Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis

Cell Death and Differentiation

Volumn 11, Issue 3, 2004, Pages 252-260

  England, K ^a   O'Driscoll, C ^a   Cotter, T G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Carbonylation; Glycolysis; Protein oxidation; Proteomics; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CHAPERONE; CYTOTOXIC AGENT; ETOPOSIDE; GLUCOSE; GLYCOLYTIC ENZYME; GLYCOSYLATED PROTEIN; PENTOSE PHOSPHATE;

APOPTOSIS; ARTICLE; CARBONYLATION; CELL DEATH; CELL FUNCTION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GLYCOLYSIS; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; STATISTICAL SIGNIFICANCE; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ACETYLCYSTEINE; APOPTOSIS; BLOTTING, WESTERN; CARBON; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ETOPOSIDE; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GLYCOLYSIS; HL-60 CELLS; HUMANS; HYDRAZINES; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PRECIPITIN TESTS; PROTEINS; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 1542359582     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401338     Document Type: Article

References (48)

1. Melino G, Bernassola F, Catani MV, Rossi A, Corazzari M, Sabatini S, Vilbois F and Green DR (2000) Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation. Cancer Res. 60: 2377-2383
2. Curtin JF, Donovan M and Cotter TG (2002) Regulation and measurement of oxidative stress in apoptosis. J. Immunol. Methods 265: 49-72
3. Carmody RJ and Cotter TG (2001) Signalling apoptosis:a radical approach. Redox Rep. 6: 77-90
4. Gorman A, McGowan A and Cotter TG (1997) Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett. 404: 27-33
5. McGowan AJ, Fernandes RS, Samali A and Cotter TG (1996) Anti-oxidants and apoptosis. Biochem. Soc. Trans. 24: 299-303
6. Troyano A, Fernandez C, Sancho P, de Plas E and Aller P (2001) Effect of glutathione depeation on antitumour drug toxicity (apoptosis and necrosis) in U937 human promonocytic cells. The role of intracellular oxidation. J. Biolog. Chem. 276: 47107-47115
7. Chevion M, Berenshtein E and Stadtman ER (2000) Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radical Res. 33: S99-S108
8. Levine RL (2002) Carbonyl modified proteins in cellular regulation, aging and disease. Free Radical Biol. Med. 32: 790-796
9. Stadtman ER and Levine RL (2000) Protein oxidation. Ann. N.Y. Acad. Sci. 899: 191-208
10. Wondrak GT, Cervantes-Laurean D, Jacobson EL and Jacobson MK (2000) Histone carbonylation in vivo and in vitro. Biochem. J. 351: 769-777
11. Berlett BS and Stadtman ER (1997) Protein oxidation in aging, disease, and oxidative stress. J. Biolog. Chem. 272: 20313-20316
12. Stadtman ER (1995) Role of oxidized amino-acids in protein breakdown and stability. In: Redox-Active Amino Acids in Biology. St Louis, MO, USA: Elsevier Science and Technology Books, pp. 379-393
13. Dean RT, Fu SL, Stocker R and Davies MJ (1997) Biochemistry and pathology of radical-mediated protein oxidation. Bochem. J. 324: 1-18
14. Stadtman ER and Berlett BS (1999) Reactive oxygen mediated protein oxidation in aging and disease. In Reactive Oxygen Species in Biological Systems Gilbert DJ, ed. New York: Kluwer Academic/Plenum Publishers, pp. 657-675
15. Burcham PC and Kuhan YT (1997) Diminished susceptibility to proteolysis after protein modification by the lipid peroxidation product malondialdehyde: Inhibitory role for crosslinked and noncrosslinked adducted proteins. Arch. Biochem. Biophys. 340: 331-337
16. Keller JN, Gee J and Ding QX (2002) The proteasome in brain ageing. Age. Res. Rev. 1: 279-293
17. Dukan S, Farewell A, Ballesteros M, Taddei F, Radman M and Nystrom T (2000) Protein oxidation in response to increased transcriptional or translational errors. Proc. Nat. Acad. Sci. USA 97 (11): 5746-5749
18. Sitte N, Merker K and Grune T (1998) Proteasome dependent degradation of oxidised proteins. FEBS Lett. 440: 399-402
19. Friguet B and Szweda LY (1997) Inhibtion of the multicatalytic protease (proteasome) by 4-hydroxy-2-nonenal crosslinked protein. FEBS Lett. 405: 21-25
20. Grune T (2000) Oxidative stress, aging and the proteasomal system. Biogerontology 1: 31-40
21. Fucci L, Oliver CN, Coon MJ and Stadtman ER (1983) Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proc. Nat. Acad. Sci. USA 80: 1521-1525
22. Ma YS, Chao CC and Stadtman ER (1999) Oxidative modification of glutamine synthetase by 2,2′- azobis(2-amidinopropane) dihydrochloride. Arch. Biochem. Biophys. 363: 129-134
23. Aulak KS, Miyagi M, West KA, Massillon D, Crabb JW and Stuehr DJ (2001) Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc. Nat. Acad. Sci. USA 98: 12056-12061
24. Nakamura A and Goto S (1996) Analysis of protein carbonyls with 2,4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis. J. Biochem. 119: 768-774
25. Korolainen MA, Goldsteins G, Alafuzoff I, Koistinaho J and Pirttila T (2002) Proteomic analysis of protein oxidation in Alzheimer's disease brain. Electrophoresis 23: 3428-3433
26. Das N, Levine RL, Orr WC and Sohal RS (2001) Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Biochem. J. 360: 209-216
27. Jana CK, Das N and Sohal RS (2002) Specificity of age-related carbonylation of plasma proteins in the mouse and rat. Arch. Biochem. Biophys. 397: 433-439
28. Leunda-Casi A, Genicot G, Donnay I, Pampfer S and De Hertogh R (2002) Increased cell death in mouse blastocysts exposed to high D-glucose in vitro: implications of an oxidative stress and alterations in glucose metabolism. Diabetologia 45: 571-579
29. 2-induced block of glycolysis as an active ADP-ribosylation reaction protecting cells from apoptosis. FASEB J. 14: 2266-2276
30. Levine RL (1984) Mixed-function oxidation of histidine residues. Methods Enzymol. 107: 370-376
31. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ann BW, Shaltiel S and Stadtman ER (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186: 464-478
32. Dalle-Donne I, Rossi R, Milzani A, Di Simplicio P and Colombo R. (2001) The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. Free Radical Bio. Med. 31: 1624-1632
33. Dalle-Donne I, Rossi R, Giustarini D, Gagliano N, Lusini L, Milzani A, Simplicio P and Colombo R (2001) Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment. Free Radical Biol. Med. 31: 1075-1083
34. Neermann J and Wagner R (1996) Comparative analysis of glucose and glutamate metabolism in transformed mammalian cell lines, insect and primary liver cells. J. Cell. Physiol. 166: 152-169
35. Dalle-Donne I, Rossi R, Giustarini D, Milzani A and Colombo R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clin. Chim. Acta 329: 23-38
36. Starke-Reed PE and Oliver CN (1989) Protein oxidation and proteolysis during ageing and oxidative stress. Arch. Biochem. Biophys. 275: 559-567
37. Starke PE, Oliver CN and Stadtman ER (1987) Modification of hepatic proteins in rats exposed to high oxygen concentration. FASEB J. 1: 36-39
38. Dukan S and Nystrom T (1998) Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon. Genes Dev. 12: 3431-3441
39. Mohanti BK, Rath GK, Anantha N, Kannan V, Das BS, Chandramouli BA, Banerjee AK, Das S, Jena A, Ravichandran R, Sahi UP, Kumar R, Kapoor N, Kalia VK, Dwarakanath BS and Jain V (1996) Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. Int. J. Radiat. Oncol. Biol. Phys. 35: 103-111
40. Gonin-Giraud S, Mathieu AL, Diocou S, Tomkowiak M, Delorme G and Marvel J (2002) Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation. Cell Death Differ. 9: 1147-1157
41. Aki T, Mizukami Y, Oka Y, Yamaguchi K, Uemura K and Fujimiya T et al. (2001) Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia. Biochem. J. 358 (Part 2): 481-987
42. Van der Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH and Thompson CB (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21: 5899-5912
43. Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB and Hay N (2001) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15: 1406-1418
44. Healy DA, Watson RW and Newsholme P (2002) Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils. Clin. Sci. (London) 103: 179-189
45. Halicka HD, Ardelt B, Li X, Melamed MM and Darzynkiewicz Z (2002) 2-Deoxy-d-glucose enhances sensitivity of human histiocytic lymphoma u937 cells to apoptosis induced by tumor-necrosis- factor. Cancer Res. 55 (2): 444-449
46. Zhou R, Vander Heiden MG and Rudin CM (2002) Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Res. 62: 3515-3520
47. Ashcroft SJL, Weerasinghe JM, Bassett JM and Randle PJ (2002) The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J. 126: 525-532
48. Katz J and Wood HG (1963) The use of C1402 yields from glucose-1- and -6- C14 for the evaluation of the pathways of glucose metabolism. J. Biolog. Chem. 238: 517-523