Interferon consensus sequence binding protein-induced cell proliferation is mediated by TGF-Β signaling and p38 MAPK activation

Laboratory Investigation

Volumn 91, Issue 9, 2011, Pages 1304-1313

  Sung, Jee Young ^a   Kim, Heejung ^a   Kim, Yong Nyun ^a   Na, Yoon Sook ^a   Park, Byung Kiu ^a  

^a National Cancer Center   (South Korea)

Author keywords

cell proliferation; ICSBP; p38; R; TAK 1; TGF

Indexed keywords

INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

APOPTOSIS; ARTICLE; ATTENUATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STABLE EXPRESSION;

BASE SEQUENCE; CELL PROLIFERATION; DNA PRIMERS; ENZYME ACTIVATION; HUMANS; INTERFERON REGULATORY FACTORS; JURKAT CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 80052290751     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.90     Document Type: Article

References (30)

1. Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 2005;21:659-693. (Pubitemid 41740650)
2. Massague J. TGFbeta in cancer. Cell 2008;134:215-230.
3. Boulanger CA, Wagner KU, Smith GH. Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGFbeta1 expression. Oncogene 2005;24:552-560. (Pubitemid 40188560)
4. Muraoka-Cook RS, Kurokawa H, Koh Y, et al. Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res 2004;64:9002-9011. (Pubitemid 39665510)
5. Bierie B, Moses HL. TGF-beta and cancer. Cytokine Growth Factor Rev 2006;17:29-40.
6. Moustakas A, Lin HY, Henis YI, et al. The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand. J Biol Chem 1993;268:22215-22218. (Pubitemid 23318253)
7. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584. (Pubitemid 37280136)
8. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700. (Pubitemid 36724933)
9. Lu T, Tian L, Han Y, et al. Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc Natl Acad Sci USA 2007;104:4365-4370. (Pubitemid 47186232)
10. Hartsough MT, Mulder KM. Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells. J Biol Chem 1995;270:7117-7124.
11. Bakin AV, Tomlinson AK, Bhowmick NA, et al. Phosphatidylinositol 3-kinase function is required for transforming growth factor betamediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000;275:36803-36810. (Pubitemid 32002090)
12. Wilkes MC, Mitchell H, Penheiter SG, et al. Transforming growth factorbeta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 2005;65:10431-10440. (Pubitemid 41743737)
13. Driggers PH, Ennist DL, Gleason SL, et al. An interferon gammaregulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci USA 1990;87:3743-3747.
14. Tamura T, Yanai H, Savitsky D, et al. The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008; 26:535-584. (Pubitemid 351600385)
15. Tamura T, Nagamura-Inoue T, Shmeltzer Z, et al. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 2000;13:155-165.
16. Sharf R, Meraro D, Azriel A, et al. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. J Biol Chem 1997;272:9785-9792. (Pubitemid 27171643)
17. Holtschke T, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 1996;87:307-317. (Pubitemid 26359008)
18. Schmidt M, Nagel S, Proba J, et al. Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. Blood 1998;91:22-29. (Pubitemid 28018725)
19. Lee KY, Geng H, Ng KM, et al. Epigenetic disruption of interferongamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas. Oncogene 2008;27:5267-5276.
20. Eroshkin A, Mushegian A. Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens. J Mol Med 1999;77:403-405. (Pubitemid 29302703)
21. Ju XS, Ruau D, Jantti P, et al. Transforming growth factor beta1 upregulates interferon regulatory factor 8 during dendritic cell development. Eur J Immunol 2007;37:1174-1183. (Pubitemid 46925302)
22. Miyazaki M, Sakaguchi M, Akiyama I, et al. Involvement of interferon regulatory factor 1 and S100C/A11 in growth inhibition by transforming growth factor beta 1 in human hepatocellular carcinoma cells. Cancer Res 2004;64:4155-4161. (Pubitemid 38802418)
23. Qing J, Liu C, Choy L, et al. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol 2004;24:1411-1425. (Pubitemid 38112200)
24. Weisz A, Marx P, Sharf R, et al. Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J Biol Chem 1992;267:25589-25596.
25. Ossege LM, Sindern E, Patzold T, et al. Immunomodulatory effects of interferon-beta-1b in vivo: induction of the expression of transforming growth factor-beta1 and its receptor type II. J Neuroimmunol 1998;91:73-81. (Pubitemid 28545245)
26. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009;19:128-139.
27. Maher SG, Romero-Weaver AL, Scarzello AJ, et al. Interferon: cellular executioner or white knight? Curr Med Chem 2007;14:1279-1289. (Pubitemid 46746361)
28. Zhou Y, Weyman CM, Liu H, et al. IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression. J Interferon Cytokine Res 2008;28:65-72. (Pubitemid 351271549)
29. Franke TF. PI3K/Akt: getting it right matters. Oncogene 2008;27: 6473-6488.
30. Gabriele L, Phung J, Fukumoto J, et al. Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. J Exp Med 1999;190:411-421. (Pubitemid 29374838)