Proteins interacting with monoamine transporters: Current state and future challenges

Biochemistry

Volumn 50, Issue 34, 2011, Pages 7295-7310

  Sager, Jonathan J ^a   Torres, Gonzalo E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ,4-METHYLENEDIOXYMETHAMPHETAMINE; BIOGENIC AMINES; FUTURE CHALLENGES; MOOD DISORDERS; PROTEIN INTERACTION; PROTEOMICS; PSYCHOSTIMULANTS; TEMPORAL RESOLUTION; THERAPEUTIC AGENTS; YEAST TWO HYBRID;

AMINES; BIOSYNTHESIS; CELL MEMBRANES; MOLECULAR BIOLOGY;

PROTEINS;

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; BIOGENIC AMINE; CARRIER PROTEIN; COCAINE; DOPAMINE; METHAMPHETAMINE; MONOAMINE; NORADRENALIN; PSYCHOSTIMULANT AGENT; REGULATOR PROTEIN; SEROTONIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; HUMAN; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEOMICS; TWO HYBRID SYSTEM;

ANIMALS; CELL LINE; CELL MEMBRANE; HUMANS; PROTEIN BINDING; PROTEIN TRANSPORT; TRANSPORT VESICLES; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 80052017664     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200405c     Document Type: Article

References (150)

1. Aston-Jones, G. (2005) Brain structures and receptors involved in alertness Sleep Med. 6, S3-S7
2. Joshua, M., Adler, A., and Bergman, H. (2009) The dynamics of dopamine in control of motor behavior Curr. Opin. Neurobiol. 19, 615-620
3. Fitzgerald, P. and Dinan, T. G. (2008) Prolactin and dopamine: What is the connection? A review article J. Psychopharmacol. 22, 12-19
4. Carlsson, A. (1987) Perspectives on the discovery of central monoaminergic neurotransmission Annu. Rev. Neurosci. 10, 19-40 (Pubitemid 17022767)
5. Jonnakuty, C. and Gragnoli, C. (2008) What do we know about serotonin? J. Cell. Physiol. 217, 301-306
6. Charney, D. S. (1998) Monoamine dysfunction and the pathophysiology and treatment of depression J. Clin. Psychiatry 59, s11-s14
7. Genro, J. P., Kieling, C., Rohde, L. A., and Hutz, M. H. (2010) Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses Expert Rev. Neurother. 10, 587-601
8. Hirvonen, J. and Hietala, J. (2011) Networks and Genetic Risk for Schizophrenia: Specific neurotransmitter Systems CNS Neurosci. Ther. 17, 89-96
9. Hedderick, E. F., Morris, C. M., and Singer, H. S. (2009) Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome Pediatr. Neurol. 40, 420-425
10. Debiec, J. and LeDoux, J. E. (2006) Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: Treatment implications for PTSD Ann. N.Y. Acad. Sci. 1071, 521-524 (Pubitemid 44126769)
11. Itoi, K. and Sugimoto, N. (2010) The brainstem noradrenergic systems in stress, anxiety and depression J. Neuroendocrinol. 22, 355-361
12. Durant, C., Christmas, D., and Nutt, D. (2010) The pharmacology of anxiety Curr. Top. Behav. Neurosci. 2, 303-330
13. Carlsson, A. (1972) Biochemical and pharmacological aspects of Parkinsonism Acta Neurol. Scand. Suppl. 51, 11-42
14. Adinoff, B. (2004) Neurobiologic processes in drug reward and addiction Harv. Rev. Psychiatry 12, 305-320 (Pubitemid 40144218)
15. Hertting, G. and Axelrod, J. (1961) Fate of tritiated noradrenaline at the sympathetic nerve endings Nature 192, 172-173
16. Iversen, L. L. (1971) Role of transmitter uptake mechanisms in synaptic neurotransmission Br. J. Pharmacol. 41, 571-591
17. Pacholczyk, T., Blakely, R. D., and Amara, S. G. (1991) Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter Nature 350, 350-354 (Pubitemid 21912229)
18. Usdin, T. B., Mezey, E., Chen, C., Brownstein, M. J., and Hoffman, B. J. (1991) Cloning of the cocaine-sensitive bovine dopamine transporter Proc. Natl. Acad. Sci. U.S.A. 88, 11168-11171 (Pubitemid 21916001)
19. Shimada, S., Kitayama, S., Lin, C. L., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M., and Uhl, G. (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA Science 254, 576-578 (Pubitemid 21917378)
20. Giros, B., el Mestikawy, S., Bertrand, L., and Caron, M. G. (1991) Cloning and functional characterization of a cocaine-sensitive dopamine transporter FEBS Lett. 295, 149-154
21. Kilty, J. E., Lorang, D., and Amara, G. (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter Science 254, 578-579 (Pubitemid 21917379)
22. Hoffman, B. J., Mezey, E., and Brownstein, M. J. (1991) Cloning of a serotonin transporter affected by antidepressants Science 254, 579-580 (Pubitemid 21917380)
23. Blakely, R. D., Berson, H. E., Fremeau, R. T., Jr., Caron, M. G., Peek, M. M., Prince, H. K., and Bradley, C. C. (1991) Cloning and expression of a functional serotonin transporter from rat brain Nature 354, 66-70 (Pubitemid 21896784)
24. Liu, Y., Peter, D., Roghani, A., Schuldiner, S., Privé, G. G., Eisenberg, D., Brecha, N., and Edwards, R. H. (1992) A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter Cell 70, 539-551
25. Erickson, J. D., Eiden, L. E., and Hoffman, B. J. (1992) Expression cloning of a reserpine-sensitive vesicular monoamine transporter Proc. Natl. Acad. Sci. U.S.A. 89, 10993-10997
26. Masson, J., Sagné, C., Hamon, M., and El Mestikawy, S. (1999) Neurotransmitter transporters in the central nervous system Pharmacol. Rev. 51, 439-464 (Pubitemid 29420211)
27. Alfonso, A., Grundahl, K., Duerr, J. S., Han, H. P., and Rand, J. B. (1993) The Caenorhabditis elegans unc-17 gene: A putative vesicular acetylcholine transporter Science 261, 617-619 (Pubitemid 23278375)
28. Rudnick, G. and Clark, J. (1993) From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters Biochim. Biophys. Acta 1144, 249-263 (Pubitemid 23290252)
29. Gu, H., Wall, S. C., and Rudnick, G. (1994) Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence J. Biol. Chem. 269, 7124-7130 (Pubitemid 24217896)
30. Johnson, R. G. (1988) Accumulation of biological amines into chromaffin granules: A model for hormone and neurotransmitter transport Physiol. Rev. 68, 232-307
31. Pörzgen, P., Bönisch, H., Hammermann, R., and Brüss, M. (1998) The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons Biochim. Biophys. Acta 1398, 365-370 (Pubitemid 28338176)
32. Kitayama, S., Ikeda, T., Mitsuhata, C., Sato, T., Morita, K., and Dohi, T. (1999) Dominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicing J. Biol. Chem. 274, 10731-10736
33. Talkowski, M. E., McCann, K. L., Chen, M., McClain, L., Bamne, M., Wood, J., Chowdari, K. V., Watson, A., Prasad, K. M., Kirov, G., Georgieva, L., Toncheva, D., Mansour, H., Lewism, D. A., Owen, M., O'Donovan, M., Papasaikas, P., Sullivan, P., Ruderfer, D., Yao, J. K., Leonard, S., Thomas, P., Miyajima, F., Quinn, J., Lopez, A. J., and Nimgaonkar, V. L. (2010) Fine-mapping reveals novel alternative splicing of the dopamine transporter Am. J. Med. Genet., Part B 153B, 1434-1447
34. Lin, Z., Canales, J. J., Björgvinsson, T., Thomsen, M., Qu, H., Liu, Q. R., Torres, G. E., and Caine, S. B. (2011) Monoamine transporters vulnerable and vital doorkeepers Prog. Mol. Biol. Transl. Sci. 98, 1-46
35. Peter, D., Liu, Y., Sternini, C., de Giorgio, R., Brecha, N., and Edwards, R. H. (1995) Differential expression of two vesicular monoamine transporters J. Neurosci. 15, 6179-6188
36. Sur, C., Betz, H., and Schloss, P. (1996) Immunocytochemical detection of the serotonin transporter in rat brain Neuroscience 73, 217-223
37. Hersch, S. M., Yi, H., Heilman, C. J., Edwards, R. H., and Levey, A. I. (1997) Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra J. Comp. Neurol. 388, 211-227 (Pubitemid 27471497)
38. Schroeter, S., Apparsundaram, S., Wiley, R. G., Miner, L. H., Sesack, S. R., and Blakely, R. D. (2000) Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter J. Comp. Neurol. 420, 211-232 (Pubitemid 30185979)
39. Nirenberg, M. J., Chan, J., Pohorille, A., Vaughan, R. A., Uhl, G. R., Kuhar, M. J., and Pickel, V. M. (1997) The dopamine transporter: Comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens J. Neurosci. 17, 6899-6997
40. Zhou, F. C., Tao-Cheng, J. H., Segu, L., Patel, T., and Wang, Y. (1998) Serotonintransporters are located on the axons beyond the synaptic junctions: Anatomical and functional evidence Brain Res. 805, 241-254 (Pubitemid 29005140)
41. Miner, L. H., Schroeter, S., Blakely, R. D., and Sesack, S. R. (2003) Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals J. Comp. Neurol. 466, 478-494 (Pubitemid 37305993)
42. Miner, L. H., Jedema, H. P., Moore, F. W., Blakely, R. D., Grace, A. A., and Sesack, S. R. (2006) Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex J. Neurosci. 26, 1571-1578 (Pubitemid 43237027)
43. Mager, S., Min, C., Henry, D. J., Chavkin, C., Hoffman, B. J., Davidson, N., and Lester, H. A. (1994) Conducting states of a mammalian serotonin transporter Neuron 12, 845-859 (Pubitemid 24126245)
44. Sonders, M. S., Zhu, S. J., Zahniser, N. R., Kavanaugh, M. P., and Amara, S. G. (1997) Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants J. Neurosci. 17, 960-974 (Pubitemid 27043955)
45. Ingram, S. L. and Amara, S. G. (2000) Arachidonic acid stimulates a novel cocaine-sensitive cation conductance associated with the human dopamine transporter J. Neurosci. 20, 550-557 (Pubitemid 30225557)
46. Binda, F., Lute, B. J., Dipace, C., Blakely, R. D., and Galli, A. (2006) The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current Neuropharmacology 50, 354-361 (Pubitemid 43184363)
47. Buck, K. J. and Amara, S. G. (1994) Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium Proc. Natl. Acad. Sci. U.S.A. 91, 12584-12588
48. Chen, J. G. and Rudnick, G. (2000) Permeation and gating residues in serotonin transporter Proc. Natl. Acad. Sci. U.S.A. 97, 1044-1049 (Pubitemid 30080809)
49. Sulzer, D., Chen, T. K., Lau, Y. Y., Kristensen, H., Rayport, S., and Ewing, A. (1995) Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport J. Neurosci. 15, 4102-4108
50. Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, U., Javitch, J. A., Erreger, K., and Galli, A. (2008) Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux Mol. Pharmacol. 74, 1101-1108
51. Johnson, L. A., Guptaroy, B., Lund, D., Shamban, S., and Gnegy, M. E. (2005) Regulation of amphetamine-stimulated dopamine efflux by protein kinase Cβ J. Biol. Chem. 280, 10914-10919 (Pubitemid 40418392)
52. Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A., and Gether, U. (2006) Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport Neuron 51, 417-429 (Pubitemid 44219035)
53. Torres, G. E., Gainetdinov, R. R., and Caron, M. G. (2003) Plasma membrane monoamine transporters: Structure, regulation and function Nat. Rev. Neurosci. 4, 13-25 (Pubitemid 37271085)
54. Gulley, J. M. and Zahniser, N. R. (2003) Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands Eur. J. Pharmacol. 479, 139-152 (Pubitemid 37377883)
55. Vaughan, R. A. (2004) Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transporters J. Pharmacol. Exp. Ther. 310, 1-7 (Pubitemid 38812688)
56. Melikian, H. E. (2004) Neurotransmitter transporter trafficking: Endocytosis, recycling, and regulation Pharmacol. Ther. 104, 17-27 (Pubitemid 39410560)
57. Ramamoorthy, S., Shippenberg, T. S., and Jayanthi, L. D. (2011) Regulation of monoamine transporters: Role of transporter phosphorylation Pharmacol. Ther. 129, 220-238
58. Milner, H. E., Beliveau, R., and Jarvis, S. M. (1994) The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation Biochim. Biophys. Acta 1190, 185-187 (Pubitemid 24066277)
59. Jess, U., El Far, O., Kirsch, J., and Betz, H. (1996) The membrane-bound rat serotonin transporter, SERT1, is an oligomeric protein FEBS Lett. 394, 44-46 (Pubitemid 26321200)
60. Chang, A. S., Starnes, D. M., and Chang, S. M. (1998) Possible existence of quaternary structure in the high-affinity serotonin transport complex Biochem. Biophys. Res. Commun. 249, 416-421 (Pubitemid 28431768)
61. Kilic, F. and Rudnick, G. (2000) Oligomerization of serotonin transporter and its functional coznsequences Proc. Natl. Acad. Sci. U.S.A. 97, 3106-3111 (Pubitemid 30183263)
62. Schmid, J. A., Scholze, P., Kudlacek, O., Freissmuth, M., Singer, E. A., and Sitte, H. H. (2001) Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells J. Biol. Chem. 276, 3805-3810
63. Torres, G. E., Carneiro, A., Seamans, K., Fiorentini, C., Sweeney, A., Yao, W. D., and Caron, M. G. (2002) Oligomerization and trafficking of the human dopamine transporter: Mutational analysis identifies critical domains important for the functional expression of the transporter J. Biol. Chem. 278 (4) 2731-2739 (Pubitemid 36801354)
64. Sorkina, T., Doolen, S., Galperin, E., Zahniser, N. R., and Sorkin, A. (2003) Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy J. Biol. Chem. 278, 28274-28283 (Pubitemid 36900029)
65. Hastrup, H., Karlin, A., and Javitch, J. A. (2001) Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment Proc. Natl. Acad. Sci. U.S.A. 98, 10055-10060 (Pubitemid 32802973)
66. Hastrup, H., Sen, N., and Javitch, J. A. (2003) The human dopamine transporter forms a tetramer in the plasma membrane: Cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs J. Biol. Chem. 278, 45045-4508
67. Just, H., Sitte, H. H., Schmid, J. A., Freissmuth, M., and Kudlacek, O. (2004) Identification of an additional interaction domain in transmembrane domains 11 and 12 that support oligomer formation in the human serotonin transporter J. Biol. Chem. 279, 6650-6657 (Pubitemid 38248803)
68. --dependent neurotransmitter transporters Nature 437, 215-223 (Pubitemid 41294479)
69. Moszczynska, A., Saleh, J., Zhang, H., Vukusic, B., Lee, F. J., and Liu, F. (2007) Parkin disrupts the α-synuclein/dopamine transporter interaction: Consequences toward dopamine-induced toxicity J. Mol. Neurosci. 32, 217-227 (Pubitemid 47574970)
70. Jiang, H., Jiang, Q., and Feng, J. (2004) Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter J. Biol. Chem. 279, 54380-54386 (Pubitemid 40053177)
71. Farhan, H., Reiterer, V., Korkhov, V. M., Schmid, J. A., Freissmuth, M., and Sitte, H. H. (2007) Concentrative export from the endoplasmic reticulum of the γ-aminobutyric acid transporter 1 requires binding to SEC24D J. Biol. Chem. 282, 7679-7689 (Pubitemid 47093672)
72. El-Kasaby, A., Just, H., Malle, E., Stolt-Bergner, P. C., Sitte, H. H., Freissmuth, M., and Kudlacek, O. (2010) Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter J. Biol. Chem. 285, 39201-39210
73. Sucic, S., El-Kasaby, A., Kudlacek, O., Sarker, S., Sitte, H. H., Marin, P., and Freissmuth, M. (2011) The Serotonin Transporter Is an Exclusive Client of the Coat Protein Complex II (COPII) Component SEC24C J. Biol. Chem. 286, 16482-16490
74. Torres, G. E., Yao, W. D., Mohn, A. R., Quan, H., Kim, K. M., Levey, A. I., Staudinger, J., and Caron, M. G. (2001) Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1 Neuron 30, 121-134 (Pubitemid 32441681)
75. Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, K., Loland, C. J., Javitch, J. A., and Gether, U. (2004) Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions J. Neurosci. 24, 7024-7036 (Pubitemid 39045459)
76. Rickhag, M., Sørensen, G., Nørgaard-Strandfelt, K., Andresen, B., Füchtbauer, E., Gomeza, J., Wörtwein, G., Woldbye, D., and Gether, U. (2010) Two strains of dopamine transporter knock-in mice with disrupted PDZ-domain binding motifs demonstrate extensive loss of DAT-labeled synaptic terminals indicative of impaired synaptic targeting. Society for Neuroscience Annual Meeting Poster 546.9/F52.
77. Rao, A., Simmons, D., and Sorkin, A. (2011) Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons Mol. Cell. Neurosci. 46, 148-158
78. Loder, M. K. and Melikian, H. E. (2003) The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines J. Biol. Chem. 278, 22168-22174 (Pubitemid 36792628)
79. Ramamoorthy, S. and Blakely, R. D. (1999) Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants Science 285, 763-766
80. Saunders, C., Ferrer, J. V., Shi, L., Chen, J., Merrill, G., Lamb, M. E., Leeb-Lundbergm, L. M., Carvelli, L., Javitch, J. A., and Galli, A. (2000) Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism Proc. Natl. Acad. Sci. U.S.A. 97, 6850-6855 (Pubitemid 30412803)
81. Reith, M. E. (2003) Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations J. Pharmacol. Exp. Ther. 307, 729-736 (Pubitemid 37310690)
82. Furman, C. A., Chen, R., Guptaroy, B., Zhang, M., Holz, R. W., and Gnegy, M. (2009) Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: Live-cell imaging using total internal reflection fluorescence microscopy J. Neurosci. 29, 3328-3336
83. Little, K. Y., Elmer, L. W., Zhong, H., Scheys, J. O., and Zhang, L. (2002) Cocaine induction of dopamine transporter trafficking to the plasma membrane Mol. Pharmacol. 61, 436-445 (Pubitemid 34112819)
84. Daws, L. C., Callaghan, P. D., Morón, J. A., Kahlig, K. M., Shippenberg, T. S., Javitch, J. A., and Galli, A. (2002) Cocaine increases dopamine uptake and cell surface expression of dopamine transporters Biochem. Biophys. Res. Commun. 290, 1545-1550 (Pubitemid 34687434)
85. Bauman, A. L., Apparsundaram, S., Ramamoorthy, S., Wadzinski, B. E., Vaughan, R. A., and Blakely, R. D. (2000) Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A J. Neurosci. 20, 7571-7578
86. Chen, R., Furman, C. A., Zhang, M., Kim, M. N., Gereau, R. W., Leitges, M., and Gnegy, M. E. (2009) Protein kinase Cβ is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice J. Pharmacol. Exp. Ther. 328, 912-920
87. Steiner, J. A., Carneiro, A. M., Wright, J., Matthies, H. J., Prasad, H. C., Nicki, C. K., Dostmann, W. R., Buchanan, C. C., Corbin, J. D., Francis, S. H., and Blakely, R. D. (2009) cGMP-dependent protein kinase Iα associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake Mol. Brain 2, 26
88. Chanrion, B., Mannoury la Cour, C., Bertaso, F., Lerner-Natoli, M., Freissmuth, M., Millan, M. J., Bockaert, J., and Marin, P. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity Proc. Natl. Acad. Sci. U.S.A. 104, 8119-8124 (Pubitemid 47185885)
89. Lee, F. J., Pei, L., Moszczynska, A., Vukusic, B., Fletcher, P. J., and Liu, F. (2007) Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor EMBO J. 26, 2127-2136 (Pubitemid 46625791)
90. Marazziti, D., Mandillo, S., Di Pietro, C., Golini, E., Matteoni, R., and Tocchini-Valentini, G. P. (2007) GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs Proc. Natl. Acad. Sci. U.S.A. 104, 9846-9851 (Pubitemid 47175354)
91. Quick, M. W. (2002) Role of syntaxin 1A on serotonin transporter expression in developing thalamocortical neurons Int. J. Dev. Neurosci. 20, 219-224
92. Sung, U., Apparsundaram, S., Galli, A., Kahlig, K. M., Savchenko, V., Schroeter, S., Quick, M. W., and Blakely, R. D. (2003) A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity J. Neurosci. 23, 1697-1709 (Pubitemid 36314725)
93. Cervinski, M. A., Foster, J. D., and Vaughan, R. A. (2010) Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression Neuroscience 170, 408-416
94. Lee, F. J., Liu, F., Pristupa, Z. B., and Niznik, H. B. (2001) Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis FASEB J. 15, 916-926 (Pubitemid 32290778)
95. Wersinger, C. and Sidhu, A. (2003) Attenuation of dopamine transporter activity by α-synuclein Neurosci. Lett. 340, 189-192 (Pubitemid 36369670)
96. Wersinger, C., Jeannotte, A., and Sidhu, A. (2006) Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein Eur. J. Neurosci. 24, 3141-3152 (Pubitemid 44952646)
97. Wersinger, C., Rusnak, M., and Sidhu, A. (2006) Modulation of the trafficking of the human serotonin transporter by human α-synuclein Eur. J. Neurosci. 24, 55-64 (Pubitemid 44050666)
98. Carneiro, A. M., Ingram, S. L., Beaulieu, J. M., Sweeney, A., Amara, S. G., Thomas, S. M., Caron, M. G., and Torres, G. E. (2002) The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter J. Neurosci. 22, 7045-7054 (Pubitemid 35385611)
99. Müller, H. K., Wiborg, O., and Haase, J. (2006) Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2 J. Biol. Chem. 281, 28901-28909 (Pubitemid 44507033)
100. Fjorback, A. W., Müller, H. K., Haase, J., Raarup, M. K., and Wiborg, O. (2011) Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2 Biochem. Biophys. Res. Commun. 406, 165-170
101. Cremona, M. L., Matthies, H. J., Pau, K., Bowton, E., Speed, N., Lute, B. J., Anderson, M., Sen, N., Robertson, S. D., Vaughan, R. A., Rothman, J. E., Galli, A., Javitch, J. A., and Yamamoto, A. (2011) Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT Nat. Neurosci. 14, 469-477
102. Daniels, G. M. and Amara, S. G. (1999) Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters J. Biol. Chem. 274, 35794-35801 (Pubitemid 129512883)
103. Sorkina, T., Hoover, B. R., Zahniser, N. R., and Sorkin, A. (2005) Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism Traffic 6, 157-170
104. Granas, C., Ferrer, J., Loland, C. J., Javitch, J. A., and Gether, U. (2003) N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization J. Biol. Chem. 278, 4990-5000 (Pubitemid 36801008)
105. Khoshbouei, H., Sen, N., Guptaroy, B., Johnson, L., Lund, D., Gnegy, M. E., Galli, A., and Javitch, J. A. (2004) N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux PLoS Biol. 2, E78
106. Holton, K. L., Loder, M. K., and Melikian, H. E. (2005) Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization Nat. Neurosci. 8, 881-888
107. Zhu, C. B., Hewlett, W. A., Feoktistov, I., Biaggioni, I., and Blakely, R. D. (2004) Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation Mol. Pharmacol. 65, 1462-1474 (Pubitemid 38668304)
108. Zhu, C. B., Steiner, J. A., Munn, J. L., Daws, L. C., Hewlett, W. A., and Blakely, R. D. (2007) Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors J. Pharmacol. Exp. Ther. 322, 332-340 (Pubitemid 46956381)
109. Prasad, H. C., Zhu, C. B., McCauley, J. L., Samuvel, D. J., Ramamoorthy, S., Shelton, R. C., Hewlett, W. A., Sutcliffe, J. S., and Blakely, R. D. (2005) Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase Proc. Natl. Acad. Sci. U.S.A. 102, 11545-11550 (Pubitemid 41153856)
110. Zhang, Y. W., Gesmonde, J., Ramamoorthy, S., and Rudnick, G. (2007) Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder J. Neurosci. 27, 10878-10886 (Pubitemid 47535855)
111. Cass, W. A. and Gerhardt, G. A. (1994) Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake Neurosci. Lett. 176, 259-263 (Pubitemid 24241870)
112. Bolan, E. A., Kivell, B., Jaligam, V., Oz, M., Jayanthi, L. D., Han, Y., Sen, N., Urizar, E., Gomes, I., Devi, L. A., Ramamoorthy, S., Javitch, J. A., Zapata, A., and Shippenberg, T. S. (2007) D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism Mol. Pharmacol. 71, 1222-1232 (Pubitemid 46661542)
113. Lee, F. J., Pei, L., and Liu, F. (2009) Disruption of the dopamine transporter-dopamine D2 receptor interaction in schizophrenia Synapse 63, 710-712
114. Marazziti, D., Golini, E., Mandillo, S., Magrelli, A., Witke, W., Matteoni, R., and Tocchini-Valentini, G. P. (2004) Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor Proc. Natl. Acad. Sci. U.S.A. 101, 10189-10194 (Pubitemid 38891217)
115. Lee, K. H., Kim, M. Y., Kim, D. H., and Lee, Y. S. (2004) Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter Neurochem. Res. 29, 1405-1409
116. Salaun, C., James, D. J., Greaves, J., and Chamberlain, L. H. (2004) Plasma membrane targeting of exocytic SNARE proteins Biochim. Biophys. Acta 1693, 81-89 (Pubitemid 39094011)
117. Deken, S. L., Beckman, M. L., Boos, L., and Quick, M. W. (2000) Transport rates of GABA transporters: Regulation by the N-terminal domain and syntaxin 1A Nat. Neurosci. 3, 998-1003
118. Sung, U. and Blakely, R. D. (2007) Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A Mol. Cell. Neurosci. 34, 251-260 (Pubitemid 46137002)
119. Dipace, C., Sung, U., Binda, F., Blakely, R. D., and Galli, A. (2007) Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes Mol. Pharmacol. 71, 230-239 (Pubitemid 46020993)
120. Eller, M. and Williams, D. R. (2011) Review: α-Synuclein in Parkinson disease and other neurodegenerative disorders Clin. Chem. Lab. Med. 49, 403-408
121. Wersinger, C. and Sidhu, A. (2005) Disruption of the interaction of α-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter Biochemistry 44, 13612-13624 (Pubitemid 41443689)
122. Dauer, W., Kholodilov, N., Vila, M., Trillat, A. C., Goodchild, R., Larsen, K. E., Staal, R., Tieu, K., Schmitz, Y., Yuan, C. A., Rocha, M., Jackson-Lewis, V., Hersch, S., Sulzer, D., Przedborski, S., Burke, R., and Hen, R. (2002) Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP Proc. Natl. Acad. Sci. U.S.A. 99, 14524-14529 (Pubitemid 35257704)
123. Chadchankar, H., Ihalainen, J., Tanila, H., and Yavich, L. (2011) Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein Brain Res. 1382, 37-44
124. Carneiro, A. M. and Blakely, R. D. (2006) Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter J. Biol. Chem. 281, 24769-24780 (Pubitemid 44274251)
125. Gainetdinov, R. R., Sotnikova, T. D., and Caron, M. G. (2002) Monoamine transporter pharmacology and mutant mice Trends Pharmacol. Sci. 23, 367-373
126. Jones, S. R., Gainetdinovm, R. R., Jaberm, M., Girosm, B., Wightman, R. M., and Caron, M. G. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter Proc. Natl. Acad. Sci. U.S.A. 95, 4029-4034 (Pubitemid 28173248)
127. Egaña, L. A., Cuevas, R. A., Baust, T. B., Parra, L. A., Leak, R. K., Hochendoner, S., Peña, K., Quiroz, M., Hong, W. C., Dorostkar, M. M., Janz, R., Sitte, H. H., and Torres, G. E. (2009) Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3 J. Neurosci. 29, 4592-4604
128. Ferguson, S. M., Savchenko, V., Apparsundaram, S., Zwick, M., Wright, J., Heilman, C. J., Yi, H., Levey, A. I., and Blakely, R. D. (2003) Vesicular localization and activity-dependent trafficking of presynaptic choline transporters J. Neurosci. 23, 9697-9709 (Pubitemid 37371582)
129. Sulzer, D., Chen, T. K., Lau, Y. Y., Kristensen, H., Rayport, S., and Ewing, A. (1995) Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport J. Neurosci. 15, 4102-4108
130. Dipace, C., Sung, U., Binda, F., Blakely, R. D., and Galli, A. (2007) Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes Mol. Pharmacol. 71, 230-239 (Pubitemid 46020993)
131. Ciccone, M. A., Timmons, M., Phillips, A., and Quick, M. W. (2008) Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A Neuropharmacology 55, 763-770
132. Ingram, S. L., Prasad, B. M., and Amara, S. G. (2002) Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons Nat. Neurosci. 5, 971-978
133. Quick, M. (2003) Regulating the conducting states of a mammalian serotonin transporter Neuron 40, 537-549 (Pubitemid 37494703)
134. Carvelli, L., Blakely, R. D., and DeFelice, L. J. (2008) Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission Proc. Natl. Acad. Sci. U.S.A. 105, 14192-14197
135. Zhang, H., Li, S., Wang, M., Vukusic, B., Pristupa, Z. B., and Liu, F. (2009) Regulation of dopamine transporter activity by carboxypeptidase E Mol. Brain 2, 10
136. Sorkina, T., Miranda, M., Dionne, K. R., Hoover, B. R., Zahniser, N. R., and Sorkin, A. (2006) RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis J. Neurosci. 26, 8195-8205 (Pubitemid 44315144)
137. Miranda, M., Dionne, K. R., Sorkina, T., and Sorkin, A. (2007) Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter Mol. Biol. Cell 18, 313-323 (Pubitemid 46066728)
138. Nirenberg, M. J., Chan, J., Liu, Y., Edwards, R. H., and Pickel, V. M. (1996) Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: Potential sites for somatodendritic storage and release of dopamine J. Neurosci. 16, 4135-4145 (Pubitemid 26192409)
139. Nirenberg, M. J., Chan, J., Liu, Y., Edwards, R. H., and Pickel, V. M. (1997) Vesicular monoamine transporter-2: Immunogold localization in striatal axons and terminals Synapse 26, 194-198 (Pubitemid 27188164)
140. Tan, P. K., Waites, C., Liu, Y., Krantz, D. E., and Edwards, R. H. (1998) A leucine-based motif mediates the endocytosis of vesicular monoamine and acetylcholine transporters J. Biol. Chem. 273, 17351-17360 (Pubitemid 28355060)
141. 2 J. Neurosci. 20, 2131-2141 (Pubitemid 30230065)
142. Höltje, M., Winter, S., Walther, D., Pahner, I., Hörtnagl, H., Ottersen, O. P., Bader, M., and Ahnert-Hilger, G. (2003) The vesicular monoamine content regulates VMAT2 activity through Gαq in mouse platelets. Evidence for autoregulation of vesicular transmitter uptake J. Biol. Chem. 278, 15850-15858 (Pubitemid 36799700)
143. Guo, G. T., Chen, A. Q., Kong, Q., Zhu, H., Ma, C. M., and Qin, C. (2008) Inhibition of vesicular monoamine transporter-2 activity in α-synuclein stable transfected SH-SY5Y cells Cell. Mol. Neurobiol. 28, 35-47
144. Requena, D. F., Parra, L. A., Baust, T. B., Quiroz, M., Leak, R. K., Garcia-Olivares, J., and Torres, G. E. (2009) The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2 J. Neurochem. 110, 581-594
145. Tobaben, S., Thakur, P., Fernández-Chacón, R., Südhof, T. C., Rettig, J., and Stahl, B. (2001) A trimeric protein complex functions as a synaptic chaperone machine Neuron 31, 987-999 (Pubitemid 32925284)
146. Jin, H., Wu, H., Osterhaus, G., Wei, J., Davis, K., Sha, D., Floor, E., Hsu, C. C., Kopke, R. D., and Wu, J. Y. (2003) Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles Proc. Natl. Acad. Sci. U.S.A. 100, 4293-4298 (Pubitemid 36418196)
147. Cartier, E. A., Parra, L. A., Baust, T. B., Quiroz, M., Salazar, G., Faundez, V., Egaña, L., and Torres, G. E. (2010) A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles J. Biol. Chem. 15, 1957-1966
148. Witkovsky, P., Patel, J. C., Lee, C. R., and Rice, M. E. (2009) Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons Neuroscience 164, 488-496
149. Prakash, N. and Wurst, W. (2006) Development of dopaminergic neurons in the mammalian brain Cell. Mol. Life Sci. 63, 187-206 (Pubitemid 43100289)
150. Lew, R., Patel, A., Vaughan, R. A., Wilson, A., and Kuhar, M. J. (1996) Microheterogeneity of dopamine transporters in rat striatum and nucleus accumbens Brain Res. 584, 266-271