-
1
-
-
58849114615
-
Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors
-
Coxon, A.; Bush, T.; Saffran, D.; Kaufman, S.; Belmontes, B.; Rex, K.; Hughes, P.; Caenepeel, S.; Rottman, J.B.; Tasker, A.; et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin. Cancer Res. 2009, 15, 110-118.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 110-118
-
-
Coxon, A.1
Bush, T.2
Saffran, D.3
Kaufman, S.4
Belmontes, B.5
Rex, K.6
Hughes, P.7
Caenepeel, S.8
Rottman, J.B.9
Tasker, A.10
-
2
-
-
34548764511
-
Honokiol a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis
-
Munroe, M.E.; Arbiser, J.L.; Bishop, G.A. Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis. J. Immunol. 2007, 179, 753-763.
-
(2007)
J. Immunol.
, vol.179
, pp. 753-763
-
-
Munroe, M.E.1
Arbiser, J.L.2
Bishop, G.A.3
-
3
-
-
0035744348
-
Anticancer therapy with novel tubulin-interacting drugs
-
DOI 10.1054/drup.2002.0230
-
Kavallaris, M.; Verrills, N.M.; Hill, B.T. Anticancer therapy with novel tubulin-interacting drugs. Drug Resist. Updat. 2001, 4, 392-401. (Pubitemid 34746873)
-
(2001)
Drug Resistance Updates
, vol.4
, Issue.6
, pp. 392-401
-
-
Kavallaris, M.1
Verrills, N.M.2
Hill, B.T.3
-
4
-
-
0031836174
-
Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents
-
Shi, Q.; Chen, K.; Morris-Natschke, S.L.; Lee, K.H. Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents. Curr. Pharm. Des. 1998, 4, 219-248. (Pubitemid 28277446)
-
(1998)
Current Pharmaceutical Design
, vol.4
, Issue.3
, pp. 219-248
-
-
Shi, Q.1
Chen, K.2
Morris-Natschke, S.L.3
Lee, K.-H.4
-
5
-
-
0031872051
-
Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
-
DOI 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U
-
Jordan, A.; Hadfield, J.A.; Lawrence, NJ.; McGown, A.T. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev. 1998, 18, 259-296. (Pubitemid 28346389)
-
(1998)
Medicinal Research Reviews
, vol.18
, Issue.4
, pp. 259-296
-
-
Jordan, A.1
Hadfield, J.A.2
Lawrence, N.J.3
McGown, A.T.4
-
6
-
-
9144254574
-
Microtubulin binding sites as target for developing anticancer agents
-
Islam, M.N.; Iskander, M.N. Microtubulin binding sites as target for developing anticancer agents. Mini Rev. Med. Chem. 2004, 4, 1077-1104. (Pubitemid 39545451)
-
(2004)
Mini-Reviews in Medicinal Chemistry
, vol.4
, Issue.10
, pp. 1077-1104
-
-
Islam, M.N.1
Iskander, M.N.2
-
7
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan, M.A.; Wilson, L. Microtubules as a target for anticancer drugs. Nat Rev. Cancer 2004, 4, 253-265. (Pubitemid 38525281)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
8
-
-
41549130929
-
Newer cytotoxic agents: Attacking cancer broadly
-
DOI 10.1158/1078-0432.CCR-07-2249
-
Teicher, B.A. Newer cytotoxic agents: Attacking cancer broadly. Clin. Cancer Res. 2008, 14, 1610-1617. (Pubitemid 351469444)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.6
, pp. 1610-1617
-
-
Teicher, B.A.1
-
9
-
-
0033052777
-
Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
-
Dumontet, C.; Sikic, B.I. Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J. Clin. Oncol. 1999, 17, 1061-1070. (Pubitemid 29109340)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.3
, pp. 1061-1070
-
-
Dumontet, C.1
Sikic, B.I.2
-
10
-
-
33750134570
-
2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents
-
Chang, J.Y.; Yang, M.F.; Chang, C.Y.; Chen, C.M.; Kuo, C.C.; Liou, J.P. 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J. Med. Chem. 2006, 49, 6412-6415.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6412-6415
-
-
Chang, J.Y.1
Yang, M.F.2
Chang, C.Y.3
Chen, C.M.4
Kuo, C.C.5
Liou, J.P.6
-
11
-
-
33750976393
-
7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents
-
Chang, J.Y.; Hsieh, H.P.; Chang, C.Y.; Hsu, K.S.; Chiang, Y.F.; Chen, C.M.; Kuo, C.C.; Liou, J.P. 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. J. Med. Chem. 2006, 49, 6656-6659.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6656-6659
-
-
Chang, J.Y.1
Hsieh, H.P.2
Chang, C.Y.3
Hsu, K.S.4
Chiang, Y.F.5
Chen, C.M.6
Kuo, C.C.7
Liou, J.P.8
-
12
-
-
34548483407
-
4- and 5-aroylindoles as novel classes of potent antitubulin agents
-
Liou, J.P.; Wu, C.Y.; Hsieh, H.P.; Chang, C.Y.; Chen, C.M.; Kuo, C.C.; Chang, J.Y. 4- and 5-aroylindoles as novel classes of potent antitubulin agents. J. Med. Chem. 2007, 50, 4548-4552.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4548-4552
-
-
Liou, J.P.1
Wu, C.Y.2
Hsieh, H.P.3
Chang, C.Y.4
Chen, C.M.5
Kuo, C.C.6
Chang, J.Y.7
-
13
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
DOI 10.1021/np030096l
-
Newman, D.J.; Cragg, G.M.; Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat Prod. 2003, 66, 1022-1037. (Pubitemid 36909859)
-
(2003)
Journal of Natural Products
, vol.66
, Issue.7
, pp. 1022-1037
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
14
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
DOI 10.1016/j.jep.2005.05.011, PII S0378874105003259, Perspectives of Ethnopharmacology
-
Cragg, G.M.; Newman, D.J. Plants as a source of anti-cancer agents. J. Ethnopharmacol. 2005, 100, 72-79. (Pubitemid 41073525)
-
(2005)
Journal of Ethnopharmacology
, vol.100
, Issue.1-2
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
17
-
-
0029031361
-
The antitumor activities of gnidimacrin isolated from Stellera chamaejasme L
-
Feng, W.; Tetsuro, I.; Mitsuzi, Y. The antitumor activities of gnidimacrin isolated from Stellera chamaejasme L. Chin. J. Cancer Res. 1995, 17, 24-26.
-
(1995)
Chin. J. Cancer Res.
, vol.17
, pp. 24-26
-
-
Feng, W.1
Tetsuro, I.2
Mitsuzi, Y.3
-
18
-
-
48249149535
-
Development of chamaejasmin microemulsion and its biological activity against Aphis craccivora and Culex pipiens pallens
-
Tang, X.; Hou, T. Development of chamaejasmin microemulsion and its biological activity against Aphis craccivora and Culex pipiens pallens. Flavour. Fragr. J. 2008, 23, 258-262.
-
(2008)
Flavour. Fragr. J.
, vol.23
, pp. 258-262
-
-
Tang, X.1
Hou, T.2
-
19
-
-
80052201899
-
Amentoflavone and the extracts from Selaginella tamariscina and their anticancer activity
-
Jing, Y.; Zhang, G.G.; Ma, E.L.; Zhang, H.M.; Guan, J.; He, J. Amentoflavone and the extracts from Selaginella tamariscina and their anticancer activity. Asian J. Traditional Med. 2010, 5, 226-229.
-
(2010)
Asian J. Traditional Med.
, vol.5
, pp. 226-229
-
-
Jing, Y.1
Zhang, G.G.2
Ma, E.L.3
Zhang, H.M.4
Guan, J.5
He, J.6
-
20
-
-
0034518173
-
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
-
DOI 10.1146/annurev.cellbio.16.1.89
-
Downing, K.H. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu. Rev. Cell Dev. Biol. 2000, 16, 89-111. (Pubitemid 32037501)
-
(2000)
Annual Review of Cell and Developmental Biology
, vol.16
, pp. 89-111
-
-
Downing, K.H.1
-
21
-
-
0035942226
-
The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density
-
DOI 10.1073/pnas.051309398
-
Snyder, J.P.; Nettles, J.H.; Cornett, B.; Downing, K.H.; Nogales, E. The binding conformation of Taxol in beta-tubulin: A model based on electron crystallographic density. Proc. Natl. Acad. Sci. USA 2001, 98, 5312-5316. (Pubitemid 32397125)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5312-5316
-
-
Snyder, J.P.1
Nettles, J.H.2
Cornett, B.3
Downing, K.H.4
Nogales, E.5
-
22
-
-
70450284524
-
Medicinal chemistry of paclitaxel and its analogues
-
Fu, Y.; Li, S.; Zu, Y.; Yang, G.; Yang, Z.; Luo, M.; Jiang, S.; Wink, M.; Efferth, T. Medicinal chemistry of paclitaxel and its analogues. Curr. Med. Chem. 2009, 16, 3966-3985.
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 3966-3985
-
-
Fu, Y.1
Li, S.2
Zu, Y.3
Yang, G.4
Yang, Z.5
Luo, M.6
Jiang, S.7
Wink, M.8
Efferth, T.9
-
23
-
-
0035834521
-
Refined structure of αβ-tubulin at 3.5 Å resolution
-
DOI 10.1006/jmbi.2001.5077
-
Lowe, J.; Li, H.; Downing, K.H.; Nogales, E. Refined structure of alpha beta-tubulin at 3.5 A resolution. J. Mol. Biol. 2001, 313, 1045-1057. (Pubitemid 33081900)
-
(2001)
Journal of Molecular Biology
, vol.313
, Issue.5
, pp. 1045-1057
-
-
Lowe, J.1
Li, H.2
Downing, K.H.3
Nogales, E.4
-
24
-
-
80052250572
-
-
Accelrys Inc.: San Diego, CA, USA
-
InisghtII Version 2005, 2005 ed.; Accelrys Inc.: San Diego, CA, USA, 2005.
-
(2005)
InisghtII Version 2005, 2005 Ed.
-
-
-
25
-
-
7744237554
-
A possible model of benzimidazole binding to β-tubulin disclosed by invoking an inter-domain movement
-
DOI 10.1016/j.jmgm.2004.08.001, PII S1093326304000889
-
Robinson, M.W.; McFerran, N.; Trudgett, A.; Hoey, L.; Fairweather, I. A possible model of benzimidazole binding to beta-tubulin disclosed by invoking an inter-domain movement. J. Mol. Graph. Model 2004, 23, 275-284. (Pubitemid 39463106)
-
(2004)
Journal of Molecular Graphics and Modelling
, vol.23
, Issue.3
, pp. 275-284
-
-
Robinson, M.W.1
McFerran, N.2
Trudgett, A.3
Hoey, L.4
Fairweather, I.5
-
26
-
-
15744400734
-
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design
-
DOI 10.1016/j.chembiol.2005.01.004
-
Geney, R.; Sun, L.; Pera, P.; Bernacki, R.J.; Xia, S.; Horwitz, S.B.; Simmerling, C.L.; Ojima, I. Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. Chem. Biol. 2005, 12, 339-348. (Pubitemid 40406281)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.3
, pp. 339-348
-
-
Geney, R.1
Sun, L.2
Pera, P.3
Bernacki, R.J.4
Xia, S.5
Horwitz, S.B.6
Simmerling, C.L.7
Ojima, I.8
-
27
-
-
39549090639
-
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel
-
DOI 10.1073/pnas.0708153105
-
Rodríguez-Menchaca, A.A.; Navarro-Polanco, R.A.; Ferrer-Villada, T.; Rupp, J.; Sachse, F.B.; Tristani-Firouzi, M.; Sánchez-Chapula, J.A. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc. Natl. Acad. Sci. USA 2008, 105, 1364-1368. (Pubitemid 351397059)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.4
, pp. 1364-1368
-
-
Rodriguez-Menchaca, A.A.1
Navarro-Polanco, R.A.2
Ferrer-Villada, T.3
Rupp, J.4
Sachse, F.B.5
Tristani-Firouzi, M.6
Sanchez-Chapula, J.A.7
-
28
-
-
41849100659
-
Computational analyses of JAK1 kinase domain: Subtle changes in the catalytic cleft influence inhibitor specificity
-
Zhang, X.; Hu, Y.; Yuan, Z. Computational analyses of JAK1 kinase domain: subtle changes in the catalytic cleft influence inhibitor specificity. Biochem. Biophys. Res. Commun. 2008, 370, 72-76.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.370
, pp. 72-76
-
-
Zhang, X.1
Hu, Y.2
Yuan, Z.3
-
30
-
-
84961985037
-
The conformational analysis and proton transfer of the neuraminidase inhibitors: A theoretical study
-
Yang, Z.W.; Yang, G.; Zu, Y.G.; Fu, Y.J.; Zhou, L.J. The conformational analysis and proton transfer of the neuraminidase inhibitors: A theoretical study. Phys. Chem. Chem. Phys. 2009, 11, 10035-10041.
-
(2009)
Phys. Chem. Chem. Phys.
, vol.11
, pp. 10035-10041
-
-
Yang, Z.W.1
Yang, G.2
Zu, Y.G.3
Fu, Y.J.4
Zhou, L.J.5
-
31
-
-
77956878500
-
Synergistic effects in the designs of neuraminidase ligands: Analysis from docking and molecular dynamics studies
-
Yang, Z.; Nie, Y.; Yang, G.; Zu, Y.; Fu, Y.; Zhou, L. Synergistic effects in the designs of neuraminidase ligands: Analysis from docking and molecular dynamics studies. J. Theor. Biol. 2010, 267, 363-374.
-
(2010)
J. Theor. Biol.
, vol.267
, pp. 363-374
-
-
Yang, Z.1
Nie, Y.2
Yang, G.3
Zu, Y.4
Fu, Y.5
Zhou, L.6
-
32
-
-
65249121438
-
Temperature-controlled molecular dynamics studies on the folding mechanism of the tubulin active peptides
-
Wu, X.M.; Zu, Y.G.; Yang, Z.W.; Fu, Y.J.; Zhou, L.J.; Yang, G. Temperature-controlled molecular dynamics studies on the folding mechanism of the tubulin active peptides. Acta Phys. Chim. Sin. 2009, 4, 773-782.
-
(2009)
Acta Phys. Chim. Sin.
, vol.4
, pp. 773-782
-
-
Wu, X.M.1
Zu, Y.G.2
Yang, Z.W.3
Fu, Y.J.4
Zhou, L.J.5
Yang, G.6
-
33
-
-
67549109349
-
Molecular dynamic simulations on the folding and conformational insights of the truncated peptides
-
Yang, G.; Wu, X.M.; Zu, Y.G.; Yang, Z.W.; Fu, Y.J.; Zhou, L.J. Molecular dynamic simulations on the folding and conformational insights of the truncated peptides. J. Theo. Comput. Chem. 2009, 8, 317-331.
-
(2009)
J. Theo. Comput. Chem.
, vol.8
, pp. 317-331
-
-
Yang, G.1
Wu, X.M.2
Zu, Y.G.3
Yang, Z.W.4
Fu, Y.J.5
Zhou, L.J.6
-
34
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
Jorgensen, W.L.; Chandrasekhar, J.; Madura, J.D.; Impey, R.W.; Klein, M.L. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 1983, 79, 926-935.
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Impey, R.W.4
Klein, M.L.5
-
35
-
-
55949090064
-
Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules
-
Mitra, A.; Sept, D. Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules. Biophys. J. 2008, 95, 3252-3258.
-
(2008)
Biophys. J.
, vol.95
, pp. 3252-3258
-
-
Mitra, A.1
Sept, D.2
-
36
-
-
1842776332
-
-
Accelrys Inc.: San Diego, CA, USA
-
Affinity User Guide; Accelrys Inc.: San Diego, CA, USA, 2005.
-
(2005)
Affinity User Guide
-
-
-
37
-
-
36749113534
-
Generalized Langevin equation approach for atom/solid-surface scattering: General formulation for classical scattering off harmonic solids
-
Adelman, S.A.; Doll, J.D. Generalized Langevin equation approach for atom/solid-surface scattering: General formulation for classical scattering off harmonic solids. J. Chem. Phys. 1976, 64, 2375-2388.
-
(1976)
J. Chem. Phys.
, vol.64
, pp. 2375-2388
-
-
Adelman, S.A.1
Doll, J.D.2
-
38
-
-
34347236860
-
Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole
-
DOI 10.1124/mol.107.034876
-
Mooberry, S.L.; Weiderhold, K.N.; Dakshanamurthy, S.; Hamel, E.; Banner, E.J.; Kharlamova, A.; Hempel, J.; Gupton, J.T.; Brown, M.L. Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mol. Pharmacol. 2007, 72, 132-140. (Pubitemid 46998532)
-
(2007)
Molecular Pharmacology
, vol.72
, Issue.1
, pp. 132-140
-
-
Mooberry, S.L.1
Weiderhold, K.N.2
Dakshanamurthy, S.3
Hamel, E.4
Banner, E.J.5
Kharlamova, A.6
Hempel, J.7
Gupton, J.T.8
Brown, M.L.9
|