A two-compartment effect site model describes the bispectral index after different rates of propofol infusion

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 37, Issue 3, 2010, Pages 243-255

  Björnsson, Marcus A ^a,c   Norberg, Åke ^b   Kalman, Sigridur ^b   Karlsson, Mats O ^c   Simonsson, Ulrika S H ^c  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Bispectral index; NONMEM; Pharmacodynamics; Pharmacokinetics; Propofol

Indexed keywords

PROPOFOL; INTRAVENOUS ANESTHETIC AGENT;

ACCURACY; ADULT; ANESTHESIA INDUCTION; ANESTHESIA LEVEL; ANESTHESIA MECHANISM; ARTICLE; BAYES THEOREM; BISPECTRAL INDEX; BODY WEIGHT; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG ELIMINATION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFUSION RATE; INTERMETHOD COMPARISON; MALE; NONLINEAR SYSTEM; NORMAL HUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; TREATMENT DURATION; TREND STUDY; BIOLOGICAL MODEL; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PROCEDURES;

ADULT; ANESTHETICS, INTRAVENOUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE AGED; MODELS, BIOLOGICAL; PROPOFOL;

EID: 77956763921     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-010-9157-1     Document Type: Article

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