Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39201-39210

  El Kasaby, Ali ^a   Just, Herwig ^a   Malle, Elisabeth ^b   Stolt Bergner, Peggy C ^b   Sitte, Harald H ^a   Freissmuth, Michael ^a   Kudlacek, Oliver ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MOTIF; C TERMINUS; CARBOXYL TERMINUS; CARBOXYL-TERMINAL; CELL SURFACES; CHEMICAL CHAPERONE; DOCKING SITES; DOMINANT NEGATIVE; ENDOPLASMIC RETICULUM; SEROTONIN TRANSPORTERS; SOLUTE CARRIERS; WILD TYPES;

CELL MEMBRANES;

CALNEXIN; DIMETHYL SULFOXIDE; IBOGAINE; SEROTONIN TRANSPORTER;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; IMIPRAMINE; LIGANDS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR CHAPERONES; MUTATION; NEUROTRANSMITTER AGENTS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 78649870054     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.118000     Document Type: Article

References (39)

1. Nelson, N. (1998) J. Neurochem. 71, 1785-1803
2. Rudnick, G. (2006) J. Membr. Biol. 213, 101-110
3. Masson, J., Sagné, C., Hamon, M., and El Mestikawy, S. (1999) Pharmacol. Rev. 51, 439-464
4. Singh, S. K. (2008) Channels 2, 380-389
5. Just, H., Sitte, H. H., Schmid, J. A., Freissmuth, M., and Kudlacek, O. (2004) J. Biol. Chem. 279, 6650-6657
6. Scholze, P., Freissmuth, M., and Sitte, H. H. (2002) J. Biol. Chem. 277, 43682-43690
7. Moss, F. J., Imoukhuede, P. I., Scott, K., Hu, J., Jankowsky, J. L., Quick, M. W., and Lester, H. A. (2009) J. Gen. Physiol. 134, 489-521
8. Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A., and Gether, U. (2006) Neuron 51, 417-429
9. Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, U., Javitch, J. A., Erreger, K., and Galli, A. (2008) Mol. Pharmacol. 74, 1101-1108
10. Miranda, M., Dionne, K. R., Sorkina, T., and Sorkin, A. (2007) Mol. Biol. Cell 18, 313-323
11. Farhan, H., Korkhov, V. M., Paulitschke, V., Dorostkar, M. M., Scholze, P., Kudlacek, O., Freissmuth, M., and Sitte, H. H. (2004) J. Biol. Chem. 279, 28553-28563
12. Farhan, H., Reiterer, V., Korkhov, V. M., Schmid, J. A., Freissmuth, M., and Sitte, H. H. (2007) J. Biol. Chem. 282, 7679-7689
13. Farhan, H., Reiterer, V., Kriz, A., Hauri, H. P., Pavelka, M., Sitte, H. H., and Freissmuth, M. (2008) J. Cell Science 121, 753-761
14. Reiterer, V., Maier, S., Sitte, H. H., Kriz, A., Rüegg, M. A., Hauri, H. P., Freissmuth, M., and Farhan, H. (2008) J. Neuroscience 28, 12453-12464
15. Guptaroy, B., Zhang, M., Bowton, E., Binda, F., Shi, L., Weinstein, H., Galli, A., Javitch, J. A., Neubig, R. R., and Gnegy, M. E. (2009) Mol. Pharmacol. 75, 514-524
16. Sucic, S., Dallinger, S., Zdrazil, B., Weissensteiner, R., Jørgensen, T. N., Holy, M., Kudlacek, O., Seidel, S., Cha, J. H., Gether, U., Newman, A. H., Ecker, G. F., Freissmuth, M., and Sitte, H. H. (2010) J. Biol. Chem. 285, 10924-10938
17. Bauman, P. A., and Blakely, R. D. (2002) Arch. Biochem. Biophys. 404, 80-91
18. Torres, G. E., Yao, W. D., Mohn, A. R., Quan, H., Kim, K. M., Levey, A. I., Staudinger, J., and Caron, M. G. (2001) Neuron 30, 121-134
19. Fernández-Sánchez, E., Díez-Guerra, F. J., Cubelos, B., Giménez, C., and Zafra, F. (2008) Biochem. J. 409, 669-681
20. Larsen, M. B., Fjorback, A. W., and Wiborg, O. (2006) Biochemistry 45, 1331-1337
21. Korkhov, V. M., Holy, M., Freissmuth, M., and Sitte, H. H. (2006) J. Biol. Chem. 281, 13439-13448
22. Albert, A. D., and Boesze-Battaglia, K. (2005) Prog. Lipid. Res. 44, 99-124
23. Magnani, F., Tate, C. G., Wynne, S., Williams, C., and Haase, J. (2004) J. Biol. Chem. 279, 38770-38778
24. Tate, C. G., Haase, J., Baker, C., Boorsma, M., Magnani, F., Vallis, Y., and Williams, D. C. (2003) Biochim. Biophys. Acta 1610, 141-153
25. Waldo, G. S., Standish, B. M., Berendzen, J., and Terwilliger, T. C. (1999) Nat. Biotechnol. 17, 691-695
26. Ou, W. J., Cameron, P. H., Thomas, D. Y., and Bergeron, J. J. (1993) Nature 364, 771-776
27. Welch, W. J., and Brown, C. R. (1996) Cell Stress Chaperones 1, 109-115
28. Jacobs, M. T., Zhang, Y. W., Campbell, S. D., and Rudnick, G. (2007) J. Biol. Chem. 282, 29441-29447
29. Korkhov, V. M., Milan-Lobo, L., Zuber, B., Farhan, H., Schmid, J. A., Freissmuth, M., and Sitte, H. H. (2008) J. Mol. Biol. 378, 337-352
30. Bermak, J. C., Li, M., Bullock, C., and Zhou, Q. Y. (2001) Nat. Cell Biol. 3, 492-498
31. Pankevych, H., Korkhov, V., Freissmuth, M., and Nanoff, C. (2003) J. Biol. Chem. 278, 30283-30293
32. Carrel, D., Hamon, M., and Darmon, M. (2006) J. Cell Sci. 119, 4276-4284
33. Duvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D., and Wu, G. (2009) Mol. Pharmacol. 75, 751-761
34. Nezu, A., Parvin, M. N., and Turner, R. J. (2009) J. Biol. Chem. 284, 6869-6876
35. Conn, P. M., Ulloa-Aguirre, A., Ito, J., and Janovick, J. A. (2007) Pharmacol. Rev. 59, 225-250
36. Sitte, H. H., and Freissmuth, M. (2010) J. Neurochem. 112, 340-355
37. Sitte, H. H., Hiptmair, B., Zwach, J., Pifl, C., Singer, E. A., and Scholze, P. (2001) Mol. Pharmacol. 59, 1129-1137
38. Miranda, M., Sorkina, T., Grammatopoulos, T. N., Zawada, W. M., and Sorkin, A. (2004) J. Biol. Chem. 279, 30760-30770
39. Farinha, C. M., Nogueira, P., Mendes, F., Penque, D., and Amaral, M. D. (2002) Biochem. J. 366, 797-806