A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex

Journal of Neurochemistry

Volumn 82, Issue 5, 2002, Pages 1058-1064

  Garzon, Diego ^a   Yu, Guanhua ^a   Fahnestock, Margaret ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Brain derived neurotrophic factor; Gene expression; Human; mRNA; RT PCR

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC NERVE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; EXON; FOREBRAIN; GENE EXPRESSION REGULATION; GENE ISOLATION; GENETIC CODE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NERVE GROWTH; PARIETAL LOBE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA SPLICING; RNA TRANSCRIPTION; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION;

AGED; ALTERNATIVE SPLICING; ALZHEIMER DISEASE; BASE SEQUENCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; EXONS; FEMALE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PARIETAL LOBE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EUKARYOTA;

EID: 0036723891     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01030.x     Document Type: Article

References (49)

1. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
2. Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants
3. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus
4. Brain-derived neurotrophic factor is reduced in Alzheimer's disease
5. Alzheimer's disease: A disorder of cortical cholinergic innervation
6. The anatomy of the CNS cholinergic neurons
7. Brain-derived neurotrophic factor expression after long-term potentiation
8. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: Developmental and topographical expression in the brain
9. Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease
10. Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
11. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies
12. Requirement for BDNF in activity-dependent survival of cortical neurons
13. Nerve growth factor and Alzheimer's disease
14. Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
15. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
16. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: Decreased levels in Alzheimer's disease
17. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
18. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
19. Diagnosis of Alzheimer's disease
20. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3
21. Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters
22. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4
23. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
24. Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations
25. Is the pattern of nerve cell loss in aging and Alzheimer's disease a real, or only an apparent, selectivity?
26. Clinical Diagnosis of Alzheimer's Disease. Report of NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's disease
27. Brain-derived neurotrophic factor differentially regulates excitatory and inhibitory synaptic transmission in hippocampal cultures
28. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
29. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
30. Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats
31. Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
32. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
33. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
34. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor
35. Molecular mechanisms underlying activity-dependent regulation of BDNF expression
36. Identification of a signaling pathway involved in calcium regulation of BDNF expression
37. Method for quantitation of low-abundance nerve growth factor mRNA expression in human nervous tissue using competitive reverse transcription polymerase chain reaction
38. 2+ channels
39. Involvement of an upstream stimulatory factor as well as cAMP responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
40. Study of cytoskeletal proteins in fibroblasts cultured from familial Alzheimer's disease
41. Change in the cytoskeletal system in fibroblasts from patients with familial Alzheimer's disease
42. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
43. Multiple promoters direct tissue-specific expression of the rat BDNF gene
44. Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice
45. Betaamyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival is not compromised
46. Calcium regulation of neuronal gene expression
47. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
48. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
49. Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type