Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

Blood

Volumn 113, Issue 20, 2009, Pages 4930-4941

  Li, Yitang ^a,b   Jia, Yonghui ^a,b   Pichavant, Muriel ^a   Loison, Fabien ^a,b   Sarraj, Bara ^a,b   Kasorn, Anongnard ^a,b   You, Jian ^a,b   Robson, Bryanne E ^c   Umetsu, Dale T ^a   Mizgerd, Joseph P ^c   Ye, Keqiang ^d   Luo, Hongbo R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL PNEUMONIA; BONE MARROW CELL; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; HOST RESISTANCE; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; MORTALITY; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SYNTHESIS; ANIMAL; ESCHERICHIA COLI INFECTION; GENE DELETION; GENE TARGETING; GENETICS; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SURVIVAL; UPREGULATION;

ANIMALS; ESCHERICHIA COLI INFECTIONS; GENE DELETION; GENE TARGETING; IMMUNITY, INNATE; INFLAMMATION; MICE; MICE, KNOCKOUT; NEUTROPENIA; NEUTROPHIL ACTIVATION; NEUTROPHILS; PNEUMONIA, BACTERIAL; PTEN PHOSPHOHYDROLASE; SURVIVAL ANALYSIS; UP-REGULATION;

EID: 66549115702     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-161414     Document Type: Article

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