Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus

Journal of Bacteriology

Volumn 190, Issue 22, 2008, Pages 7375-7381

  Truong Bolduc, Que Chi ^a   Ding, Yanpeng ^a   Hooper, David C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CIPROFLOXACIN; NORFLOXACIN; PROTEIN MGRA; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION; INCUBATION TIME; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CIPROFLOXACIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, BACTERIAL; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; NORFLOXACIN; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 55549098541     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01068-08     Document Type: Article

References (29)

1. Ahn, B. Z., K. U. Baik, G. R. Kweon, K. Lim, and B. D. Hwang. 1995. Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. J. Med. Chem. 38:1044-1047.
2. B regulon. J. Bacteriol. 186:4085-4099.
3. Bischoff, M., J. M. Entenza, and P. Giachino. 2001. Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus. J. Bacteriol. 183:5171-5179.
4. Fournier, B., R. Aras, and D. C. Hooper. 2000. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system. J. Bacteriol. 182:664-671.
5. Fournier, B., Q. C. Truong-Bolduc, X. Zhang, and D. C. Hooper. 2001. A mutation in the 5′ untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus. J. Bacteriol. 183:2367-2371.
6. B regulon in Staphylococcus aureus. J. Bacteriol. 182:6983-6991.
7. B activity depends on RsbU in Staphylococcus aureus. J. Bacteriol. 183:1843-1852.
8. Hardwick, S. W., J. Pane-Farre, O. Delumeau, J. Marles-Wright, J. W. Murray, M. Hecker, and R. J. Lewis. 2007. Structural and functional characterization of partner switching regulating the environmental stress response in Bacillus subtilis. J. Biol. Chem. 282:11562-11572.
9. B modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J. Bacteriol. 184:5457-5467.
10. Iandolo, J. J., V. Worrell, K. H. Groicher, Y. D. Qian, R. Y. Tian, S. Kenton, A. Dorman, H. G. Ji, S. P. Lin, P. Loh, S. L. Qi, H. Zhu, and B. A. Roe. 2002. Comparative analysis of the genomes of the temperate bacteriophages phi11, phi12 and phi13 of Staphylococcus aureus 8325. Gene 289:109-118.
11. Ingavale, S., W. van Wamel, T. T. Luong, C. Y. Lee, and A. L. Cheung. 2005. Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus. Infect. Immun. 73:1423-1431.
12. Ingavale, S. S., W. Van Wamel, and A. L. Cheung. 2003. Characterization of RAT, an autolysis regulator in Staphylococcus aureus. Mol. Microbiol. 48:1451-1466.
13. Kaatz, G. W., R. V. Thyagarajan, and S. M. Seo. 2005. Effect of promoter region mutations and mgrA overexpression on transcription of norA, which encodes a Staphylococcus aureus multidrug efflux transporter. Antimicrob. Agents Chemother. 49:161-169.
14. Kreiswirth, B. 1983. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305:709-712.
15. B in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock. Arch. Microbiol. 167:151-159.
16. Luong, T. T., P. M. Dunman, E. Murphy, S. J. Projan, and C. Y. Lee. 2006. Transcription profiling of the mgrA regulon in Staphylococcus aureus. J. Bacteriol. 188:1899-1910.
17. Luong, T. T., S. W. Newell, and C. Y. Lee. 2003. mgr, a novel global regulator in Staphylococcus aureus. J. Bacteriol. 185:3703-3710.
18. Manna, A., and A. L. Cheung. 2001. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus. Infect. Immun. 69:885-896.
19. Manna, A. C., S. S. Ingavale, M. Maloney, W. van Wamel, and A. L. Cheung. 2004. Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus. J. Bacteriol. 186:5267-5280.
20. Niemeyer, D. M., M. J. Pucci, J. A. Thanassi, V. K. Sharma, and G. L. Archer. 1996. Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus. J. Bacteriol. 178:5464-5471.
21. B regulon in Staphylococcus aureus and its regulation. Int. J. Med. Microbiol. 296:237-258.
22. B-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. J. Bacteriol. 188:6070-6080.
23. Truong-Bolduc, Q. C., P. M. Dunman, J. Strahilevitz, S. J. Projan, and D. C. Hooper. 2005. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J. Bacteriol. 187:2395-2405.
24. Truong-Bolduc, Q. C., and D. C. Hooper. 2007. Transcriptional regulators NorG and MgrA modulate resistance to both quinolones and β-lactams in Staphylococcus aureus. J. Bacteriol. 189:2996-3005.
25. Truong-Bolduc, Q. C., J. Strahilevitz, and D. C. Hooper. 2006. NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. Antimicrob. Agents Chemother. 50:1104-1107.
26. Truong-Bolduc, Q. C., X. Zhang, and D. C. Hooper. 2003. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. J. Bacteriol. 185:3127-3138.
27. Wang, P. Z., S. J. Projan, K. R. Leason, and R. P. Novick. 1987. Translational fusion with a secretory enzyme as an indicator. J. Bacteriol. 169:3082-3087.
28. Wu, S., H. de Lencastre, and A. Tomasz. 1996. Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing. J. Bacteriol. 178:6036-6042.
29. Zhang, L., F. Fan, L. M. Palmer, M. A. Lonetto, C. Petit, L. L. Voelker, A. St. John, B. Bankosky, M. Rosenberg, and D. McDevitt. 2000. Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action. Gene 255:297-305.