Targeting MgrA-mediated virulence regulation in Staphylococcus aureus

Chemistry and Biology

Volumn 18, Issue 8, 2011, Pages 1032-1041

  Sun, Fei ^a   Zhou, Lu ^a   Zhao, Bing Chuan ^b   Deng, Xin ^a   Cho, Hoonsik ^d   Yi, Chengqi ^a   Jian, Xing ^a   Song, Chun Xiao ^a   Luan, Chi Hao ^c   Bae, Taeok ^d   Li, Zigang ^b   He, Chuan ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b PEKING UNIVERSITY   (China)

^c NORTHWESTERN UNIVERSITY   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5' METHYLENEDISALICYLIC ACID; 5,5'-METHYLENEDISALICYLIC ACID; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; SALICYLIC ACID DERIVATIVE; STAPHYLOCOCCUS PROTEIN A; TRANSCRIPTION FACTOR; VIRULENCE FACTOR;

ANIMAL; ANTIBIOTIC RESISTANCE; ARTICLE; BAGG ALBINO MOUSE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TRANSCRIPTION INITIATION; VIRULENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; SALICYLIC ACIDS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL PROTEIN A; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; VIRULENCE; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 80052158681     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.05.014     Document Type: Article

References (57)

1. M.N. Alekshun, S.B. Levy, T.R. Mealy, B.A. Seaton, and J.F. Head The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution Nat. Struct. Biol. 8 2001 710 714 (Pubitemid 32757932)
2. G.L. Archer Staphylococcus aureus: a well-armed pathogen Clin. Infect. Dis. 26 1998 1179 1181 (Pubitemid 28215485)
3. N. Balaban, T. Goldkorn, R.T. Nhan, L.B. Dang, S. Scott, R.M. Ridgley, A. Rasooly, S.C. Wright, J.W. Larrick, R. Rasooly, and J.R. Carlson Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus Science 280 1998 438 440 (Pubitemid 28208166)
4. S. Beychok Circular dichroism of biological macromolecules Science 154 1966 1288 1299
5. B.R. Borlee, G.D. Geske, H.E. Blackwell, and J. Handelsman Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening Appl. Environ. Microbiol. 76 2010 8255 8258
6. K.S. Cameron, L. Fielding, R. Mason, A.W. Muir, D.C. Rees, S. Thorn, and M.Q. Zhang Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation Bioorg. Med. Chem. Lett. 12 2002 753 755 (Pubitemid 34164611)
7. Centers for Disease Control and Prevention Invasive methicillin-resistant Staphylococcus aureus infections among dialysis patients - United States, 2005 MMWR Morb. Mortal. Wkly. Rep. 56 2007 197 199
8. S. Chang, D.M. Sievert, J.C. Hageman, M.L. Boulton, F.C. Tenover, F.P. Downes, S. Shah, J.T. Rudrik, G.R. Pupp, W.J. Brown Vancomycin-Resistant Staphylococcus aureus Investigative Team Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene N. Engl. J. Med. 348 2003 1342 1347 (Pubitemid 36384101)
9. N.M. Chau, P. Rogers, W. Aherne, V. Carroll, I. Collins, E. McDonald, P. Workman, and M. Ashcroft Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors Cancer Res. 65 2005 4918 4928 (Pubitemid 40740832)
10. P.R. Chen, T. Bae, W.A. Williams, E.M. Duguid, P.A. Rice, O. Schneewind, and C. He An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus Nat. Chem. Biol. 2 2006 591 595 (Pubitemid 44610343)
11. A.E. Clatworthy, E. Pierson, and D.T. Hung Targeting virulence: a new paradigm for antimicrobial therapy Nat. Chem. Biol. 3 2007 541 548 (Pubitemid 47294400)
12. J.E. Darnell Jr. Transcription factors as targets for cancer therapy Nat. Rev. Cancer 2 2002 740 749 (Pubitemid 37328909)
13. C. Davison, E.F. Zimmerman, and P.K. Smith On the metabolism and toxicity of methyl salicylate J. Pharmacol. Exp. Ther. 132 1961 207 211
14. P.B. Dervan, R.M. Doss, and M.A. Marques Programmable DNA binding oligomers for control of transcription Curr. Med. Chem. Anticancer Agents 5 2005 373 387 (Pubitemid 40974811)
15. J.P. Didier, A.J. Cozzone, and B. Duclos Phosphorylation of the virulence regulator SarA modulates its ability to bind DNA in Staphylococcus aureus FEMS Microbiol. Lett. 306 2010 30 36
16. R. Finkel, M. Clark, L.X. Cubeddu, R.A. Harvey, and P.C. Champe Pharmacology Fourth Edition 2009 Lippincott Williams & Wilkins Philadelphia
17. S.K. Fridkin, J.C. Hageman, M. Morrison, L.T. Sanza, K. Como-Sabetti, J.A. Jernigan, K. Harriman, L.H. Harrison, R. Lynfield, M.M. Farley Active Bacterial Core Surveillance Program of the Emerging Infections Program Network Methicillin-resistant Staphylococcus aureus disease in three communities N. Engl. J. Med. 352 2005 1436 1444
18. A. Gauthier, M.L. Robertson, M. Lowden, J.A. Ibarra, J.L. Puente, and B.B. Finlay Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli Antimicrob. Agents Chemother. 49 2005 4101 4109 (Pubitemid 41400952)
19. N.J. Greenfield Using circular dichroism spectra to estimate protein secondary structure Nat. Protoc. 1 2006 2876 2890
20. H.D. Gresham, J.H. Lowrance, T.E. Caver, B.S. Wilson, A.L. Cheung, and F.P. Lindberg Survival of Staphylococcus aureus inside neutrophils contributes to infection J. Immunol. 164 2000 3713 3722 (Pubitemid 30169827)
21. W. Guo, J.F. Li, N.J. Fan, W.W. Wu, P.W. Zhou, and C.Z. Xia A simple and effective method for chemoselective esterification of phenolic acids Synth. Commun. 36 2005 145 152 (Pubitemid 40270845)
22. J.E. Gustafson, P.V. Candelaria, S.A. Fisher, J.P. Goodridge, T.M. Lichocik, T.M. McWilliams, C.T. Price, F.G. O'Brien, and W.B. Grubb Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus Antimicrob. Agents Chemother. 43 1999 990 992 (Pubitemid 29165779)
23. D.T. Hung, E.A. Shakhnovich, E. Pierson, and J.J. Mekalanos Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization Science 310 2005 670 674 (Pubitemid 41528158)
24. S. Ingavale, W. van Wamel, T.T. Luong, C.Y. Lee, and A.L. Cheung Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus Infect. Immun. 73 2005 1423 1431 (Pubitemid 40470728)
25. S.S. Ingavale, W. Van Wamel, and A.L. Cheung Characterization of RAT, an autolysis regulator in Staphylococcus aureus Mol. Microbiol. 48 2003 1451 1466 (Pubitemid 36751053)
26. G. Ji, R. Beavis, and R.P. Novick Bacterial interference caused by autoinducing peptide variants Science 276 1997 2027 2030 (Pubitemid 27443604)
27. G.W. Kaatz, R.V. Thyagarajan, and S.M. Seo Effect of promoter region mutations and mgrA overexpression on transcription of norA, which encodes a Staphylococcus aureus multidrug efflux transporter Antimicrob. Agents Chemother. 49 2005 161 169 (Pubitemid 40065788)
28. A. Kiessling, R. Wiesinger, B. Sperl, and T. Berg Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine ChemMedChem 2 2007 627 630
29. L. Lan, A. Cheng, P.M. Dunman, D. Missiakas, and C. He Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus J. Bacteriol. 192 2010 3068 3077
30. M. Lauth, A. Bergström, T. Shimokawa, and R. Toftgrd Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists Proc. Natl. Acad. Sci. USA 104 2007 8455 8460 (Pubitemid 47175509)
31. M.C. Lo, A. Aulabaugh, G. Jin, R. Cowling, J. Bard, M. Malamas, and G. Ellestad Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery Anal. Biochem. 332 2004 153 159 (Pubitemid 39099482)
32. F.D. Lowy Staphylococcus aureus infections N. Engl. J. Med. 339 1998 520 532
33. Z. Lu, S.P. Rowe, B.B. Brennan, S.E. Davis, R.E. Metzler, J.J. Nau, C.Y. Majmudar, A.K. Mapp, and A.Z. Ansari Unraveling the mechanism of a potent transcriptional activator J. Biol. Chem. 280 2005 29689 29698 (Pubitemid 41177046)
34. T.T. Luong, P.M. Dunman, E. Murphy, S.J. Projan, and C.Y. Lee Transcription profiling of the mgrA regulon in Staphylococcus aureus J. Bacteriol. 188 2006 1899 1910 (Pubitemid 43346869)
35. A.C. Manna, S.S. Ingavale, M. Maloney, W. van Wamel, and A.L. Cheung Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus J. Bacteriol. 186 2004 5267 5280 (Pubitemid 39038130)
36. R.G. Martin, and J.L. Rosner Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences Proc. Natl. Acad. Sci. USA 92 1995 5456 5460
37. J. Park, R. Jagasia, G.F. Kaufmann, J.C. Mathison, D.I. Ruiz, J.A. Moss, M.M. Meijler, R.J. Ulevitch, and K.D. Janda Infection control by antibody disruption of bacterial quorum sensing signaling Chem. Biol. 14 2007 1119 1127 (Pubitemid 47599985)
38. I.C. Perera, and A. Grove Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators J. Mol. Cell. Biol. 2 2010 243 254
39. C.T. Price, G.W. Kaatz, and J.E. Gustafson The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus Int. J. Antimicrob. Agents 20 2002 206 213 (Pubitemid 35248141)
40. G.J. Rainey, and J.A. Young Antitoxins: novel strategies to target agents of bioterrorism Nat. Rev. Microbiol. 2 2004 721 726 (Pubitemid 39200063)
41. J.T. Riordan, A. Muthaiyan, W. Van Voorhies, C.T. Price, J.E. Graham, B.J. Wilkinson, and J.E. Gustafson Response of Staphylococcus aureus to salicylate challenge J. Bacteriol. 189 2007 220 227 (Pubitemid 46036237)
42. V. Rishi, T. Potter, J. Laudeman, R. Reinhart, T. Silvers, M. Selby, T. Stevenson, P. Krosky, A.G. Stephen, and A. Acharya A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors Anal. Biochem. 340 2005 259 271 (Pubitemid 40544865)
43. E.A. Shakhnovich, D.T. Hung, E. Pierson, K. Lee, and J.J. Mekalanos Virstatin inhibits dimerization of the transcriptional activator ToxT Proc. Natl. Acad. Sci. USA 104 2007 2372 2377 (Pubitemid 46391404)
44. E.P. Skaar The battle for iron between bacterial pathogens and their vertebrate hosts PLoS Pathog. 6 2010 e10000949
45. J.R. Stringer, J.A. Crapster, I.A. Guzei, and H.E. Blackwell Construction of peptoids with all trans-amide backbones and peptoid reverse turns via the tactical incorporation of N-aryl side chains capable of hydrogen bonding J. Org. Chem. 75 2010 6068 6078
46. J.G. Swoboda, J. Campbell, T.C. Meredith, and S. Walker Wall teichoic acid function, biosynthesis, and inhibition ChemBioChem 11 2010 35 45
47. M.P. Trotonda, Y.Q. Xiong, G. Memmi, A.S. Bayer, and A.L. Cheung Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics J. Infect. Dis. 199 2009 209 218
48. Q.C. Truong-Bolduc, Y. Ding, and D.C. Hooper Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus J. Bacteriol. 190 2008 7375 7381
49. Q.C. Truong-Bolduc, P.M. Dunman, J. Strahilevitz, S.J. Projan, and D.C. Hooper MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus J. Bacteriol. 187 2005 2395 2405 (Pubitemid 40389138)
50. Q.C. Truong-Bolduc, and D.C. Hooper The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus J. Bacteriol. 189 2007 2996 3005 (Pubitemid 46697388)
51. Q.C. Truong-Bolduc, and D.C. Hooper Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus J. Bacteriol. 192 2010 2525 2534
52. Q.C. Truong-Bolduc, J. Strahilevitz, and D.C. Hooper NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus Antimicrob. Agents Chemother. 50 2006 1104 1107 (Pubitemid 43327822)
53. L.T. Vassilev, B.T. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, N. Kong, U. Kammlott, C. Lukacs, and C. Klein In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 Science 303 2004 844 848 (Pubitemid 38174664)
54. C.T. Walsh Vancomycin resistance: decoding the molecular logic Science 261 1993 308 309 (Pubitemid 23281001)
55. L.M. Weigel, D.B. Clewell, S.R. Gill, N.C. Clark, L.K. McDougal, S.E. Flannagan, J.F. Kolonay, J. Shetty, G.E. Killgore, and F.C. Tenover Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus Science 302 2003 1569 1571 (Pubitemid 37475701)
56. S.P. Wilkinson, and A. Grove Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins Curr. Issues Mol. Biol. 8 2006 51 62 (Pubitemid 43141390)
57. J.S. Wright 3rd, R. Jin, and R.P. Novick Transient interference with staphylococcal quorum sensing blocks abscess formation Proc. Natl. Acad. Sci. USA 102 2005 1691 1696 (Pubitemid 40209229)