Hydrophobic anions potently and uncompetitively antagonize GABA A receptor function in the absence of a conventional binding site

British Journal of Pharmacology

Volumn 164, Issue 2 B, 2011, Pages 667-680

  Chisari, M ^a   Wu, K ^a   Zorumski, C F ^a   Mennerick, S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antagonist; GABA A receptors; hippocampal; membrane capacitance; voltage sensor

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ANION; DIPICRYLAMINE; NEUROSTEROID; PREGNENOLONE SULFATE; TETRAPHENYLBORON; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; CONCENTRATION RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG SENSITIVITY; FEMALE; GABAERGIC TRANSMISSION; HIPPOCAMPUS; HORMONE INHIBITION; HYDROPHOBICITY; IC 50; IN VITRO STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; NONHUMAN; OOCYTE; PHYSICAL CHEMISTRY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; STEADY STATE; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANIONS; BINDING SITES; CELL MEMBRANE; CELLS, CULTURED; ELECTRIC CAPACITANCE; FEMALE; GABA-A RECEPTOR ANTAGONISTS; HIPPOCAMPUS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; NEURONS; PATCH-CLAMP TECHNIQUES; PICRATES; PREGNENOLONE; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GABA-A; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC POTENTIALS; SYNAPTIC TRANSMISSION; TETRAPHENYLBORATE; XENOPUS LAEVIS;

EID: 80052213062     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01396.x     Document Type: Article

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