Tumour necrosis factor-α suppresses the hypoxic response by NF-κB-dependent induction of inhibitory PAS domain protein in PC12 cells

Journal of Biochemistry

Volumn 150, Issue 3, 2011, Pages 311-318

  Goryo, Kenji ^a   Torii, Satoru ^a   Yasumoto, Ken Ichi ^a   Sogawa, Kazuhiro ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

HIF 1; hypoxic response; IPAS; NF B; TNF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITORY PAS DOMAIN PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INFLAMMATION; METABOLIC NETWORKS AND PATHWAYS; NF-KAPPA B; PC12 CELLS; RATS; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE 3-MONOOXYGENASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 80052201687     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvr061     Document Type: Article

References (33)

1. Karhausen, J., Haase, V.H., and Colgan, S.P. (2005) Inflammatory hypoxia: Role of hypoxia-inducible factor. Cell Cycle 4, 256-258 (Pubitemid 41365330)
2. Nizet, V. and Johnson, R.S. (2009) Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 9, 609-617
3. Hatoum, O.A., Miura, H., and Binion, D.G. (2003) The vascular contribution in the pathogenesis of inflammatory bowel disease. Am. J. Physiol. Heart Circ. Physiol. 285, H1791-H1796 (Pubitemid 37305919)
4. Semenza, G.L. (2007) Life with Oxygen. Science 318, 62-64 (Pubitemid 47538005)
5. Wang, G.L., Jiang, B.H., Rue, E.A., and Semenza, G.L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA. 92, 5510-5514
6. Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., and Fujii-Kuriyama, Y. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl Acad. Sci. USA. 94, 4273-4278
7. Wiesener, M.S., Turley, H., Allen, W.E., Willam, C., Eckardt, K.U., Talks, K.L., Wood, S.M., Gatter, K.C., Harris, A.L., Pugh, C.W., Ratcliffe, P.J., and Maxwell, P.H. (1998) Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α. Blood 92, 2260-2268 (Pubitemid 28452966)
8. Gu, Y.Z., Moran, S.M., Hogenesch, J.B., Wartman, L., and Bradfield, C.A. (1998) Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 7, 205-213 (Pubitemid 28527216)
9. Hara, S., Hamada, J., Kobayashi, C., Kondo, Y., and Imura, N. (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: Suppression of HIF-mediated gene expression by HIF-3α. Biochem. Biophys. Res. Commun. 287, 808-813 (Pubitemid 32953545)
10. Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., and Poellinger, L. (2001) Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414, 550-554 (Pubitemid 33131538)
11. Makino, Y. (2002) Inhibitory PAS Domain Protein (IPAS) Is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus. J. Biol. Chem. 277, 32405-32408 (Pubitemid 34984738)
12. Makino, Y., Uenishi, R., Okamoto, K., Isoe, T., Hosono, O., Tanaka, H., Kanopka, A., Poellinger, L., Haneda, M., and Morimoto, C. (2007) Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J. Biol. Chem. 282, 14073-14082 (Pubitemid 47100468)
13. Torii, S., Kobayashi, K., Takahashi, M., Katahira, K., Goryo, K., Matsushita, N., Yasumoto, K., Fujii-Kuriyama, Y., and Sogawa, K. (2009) Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells. J. Biol. Chem. 284, 19077-19089
14. Bradley, J.R. (2008) TNF-mediated inflammatory disease. J. Pathol. 214, 149-160 (Pubitemid 351160153)
15. Chen, G. (2002) TNF-R1 Signaling: A beautiful pathway. Science 296, 1634-1635 (Pubitemid 34579145)
16. Faustman, D. and Davis, M. (2010) TNF receptor 2 pathway: Drug target for autoimmune diseases. Nat. Rev. Drug Discov. 9, 482-493
17. Hayden, M. and Ghosh, S. (2008) Shared principles in NF-kB signaling. Cell 132, 344-362
18. Frede, S., Berchner-Pfannschmidt, U., and Fandrey, J. (2007) Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol. 435, 403-419
19. Ishiniwa, H., Sogawa, K., Yasumoto, K., and Sekijima, T. (2010) Polymorphisms and functional differences in aryl hydrocarbon receptors (AhR) in Japanese field mice, Apodemus speciosus. Environ. Toxicol. Pharmacol. 29, 280-289
20. Sogawa, K., Numayama-Tsuruta, K., Ema, M., Abe, M., Abe, H., and Fujii-Kuriyama, Y. (1998) Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc. Natl Acad. Sci. USA. 95, 7368-7373 (Pubitemid 28293258)
21. Vancha, A.R., Govindaraju, S., Parsa, K.V., Jasti, M., Gonzalez-Garcia, M., and Ballestero, R.P. (2004) Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer. BMC Biotechnol. 4, 23
22. Torii, S., Okamura, N., Suzuki, Y., Ishizawa, T., Yasumoto, K., and Sogawa, K. (2009) Cyclic AMP Represses the Hypoxic Induction of Hypoxia-inducible Factors in PC12 Cells. J. Biochem. . 146, 839-844
23. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (Pubitemid 14203433)
24. Kuo, H.-P., Lee, D.-F., Xia, W., Wei, Y., and Hung, M.-C. (2009) TNFα induces HIF-1α expression through activation of IKKβ. Biochem. Biophys. Res. Commun. 389, 640-644
25. Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A.S., Nizet, V., Johnson, R.S., Haddad, G.G., and Karin, M. (2008) NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453, 807-811 (Pubitemid 351793778)
26. van Uden, P., Kenneth, N.S., and Rocha, S. (2008) Regulation of hypoxia-inducible factor-1α by NF-kB. Biochem. J. 412, 477
27. Jiang, H., Zhu, Y.S., Xu, H., Sun, Y., and Li, Q.F. (2010) Inflammatory stimulation and hypoxia cooperatively activate HIF-1α in bronchial epithelial cells: Involvement of PI3K and NF-kB. Am. J. Physiol. Lung Cell Mol. Physiol. 298, L660-L669
28. Walmsley, S.R. (2005) Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-kB activity. J. Exp. Med. 201, 105-115 (Pubitemid 40130088)
29. Cummins, E.P., Berra, E., Comerford, K.M., Ginouves, A., Fitzgerald, K.T., Seeballuck, F., Godson, C., Nielsen, J.E., Moynagh, P., Pouyssegur, J., and Taylor, C.T. (2006) Prolyl hydroxylase-1 negatively regulates IkB kinase-β, giving insight into hypoxia-induced NFkB activity. Proc. Natl Acad. Sci. USA 103, 18154-18159 (Pubitemid 44871628)
30. Taylor, C.T. (2008) Interdependent roles for hypoxia inducible factor and nuclear factor-kB in hypoxic inflammation. J. Physiol. 586, 4055-4059
31. O'Connell, R.M., Rao, D.S., Chaudhuri, A.A., Boldin, M.P., Taganov, K.D., Nicoll, J., Paquette, R.L., and Baltimore, D. (2008) Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J. Exp. Med. 205, 585-594 (Pubitemid 351439306)
32. Ridder, D.A. and Schwaninger, M. (2009) NF-kB signaling in cerebral ischemia. Neuroscience 158, 995-1006
33. Torii, S., Goto, Y., Ishizawa, T., Hoshi, H., Goryo, K., Yasumoto, K., Fukumura, H., and Sogawa, K. (2011) Pro-Apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ, doi:10.1038/cdd.2011.47