Comprehensive characterization of extracellular herpes simplex virus type 1 virions

Journal of Virology

Volumn 82, Issue 17, 2008, Pages 8605-8618

  Loret, Sandra ^a   Guay, Ginette ^a   Lippé, Roger ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS GLYCOPROTEIN; VIRUS PROTEIN;

ACCURACY; ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; INTEGUMENT; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENSITIVITY AND SPECIFICITY; VIRION; VIRUS CAPSID; VIRUS REPLICATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CRICETINAE; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PEPTIDES; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILVER STAINING; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS; VIRION;

HUMAN HERPESVIRUS 1; MIRIDAE;

EID: 50149119228     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00904-08     Document Type: Article

References (111)

1. Adams, R., C. Cunningham, M. D. Davison, C. A. MacLean, and A. J. Davison. 1998. Characterization of the protein encoded by gene UL49A of herpes simplex virus type 1. J. Gen. Virol. 79:813-823.
2. America, A. H., and J. H. Cordewener. 2008. Comparative LC-MS: a landscape of peaks and valleys. Proteomics 8:731-749.
3. Anderson, L., and C. L. Hunter. 2006. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol. Cell. Proteomics 5:573-588.
4. Baines, J., and C. Duffy. 2006. Nucleocapsid assembly and envelopment of herpes simplex virus, p. 175-204. In R. M. Sandri-Goldin (ed.), Alpha herpesviruses: molecular and cellular biology. Caister Academic Press, Norfolk, United Kingdom.
5. L21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells. J. Virol. 68:2929-2936.
6. L11 gene of herpes simplex virus 1 encodes a function that facilitates nucleocapsid envelopment and egress from cells. J. Virol. 66:5168-5174.
7. Baldick, C. J., Jr., and T. Shenk. 1996. Proteins associated with purified human cytomegalovirus particles. J. Virol. 70:6097-6105.
8. Beard, P. M., and J. D. Baines. 2004. The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids. Virology 324:475-482.
9. Bechtel, J. T., R. C. Winant, and D. Ganem. 2005. Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79:4952-4964.
10. Blondeau, F., B. Ritter, P. D. Allaire, S. Wasiak, M. Girard, N. K. Hussain, A. Angers, V. Legendre-Guillemin, L. Roy, D. Boismenu, R. E. Kearney, A. W. Bell, J. J. Bergeron, and P. S. McPherson. 2004. Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc. Natl. Acad. Sci. USA 101:3833-3838.
11. Bortz, E., J. P. Whitelegge, Q. Jia, Z. H. Zhou, J. P. Stewart, T. T. Wu, and R. Sun. 2003. Identification of proteins associated with murine gammaherpesvirus 68 virions. J. Virol. 77:13425-13432.
12. Brown, S. M., A. R. MacLean, J. D. Aitken, and J. Harland. 1994. ICP34.5 influences herpes simplex virus type 1 maturation and egress from infected cells in vitro. J. Gen. Virol. 75:3679-3686.
13. Cartier, A., E. Broberg, T. Komai, M. Henriksson, and M. G. Masucci. 2003. The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B. Cell Death Differ. 10:1320-1328.
14. Crump, C. M., B. Bruun, S. Bell, L. E. Pomeranz, T. Minson, and H. M. Browne. 2004. Alphaherpesvirus glycoprotein M causes the relocalization of plasma membrane proteins. J. Gen. Virol. 85:3517-3527.
15. Cunningham, C., A. J. Davison, A. Dolan, M. C. Frame, D. J. McGeoch, D. M. Meredith, H. W. Moss, and A. C. Orr. 1992. The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinase. J. Gen. Virol. 73:303-311.
16. L14: phenotype of a null mutant and identification of the encoded protein. J. Virol. 74:33-41.
17. Daikoku, T., K. Ikenoya, H. Yamada, F. Goshima, and Y. Nishiyama. 1998. Identification and characterization of the herpes simplex virus type 1 UL51 gene product. J. Gen. Virol. 79:3027-3031.
18. del Rio, T., T. H. Ch'ng, E. A. Flood, S. P. Gross, and L. W. Enquist. 2005. Heterogeneity of a fluorescent tegument component in single pseudorabies virus virions and enveloped axonal assemblies. J. Virol. 79:3903-3919.
19. Desai, P. J. 2000. A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells. J. Virol. 74:11608-11618.
20. Dohner, K., A. Wolfstein, U. Prank, C. Echeverri, D. Dujardin, R. Vallee, and B. Sodeik. 2002. Function of dynein and dynactin in herpes simplex virus capsid transport. Mol. Biol. Cell 13:2795-2809.
21. Dry, I., D. M. Haig, N. F. Inglis, L. Imrie, J. P. Stewart, and G. C. Russell. 2008. Proteomic analysis of pathogenic and attenuated alcelaphine herpesvirus 1. J. Virol. 82:5390-5397.
22. Elliott, G., W. Hafezi, A. Whiteley, and E. Bernard. 2005. Deletion of the herpes simplex virus VP22-encoding gene (UL49) alters the expression, localization, and virion incorporation of ICP0. J. Virol. 79:9735-9745.
23. Elliott, G. D., and D. M. Meredith. 1992. The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49. J. Gen. Virol. 73:723-726.
24. Everett, R. D. 2000. ICP0, a regulator of herpes simplex virus during lytic and latent infection. Bioessays 22:761-770.
25. Fenwick, M. L., and R. D. Everett. 1990. Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2. J. Gen. Virol. 71:2961-2967.
26. Foster, T. P., J. M. Melancon, J. D. Baines, and K. G. Kousoulas. 2004. The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion. J. Virol. 78:5347-5357.
27. Foster, T. P., G. V. Rybachuk, and K. G. Kousoulas. 2001. Glycoprotein K specified by herpes simplex virus type 1 is expressed on virions as a Golgi complex-dependent glycosylated species and functions in virion entry. J. Virol. 75:12431-12438.
28. Frame, M. C., D. J. McGeoch, F. J. Rixon, A. C. Orr, and H. S. Marsden. 1986. The 10K virion phosphoprotein encoded by gene US9 from herpes simplex virus type 1. Virology 150:321-332.
29. Fuchs, W., H. Granzow, R. Klopfleisch, B. G. Klupp, D. Rosenkranz, and T. C. Mettenleiter. 2005. The UL7 gene of pseudorabies virus encodes a nonessential structural protein which is involved in virion formation and egress. J. Virol. 79:11291-11299.
30. Fuchs, W., H. Granzow, B. G. Klupp, M. Kopp, and T. C. Mettenleiter. 2002. The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virions. J. Virol. 76:6729-6742.
31. Fuchs, W., H. Granzow, and T. C. Mettenleiter. 2003. A pseudorabies virus recombinant simultaneously lacking the major tegument proteins encoded by the UL46, UL47, UL48, and UL49 genes is viable in cultured cells. J. Virol. 77:12891-12900.
32. Ghiasi, H., A. B. Nesburn, S. Cai, and S. L. Wechsler. 1998. The US5 open reading frame of herpes simplex virus type 1 does encode a glycoprotein (gJ). Intervirology 41:91-97.
33. Granzow, H., B. G. Klupp, and T. C. Mettenleiter. 2005. Entry of pseudorabies virus: an immunogold-labeling study. J. Virol. 79:3200-3205.
34. Harland, J., P. Dunn, E. Cameron, J. Conner, and S. M. Brown. 2003. The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins. J. Neurovirol. 9:477-488.
35. Hong-Yan, Z., T. Murata, F. Goshima, H. Takakuwa, T. Koshizuka, Y. Yamauchi, and Y. Nishiyama. 2001. Identification and characterization of the UL24 gene product of herpes simplex virus type 2. Virus Genes 22:321-327.
36. Hutchinson, L., C. Roop-Beauchamp, and D. C. Johnson. 1995. Herpes simplex virus glycoprotein K is known to influence fusion of infected cells, yet is not on the cell surface. J. Virol. 69:4556-4563.
37. Jiang, Y. M., H. Yamada, F. Goshima, T. Daikoku, S. Oshima, K. Wada, and Y. Nishiyama. 1998. Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene product and a US2-deficient HSV-2 mutant. J. Gen. Virol. 79:2777-2784.
38. Johannsen, E., M. Luftig, M. R. Chase, S. Weicksel, E. Cahir-McFarland, D. Illanes, D. Sarracino, and E. Kieff. 2004. Proteins of purified Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 101:16286-16291.
39. L41 gene. J. Virol. 82:1701-1713.
40. Kattenhorn, L. M., R. Mills, M. Wagner, A. Lomsadze, V. Makeev, M. Borodovsky, H. L. Ploegh, and B. M. Kessler. 2004. Identification of proteins associated with murine cytomegalovirus virions. J. Virol. 78:11187-11197.
41. Kehm, R., H. R. Gelderblom, and G. Darai. 1998. Identification of the UL56 protein of herpes simplex virus type 1 within the virion by immuno electron microscopy. Virus Genes 17:49-53.
42. Kehm, R., E. Lorentzen, A. Rosen-Wolff, and G. Darai. 1994. In vitro expression of UL56 gene of herpes simplex virus type 1; detection of UL56 gene product in infected cells and in virions. Virus Res. 33:55-66.
43. Klupp, B. G., J. Altenschmidt, H. Granzow, W. Fuchs, and T. C. Mettenleiter. 2005. Identification and characterization of the pseudorabies virus UL43 protein. Virology 334:224-233.
44. Klupp, B. G., J. Baumeister, P. Dietz, H. Granzow, and T. C. Mettenleiter. 1998. Pseudorabies virus glycoprotein gK is a virion structural component involved in virus release but is not required for entry. J. Virol. 72:1949-1958.
45. Klupp, B. G., H. Granzow, R. Klopfleisch, W. Fuchs, M. Kopp, M. Lenk, and T. C. Mettenleiter. 2005. Functional analysis of the pseudorabies virus UL51 protein. J. Virol. 79:3831-3840.
46. Klupp, B. G., H. Granzow, and T. C. Mettenleiter. 2001. Effect of the pseudorabies virus US3 protein on nuclear membrane localization of the UL34 protein and virus egress from the nucleus. J. Gen. Virol. 82:2363-2371.
47. Kopp, M., H. Granzow, W. Fuchs, B. G. Klupp, E. Mundt, A. Karger, and T. C. Mettenleiter. 2003. The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J. Virol. 77:5339-5351.
48. Kuhn, E., J. Wu, J. Karl, H. Liao, W. Zolg, and B. Guild. 2004. Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. Proteomics 4:1175-1186.
49. Leach, N., S. L. Bjerke, D. K. Christensen, J. M. Bouchard, F. Mou, R. Park, J. Baines, T. Haraguchi, and R. J. Roller. 2007. Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. J. Virol. 81:10792- 10803.
50. Liang, L., M. Tanaka, Y. Kawaguchi, and J. D. Baines. 2004. Cell lines that support replication of a novel herpes simplex virus 1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31. Virology 329:68-76.
51. Liu, H., R. G. Sadygov, and J. R. Yates III. 2004. A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal. Chem. 76:4193-4201.
52. Luxton, G. W., S. Haverlock, K. E. Coller, S. E. Antinone, A. Pincetic, and G. A. Smith. 2005. Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins. Proc. Natl. Acad. Sci. USA 102:5832-5837.
53. Luxton, G. W., J. I. Lee, S. Haverlock-Moyns, J. M. Schober, and G. A. Smith. 2006. The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport. J. Virol. 80:201-209.
54. MacLean, C. A., B. Clark, and D. J. McGeoch. 1989. Gene UL11 of herpes simplex virus type 1 encodes a virion protein which is myristylated. J. Gen. Virol. 70:3147-3157.
55. Maxwell, K. L., and L. Frappier. 2007. Viral proteomics. Microbiol. Mol. Biol. Rev. 71:398-411.
56. McLauchlan, J., C. Addison, M. C. Craigie, and F. J. Rixon. 1992. Noninfectious L-particles supply functions which can facilitate infection by HSV-1. Virology 190:682-688.
57. McLauchlan, J., K. Liefkens, and N. D. Stow. 1994. The herpes simplex virus type 1 UL37 gene product is a component of virus particles. J. Gen. Virol. 75:2047-2052.
58. McLauchlan, J., and F. J. Rixon. 1992. Characterization of enveloped tegument structures (L particles) produced by alphaherpesviruses: integrity of the tegument does not depend on the presence of capsid or envelope. J. Gen. Virol. 73:269-276.
59. McLean, G., F. Rixon, N. Langeland, L. Haarr, and H. Marsden. 1990. Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47. J. Gen. Virol. 71:2953-2960.
60. McNabb, D. S., and R. J. Courtney. 1992. Analysis of the UL36 open reading frame encoding the large tegument protein (ICP1/2) of herpes simplex virus type 1. J. Virol. 66:7581-7584.
61. Meckes, D. G., Jr., and J. W. Wills. 2007. Dynamic interactions of the UL16 tegument protein with the capsid of herpes simplex virus. J. Virol. 81:13028-13036.
62. Mettenleiter, T. C. 2004. Budding events in herpesvirus morphogenesis. Virus Res. 106:167-180.
63. Michael, K., B. G. Klupp, T. C. Mettenleiter, and A. Karger. 2006. Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E. J. Virol. 80:1332-1339.
64. Morris, J. B., H. Hofemeister, and P. O'Hare. 2007. Herpes simplex virus infection induces phosphorylation and delocalization of emerin, a key inner nuclear membrane protein. J. Virol. 81:4429-4437.
65. Mossman, K. L., R. Sherburne, C. Lavery, J. Duncan, and J. R. Smiley. 2000. Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event. J. Virol. 74:6287-6299.
66. S3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cells. J. Virol. 81:6459-6470.
67. Naldinho-Souto, R., H. Browne, and T. Minson. 2006. Herpes simplex virus tegument protein VP16 is a component of primary enveloped virions. J. Virol. 80:2582-2584.
68. Nalwanga, D., S. Rempel, B. Roizman, and J. D. Baines. 1996. The UL 16 gene product of herpes simplex virus 1 is a virion protein that colocalizes with intranuclear capsid proteins. Virology 226:236-242.
69. Newcomb, W. W., R. M. Juhas, D. R. Thomsen, F. L. Homa, A. D. Burch, S. K. Weller, and J. C. Brown. 2001. The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. J. Virol. 75:10923-10932.
70. Nozawa, N., T. Daikoku, Y. Yamauchi, H. Takakuwa, F. Goshima, T. Yoshikawa, and Y. Nishiyama. 2002. Identification and characterization of the UL7 gene product of herpes simplex virus type 2. Virus Genes 24:257-266.
71. Nozawa, N., Y. Kawaguchi, M. Tanaka, A. Kato, H. Kimura, and Y. Nishiyama. 2005. Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. J. Virol. 79:6947-6956.
72. O'Connor, C. M., and D. H. Kedes. 2006. Mass spectrometric analyses of purified rhesus monkey rhadinovirus reveal 33 virion-associated proteins. J. Virol. 80:1574-1583.
73. Ong, S. E., and M. Mann. 2005. Mass spectrometry-based proteomics turns quantitative. Nat. Chem. Biol. 1:252-262.
74. Overton, H. A., D. J. McMillan, L. S. Klavinskis, L. Hope, A. J. Ritchie, and P. Wong-kai-in. 1992. Herpes simplex virus type 1 gene UL13 encodes a phosphoprotein that is a component of the virion. Virology 190:184-192.
75. Park, R., and J. D. Baines. 2006. Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B. J. Virol. 80:494-504.
76. Pearson, A., and D. M. Coen. 2002. Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. J. Virol. 76:10821-10828.
77. S3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides. J. Virol. 81:1980-1989.
78. Purves, F. C., D. Spector, and B. Roizman. 1991. The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene. J. Virol. 65:5757-5764.
79. Rémillard-Labrosse, G., G. Guay, and R. Lippé. 2006. Reconstitution of herpes simplex virus type 1 nuclear capsid egress in vitro. J. Virol. 80:9741-9753.
80. L34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids. J. Virol. 75:8803-8817.
81. S3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids. J. Virol. 76:8939-8952.
82. Righetti, P. G., and E. Boschetti. 14 May 2008, posting date. The proteominer and the Fortyniners: searching for gold nuggets in the proteomic arena. Mass Spectrom. Rev. doi:10.1002/mas.20178.
83. Roller, R. J., and B. Roizman. 1992. The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits. J. Virol. 66:3624-3632.
84. L34 gene product is required for viral envelopment. J. Virol. 74:117-129.
85. Schmidt, A., N. Gehlenborg, B. Bodenmiller, L. N. Mueller, D. Campbell, M. Mueller, R. Aebersold, and B. Domon. May 29, 2008, posting date. An integrated, directed mass spectrometric approach for in-depth characterization of complex peptide mixtures. Mol. Cell. Proteomics. [Epub ahead of print.]
86. Schmitz, J. B., A. G. Albright, P. R. Kinchington, and F. J. Jenkins. 1995. The UL37 protein of herpes simplex virus type 1 is associated with the tegument of purified virions. Virology 206:1055-1065.
87. Sedlackova, L., and S. A. Rice. 2008. Herpes simplex virus type 1 immediate-early protein ICP27 is required for efficient incorporation of ICP0 and ICP4 into virions. J. Virol. 82:268-277.
88. Smibert, C. A., D. C. Johnson, and J. R. Smiley. 1992. Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41. J. Gen. Virol. 73:467-470.
89. L13. J. Virol. 82:4533-4543.
90. Sodeik, B., M. W. Ebersold, and A. Helenius. 1997. Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus. J. Cell Biol. 136:1007-1021.
91. Spear, P. G., and B. Roizman. 1972. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J. Virol. 9:143-159.
92. Szilagyi, J. F., and C. Cunningham. 1991. Identification and characterization of a novel non-infectious herpes simplex virus-related particle. J. Gen. Virol. 72:661-668.
93. L41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A. J. Virol. 80:9341-9345.
94. Taddeo, B., W. Zhang, and B. Roizman. 2006. The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. Proc. Natl. Acad. Sci. USA 103:2827-2832.
95. Turcotte, S., J. Letellier, and R. Lippé. 2005. Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress. J. Virol. 79:8847-8860.
96. Varnum, S. M., D. N. Streblow, M. E. Monroe, P. Smith, K. J. Auberry, L. Pasa-Tolic, D. Wang, D. G. Camp, 2nd, K. Rodland, S. Wiley, W. Britt, T. Shenk, R. D. Smith, and J. A. Nelson. 2004. Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J. Virol. 78:10960-10966.
97. Viswanathan, K., and K. Fruh. 2007. Viral proteomics: global evaluation of viruses and their interaction with the host. Expert Rev. Proteomics 4:815-829.
98. Wagenaar, F., J. M. Pol, B. Peeters, A. L. Gielkens, N. de Wind, and T. G. Kimman. 1995. The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleus. J. Gen. Virol. 76:1851-1859.
99. Ward, P. L., G. Campadelli-Fiume, E. Avitabile, and B. Roizman. 1994. Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1. J. Virol. 68:7406-7417.
100. L33 are located on the external surface of the viral capsid. J. Virol. 80:10894-10899.
101. Wolfstein, A., C. H. Nagel, K. Radtke, K. Dohner, V. J. Allan, and B. Sodeik. 2006. The inner tegument promotes herpes simplex virus capsid motility along microtubules in vitro. Traffic 7:227-237.
102. Yamada, H., T. Daikoku, Y. Yamashita, Y. M. Jiang, T. Tsurumi, and Y. Nishiyama. 1997. The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix. J. Gen. Virol. 78:2923-2931.
103. Yamada, H., Y. M. Jiang, S. Oshima, T. Daikoku, Y. Yamashita, T. Tsurumi, and Y. Nishiyama. 1998. Characterization of the UL55 gene product of herpes simplex virus type 2. J. Gen. Virol. 79:1989-1995.
104. Yang, K., F. Homa, and J. D. Baines. 2007. Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus. J. Virol. 81:6419-6433.
105. Yang, K., A. P. Poon, B. Roizman, and J. D. Baines. 2008. Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature. J. Virol. 82:487-494.
106. Yang, T. Y., and R. J. Courtney. 1995. Influence of the host cell on the association of ICP4 and ICP0 with herpes simplex virus type 1. Virology 211:209-217.
107. Yao, F., and R. J. Courtney. 1992. Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1. J. Virol. 66:2709-2716.
108. Yao, F., and R. J. Courtney. 1989. A major transcriptional regulatory protein (ICP4) of herpes simplex virus type 1 is associated with purified virions. J. Virol. 63:3338-3344.
109. Yu, D., and S. K. Weller. 1998. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging. J. Virol. 72:7428-7439.
110. Zhang, Y., and J. L. McKnight. 1993. Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression. J. Virol. 67:1482-1492.
111. Zhu, F. X., J. M. Chong, L. Wu, and Y. Yuan. 2005. Virion proteins of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79:800-811.