An animal model for simultaneous pharmacokinetic/pharmacodynamic investigations: Application to cocaine

Journal of Pharmacological and Toxicological Methods

Volumn 39, Issue 1, 1998, Pages 1-8

  Pan, Wei Jian ^a   Hedaya, Mohsen A ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Animal model; Cocaine; Cocaine pharmacological effects; Pharmacodynamic modeling; Pharmacokinetic modeling; Pharmacokinetic pharmacodynamic

Indexed keywords

COCAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MONITORING; HYSTERESIS; MEAN ARTERIAL PRESSURE; NONHUMAN; ORAL DRUG ADMINISTRATION; PATIENT MONITORING; PHARMACODYNAMICS; PHARMACOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; BRAIN; CATHETERIZATION; COCAINE; DOPAMINE; ELECTROCARDIOGRAPHY; HALF-LIFE; HEART RATE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; MALE; MICRODIALYSIS; MONITORING, AMBULATORY; RATS; RATS, WISTAR; TOXICITY TESTS;

ANIMALIA; SIGMOIDEA;

EID: 0031954163     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(97)00097-X     Document Type: Article

References (14)

1. Benowitz. Clinical pharmacology and toxicology of cocaine. Pharmacol. Toxicol. 72:1993;3-12.
2. Erzouki HK, Baum I, Goldberg SR, Schindler CW. Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats. J Cardiovasc Pharmacol. 22:1993;557-563.
3. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications . 1994;Swedish Pharmaceutical Press, Stockholm.
4. Gross DR. Animal Models in Cardiovascular Research. 1994;343-402 Kluwer Academic Publishers, Dordrecht.
5. Hutchaleelaha A, Sukbuntherng J, Mayersohn M. Simple apparatus for serial blood sampling in rodents permitting simultaneous measurement of locomotor activity as illustrated with cocaine. J Pharmacol Toxicol Methods. 37:1997;9-14.
6. Jeffcoat AR, Perez-Reyes M, Hill JM, Sadler BM, Cook CE. Cocaine disposition in humans after intravenous injection, nasal insufflation (snoring), or smoking. Drug Metab Dispos. 17:1989;153-159.
7. Kalivas PW, Churchill L, Klitenick MA. The circuitry mediating the translation of motivational stimuli into adaptive motor response. Kalivas PW, Barnes CD. Limbic Motor Circuits and Neuropsychiatry. 1993;237-288 CRC Press, Boca Raton.
8. Malhotra BK, Lemaire M, Sawchuk RJ. Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis. Pharm Res. 11:1994;1223-1232.
9. Menacherry S, Hubert W, Justice JB. In vivo calibration of microdialysis probes for exogenous compounds. Anal Chem. 64:1992;577-583.
10. Pan WJ, Hedaya MA. Sensitive and specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of cocaine and its metabolites in rat plasma. J Chromatography B: Biomedical Sciences and Applications. 703:1997;129-138.
11. Paxinos G, Watson C (1986) The rat brain in Sterotaxic Coordinates, 2nd ed. San Diego: Academic Press, Figure 12.
12. Pocchiari RJ, Hamlin RL, McGune SA. Electrocardiographic findings in rats with cardiomyopathy. Am J Vet Res. 54:1993;607-611.
13. Sorg BA, Kalivas P. Behavioral and neurochemical cross-sensitization between footshock stress and cocaine. Brain Res. 559:1991;29-36.
14. Travis CC, Hattemer-Frey HA. Physiological pharmacokinetic models. Krewski D, Franklin C. Statistics in Toxicology. 1991;170 Grodon and Breach, New York.