Effects of tryptophan depletion on central and peripheral chemoreflexes in man

Respiratory Physiology and Neurobiology

Volumn 133, Issue 3, 2002, Pages 183-195

  Struzik, Lukasz ^a   Duffin, James ^a   Vermani, Monica ^a   Hegadoren, Kathleen ^b   Katzman, Martin A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Carbon dioxide, response, central, peripheral; Control of breathing, CO2 response, central, peripheral; Depletion, tryptophan; Disease, panic disorder; Mammals, humans; Mediators, serotonin

Indexed keywords

CARBON DIOXIDE; SEROTONIN; TRYPTOPHAN;

ADULT; ARTICLE; ASPHYXIA; BREATHING; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; DEPLETION; HUMAN; HUMAN EXPERIMENT; LUNG VENTILATION; MALE; NEUROMODULATION; NEUROTRANSMISSION; NORMAL HUMAN; PANIC; PRIORITY JOURNAL; THEORY;

ADULT; CARBON DIOXIDE; CHEMORECEPTORS; DIET; HUMANS; MALE; PAIN MEASUREMENT; PLASMA; RESPIRATION; SENSORY THRESHOLDS; SEROTONIN; TIME FACTORS; TRYPTOPHAN; VENTILATION;

EID: 0037137162     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(02)00170-2     Document Type: Article

References (65)

1. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press.
2. Anderson I.M., Mortimore C. 5-HT and human anxiety. Evidence from studies using acute tryptophan depletion. Adv. Exp. Med. Biol. 467:1999;43-55.
3. Armijo J.A., Florez J. The influence of increased brain 5-hydroxytryptamine upon respiratory activity of cats. Neuropharmacology. 13:1974;977-986.
4. Bernard D.J., Li A., Nattie E.E. Evidence for central chemoreception in the midline raphe. J. Appl. Physiol. 80:(1):1996;108-115.
5. Biggio G., Fadda F., Fanni P., Tagliamonte A., Gessa G.L. Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci. 14:1974;1321-1329.
6. Blier P., de Montigny C., Choput Y. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol. 7:(Suppl.):1987;24-35.
7. Carpenter L.L., Anderson G.M., Pelton G.H., Gudin J.A., Kirwin P.D.S., Price L.H., Henninger G.R., McDougle C.J. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology. 19:1998;26-35.
8. 2 in panic disorder and premenstrually normals. Paper presented at the 140th Annual Meeting of the Am. Psychiatric Assoc., Chicago.
9. Clark D.M. A cognitive model of panic attacks. Rachman S., Maser J., Panic: Psychological Perspectives. 1988;Erlbaum, New Jersey.
10. Coplan J.D., Gorman J.M., Klein D.F. Serotonin-related function in panic disorder: a critical overview. Neuropsychopharmacology. 6:1992;189-200.
11. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5:1991;305-315.
12. Delgado P.L., Charney D.S., Price L.H., Aghajanian G.K., Landis H., Heninger G.R. Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch. Gen. Psychiatry. 47:1990;411-418.
13. Den Boer J.A., Westenberg H.G. Effect of a serotonin and noradrenaline uptake inhibitor in panic disorder: a double blind comparative study with fluvoxamine and maprotiline. Int. Clin. Psychopharmacol. 3:1988;59-74.
14. 2. Respir. Physiol. 111:1998;15-23.
15. Duffin J., McAvoy G.V. The peripheral-chemoreceptor threshold to carbon dioxide in man. J. Physiol., London. 406:1988;15-26.
16. Duffin J., Mohan R., Vasiliou P., Stephenson R., Mahamed S. A model of the chemoreflex control of breathing in humans: model parameter measurement. Respir. Physiol. 120:2000;13-26.
17. Evans L., Kenardy J., Schneider P., Hoey H. Effect of a selective serotonin uptake inhibitor in agoraphobia with panic attacks. Acta Psychiatr. 73:1986;49-53.
18. Fernstrom J.D. The role of precursor availability in the control of monoamine biosynthesis in the brain. Physiol. Rev. 63:1983;484-564.
19. Fink B.R. Influence of cerebral activity in wakefulness on regulation of breathing. J. Appl. Physiol. 16:1961;15-20.
20. Gessa G.L., Biggio G., Fadda F., Corsini G.U., Tagliamonte A. Tryptophan-free diet: a new means for rapidly decreasing brain tryptophan content and serotonin synthesis. Acta Vitamin Enzymol. 29:1975;72-78.
21. Gorman J.M., Liebowitz M.R., Fyer A.J., Goetz D., Compeas R.B., Fyer M.R., Davies S.O., Klein D.F. An open trial of fluoxetine in the treatment of panic attacks. J. Clin. Psychopharmacol. 7:1987;329-332.
22. 2-induced panic. Am. J. Psychiatry. 150:(2):1993;250-257.
23. Gorman J.M., Fyer M.R., Goetz R., Askanazi J., Liebowitz M.R., Fyer A.J., Kinney J., Klein D.F. Ventilatory physiology of patients with panic disorder. Arch. Gen. Psychiatry. 45:1988;31-39.
24. 2 vulnerability in panic disorder. Psychiatry Res. 20:1987;87-95.
25. Grove G., Coplan J.D., Hollander E. The neuroanatomy of 5-HT dysregulation in panic disorder. J. Neuropsychiatry Clin. Neurosci. 9:1997;198-207.
26. Hilarie G., Bou C., Monteau R. Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study. Eur. J. Pharmacol. 329:1997;115-126.
27. Hroboticky N., Leiter L.A., Anderson G.H. Menstrual cycle effects on the metabolism of tryptophan loads. Am. J. Clin. Nutr. 50:1989;46-52.
28. Kent J.M., Coplan J.D., Martinez J., Karmally W., Papp L.A., Gorman J.M. Ventilatory effects of tryptophan depletion in panic disorder: a preliminary report. Psychiatry Res. 64:1996;83-90.
29. Kent J.M., Coplan J.D., Gorman J.M. Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety. Biol. Psychiatry. 44:1998;812-824.
30. Kessler R.C., McGonagle K.A., Zhao S., Nelson C.B., Hughes M., Eshleman S., Wittchen H.-U., Kendler K.S. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Arch. Gen. Psychiatry. 51:1994;8-19.
31. Klaassen T., Klumperbeek J., Deutz N.E.P., van Praag H.M., Griez E. Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge. Psychiatry Res. 77:1998;167-174.
32. Klaassen T., Riedel W.J., Deuts Astrin van Somersen N.E.P., van Praag H.M. Specificity of the tryptophan depletion method. Psychopharmacology. 141:1999;279-286.
33. Klein D.F. False suffocation alarms, spontaneous panics, and related conditions. Arch. Gen. Psychiatry. 50:1993;306-317.
34. Koszycki D., Bradwejn J., Bourin M. Comparison of the effects of cholecystokinin-tetrapeptide and carbon dioxide in health volunteers. Eur. Neuropsychopharmacol. 1:(2):1991;137-141.
35. Lalley P.M. Responses of phrenic motoneurons of the cat to stimulation of medullary raphe nuclei. J. Physiol., London. 380:1986;349-371.
36. 2 chemosensitivity in panic disorder. Acta Psychiatr. 77:1988;214-218.
37. Lundberg D.B.A., Mueller R.A., Breese G.R. An evaluation of the mechanism by which serotonergic activation depresses ventilation. J. Pharmacol. Exp. Ther. 212:1980;397-404.
38. Mahamed S., Duffin J. Repeated hypoxic exposures change respiratory chemoreflex control in humans. J. Physiol., London. 534:2001;595-603.
39. Mahamed S., Ali A.F., Ho D., Wang B., Duffin J. The contribution of chemoreflex drives to resting breathing in man. Exp. Physiol. 86:2001;109-116.
40. Miller H., Deakin J.E.W., Anderson I. Acute tryptophan depletion increases panic anxiety in panic disorder patients. J. Psychopharmacol. 9:1996;72.
41. 2-induced anxiety in patients with panic disorder and normal volunteers. Br. J. Psychiatry. 176:2000;182-188.
42. Mitchell G.A., Smith C.A., Jameson L.C., Vidruk E.H., Dempsey J.A. The effects of p-chlorophenylalanine on ventilatory control in goats. J. Appl. Physiol. 54:1983;277-283.
43. Mohan R., Duffin J. The effect of hypoxia on the ventilatory response to carbon dioxide in man. Respir. Physiol. 108:1997;101-115.
44. Moja E.A., Cipollo P., Castoldi D., Tofanetti O. Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats. Life Sci. 44:1989;971-976.
45. Mueller R.A., Lundberg D., Breese G.R. Evidence that respiratory depression by serotonin agonists may be exerted in the central nervous system. Pharmacol. Biochem. Behav. 13:1980;247-255.
46. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., Blier P., Diksic M. Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl. Acad. Sci. USA. 94:1997;5308-5393.
47. Olson E.B., Dempsey J.A., McCrimmon D.R. Serotonin and control of ventilation in the awake rat. J. Clin. Invest. 64:1979;689-693.
48. Phillipson E.A., Bowes G. Control of breathing during sleep. Cherniack N.S., Widdicombe J.G., Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, part 2. 1986;649-689 American Physiological Society, Bethesda.
49. Price L.H., Malison R.T., McDougle C.J., Pelton G.H., Heninger G.R. The neurobiology of tryptophan depletion in depression: effects of intravenous tryptophan infusion. Biol. Psychiatry. 43:1998;339-347.
50. Rasmusson A.M., Anderson G.M., Lynch K.A., McSwiggan-Hardin M., Scahill L.D., Mazure C.M., Goodman W.K., Price L.H., Cohen D.J., Leckman J.F. A preliminary study of tryptophan depletion on ticks, obsessive-compulsive symptoms, and mood in Tourette's syndrome. Biol. Psychiatry. 41:1997;117-121.
51. Reilly J.G., McTavish S.F.B., Young A.H. Rapid depletion of plasma tryptophan: a review of studies and experimental methodology. J. Psychopharmacol. 11:1997;381-392.
52. 2 of neurons in the rostral medulla in vitro. J. Neurophysiol. 73:(3):1995;933-944.
53. Sanderson W.C., Rapee R.M., Barlow D.H. The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide enriched air. Arch. Gen. Psychiatry. 46:1989;157-162.
54. Schneier F.R., Liebowitz M.R., Davies S.O., Fairbanks J., Hollander E., Campeas R., Klein D.F. Fluoxetine in panic disorder. J. Clin. Psychopharmacol. 10:1990;119-121.
55. Schruers K., Klaassen T., Pols H., Overbeek T., Deutz N.E.P., Griez E. Effects of tryptophan depletion on carbon dioxide provoked panic in panic disorder patients. Psychiatry Res. 93:2000;179-187.
56. Stancampiano R., Melis F., Sarais L., Cocco S., Cugusi C., Fadda F. Acute administration of a tryptophan-free amino-acid mixture decreases 5-HT release in rat hippocampus in vivo. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 272:1997;R991-R994.
57. Struzik L., Katzman M., Vijay N., Coonerty-Femiano A., Mahamed S., Duffin J. Central and peripheral chemoreflex characteristics: panic disorder patients vs. healthy volunteers. Poon C.-S., Kazemi H., Frontiers in Modelling and Control of Breathing: Integration at Cellular and Systems Levels. 2001;435-438 Kluwer Acedamic/Plenum Publishers, New York.
58. Torrance R.W. Chemoreception upstream of transmitters. Zapata P., Eyzaguirre C., Torrence R.W., Frontiers of Arterial Chemoreception. 1996;13-38 Plenum Press, New York.
59. Wang W., Pizzonia J.H., Richerson G.B. Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J. Physiol., London. 511:1998;433-450.
60. Weltzin T.E., Fernstrom J.D., McConaha C., Kaye W.H. Acute tryptophan depletion in bulimia: effects on large neutral amino acids. Biol. Psychiatry. 35:1994;388-397.
61. Williams W.A., Shoaf S.E., Hommer D., Rawlings R., Linnoila M. Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers. J. Neurochem. 72:1999;1641-1647.
62. Wittchen H.U., Essan C.A. Epidimiology of panic disorder: progress and unresolved issues. J. Psych. Res. 27:(Suppl 1):1993;47-68.
63. Woods S.W., Charney D.S., Loke W.K., Goodman G.R., Redmond D.E., Henniger G.R. Carbon dioxide sensitivity in panic anxiety. Arch. Gen. Psychiatry. 43:1986;900-909.
64. Young S.N., Smith S.E., Phil R., Ervin F.R. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology. 87:1985;173-177.
65. Young S.N., Ervin F.R., Pihl R.O., Finn P. Biochemical aspects of tryptophan depletion in primates. Psychopharmacology. 98:1989;508-511.