNITY; IMMUNOPATHOLOGY; LOWER RESPIRATORY TRACT INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; B-LYMPHOCYTES; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNE SERA; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN ISOTYPES; MICE; MICE, INBRED STRAINS; PNEUMOCOCCAL INFECTIONS; SPECIES SPECIFICITY; STREPTOCOCCUS PNEUMONIAE;

EID: 4644290141     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.10.5807-5813.2004     Document Type: Article

References (36)

1. Amsbaugh, D., C. Hansen, B. Prescott, P. Stashak, D. Barthold, and P. Baker. 1972. Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J. Exp. Med. 136:931-949.
2. Austrian, R. 1986. Some aspects of the pneumococcal carrier state. J. Antimicrob. Chemother. 18:35-45.
3. Autenrieth, I., M. Beer, E. Bohn, S. Kaufmann, and J. Heesemann. 1994. Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect. Immun. 62:2590-2599.
4. Blunt, T., N. Finnie, G. Taccioli, G. Smith, J. Demengeot, T. Gottlieb, R. Mizuta, A. Varghese, F. Alt, P. Jeggo, and S. Jackson. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813-823.
5. Bogaert, D., R. de Groot, and P. Hermans. 2004. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect. Dis. 4:144-154.
6. Briles, D., E. Ades, J. Paton, J. Sampson, G. Carlone, R. Huebner, E. Virolainen, E. Swiatlo, and S. Hollingshead. 2000. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68:796-800.
7. Concepcion, N., and C. Frasch. 2001. Pneumococcal type 22F polysaccharide absorption improves the specificity of a pneumococcal-polysaccharide enzyme-linked immunosorbent assay. Clin. Diagn. Lab. Immunol. 8:266-272.
8. Dagan, R., N. Givon-Lavi, O. Zamir, M. Sikuler-Cohen, L. Guy, J. Janco, P. Yagupsky, and D. Fraser. 2002. Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J. Infect. Dis. 185:927-936.
9. Dagan, R., M. Muallem, R. Melamed, O. Leroy, and P. Yagupsky. 1997. Reduction of pneumococcal nasopharyngeal carriage in early infancy after immunization with tetravalent pneumococcal vaccines conjugated to either tetanus toxoid or diphtheria toxoid. Pediatr. Infect. Dis. J. 16:1060-1064.
10. Ekdahl, K., I. Ahlinder, H. Hansson, E. Melander, S. Molstad, M. Soderstrom, and K. Persson. 1997. Duration of nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae: experiences from the South Swedish Pneumococcal Intervention Project. Clin. Infect. Dis. 25:1113-1117.
11. Ghaffar, F., I. Friedland, and G. McCracken, Jr. 1999. Dynamics of nasopharyngeal colonization by Streptococcus pneumoniae. Pediatr. Infect. Dis. J. 18:638-646.
12. Gray, B., G. Converse III, and H. Dillon, Jr. 1980. Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life. J. Infect. Dis. 142:923-933.
13. Gundel, M. 1933. Bakteriologische und Epidemiologische Untersuchungen über die Besiedlung der oberen Atmungswege Gesunder mit Pneumokokken. Z. Hyg. Infektionskr. 114:659-704.
14. Gwaltney, J. J., M. Sande, R. Austrian, and J. Hendley. 1975. Spread of Streptococcus pneumoniae in families. II. Relation of transfer of S. pneumoniae to incidence of colds and serum antibody. J. Infect. Dis. 132:62-68.
15. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426.
16. MacLeod, C. M., R. G. Hodges, M. Heidelberger, and W. G. Bernhard. 1945. Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J. Exp. Med. 82:445-465.
17. Magee, A., and J. Yother. 2001. Requirement for capsule in colonization by Streptococcus pneumoniae. Infect. Immun. 69:3755-3761.
18. Malley, R., M. Lipsitch, A. Stack, R. Saladino, G. Fleisher, S. Pelton, C. Thompson, D. Briles, and P. Anderson. 2001. Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect. Immun. 69:4870-4873.
19. Mbelle, N., R. Huebner, A. Wasas, A. Kimura, I. Chang, and K. Klugman. 1999. Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine. J. Infect. Dis. 180:1171-1176.
20. McCool, T., T. Cate, G. Moy, and J. Weiser. 2002. The immune response to pneumococcal proteins during experimental human carriage. J. Exp. Med. 195:359-365.
21. McCool, T., T. Cate, E. Tuomanen, P. Adrian, T. Mitchell, and J. Weiser. 2003. The serum IgG response to candidate vaccine antigens during experimental human pneumococcal colonization. Infect. Immun. 71:5724-5732.
22. McCool, T., C. Harding, N. Greenspan, and J. Schreiber. 1999. B- and T-cell immune responses to pneumococcal conjugate vaccines: divergence between carrier- and polysaccharide-specific immunogenicity. Infect. Immun. 67:4862-4869.
23. McCool, T., J. Schreiber, and N. Greenspan. 2003. Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine. Infect. Immun. 71:5402-5406.
24. Morch, E. 1943. Virulence of the pneumococcus types for mice, p. 157-163. In F. A. Richard (ed.), Serological studies on the pneumococci. Einar Munksgaard, Copenhagen, Denmark.
25. O'Brien, D., D. Briles, A. Szalai, A. Tu, I. Sanz, and M. Nahm. 1999. Tumor necrosis factor alpha receptor I is important for survival from Streptococcus pneumoniae infections. Infect. Immun. 67:595-601.
26. Rawlings, D., D. Saffran, S. Tsukada, D. Largaespada, J. Grimaldi, L. Cohen, R. Mohr, J. Bazan, M. Howard, N. Copeland, N. Jenkins, and O. Witte. 1993. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261:358-361.
27. Simell, B., T. Kilpi, and H. Kayhty. 2002. Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal capsular polysaccharides in children. J. Infect. Dis. 186:1106-1114.
28. Simell, B., M. Korkeila, H. Pursiainen, T. Kilpi, and H. Kayhty. 2001. Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin A, pneumolysin, and pneumococcal surface protein A in children. J. Infect. Dis. 183:887-896.
29. Syrjanen, R., T. Kilpi, T. Kaijalainen, E. Herva, and A. Takala. 2001. Nasopharyngeal carriage of Streptococcus pneumoniae in Finnish children younger than 2 years old. J. Infect. Dis. 184:451-459.
30. Thomas, J., P. Sideras, C. Smith, I. Vorechovsky, V. Chapman, and W. Paul. 1993. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 261:355.
31. Wani, J., J. Gilbert, A. Plant, and J. Weiser. 1996. Identification, cloning and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae. Infect. Immun. 64:3967-3974.
32. Weiser, J. 2004. Mechanisms of carriage, p. 169-182. in E. Tuomanen (ed.), The Pneumococcus. ASM Press, Washington, D.C.
33. Weiser, J., D. Bae, C. Fasching, R. Scamurra, A. Ratner, and E. Janoff. 2003. Antibody-enhanced pneumococcal adherence requires IgA1 protease. Proc. Natl. Acad. Sci. USA 100:415-420.
34. Weiser, J. N., R. Austrian, P. K. Sreenivasan, and H. R. Masure. 1994. Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization. Infect. Immun. 62:2582-2589.
35. Wu, H., A. Virolainen, B. Mathews, J. King, M. Russell, and D. Briles. 1997. Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice. Microb. Pathog. 23:127-137.
36. Zhang, Q., K. Arnaoutakis, C. Murdoch, R. Lakshman, G. Race, R. Burkinshaw, and A. Finn. 2004. Mucosal immune responses to capsular pneumococcal polysaccharides in immunized preschool children and controls with similar nasal pneumococcal colonization rates. Pediatr. Infect. Dis. J. 23:307-313.