Mechanism-based pharmacokinetic-pharmacodynamic modeling of the estrogen-like effect of ginsenoside Rb1 on neural 5-HT in ovariectomized mice

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 1-2, 2011, Pages 117-126

  Hao, Kun ^a   Gong, Ping ^a   Sun, Shi Qing ^a   Hao, Hai Ping ^a   Wang, Guang Ji ^a   Dai, Yue ^a   Chen, Yuan Cheng ^b   Liang, Yan ^a   Xie, Lin ^a   Li, Fei Yan ^a   Li, Hao Ye ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

5 Hydroxytryptamine; Estradiol; Ginsenoside Rb1; Pharmacokinetic pharmacodynamic model

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHAN; AMINE OXIDASE (FLAVIN CONTAINING); AROMATIC LEVO AMINO ACID DECARBOXYLASE; ESTRADIOL; GINSENOSIDE RB 1; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ANALYSIS; ESTROGEN ACTIVITY; FEMALE; MOUSE; NONHUMAN; OVARIECTOMY; PHARMACODYNAMICS; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; SINGLE DRUG DOSE;

5-HYDROXYTRYPTOPHAN; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GINSENOSIDES; INDOLES; MICE; MICE, INBRED STRAINS; MODELS, BIOLOGICAL; NEURONS; OVARIECTOMY; PHYTOESTROGENS; SEROTONIN; TIME FACTORS;

EID: 80052037690     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.06.014     Document Type: Conference Paper

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