A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus

Metabolic Brain Disease

Volumn 26, Issue 3, 2011, Pages 185-194

  Wang, Zhi Yu ^a,b   Miki, Takanori ^b   Ding, Yan ^a   Wang, Shi Jie ^a   Gao, Yu Huan ^a   Wang, Xiao Ling ^a   Wang, Yu Hua ^a   Yokoyama, Toshifumi ^b   Warita, Katsuhiko ^b   Ohta, Ken Ichi ^b   Suzuki, Shingo ^b   Ohnishi, Taira ^b   Obama, Takashi ^c   Bedi, Kuldip S ^d   Takeuchi, Yoshiki ^b   Shan, Bao En ^a  

^a Hebei Provincial Tumor Hospital   (China)

^b KAGAWA UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d BOND UNIVERSITY   (Australia)

Author keywords

Alzheimer's disease; apoE knockout mouse; Cholesterol metabolism; Hippocampus; Neuro degeneration; Neurotrophin

Indexed keywords

APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; NEUROTROPHIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; BRAIN WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEGENERATIVE DISEASE; DIETARY INTAKE; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEINS E; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL, DIETARY; HIPPOCAMPUS; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTOR, TRKB; RNA, MESSENGER;

ANIMALIA; MUS;

EID: 80052300012     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-011-9252-z     Document Type: Article

References (68)

1. SJ Allen GK Wilcock D Dawbarn 1999 Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease Biochem Biophys Res Commun 264 648 651 10543986 10.1006/bbrc.1999.1561 1:CAS:528:DyaK1MXmvFOntLY%3D
2. L Baum L Chen HK Ng CP Pang 2000 Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology Microsc Res Tech 50 278 281 10936880 10.1002/1097-0029(20000815)50:4<278::AID-JEMT5>3.0.CO;2-T 1:CAS:528:DC%2BD3cXmsVWiu7o%3D (Pubitemid 30651166)
3. AM Bennet E Di Angelantonio Z Ye F Wensley A Dahlin A Ahlbom B Keavney R Collins B Wiman U de Faire J Danesh 2007 Association of apolipoprotein E genotypes with lipid levels and coronary risk JAMA 298 1300 1311 17878422 10.1001/jama.298.11.1300 1:CAS:528:DC%2BD2sXhtVygsLnM (Pubitemid 47443344)
4. P Bernd LA Greene 1984 Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors J Biol Chem 259 15509 15516 6096376 1:CAS:528: DyaL2cXmt1emsLk%3D (Pubitemid 15193781)
5. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2009) The AlzGene Database (Alzheimer Research Forum). http://www.alzgene.org.
6. Z Chen S Ishibashi S Perrey O Ji T Gotoda T Kitamine Y Tamura H Okazaki N Yahagi Y Iizuka F Shionoiri K Ohashi K Harada H Shimano R Nagai N Yamada 2001 Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL Arterioscler Thromb Vasc Biol 21 372 377 11231916 10.1161/01.ATV.21.3.372 1:CAS:528:DC%2BD3MXhvVyrsbw%3D (Pubitemid 32199118)
7. B Connor D Young P Lawlor W Gai H Waldvogel RL Faull M Dragunow 1996 Trk receptor alterations in Alzheimer's disease Mol Brain Res 42 1 17 8915574 10.1016/S0169-328X(96)00040-X 1:CAS:528:DyaK28XlvVeisrg%3D (Pubitemid 26345400)
8. B Connor D Young Q Yan RL Faull B Synek M Dragunow 1997 Brain-derived neurotrophic factor is reduced in Alzheimer's disease Mol Brain Res 49 71 81 9387865 10.1016/S0169-328X(97)00125-3 1:CAS:528:DyaK2sXlsleqtLc%3D (Pubitemid 27453116)
9. EH Corder AM Saunders WJ Strittmatter DE Schmechel PC Gaskell GW Small AD Roses JL Haines MA Pericak-Vance 1993 Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 921 923 8346443 10.1126/science.8346443 1:CAS:528:DyaK3sXmtVWjur8%3D (Pubitemid 23275809)
10. C Cordon-Cardo P Tapley SQ Jing V Nanduri E O'Rourke F Lamballe K Kovary R Klein KR Jones LF Reichardt M Barbacid 1991 The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3 Cell 66 173 183 1649007 10.1016/0092-8674(91)90149-S 1:CAS:528:DyaK3MXmt1Clsbw%3D (Pubitemid 121001357)
11. Cordy JM, Wolozin B (2007) Cholesterol and Alzheimer's disease. In: Barrow CJ, Small DH (eds) Abeta peptide and Alzheimer's disease: celebrating a century of research. Springer, London, pp 142-158
12. Dahle CE, Macfarlane DE (1993) Isolation of RNA from cells in culture using Catrimox-14 cationic surfactant. Biotechniques 15:1102-1105 (Pubitemid 2025274)
13. JM Dietschy SD Turley 2004 Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal J Lipid Res 45 1375 1397 15254070 10.1194/jlr.R400004- JLR200 1:CAS:528:DC%2BD2cXmsFequ7o%3D (Pubitemid 39022664)
14. JE Donahue CE Johanson 2008 Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease J Neuropathol Exp Neurol 67 261 270 18379441 10.1097/NEN.0b013e31816a0dc8 1:CAS:528:DC%2BD1cXltFClt7g%3D Erratum in: J Neuropathol Exp Neurol. 2008 67:634 (Pubitemid 351507482)
15. MM Dugich-Djordjevic G Tocco PA Lapchak GM Pasinetti I Najm M Baudry F Hefti 1992 Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid Neuroscience 47 303 315 1641125 10.1016/0306-4522(92)90246-X 1:CAS:528:DyaK38XhslWms7g%3D
16. N Durany T Michel J Kurt FF Cruz-Sánchez J Cervás-Navarro P Riederer 2000 Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains Int J Dev Neurosci 18 807 813 10.1016/S0736-5748(00) 00046-0 1:CAS:528:DC%2BD3MXitlCjsg%3D%3D (Pubitemid 32037055)
17. Eikelenboom P, van Gool WA, Rozemuller AJM, Scheper W, Veerhuis R, Hoozemans JJM (2006) The involvement of Ab in the neuroinflamatory response. In: Barrow CJ, Small DH (eds) Abeta peptide and Alzheimer's disease: celebrating a century of research. Springer, London, pp 52-82
18. P Ernfors J Bengzon Z Kokaia H Persson O Lindvall 1991 Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis Neuron 7 165 176 1829904 10.1016/0896-6273(91)90084-D 1:CAS:528:DyaK3MXlvVSlu7w%3D
19. M Fahnestock SA Scott N Jetté JA Weingartner KA Crutcher 1996 Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex Mol Brain Res 42 175 178 8915599 10.1016/S0169-328X(96)00193-3 1:CAS:528:DyaK28XlvVeisLo%3D (Pubitemid 26345425)
20. I Ferrer C Marín MJ Rey T Ribalta E Goutan R Blanco E Tolosa E Martí 1999 BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies J Neuropathol Exp Neurol 58 729 739 10411343 10.1097/00005072-199907000-00007 1:CAS:528: DyaK1MXltVWhs7s%3D (Pubitemid 29328502)
21. N Filippini BJ MacIntosh MG Hough GM Goodwin GB Frisoni SM Smith PM Matthews CF Beckmann CE Mackay 2009 Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele Proc Natl Acad Sci USA 106 7209 7214 19357304 10.1073/pnas.0811879106 1:CAS:528:DC%2BD1MXlvVymurw%3D
22. D Garzon G Yu M Fahnestock 2002 A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex J Neurochem 82 1058 1064 12358753 10.1046/j.1471-4159.2002.01030.x 1:CAS:528:DC%2BD38XmvVert7c%3D (Pubitemid 34966618)
23. CM Gall PJ Isackson 1989 Limbic seizures increase neuronal production of messenger RNA for nerve growth factor Science 245 758 761 2549634 10.1126/science.2549634 1:CAS:528:DyaL1MXlvFamtrs%3D (Pubitemid 19214012)
24. M Goedert A Fine SP Hunt A Ullrich 1986 Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease Brain Res 387 85 92 3742235 1:STN:280:DyaL283pslGrug%3D%3D
25. F Hallböök 1999 Evolution of the vertebrate neurotrophin and Trk receptor gene families Curr Opin Neurobiol 9 616 621 10508739 10.1016/S0959-4388(99)00011-2 (Pubitemid 29484387)
26. CH Hock K Heese G Olivieri CH Hulette C Rosenberg RM Nitsch U Otten 2000 Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease J Neural Transm Suppl 59 171 174 10961429 1:CAS:528:DC%2BD3MXltFGitA%3D%3D (Pubitemid 30479417)
27. C Hock K Heese C Hulette C Rosenberg U Otten 2000 Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas Arch Neurol 57 846 851 10867782 10.1001/archneur.57.6.846 1:STN:280:DC%2BD3czivVWnsw%3D%3D (Pubitemid 30397187)
28. DM Holtzman 2004 In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology J Mol Neurosci 23 247 254 15181253 10.1385/JMN:23:3:247 1:CAS:528:DC%2BD2cXltlajurY%3D
29. EJ Huang LF Reichardt 2001 Neurotrophins: roles in neuronal development and function Annu Rev Neurosci 24 677 736 11520916 10.1146/annurev.neuro.24.1. 677 1:CAS:528:DC%2BD3MXls1ShsL4%3D (Pubitemid 32695243)
30. PJ Isackson 1995 Trophic factor response to neuronal stimuli or injury Curr Opin Neurobiol 5 350 357 7580158 10.1016/0959-4388(95)80048-4 1:CAS:528:DyaK2MXmsl2hs7o%3D
31. N Jetté MS Cole M Fahnestock 1994 NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients Mol Brain Res 25 242 250 7808223 10.1016/0169-328X(94)90159-7 (Pubitemid 24266074)
32. C Kessler C Spitzer D Stauske S Mende J Stadlmüller R Walther R Rettig 1997 The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease Arterioscler Thromb Vasc Biol 17 2880 2884 9409270 10.1161/01.ATV.17.11.2880 1:CAS:528:DyaK1cXisV2itA%3D%3D (Pubitemid 28016036)
33. J Kim JM Basak DM Holtzman 2009 The role of apolipoprotein E in Alzheimer's disease Neuron 63 287 303 19679070 10.1016/j.neuron.2009.06.026 1:CAS:528:DC%2BD1MXhtFyhsb%2FK
34. M Kivipelto EL Helkala MP Laakso T Hanninen M Hallikainen K Alhainen H Soininen J Tuomilehto A Nissinen 2001 Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study BMJ 322 1447 1451 11408299 10.1136/bmj.322.7300.1447 1:STN:280:DC%2BD3MzksFSrtw%3D%3D (Pubitemid 32575406)
35. S Kobori N Nakamura H Uzawa M Shichiri 1988 Influence of apolipoprotein E polymorphism on plasma lipid and apolipoprotein levels, and clinical characteristics of type III hyperlipoproteinemia due to apolipoprotein E phenotype E2/2 in Japan Atherosclerosis 69 81 88 3355609 10.1016/0021-9150(88) 90291-2 1:STN:280:DyaL1c7otlGrug%3D%3D (Pubitemid 18003511)
36. R Kraemer PJ Baker KC Kent Y Ye JJ Han R Tejada M Silane R Upmacis R Deeb Y Chen DM Levine B Hempstead 2005 Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse Circulation 112 3644 3653 16330706 10.1161/CIRCULATIONAHA.105.587980 1:CAS:528:DC%2BD2MXht1Krt77N (Pubitemid 43739543)
37. MH Laitinen T Ngandu S Rovio EL Helkala U Uusitalo M Viitanen A Nissinen J Tuomilehto H Soininen M Kivipelto 2006 Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study Dement Geriatr Cogn Disord 22 99 107 16710090 10.1159/000093478 1:STN:280:DC%2BD28zmtlGrtQ%3D%3D
38. F Lamballe R Klein M Barbacid 1991 trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 Cell 66 967 979 1653651 10.1016/0092-8674(91)90442-2 1:CAS:528:DyaK38Xmt12jsro%3D (Pubitemid 121001730)
39. GR Lewin YA Barde 1996 Physiology of the neurotrophins Annu Rev Neurosci 19 289 317 8833445 10.1146/annurev.ne.19.030196.001445 1:CAS:528: DyaK28XhsVCksrw%3D (Pubitemid 26080831)
40. Macfarlane DE, Dahle (1993) Isolating RNA from whole blood - the dawn of RNA-based diagnosis? Nature 362:186-188
41. RW Mahley SC Rall Jr 2000 Apolipoprotein E: far more than a lipid transport protein Annu Rev Genomics Hum Genet 1 507 537 11701639 10.1146/annurev.genom.1.1.507 1:CAS:528:DC%2BD3cXnsVarsrY%3D
42. MO McCarron KL Hoffmann DM DeLong L Gray AM Saunders MJ Alberts 1999 Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes Neurology 53 2176 2179 10599801 1:STN:280:DC%2BD3c%2Fms1Ortg%3D%3D
43. T Miki H Kuma T Yokoyama K Sumitani Y Matsumoto T Kusaka K Warita ZY Wang N Hosomi T Imagawa KS Bedi S Itoh Y Nakamura Y Takeuchi 2008 Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus Acta Neurobiol Exp (Wars) 68 484 93
44. KD Murray CM Gall EG Jones PJ Isackson 1994 Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease Neuroscience 60 37 48 8052419 10.1016/0306-4522(94)90202-X 1:STN:280:DyaK2czivFejug%3D%3D (Pubitemid 24147606)
45. RH Myers EJ Schaefer PW Wilson R D'Agostino JM Ordovas A Espino R Au RF White JE Knoefel JL Cobb KA McNulty A Beiser PA Wolf 1996 Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study Neurology 46 673 677 8618665 1:STN:280:DyaK287ntlKktg%3D%3D
46. M Narisawa-Saito K Wakabayashi S Tsuji H Takahashi H Nawa 1996 Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease Neuroreport 7 2925 2928 9116211 10.1097/00001756-199611250-00024 1:STN:280:DyaK2s7ms1elsg%3D%3D (Pubitemid 26426361)
47. S Peng J Wuu EJ Mufson M Fahnestock 2005 Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease J Neurochem 93 1412 1421 15935057 10.1111/j.1471-4159.2005.03135.x 1:CAS:528:DC%2BD2MXlsFems74%3D (Pubitemid 40853264)
48. HS Phillips JM Hains M Armanini GR Laramee SA Johnson JW Winslow 1991 BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease Neuron 7 695 702 1742020 10.1016/0896-6273(91)90273-3 1:CAS:528:DyaK38Xht1KisLo%3D
49. JA Piedrahita SH Zhang JR Hagaman PM Oliver N Maeda 1992 Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells Proc Natl Acad Sci USA 89 4471 4475 1584779 10.1073/pnas.89.10.4471 1:CAS:528:DyaK38XktVGms7o%3D
50. AS Plump JD Smith T Hayek K Aalto-Setälä A Walsh JG Verstuyft EM Rubin JL Breslow 1992 Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells Cell 71 343 353 1423598 10.1016/0092-8674(92)90362-G 1:CAS:528: DyaK38XmsV2ns74%3D
51. AD Roses 1996 Apolipoprotein E alleles as risk factors in Alzheimer's disease Annu Rev Med 47 387 400 8712790 10.1146/annurev.med.47.1.387 1:CAS:528:DyaK28XitlSntLs%3D (Pubitemid 26138899)
52. PP Roux PA Barker 2002 Neurotrophin signaling through the p75 neurotrophin receptor Prog Neurobiol 67 203 233 12169297 10.1016/S0301-0082(02) 00016-3 1:CAS:528:DC%2BD38XmtVSksLo%3D
53. T Sabo L Lomnitski A Nyska S Beni RR Maronpot E Shohami AD Roses DM Michaelson 2000 Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities Neuroscience 101 879 884 11113336 10.1016/S0306- 4522(00)00438-3 1:CAS:528:DC%2BD3cXosFemtbo%3D
54. Saunders AM (2001) Apolipoprotein E as a risk factor for Alzheimer's disease. In: Dawbarn D, Allen SJ (eds) Neurobiology of Alzeimer's disease. Oxford University Press, Oxford, pp 207-226
55. AM Saunders WJ Strittmatter D Schmechel PH George-Hyslop MA Pericak-Vance SH Joo BL Rosi JF Gusella DR Crapper-MacLachlan MJ Alberts C Hulette B Crain D Goldgaber ADMD Roses 1993 Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease Neurology 43 1467 1472 8350998 1:CAS:528:DyaK2cXhvVyksbc%3D (Pubitemid 23230526)
56. SA Scott EJ Mufson JA Weingartner KA Skau KA Crutcher 1995 Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis J Neurosci 15 6213 6221 7666203 1:CAS:528:DyaK2MXnvFChurw%3D
57. GJ Siegel NB Chauhan 2000 Neurotrophic factors in Alzheimer's and Parkinson's disease brain Brain Res Rev 33 199 227 11011066 10.1016/S0165- 0173(00)00030-8 1:CAS:528:DC%2BD3cXmslyjtr8%3D
58. Y Song MJ Stampfer S Liu 2004 Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease Ann Intern Med 141 137 147 15262670 (Pubitemid 38937836)
59. F Suzuki MP Junier D Guilhem JC Sørensen B Onteniente 1995 Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor Neuroscience 64 665 674 7715779 10.1016/0306-4522(94)00463-F 1:CAS:528:DyaK2MXjt1Kksr0%3D
60. S Suzuki K Kiyosue S Hazama A Ogura M Kashihara T Hara H Koshimizu M Kojima 2007 Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development J Neurosci 27 6417 6427 17567802 10.1523/JNEUROSCI.0690- 07.2007 1:CAS:528:DC%2BD2sXntVKrtLY%3D (Pubitemid 46920374)
61. L Tapia-Arancibia E Aliaga M Silhol S Arancibia 2008 New insights into brain BDNF function in normal aging and Alzheimer disease Brain Res Rev 59 201 220 18708092 10.1016/j.brainresrev.2008.07.007 1:CAS:528:DC%2BD1cXht1KnsbrP
62. T Ueno T Miki ZY Wang T Yokoyama KY Lee T Kusaka K Warita K Sumitani Y Matsumoto T Yakura JQ Liu KS Bedi Y Takeuchi 2010 Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus Curr Neurobiol 1 40 45 1:CAS:528:DC%2BC3cXksVKjtrY%3D
63. K Ueshima H Akihisa-Umeno M Sawada A Nagayoshi T Ozaki S Takakura T Manda S Mutoh 2004 Possible involvement of enhanced intestinal microsomal triglyceride transfer protein (MTP) gene expression in acceleration of lipid absorption by a western-type diet in apolipoprotein E knockout mice Life Sci 76 179 190 15519363 10.1016/j.lfs.2004.05.037 1:CAS:528:DC%2BD2cXptFKqtL4%3D (Pubitemid 39425223)
64. Wahrle SE, Holtzman DM (2007) Apolipoprotein E, amyloid b peptide, and Alzheimer's disease. In: Dawbarn D, Allen SJ (eds) Neurobiology of Alzheimer's disease. Oxford University Press, Oxford, pp 161-172
65. ZY Wang T Miki KY Lee T Yokoyama T Kusaka K Sumitani K Warita Y Matsumoto T Yakura N Hosomi K Ameno KS Bedi Y Takeuchi 2010 Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum Neuroscience 165 485 491 19861148 10.1016/j.neuroscience.2009.10.045 1:CAS:528:DC%2BD1MXhsFGhtbfP
66. G Weskamp LF Reichardt 1991 Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors Neuron 6 649 663 1849725 10.1016/0896-6273(91)90067-A 1:CAS:528:DyaK3MXlsFWksr4%3D
67. PW Wilson RH Myers MG Larson JM Ordovas PA Wolf EJ Schaefer 1994 Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study JAMA 272 1666 1671 7966894 10.1001/jama.272.21.1666 1:STN:280:DyaK2M%2Fls1elsQ%3D%3D (Pubitemid 24359137)
68. SH Zhang RL Reddick JA Piedrahita N Maeda 1992 Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E Science 258 468 471 1411543 10.1126/science.1411543 1:CAS:528:DyaK38XmsV2nsr0%3D