Herbal medicines for liver diseases in India

Journal of Gastroenterology and Hepatology (Australia)

Volumn 17, Issue SUPPL. 3, 2002, Pages

  Thyagarajan, S P ^a   Jayaram, S ^a   Gopalakrishnan, V ^a   Hari, R ^a   Jeyakumar, P ^a   Sripathi, M S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Herbal medicine for liver diseases; Indian systems of medicine; Phyllanthus amarus; Picrorhiza kurroa

Indexed keywords

GLYCYRRHIZA EXTRACT; HERBACEOUS AGENT; INTERFERON; LIVER PROTECTIVE AGENT; PHYLLANTHUS AMARUS EXTRACT; PICRORHIZA KURROA EXTRACT; PLANT EXTRACT; SYLIBUM MARIANUM EXTRACT; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; CHRONIC LIVER DISEASE; CONFERENCE PAPER; CYTOKINE PRODUCTION; DRUG ACTIVITY; FIBROSIS; GLYCYRRHIZA; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HERBAL MEDICINE; HUMAN; IMMUNOMODULATION; INDIA; JAUNDICE; LIPID PEROXIDATION; LIVER PROTECTION; LIVER REGENERATION; OXIDATION; PLANT; PRIORITY JOURNAL;

GLYCYRRHIZA GLABRA; PHYLLANTHUS AMARUS; PICRORHIZA KURROA; SYLIBUM MARIANUM;

EID: 0036458498     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.17.s3.30.x     Document Type: Conference Paper

References (77)

1. Schuppan D, Jia J-D, Brinkhaus B, Hahn EG. Herbal products for liver diseases: A therapeutic challenge for the new millennium. Hepatology 1999; 30: 1099-104.
2. Thyagarajan SP. Changing therapy: Treatment of viral hepatitis in modern and alternative medicine systems. IAP J. Pract. Pediatr. 1996; 4: 161-7.
3. Handa SS, Sharma A, Chakraborty KK. Natural products and plants as liver protecting drugs. Fitoterapia 1989; 57: 307-51.
4. Hikino H, Kiso Y. Natural products for liver diseases. In: Economic and Medicinal Plant Research, vol. 2. London: Academic Press, 1988; 39-72.
5. Evans WC. An overview of drugs having antihepatotoxic and oral hypoglycemic activities. In: Trease AK, Evans WC, eds. Pharmacognosy, 14th Edn. UK: WD Sanders, 1996.
6. Sharma A, Shing RT, Sehgal V, Handa SS. Antihepatotoxic activity of some plants used in herbal formulations. Fitoterapia 1991; 62: 131-8.
7. Doreswamy R, Sharma D. Plant drugs for liver disorders management. Indian Drugs 1995; 32: 139-44.
8. Jayasekhar P, Mohanan PV, Rathinum K. Hepatoprotective activity of ethyl acetate extract of Acacia catechu. Indian J. Pharmaocol. 1997; 29: 426-8.
9. Gadgoli C, Mishra SH. Preliminary screening of Achillea millefolium, Cichorium intybus and Capparis spinosa for anti-hepatotoxic activity. Fitoterapia 1995; 66: 319-23.
10. Chattopadhyay RR, Sarkar SK, Ganguly S, Banerjee RN, Basu TK, Mukherjee A. Hepatoprotective activity of Azadiracha indica leaves on paracetamol-induced hepatic damage in rats. Indian J. Pharmacol. 1994; 24: 35-40.
11. Handa SS, Sharma A. Hepatoprotective andrographolide from Andrographis paniculata. Indian J. Med. Res. 1990; 92: 276-92.
12. Rawat AKS, Mehrotra S, Tripathi SC, Shome U. Hepato-protective activity of Boerhaavia diwffusa L roots, a popular Indian ethnomedicine. J. Ethnopharmacol. 1997; 56: 61-5.
13. Cakraborti KK, Handa SS. Antihepatotoxic activity of Boerhaavia diffusa and B. repanda. Indian Drugs 1989; 27: 19-24 and 161-6.
14. Gadgoli C, Mishra SH. Antihepatotoxic activity of Cichorium intybus. J. Ethanopharmacol. 1997; 58: 131-4.
15. Bishayee A, Sarkar A, Chatterjee M. Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetra-chloride intoxication in mouse liver. J. Ethanopharmacol. 1995; 7: 69-94.
16. Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J. Ethnopharmacol. 1993; 40: 155-61.
17. Subramoniam A, Rajasekharan S, Vinodkumar TG, Pushpangadan P. Studies on the hepatoprotective activity of Geophila renifbrmis. In: 6th World Congress on Holistic Life and Medicine, 5-7 January, Kozhikode, India (Abstract), 1996.
18. Mitra S, Sur RK. Hepatoprotection with Glycosmis pentaphylla. Indian J. Exp. Biol. 1997; 35: 1306-9.
19. Mandal PK, Bishayee A, Chatterjee M. Stimulation of tissue repair by Mikania cordata extract on CCl4 induced liver injury in mice. Phytother. Res. 1993; 7: 103-5.
20. Ruckmani K, Kavimani S, Anandan R, Jaykar B. Effect of Moringa oleifera Lam on paracetamol-induced hepatotoxicity. Indian J. Pharm. Sci. 1998; 60: 33-5.
21. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK. Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian J. Pharmacol. 1992; 24: 163-5.
22. Gulati RK, Agarwal SS. Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin. Indian J. Exp. Biol. 1994; 33: 261-8.
23. Sane RT, Kuber VV, Mary SC, Menon S. Hepatoprotection by Phyllanthus amarus and P. debelis in CCl4 induced liver dysfunction. Curr. Sci. 1995; 68: 1242-6.
24. Asha VV, Pushpangadan P. Preliminary evaluation of antihepatotoxic activity of Phyllanthus maderaspatensis, P. kozhikodianus and Solanum indicum. Fitoterapia 1998; 69: 260-4.
25. Reddy BP, Murthy VN, Venkateshwarulu V, Kokate CK, Rambhau D. Antihepatotoxic activity of Phyllanthus niruri, Tinospora cordifolia and Ricinus communis. Indian Drugs 1993; 30: 338-41.
26. Ansari RA, Aswal BS, Chander Ret al. Hepatoprotective activity of Kutkin, the iridold glycoside mixture of Picrorrhiza kurroa. Indian J. Med. Res. 1998; 87: 401-4.
27. Saraswat B, Visen PKS, Patnaik GK, Dhawan BN. Protective affect of picroliv, active principle of Picrorrhiza kurroa against oxytetracycline-induced hepatic damage. Indian J. Exp. Biol. 1997; 35: 1302-15.
28. Dwivedi Y, Rastogi R, Garag NK, Dhawan BN. Prevention of paracetamol-induced hepatic damage in rats by picroliv, the standardized active fraction from Picrorrhiza kurroa. Phytother. Res. 1991; 5: 115-19.
29. Kumar SR, Mishra SH. Isolation and assessment of hepatoprotective activity of fumaric acid obtained for the first time from Sida cordifolia Linn. Indian Drugs 1997; 34: 702-6.
30. Kumar SR, Mishra SH. Antiinflammatory and hepatoprotective activities of Sida rhombifolia. Indian J. Pharmacol. 1997; 29: 110-16.
31. Mukherjee S, Sur A, Maiti BR. Hepatoprotective effects of Swertia chirata on rats.Indian J. Exp. Biol. 1997; 35: 384-8.
32. Ramamurthy SM, Srinivasan M. Hepatoprotective effects of Tephrosia purpurea in experimental animals. Indian J. Pharmacol. 1993; 25: 34-8.
33. Subramoniam A, Evans DA, Rajasekharan S, Pushpangadan P. Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol induced hepatic damage in rats. Indian J. Exp. Biol. 1998; 36: 385-9.
34. Singh B, Saxena AK, Chandan BKet al. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fitoterapia 1998; 69: 135-41.
35. Sharma AK, Anand KK, Pushpangadan P et al. Hepatoprotective effects of Wedelia calendulacea. J. Ethnopharmacol. 1989; 25: 93-102.
36. Sudhir S, Budhiraja RD. Protective effect of Witthferin against an experimental model of hepatitis. Indian J. Pharmacol. 1991; 23: 16-20.
37. Mehrotra P, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN. Invitro studies on the effect of certain natural products against hepatitis B virus. Indian J. Med. Res. 1990; 92: 133-8.
38. Dwivedi Y, Rastogi R, Sharma SK, Mehrotra R, Garg NK, Dhawan BN. Picroliv protects against monocrotaline-induced hepatic damage in rats. Pharmacol. Res. 1991; 23: 399-407.
39. Dwivedi Y, Rastogi R, Sharma SK, Garg NK, Dhawan BN. Picroliv affords protection against thioacetamide-induced hepatic damage in rats. Plants Med. 1991; 57: 25-8.
40. Dwivedi Y, Rastogi R, Chander R. et al. Hepatoprotective activity of picroliv against carbon tetrachloride induced liver damage in rats. Indian J. Med. Res. 1990; 92: 195-200.
41. Shukla B, Visen PK, Patnaik GK, Dhawan BN. Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Plants Med. 1991; 57: 29-33.
42. Chander R, Dwivedi Y, Rastogi R et al. Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei. Indian J. Med. Res. 1990; 92: 34-7.
43. Pandey BL, Das PK. Immunopharmacological studies on Picrorhiza kurroa Royle-Ex-Benth. Part IV. Cellular mechanisms of anti-inflammatory action. Indian J. Physiol. Pharmacol. 1989; 33: 28-30.
44. Pandey BL, Das PK. Immunopharmacological studies on picrorohiza kurroa Royle-Ex-Benth. Part V. Anti-inflammatory action: Relation with cell types involved in inflammation. Indian J. Physiol. Pharmacol. 1988; 32: 289-92.
45. Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. I. Preliminary screening. J. Ethnopharmacol. 1986; 18: 133-41.
46. Rajalakshmi S, Sivanandam G, Veluchamy G. Effect of Kadugurohini (Picrorhiza kurroa Royle) in the treatment of Viral Hepatitis: A double blind study with placebo control. J. Res. Ayurvedha Siddha. 1990; 13: 27-34.
47. Jayaram S. Studies on Prevention and Control of Hepatitis B Virus Infection. PhD Thesis, University of Madras, India. 1992.
48. Thyagarajan SP. Studies on Hepatitis B Virus Infection in Tamilnadu, Laying Special Emphasis on the Immunological and Biochemical Markers with an Assessment on the Antiviral Properties of Certain Indigenous Herbs. PhD Thesis, University of Madras, India. 1979.
49. Thyagarajan SP, Thiruneelakandan K, Subramanian S, Sundaravelu T. Invitro inactivation of HBsAg by Eclipta alba Hassk and Phyllanthus niruri Linn. Indian J. Med. Res. 1982; 76 (Suppl.): 124-30.
50. Venkateswaran PS, Millman I, Blumberg BS. Effect and an extract from Phyllanthus niruri on hepatitis B and woodchuch hepatitis viruses: Invitro and invivo studies. Proc. Natl Acad. Sci. USA 1987; 84: 274-8.
51. Blumberg BS, Millman I, Venkateswaran PS, Thyagarajan SP. Hepatitis B Virus and primary hepatocellular carcinoma: Treatment of HBV carriers with Phyllanthus amarus. Cancer Detect. Prev. 1989; 14: 195-202.
52. Yanagi M, Unoura M, Kobayashi K et al. Inhibitory effect of an extract from Phyllanthus niruri on reaction of endogenous HBV-DNA polymerase and other DNA synthetases. In: Abstracts of Papers Presented at the 1989 Meeting on Hepatitis, B viruses. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory, 1989; 77, 25-8.
53. Shead A, Vickery K, Medhurst R, Freiman J, Cossart Y. Neutralisation but not cure of duck hepatitis b by Australian Phyllanthus extracts. In: Scientific Program and Abstract Volume, the 1990 International Symposium on Viral Hepatitis and Liver Disease. Houston, Texas, 1990.
54. Niu J, Wang Y, Qiau Met al. Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo. J. Med. Virol. 1990; 32: 212-18.
55. Jayaram S, Thyagarajan SP. Inhibition of HBsAg secretion from Alexander cell line by Phyllanthus amarus. Indian J. Pathol. Microbiol. 1996; 39: 211-15.
56. Lee CD, Ott M, Thyagarajan SP, Sharfritz DA, Burk RD, Gupta S. Phyllanthus amarus down regulates hepatitis B virus mRNA transcription and replication. Eur. J. Clin. Invest. 1996; 4: 161-8.
57. Ott M, Thyagarajan SP, Gupta S. Phyllanthus amarus suppresses hepatitis B virus by interrupting interactions between HBV-enhancer I and cellular transcription factors. Eur. J. Clin. Invest. 1997; 27: 908-15.
58. Mokkhasmit M, Swasdimongkol K, Satrwaha P. Study on toxicity of Thai medicinal plants. Bull. Med. Sci. 1971; 12: 36-65 (Abstract).
59. Rao YS. Experimental production of liver damage and its protection with Phyllanthus niruri and Cappris spinosa (both ingredients of Liv 52) in white albino rats. Probe 1985; 3: 117-19.
60. Syamasundar KV, Singh B, Thakur RS, Hussain A, Kiso H. Antihepatotoxic principles of Phyllanthus niruri herbs. J. Ethanopharmacol. 1985; 14: 41-4.
61. Jayaram S, Thyagarajan SP, Panchanadam M, Subramanian S. Anti hepatitis B virus properties of Phyllanthus niruri Linn. and Eclipta alba Hassk: Invitro and Invivo safety studies. Biomedicine 1987; 7: 9-16.
62. Jayaram S, Udaya Shankar K, Rajendran P, Thyagarajan SP. Antihepatotoxicity potentials of Phyllanthus amarus: An invitro study using isolated rat hepatocyte cultures. Indian J. Med. Microbiol. 1994; 12: 248-51.
63. Jayanthi V, Madanagopalan N, Thyagarajan SP, Balakumar V, Parimalam S, Malathi S. Value of herbal medicines, Phyllanthus niruri, Eclipta alba, Piper Longus, Thippili (Tamil) and combination of Phyllanthus niruri and Ricinus communis (Icterus-Pharm. products) in acute viral hepatitis. J. Gasteroenterol. Hepatol. 1988; 3: 533-4.
64. Geetha J, Manjula R, Malathi S et al. Efficacy of 'Essential Phospholipid substance' of Soya Bean oil and Phyllanthus niruri in acute viral hepatitis. J. Gen. Med. 1992; 4: 53-8.
65. Thyagarajan SP, Subramanian S, Thirunalasundari T, Venkateswaran PS, Blumberg BS. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet 1988; 2: 764-6.
66. Thyagarajan SP, Jayaram S, Valliammai T, Madanagopalan N, Pal VG, Jayaraman K. Phyllanthus amarus and hepatitis B.Lancet 1990; 336: 949-50.
67. Leelarasamee A, Trakulsomboon S, Maunwongyathi P et al. Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers. Lancet 1990; 1: 1600-1.
68. Wang M, Zhou H-B, Zhao G-I, Zhao S, Mai K. Phyllanthus amarus cannot eliminate HBsAg in chronic hepatitis B virus infection. Hepatology 1991; 21: 22-4.
69. Thyagarajan SP, Jayaram S, Panneerselvam A et al. Effect of Phyllanthus amarus, an Indian medicinal plant on healthy carriers of hepatitis B virus: Results of six clinical trials, 1990-1996. Indian J. Gastroenterol. 1999; 18 (Suppl. 1): S26.
70. Mitra RL, Jain SK. Concept of Phyllanthus niruri (Euphorbiaceae) in Indian Floras. Bull. Botan. Surv. India 1985; 27: 161-76.
71. Unander DW, Webster GL, Blumberg BS. Use age and bioassays in Phyllanthus (Euphorbiaceae): A compilation II. The subgenus Phyllanthus. J. Ethanopharmacol. 1991; 34: 97-133.
72. Yogeeswaran G, Sathyakumar J. Convergence of Indian systems and modern medicine: A new promise in health care. LABCON 2002; 2: 1-8.
73. Shaw D, Leon C, Koleu S, Murray V. Traditional remedies and food supplements. A five-year toxicological study (1991-1995).Drug Safety 1997; 17: 342-56.
74. Yoshida EM, McLean CA, Chen ES et al. Chinese herbal medicine, fulminant hepatitis and liver transplantation. Am. J. Gastroenterol. 1996; 91: 1436-8.
75. Larrey D, Pageaux GP. Hepatotoxicity of herbal remedies and mushrooms. Semin. Liver Dis. 1995; 15: 183-8.
76. Kaplowitz N. Hepatotoxicity of herbal remedies: Insight into the intricacies of plant-animal warfare and cell death. Gastroenterology 1997; 113: 1408-12.
77. Thyagarajan SP, Jayaram S. Natural History of Phyllanthus amarus in the treatment of hepatitis B. Indian J. Med. Microbiol. 1992; 10: 64-80.