Proteomic characterization of pseudorabies virus extracellular Virions

Journal of Virology

Volumn 85, Issue 13, 2011, Pages 6427-6441

  Kramer, T ^a   Greco, T M ^a   Enquist, L W ^a   Cristea, I M ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEINASE K; PUL20 PROTEIN; PUL26 PROTEIN; PUL32 PROTEIN; PUL36 PROTEIN; PUL40 PROTEIN; PUL42 PROTEIN; PUL46 PROTEIN; PUL48 PROTEIN; PUL50 PROTEIN; PUL8 PROTEIN; RSP40 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSKELETON; HOST; INTEGUMENT; INTRACELLULAR SPACE; MASS SPECTROMETRY; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEOMICS; PSEUDORABIES; PSEUDORABIES HERPETOVIRUS; RNA PROCESSING; RNA TRANSLATION; SIGNAL TRANSDUCTION; VIRION; VIRUS CAPSID; VIRUS ENVELOPE; ANIMAL; CYTOLOGY; GENETICS; ISOLATION AND PURIFICATION; KIDNEY; METABOLISM; VIROLOGY;

ALPHAHERPESVIRINAE; HERPESVIRIDAE; MIRIDAE; SUID HERPESVIRUS 1;

ANIMALS; HERPESVIRUS 1, SUID; KIDNEY; MASS SPECTROMETRY; PROTEINS; PROTEOMICS; PSEUDORABIES; VIRAL PROTEINS; VIRION;

EID: 80052069079     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02253-10     Document Type: Article

References (144)

1. Advani, S. J., R. R. Weichselbaum, and B. Roizman. 2003. Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. Proc. Natl. Acad. Sci. U. S. A. 100:4825-4830.
2. Antinone, S. E., S. V. Zaichick, and G. A. Smith. 2010. Resolving the assembly state of herpes simplex virus during axon transport by live-cell imaging. J. Virol. 84:13019-13030.
3. Atanasiu, D., et al. 2010. Bimolecular complementation defines functional regions of herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. J. Virol. 84:3825-3834.
4. Au, C. E., et al. 2007. Organellar proteomics to create the cell map. Curr. Opin. Cell Biol. 19:376-385.
5. Baines, J. D., P. L. Ward, G. Campadelli-Fiume, and B. Roizman. 1991. The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress. J. Virol. 65:6414-6424.
6. Baldick, C. J., and T. Shenk. 1996. Proteins associated with purified human cytomegalovirus particles. J. Virol. 70:6097-6105.
7. Bastian, T. W., C. M. Livingston, S. K. Weller, and S. A. Rice. 2010. Herpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection. J. Virol. 84:2384-2394.
8. Bechtel, J. T., R. C. Winant, and D. Ganem. 2005. Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79:4952-4964.
9. Bortz, E., et al. 2003. Identification of proteins associated with murine gammaherpesvirus 68 virions. J. Virol. 77:13425-13432.
10. Böttcher, S., et al. 2007. Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virus. J. Virol. 81:13403-13411.
11. Böttcher, S., et al. 2006. Identification of a 709-amino-acid internal nonessential region within the essential conserved tegument protein (p)UL36 of pseudorabies virus. J. Virol. 80:9910-9915.
12. Bowman, J. J., J. S. Orlando, D. J. Davido, A. S. Kushnir, and P. A. Schaffer. 2009. Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. J. Virol. 83:8733-8743.
13. Brack, A. R., et al. 2000. Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation. J. Virol. 74:4004-4016.
14. Brideau, A. D., B. W. Banfield, and L. Enquist. 1998. The Us9 gene product of pseudorabies virus, an alphaherpesvirus, is a phosphorylated, tail-anchored type II membrane protein. J. Virol. 72:4560-4570.
15. Brideau, A. D., J. P. Card, and L. Enquist. 2000. Role of pseudorabies virus Us9, a type II membrane protein, in infection of tissue culture cells and the rat nervous system. J. Virol. 74:834-845.
16. Brideau, A. D., L. Enquist, and R. S. Tirabassi. 2000. The role of virion membrane protein endocytosis in the herpesvirus life cycle. J. Clin. Virol. 17:69-82.
17. Brukman, A., and L. Enquist. 2006. Pseudorabies virus EP0 protein counteracts an interferon-induced antiviral state in a species-specific manner. J. Virol. 80:10871-10873.
18. Bucks, M. A., K. J. O'Regan, M. A. Murphy, J. W. Wills, and R. J. Courtney. 2007. Herpes simplex virus type 1 tegument proteins VP1/2 and UL37 are associated with intranuclear capsids. Virology 361:316-324.
19. Calistri, A., et al. 2007. Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies. J. Virol. 81:11468-11478.
20. Chi, J. H. I., C. A. Harley, A. Mukhopadhyay, and D. W. Wilson. 2005. The cytoplasmic tail of herpes simplex virus envelope glycoprotein D binds to the tegument protein VP22 and to capsids. J. Gen. Virol. 86:253-261.
21. Choudhary, C., and M. Mann. 2010. Decoding signalling networks by mass spectrometry-based proteomics. Nat. Rev. Mol. Cell Biol. 11:427-439.
22. Chowdary, T. K., et al. 2010. Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat. Struct. Mol. Biol. 17:882-888.
23. Clase, A. C., et al. 2003. The pseudorabies virus Us2 protein, a virion tegument component, is prenylated in infected cells. J. Virol. 77:12285-12298.
24. Coller, K. E., J. I.-H. Lee, A. Ueda, and G. A. Smith. 2007. The capsid and tegument of the alphaherpesviruses are linked by an interaction between the UL25 and VP1/2 proteins. J. Virol. 81:11790-11797.
25. Copeland, A., W. Newcomb, and J. Brown. 2009. Herpes simplex virus replication: roles of viral proteins and nucleoporins in capsid-nucleus attachment. J. Virol. 83:1660-1668.
26. Crump, C. M., C. Yates, and T. Minson. 2007. Herpes simplex virus type 1 cytoplasmic envelopment requires functional Vps4. J. Virol. 81:7380-7387.
27. Cunningham, C., et al. 1992. The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinase. J. Gen. Virol. 73:303-311.
28. Curanovic, D., and L. Enquist. 2009. Virion-incorporated glycoprotein b mediates transneuronal spread of pseudorabies virus. J. Virol. 83:7796-7804.
29. Curanovic, D., M. G. Lyman, C. Bou-Abboud, J. P. Card, and L. Enquist. 2009. Repair of the UL21 locus in pseudorabies virus Bartha enhances the kinetics of retrograde, transneuronal infection in vitro and in vivo. J. Virol. 83:1173-1183.
30. del Rio, T., C. J. DeCoste, and L. Enquist. 2005. Actin is a component of the compensation mechanism in pseudorabies virus virions lacking the major tegument protein VP22. J. Virol. 79:8614-8619.
31. Dietz, P., et al. 2000. Pseudorabies virus glycoprotein K requires the UL20 gene product for processing. J. Virol. 74:5083-5090.
32. Dijkstra, J. M., N. Visser, T. C. Mettenleiter, and B. G. Klupp. 1996. Identification and characterization of pseudorabies virus glycoprotein gM as a nonessential virion component. J. Virol. 70:5684-5688.
33. Dry, I., et al. 2008. Proteomic analysis of pathogenic and attenuated alcelaphine herpesvirus 1. J. Virol. 82:5390-5397.
34. Edson, C. M. 1993. Phosphorylation of neurotropic alphaherpesvirus envelope glycoproteins: herpes simplex virus type 2 gE2 and pseudorabies virus gI. Virology 195:268-270.
35. Ekstrand, M. I., L. Enquist, and L. E. Pomeranz. 2008. The alpha-herpesviruses: molecular pathfinders in nervous system circuits. Trends Mol. Med. 14:134-140.
36. Fossum, E., et al. 2009. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathogens 5:e1000570.
37. Fuchs, W., et al. 2005. The UL7 gene of pseudorabies virus encodes a nonessential structural protein which is involved in virion formation and egress. J. Virol. 79:11291-11299.
38. Fuchs, W., H. Granzow, B. G. Klupp, M. Kopp, and T. C. Mettenleiter. 2002. The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virions. J. Virol. 76:6729-6742.
39. Fuchs, W., et al. 2002. Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49. J. Virol. 76:8208-8217.
40. Fuchs, W., B. G. Klupp, H. Granzow, T. Leege, and T. C. Mettenleiter. 2009. Characterization of pseudorabies virus (PrV) cleavage-encapsidation proteins and functional complementation of PrV pUL32 by the homologous protein of herpes simplex virus type 1. J. Virol. 83:3930-3943.
41. Fuchs, W., B. G. Klupp, H. Granzow, and T. C. Mettenleiter. 2004. Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 protein. J. Virol. 78:11879-11889.
42. Fuchs, W., B. G. Klupp, H. Granzow, and T. C. Mettenleiter. 1997. The UL20 gene product of pseudorabies virus functions in virus egress. J. Virol. 71:5639-5646.
43. Fuchs, W., B. G. Klupp, H. Granzow, N. Osterrieder, and T. C. Mettenleiter. 2002. The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions. J. Virol. 76:364-378.
44. Geraghty, R. J., C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptorrelated protein 1 and poliovirus receptor. Science 280:1618-1620.
45. Gottlieb, J., A. I. Marcy, D. M. Coen, and M. D. Challberg. 1990. The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. J. Virol. 64:5976-5987.
46. Granzow, H., B. G. Klupp, and T. C. Mettenleiter. 2005. Entry of pseudorabies virus: an immunogold-labeling study. J. Virol. 79:3200-3205.
47. Granzow, H., B. G. Klupp, and T. C. Mettenleiter. 2004. The pseudorabies virus US3 protein is a component of primary and of mature virions. J. Virol. 78:1314-1323.
48. Greco, T. M., F. Yu, A. J. Guise, and I. M. Cristea. 2011. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol. Cell Proteomics 10:M110.004317.
49. Grünewald, K., et al. 2003. Three-dimensional structure of herpes simplex virus from cryo-electron tomography. Science 302:1396-1398.
50. Hampl, H., T. Ben-Porat, L. Ehrlicher, K. O. Habermehl, and A. S. Kaplan. 1984. Characterization of the envelope proteins of pseudorabies virus. J. Virol. 52:583-590.
51. Heldwein, E. E., and C. Krummenacher. 2008. Entry of herpesviruses into mammalian cells. Cell. Mol. Life Sci. 65:1653-1668.
52. Heldwein, E. E., et al. 2006. Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220.
53. Herold, B. C., R. J. Visalli, N. Susmarski, C. R. Brandt, and P. G. Spear. 1994. Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B. J. Gen. Virol. 75:1211-1222.
54. Jacobs, L. 1994. Glycoprotein E of pseudorabies virus and homologous proteins in other alphaherpesvirinae. Arch. Virol. 137:209-228.
55. Jakubowicz, T., and D. P. Leader. 1987. A major phosphoprotein of cells infected with pseudorabies virus is phosphorylated by cellular casein kinase II. J. Gen. Virol. 68:1159-1163.
56. Johannsen, E., et al. 2004. Proteins of purified Epstein-Barr virus. Proc. Natl. Acad. Sci. U. S. A. 101:16286-16291.
57. Jöns, A., H. Granzow, R. Kuchling, and T. C. Mettenleiter. 1996. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. J. Virol. 70:1237-1241.
58. Jöns, A., and T. C. Mettenleiter. 1996. Identification and characterization of pseudorabies virus dUTPase. J. Virol. 70:1242-1245.
59. Kaelin, K., S. Dezélée, M. J. Masse, F. Bras, and A. Flamand. 2000. The UL25 protein of pseudorabies virus associates with capsids and localizes to the nucleus and to microtubules. J. Virol. 74:474-482.
60. Karger, A., B. Bettin, H. Granzow, and T. C. Mettenleiter. 1998. Simple and rapid purification of alphaherpesviruses by chromatography on a cation exchange membrane. J. Virol. Methods 70:219-224.
61. Kattenhorn, L. M., et al. 2004. Identification of proteins associated with murine cytomegalovirus virions. J. Virol. 78:11187-11197.
62. Kehm, R., H. R. Gelderblom, and G. Darai. 1998. Identification of the UL56 protein of herpes simplex virus type 1 within the virion by immuno electron microscopy. Virus Genes 17:49-53.
63. Keller, A., A. I. Nesvizhskii, E. Kolker, and R. Aebersold. 2002. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 74:5383-5392.
64. Klopfleisch, R., et al. 2006. Influence of pseudorabies virus proteins on neuroinvasion and neurovirulence in mice. J. Virol. 80:5571-5576.
65. Klupp, B., J. Altenschmidt, H. Granzow, W. Fuchs, and T. C. Mettenleiter. 2008. Glycoproteins required for entry are not necessary for egress of pseudorabies virus. J. Virol. 82:6299-6309.
66. Klupp, B. G., J. Altenschmidt, H. Granzow, W. Fuchs, and T. C. Mettenleiter. 2005. Identification and characterization of the pseudorabies virus UL43 protein. Virology 334:224-233.
67. Klupp, B. G., J. Baumeister, P. Dietz, H. Granzow, and T. C. Mettenleiter. 1998. Pseudorabies virus glycoprotein gK is a virion structural component involved in virus release but is not required for entry. J. Virol. 72:1949-1958.
68. Klupp, B. G., J. Baumeister, A. Karger, N. Visser, and T. C. Mettenleiter. 1994. Identification and characterization of a novel structural glycoprotein in pseudorabies virus, gL. J. Virol. 68:3868-3878.
69. Klupp, B. G., W. Fuchs, H. Granzow, R. Nixdorf, and T. C. Mettenleiter. 2002. Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein. J. Virol. 76:3065-3071.
70. Klupp, B. G., W. Fuchs, E. Weiland, and T. C. Mettenleiter. 1997. Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H. J. Virol. 71:7687-7695.
71. Klupp, B. G., H. Granzow, A. Karger, and T. C. Mettenleiter. 2005. Identification, subviral localization, and functional characterization of the pseudorabies virus UL17 protein. J. Virol. 79:13442-13453.
72. Klupp, B. G., H. Granzow, and T. C. Mettenleiter. 2000. Primary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product. J. Virol. 74:10063-10073.
73. Klupp, B. G., H. Granzow, E. Mundt, and T. C. Mettenleiter. 2001. Pseudorabies virus UL37 gene product is involved in secondary envelopment. J. Virol. 75:8927-8936.
74. Klupp, B. G., N. Visser, and T. C. Mettenleiter. 1992. Identification and characterization of pseudorabies virus glycoprotein H. J. Virol. 66:3048-3055.
75. Kopp, M., et al. 2003. The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J. Virol. 77:5339-5351.
76. Kopp, M., B. G. Klupp, H. Granzow, W. Fuchs, and T. C. Mettenleiter. 2002. Identification and characterization of the pseudorabies virus tegument proteins UL46 and UL47: role for UL47 in virion morphogenesis in the cytoplasm. J. Virol. 76:8820-8833.
77. Laquerre, S., et al. 1998. Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread. J. Virol. 72:6119-6130.
78. Lee, J. H., V. Vittone, E. Diefenbach, A. L. Cunningham, and R. J. Diefenbach. 2008. Identification of structural protein-protein interactions of herpes simplex virus type 1. Virology 378:347-354.
79. Lee, J. I.-H., G. W. G. Luxton, and G. A. Smith. 2006. Identification of an essential domain in the herpesvirus VP1/2 tegument protein: the carboxy terminus directs incorporation into capsid assemblons. J. Virol. 80:12086-12094.
80. Lemaster, S., and B. Roizman. 1980. Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion. J. Virol. 35:798-811.
81. Lenk, M., N. Visser, and T. C. Mettenleiter. 1997. The pseudorabies virus UL51 gene product is a 30-kilodalton virion component. J. Virol. 71:5635-5638.
82. Lin, H.-W., Y.-Y. Chang, M.-L. Wong, J.-W. Lin, and T.-J. Chang. 2004. Functional analysis of virion host shutoff protein of pseudorabies virus. Virology 324:412-418.
83. Loret, S., G. Guay, and R. Lippé. 2008. Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. 82:8605-8618.
84. Luo, Y., T. Li, F. Yu, T. Kramer, and I. M. Cristea. 2010. Resolving the composition of protein complexes using a MALDI LTQ Orbitrap. J. Am. Soc. Mass Spectrom. 21:34-46.
85. Luxton, G. W. G., et al. 2005. Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins. Proc. Natl. Acad. Sci. U. S. A. 102:5832-5837.
86. Luxton, G. W. G., J. I.-H. Lee, S. Haverlock-Moyns, J. M. Schober, and G. A. Smith. 2006. The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport. J. Virol. 80:201-209.
87. Lyman, M. G., G. L. Demmin, and B. W. Banfield. 2003. The attenuated pseudorabies virus strain Bartha fails to package the tegument proteins Us3 and VP22. J. Virol. 77:1403-1414.
88. Lyman, M. G., J. A. Randall, C. M. Calton, and B. W. Banfield. 2006. Localization of ERK/MAP kinase is regulated by the alphaherpesvirus tegument protein Us2. J. Virol. 80:7159-7168.
89. MacLean, C. A., S. Efstathiou, M. L. Elliott, F. E. Jamieson, and D. J. McGeoch. 1991. Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins. J. Gen. Virol. 72:897-906.
90. Matsuzaki, A., et al. 2005. US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles. J. Gen. Virol. 86:1979-1985.
91. Maxwell, K. L., and L. Frappier. 2007. Viral proteomics. Microbiol. Mol. Biol. Rev. 71:398-411.
92. McNabb, D. S., and R. J. Courtney. 1992. Characterization of the large tegument protein (ICP1/2) of herpes simplex virus type 1. Virology 190: 221-232.
93. Meckes, D. G., and J. W. Wills. 2007. Dynamic interactions of the UL16 tegument protein with the capsid of herpes simplex virus. J. Virol. 81: 13028-13036.
94. Mettenleiter, T. C. 2004. Budding events in herpesvirus morphogenesis. Virus Res. 106:167-180.
95. Mettenleiter, T. C. 2006. Intriguing interplay between viral proteins during herpesvirus assembly or: the herpesvirus assembly puzzle. Vet. Microbiol. 113:163-169.
96. Mettenleiter, T. C., B. G. Klupp, and H. Granzow. 2009. Herpesvirus assembly: an update. Virus Res. 143:222-234.
97. Mettenleiter, T. C., et al. 1990. Interaction of glycoprotein gIII with a cellular heparinlike substance mediates adsorption of pseudorabies virus. J. Virol. 64:278-286.
98. Michael, K., B. G. Klupp, A. Karger, and T. C. Mettenleiter. 2007. Efficient incorporation of tegument proteins pUL46, pUL49, and pUS3 into pseudorabies virus particles depends on the presence of pUL21. J. Virol. 81: 1048-1051.
99. Michael, K., B. G. Klupp, T. C. Mettenleiter, and A. Karger. 2006. Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E. J. Virol. 80:1332-1339.
100. Mijatov, B., A. L. Cunningham, and R. J. Diefenbach. 2007. Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37. Virology 368:26-31.
101. Milne, R. S., S. A. Connolly, C. Krummenacher, R. J. Eisenberg, and G. H. Cohen. 2001. Porcine HveC, a member of the highly conserved HveC/nectin 1 family, is a functional alphaherpesvirus receptor. Virology 281:315-328.
102. Möhl, B., et al. 2009. Intracellular localization of the pseudorabies virus large tegument protein pUL36. J. Virol. 83:9641-9651.
103. Möhl, B. S., et al. 2010. Random transposon-mediated mutagenesis of the essential large tegument protein pUL36 of pseudorabies virus. J. Virol. 84:8153-8162.
104. Moorman, N. J., R. Sharon-Friling, T. Shenk, and I. M. Cristea. 2010. A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation. Mol. Cell Proteomics 9:851-860.
105. Morrison, E. E., Y. F. Wang, and D. M. Meredith. 1998. Phosphorylation of structural components promotes dissociation of the herpes simplex virus type 1 tegument. J. Virol. 72:7108-7114.
106. Ng, T. I., W. O. Ogle, and B. Roizman. 1998. UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: glycoproteins E and I. Virology 241:37-48.
107. O'Connor, C. M., and D. H. Kedes. 2006. Mass spectrometric analyses of purified rhesus monkey rhadinovirus reveal 33 virion-associated proteins. J. Virol. 80:1574-1583.
108. Ono, E., S. Watanabe, H. Nikami, T. Tasaki, and H. Kida. 1998. Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA. Vet. Microbiol. 63:99-107.
109. O'Reilly, D., O. Hanscombe, and P. O'Hare. 1997. A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II. EMBO J. 16:2420-2430.
110. Orlando, J. S., et al. 2006. ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. J. Virol. 80:9381-9390.
111. Pawliczek, T., and C. M. Crump. 2009. Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression. J. Virol. 83:11254-11264.
112. Platt, K. B., C. J. Maré, and P. N. Hinz. 1979. Differentiation of vaccine strains and field isolates of pseudorabies (Aujeszky's disease) virus: thermal sensitivity and rabbit virulence markers. Arch. Virol. 60:13-23.
113. Pomeranz, L. E., A. E. Reynolds, and C. J. Hengartner. 2005. Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine. Microbiol. Mol. Biol. Rev. 69:462-500.
114. Radtke, K., et al. 2010. Plus-and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. PLoS Pathogens 6:e1000991.
115. Ray, N., and L. Enquist. 2004. Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses. J. Virol. 78:3489-3501.
116. Richman, D. D., A. Buckmaster, S. Bell, C. Hodgman, and A. C. Minson. 1986. Identification of a new glycoprotein of herpes simplex virus type 1 and genetic mapping of the gene that codes for it. J. Virol. 57:647-655.
117. Roberts, A. P. E., et al. 2009. Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1. J. Virol. 83:105-116.
118. Ryan, J. P., M. E. Whealy, A. K. Robbins, and L. Enquist. 1987. Analysis of pseudorabies virus glycoprotein gIII localization and modification by using novel infectious viral mutants carrying unique EcoRI sites. J. Virol. 61: 2962-2972.
119. Sherman, G., J. Gottlieb, and M. D. Challberg. 1992. The UL8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization. J. Virol. 66:4884-4892.
120. Shiba, C., et al. 2000. The UL34 gene product of herpes simplex virus type 2 is a tail-anchored type II membrane protein that is significant for virus envelopment. J. Gen. Virol. 81:2397-2405.
121. Smith, C. C. 2005. The herpes simplex virus type 2 protein ICP10PK: a master of versatility. Front. Biosci. 10:2820-2831.
122. Smith, C. C., and L. Aurelian. 1997. The large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is associated with the virion tegument and has PK activity. Virology 234:235-242.
123. Smith, G. A., S. P. Gross, and L. Enquist. 2001. Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons. Proc. Natl. Acad. Sci. U. S. A. 98:3466-3470.
124. Solomon, K. A., A. K. Robbins, and L. Enquist. 1991. Mutations in the C-terminal hydrophobic domain of pseudorabies virus gIII affect both membrane anchoring and protein export. J. Virol. 65:5952-5960.
125. Spear, P. G., and R. Longnecker. 2003. Herpesvirus entry: an update. J. Virol. 77:10179-10185.
126. Stevely, W. S. 1975. Virus-induced proteins in pseudorabies-infected cells. II. Proteins of the virion and nucleocapsid. J. Virol. 16:944-950.
127. Stevely, W. S., M. Katan, V. Stirling, G. Smith, and D. P. Leader. 1985. Protein kinase activities associated with the virions of pseudorabies and herpes simplex virus. J. Gen. Virol. 66:661-673.
128. Szilágyi, J. F., and C. Cunningham. 1991. Identification and characterization of a novel non-infectious herpes simplex virus-related particle. J. Gen. Virol. 72:661-668.
129. Szpara, M. L., O. Kobiler, and L. Enquist. 2010. A common neuronal response to alphaherpesvirus infection. J. Neuroimmune Pharmacol. 5:418-427.
130. Taddeo, B., W. Zhang, and B. Roizman. 2006. The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. Proc. Natl. Acad. Sci. U. S. A. 103:2827-2832.
131. Tirabassi, R. S., and L. Enquist. 1999. Mutation of the YXXL endocytosis motif in the cytoplasmic tail of pseudorabies virus gE. J. Virol. 73:2717-2728.
132. Tirabassi, R. S., and L. Enquist. 2000. Role of the pseudorabies virus gI cytoplasmic domain in neuroinvasion, virulence, and posttranslational Nlinked glycosylation. J. Virol. 74:3505-3516.
133. Varnum, S. M., et al. 2004. Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J. Virol. 78:10960-10966.
134. Vittone, V., et al. 2005. Determination of interactions between tegument proteins of herpes simplex virus type 1. J. Virol. 79:9566-9571.
135. Ward, P. L., G. Campadelli-Fiume, E. Avitabile, and B. Roizman. 1994. Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1. J. Virol. 68:7406-7417.
136. Watanabe, S., E. Ono, Y. Shimizu, and H. Kida. 1995. Pseudorabies virus early protein 0 transactivates the viral gene promoters. J. Gen. Virol. 76:2881-2885.
137. Whealy, M. E., et al. 1993. Specific pseudorabies virus infection of the rat visual system requires both gI and gp63 glycoproteins. J. Virol. 67:3786-3797.
138. Wisniewski, J. R., A. Zougman, N. Nagaraj, and M. Mann. 2009. Universal sample preparation method for proteome analysis. Nat. Methods 6:359-362.
139. Wong, M. L., and C. H. Chen. 1998. Evidence for the internal location of actin in the pseudorabies virion. Virus Res. 56:191-197.
140. WuDunn, D., and P. G. Spear. 1989. Initial interaction of herpes simplex virus with cells is binding to heparan sulfate. J. Virol. 63:52-58.
141. Yao, F., and R. J. Courtney. 1992. Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1. J. Virol. 66:2709-2716.
142. Zahariadis, G., et al. 2008. Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46. J. Virol. 82:6098-6108.
143. Zhang, W., and B. T. Chait. 2000. ProFound: an expert system for protein identification using mass spectrometric peptide mapping information. Anal. Chem. 72:2482-2489.
144. Zhu, F. X., J. M. Chong, L. Wu, and Y. Yuan. 2005. Virion proteins of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79:800-811.