Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 714-723

  Li, Jing ^a   Liu, Peng ^a   Zhang, Ruixiu ^a   Cao, Lu ^a   Qian, Haihua ^a   Liao, Jian ^a   Xu, Wen ^a   Wu, Mengchao ^a   Yin, Zhengfeng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Hepatic stellate cells (HSCs); Icaritin; Liver fibrosis; Mitochondrial pathway

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BMF PROTEIN; CARBON TETRACHLORIDE; COLLAGEN TYPE 1; EOSIN; FLUORESCEIN ISOTHIOCYANATE; HEMATOXYLIN; HERBACEOUS AGENT; HYDROXYPROLINE; ICARITIN; LIPOCORTIN 5; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CELL COUNT; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; LIVER; LIVER FIBROSIS; LIVER TOXICITY; MALE; MITOCHONDRION; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; STELLATE CELL; TIME; TOXICITY TESTING; TREATMENT DURATION; UPREGULATION;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ASPARTATE AMINOTRANSFERASES; CELL LINE; CELL PROLIFERATION; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; HYDROXYPROLINE; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MITOCHONDRIA, LIVER; RATS; RATS, WISTAR; TIME FACTORS;

EPIMEDIUM SAGITTATUM; RATTUS; RATTUS NORVEGICUS;

EID: 80052030558     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.030     Document Type: Article

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