DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity

American Journal of Clinical Nutrition

Volumn 94, Issue 3, 2011, Pages 742-748

  Newens, Katie J ^a   Thompson, Abby K ^a   Jackson, Kim G ^a   Wright, John ^a   Williams, Christine M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BIOLOGICAL MARKER; CHOLESTEROL; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FISH OIL; GLUCOSE; LINOLEIC ACID; OLEIC ACID; OMEGA 3 FATTY ACID; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID; TRIACYLGLYCEROL; TRISTEARIN;

ADULT; ARTERY DILATATION; ARTICLE; BLOOD CLOTTING; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR PARAMETERS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DIGITAL VOLUME PULSE; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; FLOW MEDIATED DILATATION; GLUCOSE BLOOD LEVEL; HUMAN; IONTOPHORESIS; LASER DOPPLER IONTOPHORESIS; LIPID ANALYSIS; MALE; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR ENDOTHELIUM;

ADULT; DIETARY FATS; DILATATION; DOCOSAHEXAENOIC ACIDS; ENDOTHELIUM, VASCULAR; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; FEMALE; FISH OILS; HEPARIN; HUMANS; IONTOPHORESIS; MALE; PLANT OILS; POSTPRANDIAL PERIOD; STATISTICS, NONPARAMETRIC; VASCULAR DISEASES;

EID: 80051965816     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.009233     Document Type: Article

References (44)

1. He K., Song Y., Daviglus M.L., Van Horn L., Dyer A.R., Greenland P. Accumulated evidence on fish consumption and coronary heart disease mortality: A meta-analysis of cohort studies. Circulation 2004;109(22):2705-11.
2. Khan F., Elherik K., Bolton-Smith C., et al. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 2003;59(4):955-62. (Pubitemid 38366251)
3. McVeigh G.E., Brennan G.M., Johnston G.D., Galli A., Iantorno M., Gigli F., Sbraccia P., Federici M., Quon M.J., Lauro D. Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin- dependent) diabetes mellitus. Diabetologia 1993;36:33-8. (Pubitemid 23018332)
4. Rizza S., Tesauro M., Cardillo C., Galli A., Iantorno M., Gigli F., Sbraccia P., Federici M., Quon M.J., Lauro D. Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis 2009;206(2):569-74.
5. Morgan D.R., Dixon L.J., Hanratty C.G., El-Sherbeeny N., Hamilton P.B., McGrath L.T., Leahey W.J., Johnston G.D., McVeigh G.E. Effects of dietary omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic heart failure. Am J Cardiol 2006;97(4):547-51. (Pubitemid 43190048)
6. Tagawa H., Shimokawa H., Tagawa T., Kuroiwa-Matsumoto M., Hirooka Y., Takeshita A. Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. J Cardiovasc Pharmacol 1999;33:633-40. (Pubitemid 29164828)
7. Goodfellow J., Bellamy M.F., Ramsey M.W., Jones C.J., Lewis M.J. Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 2000;35(2):265-70. (Pubitemid 30125512)
8. Wright S.A., O'Prey F.M., McHenry M.T., Leahey W.J., Devine A.B., Duffy E.M., Johnston D.G., Finch M.B., Bell A.L., McVeigh G.E. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis 2008;67(6):841-8.
9. Armah C.K., Jackson K.G., Doman I., James L., Cheghani F., Minihane A.M. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci (Lond) 2008;114(11):679-86. (Pubitemid 351799327)
10. Hall W.L., Sanders K.A., Sanders T.A., Chowienczyk P.J. A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness measured by digital volume pulse analysis in healthy men. J Nutr 2008;138(2):287-91. (Pubitemid 351213641)
11. Fahs C.A., Yan H., Ranadive S., Rossow L.M., Agiovlasitis S., Wilund K.R., Fernhall B. The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal. Appl Physiol Nutr Metab 2010;35(3):294-302.
12. Massaro M., Scoditti E., Carluccio M.A., De Caterina R. Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease. Prostaglandins Leukot Essent Fatty Acids 2008;79:109-15.
13. Steinberg H.O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A.D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997;100:1230-9.
14. Lind L., Fugmann A., Branth S., Vessby B., Millgard J., Berne C., Lithell H. The impairment in endothelial function induced by non-esterified fatty acids can be reversed by insulin. Clin Sci (Lond) 2000;99:169-74.
15. Pleiner J., Schaller G., Mittermayer F., Bayerle-Eder M., Roden M., Wolzt M. FFA-induced endothelial dysfunction can be corrected by vitamin C. J Clin Endocrinol Metab 2002;87:2913-7.
16. Steer P., Millgard J., Basu S., Lithell H., Vessby B., Berne C., Lind L. Vitamin C, diclophenac, and L-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humans. Atherosclerosis 2003;168(1):65-72. (Pubitemid 36555812)
17. Mittermayer F., Schaller G., Pleiner J., Krzyzanowska K., Kapiotis S., Roden M., Wolzt M. Rosiglitazone prevents free fatty acid-induced vascular endothelial dysfunction. J Clin Endocrinol Metab 2007;92(7):2574-80.
18. Wang X.L., Zhang L., Youker K., Zhang M.X., Wang J., LeMaire S.A., Coselli J.S., Shen Y.H. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 2006;55(8):2301-10.
19. Xiao-Yun X., Zhuo-Xiong C., Min-Xiang L., Xingxuan H., Schuchman E.H., Feng L., Han-Song X., An-Hua L. Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. Med Sci Monit 2009;15(9):BR254-61.
20. Kim F., Tysseling K.A., Rice J., Pham M., Haji L., Gallis B.M., Baas A.S., Paramsothy P., Giachelli C.M., Corson M.A., et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 2005;25:989-94. (Pubitemid 40627844)
21. Bredt D.S. Endogenous nitric oxide synthesis: Biological functions and pathophysiology. Free Radic Res 1999;31:577-96.
22. Beysen C., Belcher A.K., Karpe F., Fielding B.A., Herrera E., Frayn K.N. Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans. Am J Physiol Endocrinol Metab 2003;284(1):E18-24. (Pubitemid 36076218)
23. Newens K.J., Thompson A.K., Jackson K.G., Wright J., Williams C.M. Acute effects of elevated NEFA on vascular function: A comparison of SFA and MUFA. Br J Nutr 105(9):1343-51.
24. Corretti M.C., Anderson T.J., Benjamin E.J., Celermajer D., Charbonneau F., Creager M.A., Deanfield J., Drexler H., Gerhard-Herman M., Herrington D., et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39:257-65. (Pubitemid 34084631)
25. Stehouwer C.D. Is measurement of endothelial dysfunction clinically useful? Eur J Clin Invest 1999;29(6):459-61. (Pubitemid 29271633)
26. George T.W., Niwat C., Waroonphan S., Gordon M.H., Lovegrove J.A. Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism. Proc Nutr Soc 2009;68(2):148-61.
27. Wykretowicz A., Gerstenberger P., Guzik P., Milewska A., Krauze T., Adamska K., Rutkowska A., Wysocki H. Arterial stiffness in relation to subclinical atherosclerosis. Eur J Clin Invest 2009;39(1):11-6.
28. Chowienczyk P.J., Kelly R.P., MacCallum H., et al. Photoplethysmographic assessment of pulse wave reflection: Blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus. J Am Coll Cardiol 1999;34(7):2007-14.
29. Kew S., Mesa M.D., Tricon S., Buckley R., Minihane A.M., Yaqoob P. Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. Am J Clin Nutr 2004;79:674-81. (Pubitemid 41103914)
30. Corretti M.C., Anderson T.J., Benjamin E.J., Celermajer D., Charbonneau F., Creager M.A., Deanfield J., Drexler H., Gerhard-Herman M., Herrington D., et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39(2):257-65. (Pubitemid 34084631)
31. Borucki K., Aronica S., Starke I., Luley C., Westphal S. Addition of 2.5 g L-arginine in a fatty meal prevents the lipemia-induced endothelial dysfunction in healthy volunteers. Atherosclerosis 2009;205(1):251-4.
32. Nicholls S.J., Lundman P., Harmer J.A., Cutri B., Griffiths K.A., Rye K.A., Barter P.J., Celermajer D.S. Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J Am Coll Cardiol 2006;48(4):715-20. (Pubitemid 44175720)
33. Raitakari O.T., Lai N., Griffiths K., McCredie R., Sullivan D., Celermajer D.S. Enhanced peripheral vasodilation in humans after a fatty meal. J Am Coll Cardiol 2000;36(2):417-22.
34. Berry S.E., Tucker S., Banerji R., et al. Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J Nutr 2008;138(10):1910-4.
35. Marchesi S., Lupattelli G., Schillaci G., Pirro M., Siepi D., Roscini A.R., Pasqualini L., Mannarino E. Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men. Atherosclerosis 2000;153(2):397-402. (Pubitemid 32120339)
36. Bae J.H., Schwemmer M., Lee I.K., Lee H.J., Park K.R., Kim K.Y., Bassenge E. Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int J Cardiol 2003;87(2-3):259-67. (Pubitemid 36135984)
37. Vogel R.A., Corretti M.C., Plotnick G.D. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol 1997;79(3):350-4.
38. Pyke K.E., Tschakovsky M.E. The relationship between shear stress and flow-mediated dilatation: Implications for the assessment of endothelial function. J Physiol 2005;568(Pt 2):357-69. (Pubitemid 41555444)
39. Wang R.X., Chai Q., Lu T., Lee H.C. Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. Cardiovasc Res 2010;90(2):344-2.
40. Huang A., Sun D., Jacobson A., Carroll M.A., Falck J.R., Kaley G. Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. Circ Res 2005;96(3):376-83. (Pubitemid 40279913)
41. Bai Y., Sun L., Yang T., Sun K., Chen J., Hui R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: A meta-analysis of randomized controlled trials. Am J Clin Nutr 2009;89(1):77-84.
42. Witte D.R., Westerink J., De Koning E.J., Van der Graaf Y., Grobbee D.E., Bots M.L. Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? J Am Coll Cardiol 2005;45(12):1987-93.
43. Smith J., Ferland A., Methot J., Brassard P., Lacroix S., Poirier P., Cianflone K. The beta-1 adrenergic antagonist, atenolol, decreases acylation stimulating protein, exercise capacity and plasma free fatty acids in men with type 2 diabetes. Nutr Metab Cardiovasc Dis (Epub ahead of print 17 January 2011).
44. Jackson K.G., Wolstencroft E.J., Bateman P.A., Yaqoob P., Williams C.M. Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: Implications for insulin sensitivity and lipoprotein regulation? Br J Nutr 2005;93(5):693-700. (Pubitemid 43906354)