Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling

Pharmaceutical Research

Volumn 22, Issue 4, 2005, Pages 603-612

  Raje, Sangeeta ^a   Cornish, Jennifer ^b   Newman, Amy H ^b   Cao, Jianjing ^b   Katz, Jonathan L ^b   Eddington, Natalie D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Benztropine; Cocaine; Dopamine; Pharmacodynamics; Pharmacokinetics

Indexed keywords

AHN 1055; AHN 2005; BENZATROPINE; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; ELECTROCHEMICAL DETECTION; EVALUATION; EXTRACELLULAR FLUID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MALE; MATHEMATICAL MODEL; MICRODIALYSIS; MOLECULAR PROBE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; STANDARDIZATION; STEREOTAXIC SURGERY;

ANIMALS; BENZTROPINE; BRAIN; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; EXTRACELLULAR FLUID; MALE; MICRODIALYSIS; MODELS, BIOLOGICAL; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 18044363842     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-2488-8     Document Type: Article

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